OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Translational Medicine is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Seize the engine: Emerging cell cycle targets in breast cancer	926
	328
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation	235
The deubiquitinase OTUD3 plays a neuroprotective role by reducing ferroptosis induced by cerebral ischaemia reperfusion via stabilizing PLK1 via deubiquitination	183
Targeting receptor for activated C kinase 1 with a small molecule induces mitotic catastrophe and suppresses lipid metabolic reprogramming in hepatocellular carcinoma	152
Profiling of host entry factors in adults and fetuses for severe acute respiratory syndrome coronavirus‐2 infection indicates its developmental regulation	150
Corrigendum to Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway	140
Integrative genome‐wide chromatin accessibility and transcriptome profiling of diffuse large B‐cell lymphoma	133
Glucosamine regulates macrophage function in heart failure	123
Sendotypes predict worsening renal function in chronic kidney disease patients	119
High‐fidelity CRISPR/Cas12a dual‐crRNA screening reveals novel synergistic interactions in hepatocellular carcinoma	118
The future of G protein‐coupled receptor therapeutics: Apelin receptor acts as a prototype for the advancement of precision drug design	115
Predictive medicine in a testis trio‐family through a combined multi‐omics approach	111
Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC	107
	106
Clinical translation potential of self‐inspired live‐cell super‐resolution microscopy	104
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives	101
Deep learning‐based multi‐omics study reveals the polymolecular phenotypic of diabetic kidney disease	98
The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis	86
Towards next‐generation TIL therapy: TILs enriched in neoepitope‐specific T cells	84
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca²⁺ signalling	82
Computational repurposing of oncology drugs through off‐target drug binding interactions from pharmacological databases	79
Emerging point‐of‐care autologous cellular therapy using adipose‐derived stromal vascular fraction for neurodegenerative diseases	79
Deciphering the secret codes in N⁷‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases	78
Dissecting the effect of ileal faecal diversion on the intestine using single‐cell sequencing	77

Faecal zonulin, calprotectin and the infant microbiome in early life	75
Clinical implications of EGFR‐associated MAPK/ERK pathway in multiple primary lung cancer	74
Lysine‐specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti‐programmed death 1 therapy in liver cancer	73
HBV‐integrated local genomic alterations reveal multicentric independent occurrences of multifocal HCC	72
Effect of epigenetic treatment on SST₂ expression in neuroendocrine tumour patients	69
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients	65
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma	65
Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target	63
Illuminating the genomic frontier of invasive non‐typhoidal Salmonella infections	63
MicroRNAs affecting the susceptibility of melanoma cells to CD8⁺ T cell‐mediated cytolysis	62
Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome	61
Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1–Wnt/β‐catenin–TFE3 feedback loop signalling	61
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia	60
Molecular heterogeneity of BCL2/MYC double expressor lymphoma underlies sensitivity to histone deacetylase inhibitor	59
B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging	59
Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways	59
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA	59
Hsa_circ_0057105 modulates a balance of epithelial‐mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma	58
Predictive nomogram integrating radiomics and multi‐omics for improved prognosis‐model in cholangiocarcinoma	56
Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development	56
Mitochondrial and immune response dysregulation in melanoma recurrence	56
Lipids and genes: Regulatory roles of lipids in RNA expression	54
PADI4 facilitates stem‐like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma	54
Low‐intensity pulsed ultrasound improves myocardial ischaemia‒reperfusion injury via migrasome‐mediated mitocytosis	53
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib	50
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NDP‐β‐d‐manno‐heptoses are small molecule agonists sensed by the vertebrates to discriminate organisms of different kingdoms	50
The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease	50
Pericardial delta like non‐canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition	49
Nano‐optogenetic immunotherapy	48
Clinical medicine journals lag behind science journals with regards to “microbiota sequence” data availability	47
Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of ^AGTR1+CAFs in intrahepatic cholangiocarcinoma	47
Multi‐omics molecular phenotyping reveals the potential mechanisms of chemotherapy response and resistance in small cell lung cancer	47
Suicide among patients with cancer: a call to action for researchers and clinical caregivers	47
Synergistic inhibition of progesterone receptor‐A/B signalling by simvastatin and mifepristone in human uterine leiomyomas	47
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Genomic classification of intrapulmonary metastasis and multiple primary lung cancer	45
Predicted early fusion intermediates in the spike of ACE2‐utilising bat coronavirus unveil broad‐spectrum antiviral mechanisms	44
Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia	43
Integrated multi‐omics data reveals the molecular subtypes and guides the androgen receptor signalling inhibitor treatment of prostate cancer	43
Identification of the c‐Jun/H19/miR‐19/JNK1 cascade during hepatic stellate cell activation	43
Major cell types in the coronary thrombosis of acute myocardial infarction patients revealed by scRNA‐seq	43
Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer	42
Translational inhalable extracellular vesicle‐based mRNA therapy for the treatment of lung cancer	42
OXA1L deficiency causes mitochondrial myopathy via reactive oxygen species regulated nuclear factor kappa B signalling pathway	42
PIM1 genetic alterations associated with distinct molecular profiles, phenotypes and drug responses in diffuse large B‐cell lymphoma	41
Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4	41
Blockade of V‐domain immunoglobulin suppressor of T‐cell activation reprograms tumour‐associated macrophages and improves efficacy of PD‐1 inhibitor in gastric cancer	41
KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression	41
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2	40

Plasma tsRNAs as novel diagnostic biomarkers for renal cell carcinoma	39
Dynamics of the intratumoural microbiome across malignant transformation and treatment in breast cancer	39
Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity	38
CAR‐DC combined with CAR‐T therapy for relapsed/refractory acute myeloid leukaemia: Research progress and future perspectives	38
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2	38
The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma	38
The genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer	38
Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis	38
Nanopore sequencing with T2T‐CHM13 for accurate detection and preventing the transmission of structural rearrangements in highly repetitive heterochromatin regions in human embryos	38
Disproportional enrichment of FoxP3⁺CD4⁺ regulatory T cells shapes a suppressive tumour microenvironment in head and neck squamous cell carcinoma	37
The m⁵C methyltransferase NSUN2 promotes codon‐dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer	37
The role of cell‐penetrating peptides in potential anti‐cancer therapy	37
Transcriptomic analysis for the retested positive COVID‐19 patients with long‐term persistent SARS‐CoV‐2 but without symptoms in Wuhan	36
Long‐term survival and association of neoadjuvant chemotherapy with or without immunotherapy in resectable esophageal squamous cell carcinoma	36
WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation	36
In vitro reconstitution of SPO11‐mediated DNA cleavage reveals mechanistic and clinical insights into meiotic DNA double‐strand break formation	36
Efficacy and safety of pyrotinib combined with albumin‐bound paclitaxel as first‐line treatment for HER2‐positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuva	36
Vitamin D receptor activation in microglia suppresses NOX2‐mediated oxidative damage via PAT1 in vitro and in vivo	36
Combination anti‐HIV antibodies to achieve antiretroviral therapy‐free virological suppression in infected individuals	36
Transcriptomic evidence of lung repair in paediatric ARDS survival	35
Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport	35
Identification of hypoxic macrophages in glioblastoma: Unveiling therapeutic insights from tumour microenvironment analysis	35
Illuminating spatial pharmacology with in situ drug imaging	35
17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells	35
In a search of a protective titer: Do we or do we not need to know?	34
The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications	34
Natural killer cell engagers: From bi‐specific to tri‐specific and tetra‐specific engagers for enhanced cancer immunotherapy	34
Downregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy	34
Pathogen sharing in the digital age: The unfinished agenda of the WHO pandemic agreement	34
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Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback loops enhance oncogenic	33
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Transcriptomic profiling reveals the dynamics of fibrotic progression‐related gene expression into post‐coronavirus disease 2019 pulmonary fibrosis	33
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Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer	33
Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics	33
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Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes	32
Gene signature related to cancer stem cells and fibroblasts of stem‐like gastric cancer predicts immunotherapy response	32
The central role of a two‐way positive feedback pathway in molecular targeted therapies‐mediated pyroptosis in anaplastic thyroid cancer	32
Single‐cell sequencing of multi‐region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma	32
The potential of gas plasma technology for targeting breast cancer	32
Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism	32
Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activity	32
Evaluation of on‐ and off‐target effects of self‐assembled epidermal growth factor receptor small interfering RNA delivery system	31
Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long‐chain acyl‐coenzyme A synthase 5	31
Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases	31
Spatial‒temporal heterogeneities of liver cancer and the discovery of the invasive zone	31
Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2	31
IGF2BP3 mediates the mRNA degradation of NF1 to promote triple‐negative breast cancer progression via an m6A‐dependent manner	31
Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm delivery	30
Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil	30
Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat	30
TRIM28 attenuates Bortezomib sensitivity of hepatocellular carcinoma cells through enhanced proteasome expression	30
m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency	30
Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arachidonic acid pathway	29
Interventional‐ and amputation‐stage muscle proteomes in the chronically threatened ischemic limb	29
Multi‐omics analysis of pyroptosis‐related genes for prognosis and immune landscape in head and neck cancer	29
A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcera	29
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Brain cholesterol therapy for Huntington's disease – Does it make sense?	29
Managing noradrenaline after traumatic brain injury	28
Hepatic interleukin‐1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease	28
OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6	28
How the brain produces generalized fear	28
BRAF^V600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization	28
Single‐cell and bulk characterisation of the distinct immune landscape and possible regulatory mechanisms in coronary plaques vulnerability	28
Metastasis ability, genomic profile, subtype characteristic and curative efficacy of multiple pulmonary hematogenous metastases in lung cancer	28
Dynamic alterations of ctDNA associate with the therapeutic outcome in the advanced non‐small cell lung cancer patients who received sintilimab plus anlotinib regime as 1st line therapy	28
Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR‐769‐3p and interaction with GOLM1	28
Gene therapy for Whiskott–Aldrich syndrome: The latest news	27
Neuronal loss drives differentially expressed protein‐pathways in the PSP globus pallidus	27
SAA1 and metabolomic signatures predict hyperprogression with immunotherapy in pan cancers	27
Evaluation of pulmonary single‐cell identity specificity in scRNA‐seq analysis	27
Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma	27
RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples	26
Single‐cell RNA‐seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma	26
Crosstalk between m6A modification and alternative splicing during cancer progression	26
Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy	26
Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies	26

Integrated multi‐omics profiling landscape of organising pneumonia	26
Ensemble biomarkers for guiding anti‐angiogenesis therapy for ovarian cancer using deep learning	26
CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells	26
Human umbilical cord mesenchymal stem cells therapy alleviates kidney injury and podocyte apoptosis in Col4a5 knockout male mice	26
T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma	26
RNA interference therapy for targeting ANGPTL3 and atherogenic lipoproteins: Findings and implications of a recent phase I study	26
Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19	26
Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids	26
Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer	26
Single‐nucleus and spatial transcriptomics of paediatric ovary: Molecular insights into the dysregulated signalling pathways underlying premature ovarian insufficiency in classic galactosemia	26
Evaluation of vaccine effectiveness against SARS‐CoV‐2 variants by serological epitope profiling	25
Issue Information	25
Issue Information	25
Correction to VEGF‐C/VEGFR‐3 axis protects against pressure‐overload‐induced cardiac dysfunction through regulation of lymphangiogenesis	25
Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts	25
Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis	25
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing	25
Interleukin‐2/anti‐interleukin‐2 immune complex attenuates cold ischemia‐reperfusion injury after kidney transplantation by increasing renal regulatory T cells	25
Integrated mPD‐L1 and metabolic analysis identifies new prognostic subgroups in lung cancers with wild‐type EGFR	25
Diagnostic and therapeutic potential of tonic gamma‐aminobutyric acid from reactive astrocytes in brain diseases	25
Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling	25
Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage	24
PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron	24
Machine learning‐based multi‐omics models for diagnostic classification and risk stratification in diabetic kidney disease	24
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing	24
Translational potential of human brain charts	24
How the environment shapes our ability to navigate	24
Understanding Omicron: Transmissibility, immune evasion and antiviral intervention	24
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth	24
Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma	24
Advancing standards in biomedical image analysis validation: A perspective on Metrics Reloaded	24
Human gut‐associated lymphoid tissue: A dynamic hub propagating modulators of inflammation	23
Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin	23
CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways	23
YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2	23
Single‐cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy	23
Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease	23
Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption	23
Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion	23
Mutations of epigenetic genes and correlation with treatment response in peripheral T‐cell lymphoma	23
MiRNA‐501‐3p and MiRNA‐502‐3p: A promising biomarker panel for Alzheimer's disease	23
The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia	23
Urinary DNA methylation‐based risk stratification model to triage patients for repeat transurethral resection of bladder tumours	23
Glutamate as a therapeutic strategy to promote liver regeneration	23
Identification of growth hormone receptor as a relevant target for precision medicine in low‐EGFR expressing glioblastoma	23
Single‐nucleus transcriptomic profiling reveals temporal dynamics of neuroinflammation and myelin repair after intracerebral haemorrhage	22
Snai2‐mediated upregulation of NADSYN1 promotes bladder cancer progression by interacting with PHB	22
Single‐cell transcriptome analysis reveals functional changes in tumour‐infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma	22
lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis	22
Correction to“Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication”	22
Smad3‐mediated lncRNA HSALR1 enhances the non‐classic signalling pathway of TGF‐β1 in human bronchial fibroblasts by binding to HSP90AB1	22
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model	22
Asymmetric bilayer dressings with spatiotemporal sequence loaded with IL‐24 and GCDs for the treatment of diabetic wounds	22
Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm	22
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Clinical predictive factors and prediction models for end‐stage renal disease in Chinese patients with type 2 diabetes mellitus	22
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner	22
Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke	22
Early molecular changes predict cancer cachexia in LKB1‐deleted mouse models of NSCLC	22
KMT2C/D mutations in newly diagnosed acute myeloid leukaemia: Clinical features, genetic co‐occurrences and prognostic significance	22
Transcriptomic atlas of GNAT family members in pulmonary epithelia under pathological conditions using single‐cell and bulk cell sequencing	21
LEPRE1 shapes a non‐flamed tumour immune landscape and predicts the prognosis in esophageal squamous cell carcinoma	21
Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis	21
Issue Information	21
The co‐location of CD14+APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer	21
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Comparative spatial transcriptomics of pancreatic cancer with ductal and acinar origins in mouse models	21
Unconventional microRNA role: Enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer	21
Single‐cell isogrowth profiling: Uniform inhibition uncovers non‐uniform drug responses	21
Prognosis‐oriented molecular subtypes of retroperitoneal liposarcoma	21
Advanced mutant receptor activator of nuclear factor kappa‐Β ligand development with low affinity for osteoprotegerin	21
One step forward for nanopore protein sequencing	21
MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment	20
Atg7 in CD4⁺ T cells improves intestinal mucosal inflammation by regulating Ets1‐mediated T cell differentiation	20
Identification of hepatitis B virus infection and integration and its oncogenic role in gastric cancer	20
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity	20
Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single‐cell transcriptomes analysis	20
Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism	20
IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer	20
N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis	20
Single‐molecule epiallelic profiling of DNA derived from routinely collected Pap specimens for noninvasive detection of ovarian cancer	20
Three‐dimensional genome structure shapes the recombination landscape of chromatin features during female germline stem cell development	20
Methionine oxidation of CLK4 promotes the metabolic switch and redox homeostasis in esophageal carcinoma via inhibiting MITF selective autophagy	20
Preparation for the challenge of heavily mutated Omicron variant	20
Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome	20
CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations	19
Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype	19
Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodelling	19
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Prediction of clinical risk assessment and survival in chronic obstructive pulmonary disease with pulmonary hypertension	19
Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis‐induced formation of neutrophil extracellular traps	19
Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade	19
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double‐blind, place	19
Decoding of exosome heterogeneity for cancer theranostics	19