Clinical and Translational Medicine

Article	Citations
The future of G protein‐coupled receptor therapeutics: Apelin receptor acts as a prototype for the advancement of precision drug design	413
Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC	365
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HBV‐integrated local genomic alterations reveal multicentric independent occurrences of multifocal HCC	151
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Sendotypes predict worsening renal function in chronic kidney disease patients	123
Corrigendum to Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway	120
Predictive nomogram integrating radiomics and multi‐omics for improved prognosis‐model in cholangiocarcinoma	101
Deep learning‐based multi‐omics study reveals the polymolecular phenotypic of diabetic kidney disease	100
Targeting receptor for activated C kinase 1 with a small molecule induces mitotic catastrophe and suppresses lipid metabolic reprogramming in hepatocellular carcinoma	97
MicroRNAs affecting the susceptibility of melanoma cells to CD8+ T cell‐mediated cytolysis	96
Molecular heterogeneity of BCL2/MYC double expressor lymphoma underlies sensitivity to histone deacetylase inhibitor	92
A droplet that releases stress: Drop‐printing for conformal bioelectronics at neural and soft‐tissue interfaces	91
Macrophage Cluster of Differentiation 163 promotes post‐infarction cardiac repair and preserves left ventricular function via osteopontin	84
Predictive medicine in a testis trio‐family through a combined multi‐omics approach	83
Computational repurposing of oncology drugs through off‐target drug binding interactions from pharmacological databases	82
Dissecting the effect of ileal faecal diversion on the intestine using single‐cell sequencing	79
Emerging point‐of‐care autologous cellular therapy using adipose‐derived stromal vascular fraction for neurodegenerative diseases	77
Clinical translation potential of self‐inspired live‐cell super‐resolution microscopy	75
Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer	73
Towards next‐generation TIL therapy: TILs enriched in neoepitope‐specific T cells	70
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients	69
PADI4 facilitates stem‐like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma	68
Targeting lysine methyltransferase 2C deficiency: New frontiers in breast cancer therapy and prognosis	68
High‐fidelity CRISPR/Cas12a dual‐crRNA screening reveals novel synergistic interactions in hepatocellular carcinoma	66

The biological burden of conflict across populations worldwide	66
Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways	65
Ubc9‐mediated SUMOylation of Ninj1 alleviates inflammatory responses in hepatic ischaemia/reperfusion injury	62
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation	62
Faecal zonulin, calprotectin and the infant microbiome in early life	62
Seize the engine: Emerging cell cycle targets in breast cancer	62
Hsa_circ_0057105 modulates a balance of epithelial‐mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma	61
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia	60
Quantum biology: From mechanisms to medicine	60
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma	59
Low‐intensity pulsed ultrasound improves myocardial ischaemia‒reperfusion injury via migrasome‐mediated mitocytosis	57
Recipient‐derived macrophages mediate acute cardiac allograft rejection via GSDMD‐induced pyroptosis mechanism	57
The emerging dialogue between synthetic genomics and clinical research	57
Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases	56
Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development	55
The deubiquitinase OTUD3 plays a neuroprotective role by reducing ferroptosis induced by cerebral ischaemia reperfusion via stabilizing PLK1 via deubiquitination	55
Illuminating the genomic frontier of invasive non‐typhoidal Salmonella infections	54
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling	53
Mitochondrial and immune response dysregulation in melanoma recurrence	52
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Synergistic inhibition of progesterone receptor‐A/B signalling by simvastatin and mifepristone in human uterine leiomyomas	51
Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target	51
NDP‐β‐d‐manno‐heptoses are small molecule agonists sensed by the vertebrates to discriminate organisms of different kingdoms	51
Lysine‐specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti‐programmed death 1 therapy in liver cancer	51
Multi‐omics molecular phenotyping reveals the potential mechanisms of chemotherapy response and resistance in small cell lung cancer	50
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Predicted early fusion intermediates in the spike of ACE2‐utilising bat coronavirus unveil broad‐spectrum antiviral mechanisms	48
OXA1L deficiency causes mitochondrial myopathy via reactive oxygen species regulated nuclear factor kappa B signalling pathway	48
Dynamics of the intratumoural microbiome across malignant transformation and treatment in breast cancer	48
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib	48
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2	47
Tumour‐targeted fluorescence‐guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research	47
Identification of the c‐Jun/H19/miR‐19/JNK1 cascade during hepatic stellate cell activation	47
Nanopore sequencing with T2T‐CHM13 for accurate detection and preventing the transmission of structural rearrangements in highly repetitive heterochromatin regions in human embryos	46
Translational inhalable extracellular vesicle‐based mRNA therapy for the treatment of lung cancer	46
Erratum to “Clinic‐ready inhibitor of MMP−9/−12 restores sensory and functional decline in rodent models of spinal cord injury”	46
Major cell types in the coronary thrombosis of acute myocardial infarction patients revealed by scRNA‐seq	46
Nano‐optogenetic immunotherapy	45
CAR‐DC combined with CAR‐T therapy for relapsed/refractory acute myeloid leukaemia: Research progress and future perspectives	45
Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia	45
Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer	44
Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation	44
Pericardial delta like non‐canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition	44
ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m 1 A demethylation	44
Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity	43
Plasma tsRNAs as novel diagnostic biomarkers for renal cell carcinoma	43
Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling	43
Blockade of V‐domain immunoglobulin suppressor of T‐cell activation reprograms tumour‐associated macrophages and improves efficacy of PD‐1 inhibitor in gastric cancer	43
Adipocyte fatty acid‐binding protein as a cerebrospinal fluid–accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation	43
KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression	43

Genomic classification of intrapulmonary metastasis and multiple primary lung cancer	43
Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis	42
Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of AGTR1+CAFs in intrahepatic cholangiocarcinoma	42
The m5C methyltransferase NSUN2 promotes codon‐dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer	42
Combination anti‐HIV antibodies to achieve antiretroviral therapy‐free virological suppression in infected individuals	41
Long‐term survival and association of neoadjuvant chemotherapy with or without immunotherapy in resectable esophageal squamous cell carcinoma	41
Illuminating spatial pharmacology with in situ drug imaging	41
In vitro reconstitution of SPO11‐mediated DNA cleavage reveals mechanistic and clinical insights into meiotic DNA double‐strand break formation	41
Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm delivery	40
17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells	40
Identification of hypoxic macrophages in glioblastoma: Unveiling therapeutic insights from tumour microenvironment analysis	39
Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes	39
Single‐cell sequencing of multi‐region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma	38
IGF2BP3 mediates the mRNA degradation of NF1 to promote triple‐negative breast cancer progression via an m6A‐dependent manner	38
Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long‐chain acyl‐coenzyme A synthase 5	38
Transcriptomic analysis for the retested positive COVID‐19 patients with long‐term persistent SARS‐CoV‐2 but without symptoms in Wuhan	38
A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcera	38
Spatial‒temporal heterogeneities of liver cancer and the discovery of the invasive zone	38
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Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport	37
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Brain cholesterol therapy for Huntington's disease – Does it make sense?	37
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The potential of gas plasma technology for targeting breast cancer	36
Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics	36
Pathogen sharing in the digital age: The unfinished agenda of the WHO pandemic agreement	36
Downregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy	35
Transcriptomic profiling reveals the dynamics of fibrotic progression‐related gene expression into post‐coronavirus disease 2019 pulmonary fibrosis	35
Evaluation of on‐ and off‐target effects of self‐assembled epidermal growth factor receptor small interfering RNA delivery system	35
Vitamin D receptor activation in microglia suppresses NOX2‐mediated oxidative damage via PAT1 in vitro and in vivo	35
The rise of marine fungi: Drug discovery's blue frontier	35
Gene signature related to cancer stem cells and fibroblasts of stem‐like gastric cancer predicts immunotherapy response	35
Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activity	34
Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat	34
CLINICAL AND TRANSLATIONAL MEDICINE	34
A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity	33
Transcriptomic evidence of lung repair in paediatric ARDS survival	33
Efficacy and safety of pyrotinib combined with albumin‐bound paclitaxel as first‐line treatment for HER2‐positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuva	33
Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases	33
Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil	32
Conditional knockout of membrane‐type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function	32
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Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arachidonic acid pathway	32
The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications	32
Natural killer cell engagers: From bi‐specific to tri‐specific and tetra‐specific engagers for enhanced cancer immunotherapy	32
Human umbilical cord mesenchymal stem cells therapy alleviates kidney injury and podocyte apoptosis in Col4a5 knockout male mice	31
Metastasis ability, genomic profile, subtype characteristic and curative efficacy of multiple pulmonary hematogenous metastases in lung cancer	31
P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis	31
Dynamic alterations of ctDNA associate with the therapeutic outcome in the advanced non‐small cell lung cancer patients who received sintilimab plus anlotinib regime as 1st line therapy	31
Multi‐omics analysis of pyroptosis‐related genes for prognosis and immune landscape in head and neck cancer	31
Neuronal loss drives differentially expressed protein‐pathways in the PSP globus pallidus	31
How the brain produces generalized fear	31
Managing noradrenaline after traumatic brain injury	31
Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids	30
Single‐cell and bulk characterisation of the distinct immune landscape and possible regulatory mechanisms in coronary plaques vulnerability	30
BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization	30
Hepatic interleukin‐1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease	30
Ensemble biomarkers for guiding anti‐angiogenesis therapy for ovarian cancer using deep learning	30
CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells	30
Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy	30
SAA1 and metabolomic signatures predict hyperprogression with immunotherapy in pan cancers	30
T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma	30
Spatial and single‐cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms	30
OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6	29
Improving detection of colorectal cancer: A Bayesian approach to serial circulating tumour DNA testing following curative‐intent treatment.	29
Single‐nucleus and spatial transcriptomics of paediatric ovary: Molecular insights into the dysregulated signalling pathways underlying premature ovarian insufficiency in classic galactosemia	29
Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies	29
Evaluation of pulmonary single‐cell identity specificity in scRNA‐seq analysis	29
Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma	29
RNA interference therapy for targeting ANGPTL3 and atherogenic lipoproteins: Findings and implications of a recent phase I study	29
Integrated multi‐omics profiling landscape of organising pneumonia	29
Crosstalk between m6A modification and alternative splicing during cancer progression	28
Correction to VEGF‐C/VEGFR‐3 axis protects against pressure‐overload‐induced cardiac dysfunction through regulation of lymphangiogenesis	28
Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts	28
Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR‐769‐3p and interaction with GOLM1	28
Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer	28
Issue Information	28
Role of LncSNHG5 in MAFLD: Mechanisms of Arid1a K391 lactylation and lipid accumulation	28
Evaluation of vaccine effectiveness against SARS‐CoV‐2 variants by serological epitope profiling	28
Issue Information	28

Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth	27
Plasma cell‐free DNA markers predict occult metastases in patients with resectable pancreatic ductal adenocarcinoma	27
Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage	27
Machine learning‐based multi‐omics models for diagnostic classification and risk stratification in diabetic kidney disease	27
Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease	27
Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis	27
Integrated multi‐regional multiomic profiling of breast phyllodes tumours reveals peritumoural immune activation and stromal remodelling	27
Advancing standards in biomedical image analysis validation: A perspective on Metrics Reloaded	27
Systemic lupus erythematosus extends beyond a type I interferonopathy, as demonstrated by NET‐activated monocytes	27
Glutamate as a therapeutic strategy to promote liver regeneration	26
CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways	26
Snai2‐mediated upregulation of NADSYN1 promotes bladder cancer progression by interacting with PHB	26
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Mutations of epigenetic genes and correlation with treatment response in peripheral T‐cell lymphoma	26
Smad3‐mediated lncRNA HSALR1 enhances the non‐classic signalling pathway of TGF‐β1 in human bronchial fibroblasts by binding to HSP90AB1	26
Urinary DNA methylation‐based risk stratification model to triage patients for repeat transurethral resection of bladder tumours	26
The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia	26
Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion	26
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner	26
MiRNA‐501‐3p and MiRNA‐502‐3p: A promising biomarker panel for Alzheimer's disease	25
Single‐cell transcriptome analysis reveals functional changes in tumour‐infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma	25
Human gut‐associated lymphoid tissue: A dynamic hub propagating modulators of inflammation	25
Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption	25
Single‐nucleus transcriptomic profiling reveals temporal dynamics of neuroinflammation and myelin repair after intracerebral haemorrhage	25
Histone lactylation‐mediated up‐regulation of IGF2BP2 enhances ferroptosis resistance via Nrf2 in colorectal cancer	25
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing	25
Clinical predictive factors and prediction models for end‐stage renal disease in Chinese patients with type 2 diabetes mellitus	25
YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2	25
Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma	25
CLINICAL AND TRANSLATIONAL MEDICINE	25
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing	25
Diagnostic and therapeutic potential of tonic gamma‐aminobutyric acid from reactive astrocytes in brain diseases	25
HepAssis2 ® bioartificial liver system in treating acute‐on‐chronic liver failure patients: Findings from a phase 1 randomised, open‐label clinical t	25
Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling	25
TMEM92 shields DDX3X from TTC3‐mediated degradation to confer chemoresistance in triple‐negative breast cancer	25
Interleukin‐2/anti‐interleukin‐2 immune complex attenuates cold ischemia‐reperfusion injury after kidney transplantation by increasing renal regulatory T cells	25
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model	24
Asymmetric bilayer dressings with spatiotemporal sequence loaded with IL‐24 and GCDs for the treatment of diabetic wounds	24
Single‐cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy	24
Correction to“Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication”	24
Early molecular changes predict cancer cachexia in LKB1‐deleted mouse models of NSCLC	24
Issue Information	24
N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis	23
Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome	23
LEPRE1 shapes a non‐flamed tumour immune landscape and predicts the prognosis in esophageal squamous cell carcinoma	23
Immune cell subset profiling and metabolic dysregulation define the divergent immune microenvironments in HIV immunological non‐responders	23
Soluble IL‐2R: A potential therapeutic target for mitochondrial dysfunction in post‐COVID fatigue syndrome	23
One step forward for nanopore protein sequencing	23
Advanced mutant receptor activator of nuclear factor kappa‐Β ligand development with low affinity for osteoprotegerin	23
KMT2C/D mutations in newly diagnosed acute myeloid leukaemia: Clinical features, genetic co‐occurrences and prognostic significance	23
Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm	23
lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis	23
Evolution of aberrant brain‐wide spatiotemporal dynamics of resting‐state networks in a Huntington's disease mouse model	23
Identification of hepatitis B virus infection and integration and its oncogenic role in gastric cancer	23
Single‐molecule epiallelic profiling of DNA derived from routinely collected Pap specimens for noninvasive detection of ovarian cancer	23
A novel integrated miRNA–donor age signature enables detection of cardiac allograft vasculopathy	23
Unconventional microRNA role: Enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer	23
Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single‐cell transcriptomes analysis	22
The co‐location of CD14+APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer	22
Prognosis‐oriented molecular subtypes of retroperitoneal liposarcoma	22
Decoding innate lymphoid cell heterogeneity and plasticity in colorectal cancer	22
Activated immune cells present a lung interstitial‐to‐airway/alveolar cross‐compartment sharing pattern in severe pneumonia	22
Beyond bacterial defences: the role of lysozyme in cancer	22
Atg7 in CD4+ T cells improves intestinal mucosal inflammation by regulating Ets1‐mediated T cell differentiation	22
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity	22
PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus	22
Crosstalk between alternative splicing and inflammatory bowel disease: Basic mechanisms, biotechnological progresses and future perspectives	22
Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics	22
Rictor/mTORC2 signalling contributes to renal vascular endothelial‐to‐mesenchymal transition and renal allograft interstitial fibrosis by regulating BNIP3‐mediated mitophagy	22
Single‐cell landscape of the tumour immune microenvironment in human gynaecologic malignancies	22
Loss of Brd4 alleviates pathological bone loss via Slc9b2 suppression in osteoclastogenesis	22
P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities	21
Liquid biopsy biomarkers for early detection of gastrointestinal cancers: Current landscape and emerging technologies	21
CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations	21
Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance	21
Comparative spatial transcriptomics of pancreatic cancer with ductal and acinar origins in mouse models	21
Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism	21
Advances in gene therapy for Lafora disease: Intravenous recombinant adeno‐associated virus‐mediated delivery of EPM2A and EPM2B	21
IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer	21
Decoding of exosome heterogeneity for cancer theranostics	21
Parvimonas micra promotes carcinogenesis of colorectal cancer through phenyllactic acid‐induced DNA damage	21
Prediction of clinical risk assessment and survival in chronic obstructive pulmonary disease with pulmonary hypertension	20
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Exploring the potential role of oxidative stress‐related genes in colorectal cancer recurrence and establishing a recurrence assessment system based on single‐cell and bulk RNA‐seq analysis	20
Bortezomib in previously treated phosphatase and tension homology‐deficient patients with advanced intrahepatic cholangiocarcinoma: An open‐label, prospective and single‐centre phase II trial	20
The roles of innate and adaptive immunity in inactivated viral vaccination‐mediated protection against COVID‐19	20
Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype	20
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A vital step determines the quality of human eggs: Spindle bipolarization	20
Longitudinal metabolomic profiling unveils dynamic biomarkers for predicting immune recovery in HIV‐1 infection	20
MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment	20
Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis‐induced formation of neutrophil extracellular traps	20
CLINICAL AND TRANSLATIONAL MEDICINE	20
Multiplexed plasma protein classifiers for the diagnosis of age‐related macular degeneration	20
Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses	20