OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Translational Medicine is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals	653
Corrigendum to Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway	228
Glucosamine regulates macrophage function in heart failure	201
Faecal zonulin, calprotectin and the infant microbiome in early life	153
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca²⁺ signalling	141
Deep learning‐based multi‐omics study reveals the polymolecular phenotypic of diabetic kidney disease	140
Integrative genome‐wide chromatin accessibility and transcriptome profiling of diffuse large B‐cell lymphoma	131
B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging	127
Profiling of host entry factors in adults and fetuses for severe acute respiratory syndrome coronavirus‐2 infection indicates its developmental regulation	127
Predictive medicine in a testis trio‐family through a combined multi‐omics approach	122
Computational repurposing of oncology drugs through off‐target drug binding interactions from pharmacological databases	111
High‐fidelity CRISPR/Cas12a dual‐crRNA screening reveals novel synergistic interactions in hepatocellular carcinoma	108
Effect of epigenetic treatment on SST₂ expression in neuroendocrine tumour patients	97
PADI4 facilitates stem‐like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma	97
The future of G protein‐coupled receptor therapeutics: Apelin receptor acts as a prototype for the advancement of precision drug design	96
Lipids and genes: Regulatory roles of lipids in RNA expression	95
Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC	95
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation	92
Molecular heterogeneity of BCL2/MYC double expressor lymphoma underlies sensitivity to histone deacetylase inhibitor	91
Towards next‐generation TIL therapy: TILs enriched in neoepitope‐specific T cells	84
HBV‐integrated local genomic alterations reveal multicentric independent occurrences of multifocal HCC	82
	80
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Predictive nomogram integrating radiomics and multi‐omics for improved prognosis‐model in cholangiocarcinoma	77
MicroRNAs affecting the susceptibility of melanoma cells to CD8⁺ T cell‐mediated cytolysis	74

A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia	74
The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis	73
Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation	69
Deciphering the secret codes in N⁷‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases	68
Dissecting the effect of ileal faecal diversion on the intestine using single‐cell sequencing	68
Potential of peptide‐engineered exosomes with overexpressed miR‐92b‐3p in anti‐angiogenic therapy of ovarian cancer	63
Hsa_circ_0057105 modulates a balance of epithelial‐mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma	61
Emerging point‐of‐care autologous cellular therapy using adipose‐derived stromal vascular fraction for neurodegenerative diseases	60
Seize the engine: Emerging cell cycle targets in breast cancer	59
Clinical implications of EGFR‐associated MAPK/ERK pathway in multiple primary lung cancer	56
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma	54
Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target	54
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives	54
Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population	53
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients	53
Sendotypes predict worsening renal function in chronic kidney disease patients	53
Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome	52
Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways	52
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA	52
Low‐intensity pulsed ultrasound improves myocardial ischaemia‒reperfusion injury via migrasome‐mediated mitocytosis	52
Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1–Wnt/β‐catenin–TFE3 feedback loop signalling	51
Mitochondrial and immune response dysregulation in melanoma recurrence	51
The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease	51
Synergistic inhibition of progesterone receptor‐A/B signalling by simvastatin and mifepristone in human uterine leiomyomas	50
Clinical medicine journals lag behind science journals with regards to “microbiota sequence” data availability	49
MYTH: An algorithm to score intratumour heterogeneity based on alterations of DNA methylation profiles	48
Multi‐omics molecular phenotyping reveals the potential mechanisms of chemotherapy response and resistance in small cell lung cancer	47
Identification of the c‐Jun/H19/miR‐19/JNK1 cascade during hepatic stellate cell activation	47
The genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer	47
	47
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib	46
Disproportional enrichment of FoxP3⁺CD4⁺ regulatory T cells shapes a suppressive tumour microenvironment in head and neck squamous cell carcinoma	46
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2	45
Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts	45
Blockade of V‐domain immunoglobulin suppressor of T‐cell activation reprograms tumour‐associated macrophages and improves efficacy of PD‐1 inhibitor in gastric cancer	44
Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis	44
Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR‐302a	43
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2	43
The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma	43
Integrated multi‐omics data reveals the molecular subtypes and guides the androgen receptor signalling inhibitor treatment of prostate cancer	43
Plasma tsRNAs as novel diagnostic biomarkers for renal cell carcinoma	42
PIM1 genetic alterations associated with distinct molecular profiles, phenotypes and drug responses in diffuse large B‐cell lymphoma	42
Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity	42
Suicide among patients with cancer: a call to action for researchers and clinical caregivers	41
Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of ^AGTR1+CAFs in intrahepatic cholangiocarcinoma	41
Nanopore sequencing with T2T‐CHM13 for accurate detection and preventing the transmission of structural rearrangements in highly repetitive heterochromatin regions in human embryos	41
Major cell types in the coronary thrombosis of acute myocardial infarction patients revealed by scRNA‐seq	40
Translational inhalable extracellular vesicle‐based mRNA therapy for the treatment of lung cancer	40
NDP‐β‐d‐manno‐heptoses are small molecule agonists sensed by the vertebrates to discriminate organisms of different kingdoms	40
Pericardial delta like non‐canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition	39

	38
Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia	38
Differential miRNA plasma profiles associated with the spontaneous loss of HIV‐1 control: miR‐199a‐3p and its potential role as a biomarker for quick screening of elite controllers	37
Nano‐optogenetic immunotherapy	37
Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer	37
Protective function of interleukin‐22 in pulmonary fibrosis	36
KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression	36
Gene signature related to cancer stem cells and fibroblasts of stem‐like gastric cancer predicts immunotherapy response	35
The role of cell‐penetrating peptides in potential anti‐cancer therapy	35
In a search of a protective titer: Do we or do we not need to know?	35
The m⁵C methyltransferase NSUN2 promotes codon‐dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer	35
Illuminating spatial pharmacology with in situ drug imaging	35
Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4	35
Transcriptomic analysis for the retested positive COVID‐19 patients with long‐term persistent SARS‐CoV‐2 but without symptoms in Wuhan	34
Vitamin D receptor activation in microglia suppresses NOX2‐mediated oxidative damage via PAT1 in vitro and in vivo	34
Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport	34
Brain cholesterol therapy for Huntington's disease – Does it make sense?	33
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Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat	33
Human and mouse non‐targeted metabolomics identify 1,5‐anhydroglucitol as SGLT2‐dependent glycemic marker	33
Single‐cell sequencing of multi‐region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma	33
TRIM28 attenuates Bortezomib sensitivity of hepatocellular carcinoma cells through enhanced proteasome expression	33
LncRNA nuclear‐enriched abundant transcript 1 shuttled by prostate cancer cells‐secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR‐205‐5p/runt‐related	32
WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation	32
Spatial‒temporal heterogeneities of liver cancer and the discovery of the invasive zone	32
Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes	32
Efficacy and safety of pyrotinib combined with albumin‐bound paclitaxel as first‐line treatment for HER2‐positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuva	31
Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics	31
Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activity	31
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Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum–hippocampus cholinergic pathway	30
The potential of gas plasma technology for targeting breast cancer	30
Therapeutic targeting of SPIB/SPI1‐facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression	30
IGF2BP3 mediates the mRNA degradation of NF1 to promote triple‐negative breast cancer progression via an m6A‐dependent manner	30
Transcriptomic evidence of lung repair in paediatric ARDS survival	30
Natural killer cell engagers: From bi‐specific to tri‐specific and tetra‐specific engagers for enhanced cancer immunotherapy	30
A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity	29
The prevalence and clinical implication of rare germline deleterious alterations in Chinese patients with prostate cancer: A real‐world multicenter study	29
Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arachidonic acid pathway	29
Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases	29
Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long‐chain acyl‐coenzyme A synthase 5	29
Evaluation of on‐ and off‐target effects of self‐assembled epidermal growth factor receptor small interfering RNA delivery system	29
Combination anti‐HIV antibodies to achieve antiretroviral therapy‐free virological suppression in infected individuals	29
Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm delivery	28
Plasmatic and myocardial microRNA profiles in patients with Hypertrophic Cardiomyopathy	28
Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2	28
Transcriptomic profiling reveals the dynamics of fibrotic progression‐related gene expression into post‐coronavirus disease 2019 pulmonary fibrosis	28
Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer	28
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Identification of hypoxic macrophages in glioblastoma: Unveiling therapeutic insights from tumour microenvironment analysis	28
17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells	28
Combining single‐cell sequencing to identify key immune genes and construct the prognostic evaluation model for colon cancer patients	28
Interventional‐ and amputation‐stage muscle proteomes in the chronically threatened ischemic limb	28
A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcera	27
Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism	27
Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil	27
Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback loops enhance oncogenic	27
The central role of a two‐way positive feedback pathway in molecular targeted therapies‐mediated pyroptosis in anaplastic thyroid cancer	27
A novel role for interleukin 32 in cholestasis	26
m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency	26
Dynamic alterations of ctDNA associate with the therapeutic outcome in the advanced non‐small cell lung cancer patients who received sintilimab plus anlotinib regime as 1st line therapy	26
RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples	26
Managing noradrenaline after traumatic brain injury	26
BRAF^V600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterisation	25
Gene therapy for Whiskott–Aldrich syndrome: The latest news	25
Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy	25
Novel deep learning radiomics model for preoperative evaluation of hepatocellular carcinoma differentiation based on computed tomography data	25
SAA1 and metabolomic signatures predict hyperprogression with immunotherapy in pan cancers	25
RNA interference therapy for targeting ANGPTL3 and atherogenic lipoproteins: Findings and implications of a recent phase I study	25
CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells	25
Prognostic, clinicopathological, and immune correlation of NLRP3 promoter methylation in kidney renal clear cell carcinoma	25
Metastasis ability, genomic profile, subtype characteristic and curative efficacy of multiple pulmonary hematogenous metastases in lung cancer	25
Single‐cell and bulk characterisation of the distinct immune landscape and possible regulatory mechanisms in coronary plaques vulnerability	25
Multi‐omics analysis of pyroptosis‐related genes for prognosis and immune landscape in head and neck cancer	25
How the brain produces generalized fear	24
Interleukin enhancer‐binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma	24
Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids	24
Ensemble biomarkers for guiding anti‐angiogenesis therapy for ovarian cancer using deep learning	24
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SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases	24

Glioma glycolipid metabolism: MSI2–SNORD12B–FIP1L1–ZBTB4 feedback loop as a potential treatment target	24
Integrated multi‐omics profiling landscape of organising pneumonia	24
Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies	24
Single‐cell RNA‐seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma	24
Hepatic interleukin‐1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease	24
Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19	24
A folate/RGD‐dual‐functionalized mesoporous silica nanoparticles targeting GABA‐p38 MAPK‐MRTFs/SRF signaling pathway in rheumatoid arthritis	23
Pyroptosis, metabolism, and tumor immune microenvironment	23
Evaluation of pulmonary single‐cell identity specificity in scRNA‐seq analysis	23
The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission	23
OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6	23
Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR‐769‐3p and interaction with GOLM1	23
Single‐nucleus and spatial transcriptomics of paediatric ovary: Molecular insights into the dysregulated signalling pathways underlying premature ovarian insufficiency in classic galactosemia	23
Neuronal loss drives differentially expressed protein‐pathways in the PSP globus pallidus	22
Synthetic molecular sensors based on CRISPR‐Cas9 redirect anticancer signal flows to treat retinoblastomas	22
Issue Information	22
Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis	22
Crosstalk between m6A modification and alternative splicing during cancer progression	22
Mutations of epigenetic genes and correlation with treatment response in peripheral T‐cell lymphoma	22
Diagnostic and therapeutic potential of tonic gamma‐aminobutyric acid from reactive astrocytes in brain diseases	21
How the environment shapes our ability to navigate	21
Identification of potential vaccine targets for COVID‐19 by combining single‐cell and bulk TCR sequencing	21
Single‐cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy	21
Issue Information	21
Interleukin‐2/anti‐interleukin‐2 immune complex attenuates cold ischemia‐reperfusion injury after kidney transplantation by increasing renal regulatory T cells	21
Clinical predictive factors and prediction models for end‐stage renal disease in Chinese patients with type 2 diabetes mellitus	21
Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma	21
Correction to VEGF‐C/VEGFR‐3 axis protects against pressure‐overload‐induced cardiac dysfunction through regulation of lymphangiogenesis	21
Machine learning algorithms utilizing blood parameters enable early detection of immunethrombotic dysregulation in COVID‐19	21
Evaluation of vaccine effectiveness against SARS‐CoV‐2 variants by serological epitope profiling	21
Translational potential of human brain charts	21
Urinary DNA methylation‐based risk stratification model to triage patients for repeat transurethral resection of bladder tumours	21
Integrated mPD‐L1 and metabolic analysis identifies new prognostic subgroups in lung cancers with wild‐type EGFR	21
Understanding Omicron: Transmissibility, immune evasion and antiviral intervention	20
Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease	20
Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin	20
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner	20
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing	20
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing	20
Identification of growth hormone receptor as a relevant target for precision medicine in low‐EGFR expressing glioblastoma	20
Single‐cell transcriptome analysis reveals functional changes in tumour‐infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma	20
Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts	20
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth	20
Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption	20
Smad3‐mediated lncRNA HSALR1 enhances the non‐classic signalling pathway of TGF‐β1 in human bronchial fibroblasts by binding to HSP90AB1	20
Machine learning‐based multi‐omics models for diagnostic classification and risk stratification in diabetic kidney disease	20
Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke	20
Human gut‐associated lymphoid tissue: A dynamic hub propagating modulators of inflammation	20
Snai2‐mediated upregulation of NADSYN1 promotes bladder cancer progression by interacting with PHB	20
The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia	20
PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron	20
Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single‐cell transcriptomes analysis	19
Evolution of aberrant brain‐wide spatiotemporal dynamics of resting‐state networks in a Huntington's disease mouse model	19
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Single‐cell isogrowth profiling: Uniform inhibition uncovers non‐uniform drug responses	19
Identification of hepatitis B virus infection and integration and its oncogenic role in gastric cancer	19
Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype	19
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model	19
Serum amlyoid A: An inflammatory adipokine mediating postburn outcomes	19
Methionine oxidation of CLK4 promotes the metabolic switch and redox homeostasis in esophageal carcinoma via inhibiting MITF selective autophagy	19
Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome	19
Clinical and molecular features of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma: Results in a multi‐center trial	19
Transcriptomic atlas of GNAT family members in pulmonary epithelia under pathological conditions using single‐cell and bulk cell sequencing	19
One step forward for nanopore protein sequencing	19
Rictor/mTORC2 signalling contributes to renal vascular endothelial‐to‐mesenchymal transition and renal allograft interstitial fibrosis by regulating BNIP3‐mediated mitophagy	19
lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis	19
LEPRE1 shapes a non‐flamed tumour immune landscape and predicts the prognosis in esophageal squamous cell carcinoma	19
Ultrasound‐guided percutaneous metal‐organic frameworks based codelivery system of doxorubicin/acetazolamide for hepatocellular carcinoma therapy	19
Unconventional microRNA role: Enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer	18
Issue Information	18
Three‐dimensional genome structure shapes the recombination landscape of chromatin features during female germline stem cell development	18
Prognosis‐oriented molecular subtypes of retroperitoneal liposarcoma	18
Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation	18
Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodelling	18
P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities	18
Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis	18
Preparation for the challenge of heavily mutated Omicron variant	18
MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment	18
N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis	18
GPR65, a novel regulator of helper T‐cell polarization in inflammatory bowel disease	18
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Advanced mutant receptor activator of nuclear factor kappa‐Β ligand development with low affinity for osteoprotegerin	18
Single‐molecule epiallelic profiling of DNA derived from routinely collected Pap specimens for noninvasive detection of ovarian cancer	18
The co‐location of CD14+APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer	18
Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm	18
IRF2‐mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells by acting as a competing endogenous RNA	18
Correction to“Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication”	18
MOPSS: Toward high‐fidelity oligonucleotides for clinical applications	17
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Serum amyloid A promotes emphysema by triggering the reciprocal activation of neutrophils and ILC3s	17
AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic	17
Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma	17
Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR	17
Non‐coding RNAs and colitis‐associated cancer: Mechanisms and clinical applications	17
The roles and therapeutic implications of messenger RNA internal N⁷‐methylguanosine and N⁶‐methyladenosine modifications in chemoresistance	17