Clinical and Translational Medicine

Papers
(The TQCC of Clinical and Translational Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)
ArticleCitations
Study on feasibility of the partial meniscal allograft transplantation478
Baseline microbiome and metabolome are associated with response to ITIS diet in an exploratory trial in patients with rheumatoid arthritis164
Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2‐positive advanced gastric cancer143
Identification and validation of GABA‐driven subtypes and prognosis signature of lung adenocarcinoma137
Decitabine activates type I interferon signaling to inhibit p53‐deficient myeloid malignant cells114
Faecal zonulin, calprotectin and the infant microbiome in early life112
A 3′‐pre‐tRNA‐derived small RNA tRF‐1‐Ser regulated by 25(OH)D promotes proliferation and stemness by inhibiting the function of MBNL1 in breast cancer108
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Bortezomib in previously treated phosphatase and tension homology‐deficient patients with advanced intrahepatic cholangiocarcinoma: An open‐label, prospective and single‐centre phase II trial101
Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma101
Increased oxidized low‐density lipoprotein in mice exposed to a high‐fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway96
Therapeutic induction of Bcl2‐associated athanogene 3‐mediated autophagy in idiopathic pulmonary fibrosis93
LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus91
Dynamic modulations of sphingolipids and glycerophospholipids in COVID‐1988
Colorectal mucinous adenocarcinoma indicates a meaningful subtype: A whole genome sequencing study83
Spatial distribution of immune cells and their proximity to STING+ cells are associated with survival in glioblastoma78
Emerging point‐of‐care autologous cellular therapy using adipose‐derived stromal vascular fraction for neurodegenerative diseases77
Immunological evaluation of an mRNA vaccine booster in individuals fully immunized with an inactivated SARS‐CoV‐2 vaccine72
Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment71
Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT367
Tumour‐associated macrophages in gastric cancer: From function and mechanism to application66
Genomic profiling of the UFMylation family genes identifies UFSP2 as a potential tumour suppressor in colon cancer65
Whole‐genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer65
Prognosis‐related gene signature is enriched in cancer‐associated fibroblasts in the stem‐like subtype of gastric cancer64
Repurposing hyperpolarization‐activated cyclic nucleotide‐gated channels as a novel therapy for breast cancer64
Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials63
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour‐intrinsic innate sensing and immunogenicity62
Diabetes alters the protein secretome of human adipose‐derived stem cells and promotes tumorigenesis in hepatic cancer cells61
Cyclin C: A new responser for chemosensitivity in cancer60
Revealing the effects of maternal di(2‐ethylhexyl) phthalate exposure on the progression of early meiosis in female foetal germ cells at single‐cell resolution60
Glucosamine regulates macrophage function in heart failure59
Heterogeneity in lung cancers by single‐cell DNA sequencing57
Kynurenine catabolic enzyme KMO regulates HCC growth54
Identification of distinct metabolic characteristics of pneumonia in type 2 diabetes mellitus53
Induction of connective tissue growth factor accounts for the inability of glucocorticoid suppression on pulmonary fibrosis50
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The CYP3A5 genotypes of both liver transplant recipients and donors influence the time‐dependent recovery of tacrolimus clearance during the early stage following transplantation49
Drug–drug synthetic lethality to combat cancer: From bench to bedside49
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The TGFβ2‐Snail1‐miRNATGFβ2 Circuitry is Critical for the Development of Aggressive Functions in Breast Cancer46
Dissecting the effect of ileal faecal diversion on the intestine using single‐cell sequencing46
NAV2 positively modulates inflammatory response of fibroblast‐like synoviocytes through activating Wnt/β‐catenin signaling pathway in rheumatoid arthritis46
C20orf24 promotes colorectal cancer progression by recruiting Rin1 to activate Rab5‐mediated mitogen‑activated protein kinase/extracellular signal‐regulated kinase signalling45
Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells44
Issue Information42
Dual blocking of PI3K and mTOR signaling by DHW‐221, a novel benzimidazole derivative, exerts antitumor activity in human non‐small cell lung cancer42
Human tumour vessel heterogeneity in ovarian cancer and its association with response to neoadjuvant chemotherapy42
Functional biomarkers that distinguish between tinnitus with and without hyperacusis42
ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion42
Predictive medicine in a testis trio‐family through a combined multi‐omics approach41
Computational repurposing of oncology drugs through off‐target drug binding interactions from pharmacological databases41
Clusterin deficiency is associated with a lack of response to teriflunomide in multiple sclerosis41
AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic40
Integrated single‐cell RNA sequencing and spatial transcriptomics analysis reveals the tumour microenvironment in patients with endometrial cancer responding to anti‐PD‐1 treatment40
Integrative genome‐wide chromatin accessibility and transcriptome profiling of diffuse large B‐cell lymphoma39
COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD339
Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy38
Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non‐small‐cell lung cancer38
Roles of glutamic pyruvate transaminase 2 in reprogramming of airway epithelial lipidomic and metabolomic profiles after smoking38
A pathogenic AKAP4 variant, p.R429H, causes male in/subfertility in humans and mice38
MOPSS: Toward high‐fidelity oligonucleotides for clinical applications37
From guardian to shepherd: The novel role of p53 in collective cell migration and epithelial repair37
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YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations36
Issue Information36
Characterization of the molecular mechanisms underlying azithromycin‐induced cardiotoxicity using human‐induced pluripotent stem cell‐derived cardiomyocytes35
Issue Information35
Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple‐negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta35
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Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals35
The roles and therapeutic implications of messenger RNA internal N7‐methylguanosine and N6‐methyladenosine modifications in chemoresistance34
A combination of faecal and intratumour microbial community profiling reveals novel diagnostic and prognostic biomarkers for pancreatic tumours34
Genome‐wide virus‐integration analysis reveals a common insertional mechanism of HPV, HBV and EBV34
Gamma delta T cells in hepatocellular carcinoma: Sunrise of new therapy based on Vδ2 T cells?33
CCNB1IP1 prevents ubiquitination‐mediated destabilization of MYCN and potentiates tumourigenesis of MYCN‐amplificated neuroblastoma33
Corrigendum to “Serglycin‐induced interleukin‐1β from oesophageal cancer cells upregulate hepatocyte growth factor in fibroblasts topromote tumour angiogenesis and growth”33
RUNX1 mediates the therapeutic effects of mesenchymal stem cells‐derived microparticles in acute respiratory distress syndrome33
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Identification and functional analysis of circulating extrachromosomal circular DNA in schizophrenia implicate its negative effect on the disorder32
FMO4 shapes immuno‐metabolic reconfiguration in hepatocellular carcinoma32
PROM2 overexpression induces metastatic potential through epithelial‐to‐mesenchymal transition and ferroptosis resistance in human cancers32
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer32
Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC32
Cefoselis enhances breast cancer chemosensitivity by directly targeting GRP78/LRP5 signalling of cancer stem cells32
RNA‐seq‐driven expression analysis to investigate cardiovascular disease genes with associated phenotypes among atrial fibrillation patients31
BCL11B promotes T‐cell acute lymphoblastic leukaemia cell survival via the XRCC5/C11ORF21 axis31
Single‐cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation31
New insights into developmental fate decisions by autoreactive CD4 thymocytes31
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Paeonol could alleviate diabetes‐related spermatogenic dysfunction via SIRT3‐dependent redox rebalancing31
Exploring the potential role of oxidative stress‐related genes in colorectal cancer recurrence and establishing a recurrence assessment system based on single‐cell and bulk RNA‐seq analysis31
Role of integrin expression in the prediction of response to vedolizumab: A prospective real‐life multicentre cohort study30
Discovery of a drug to treat airway mucus hypersecretion30
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Multiplexed plasma protein classifiers for the diagnosis of age‐related macular degeneration29
Corrigendum to Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway29
How to translate the knowledge of COVID‐19 into the prevention of Omicron variants28
On the essentiality of the angiotensin converting enzyme 2 receptor for SARS‐CoV‐2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants ca28
Genomic and transcriptomic characterization reveals B‐cell hyperactivation and immune evasion in hepatitis B virus‐associated diffuse large B‐cell lymphoma28
Schisandrin B for the treatment of male infertility27
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives27
Whole‐exome sequencing in clear cell sarcoma of soft tissue uncovers novel prognostic categorization and drug targets27
Emerging role of IκBζ in inflammation: Emphasis on psoriasis27
Potential of peptide‐engineered exosomes with overexpressed miR‐92b‐3p in anti‐angiogenic therapy of ovarian cancer27
HSP90 N‐terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2‐driven breast cancer progression27
FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways26
Destabilization of microrchidia family CW‐type zinc finger 2 via the cyclin‐dependent kinase 1‐chaperone‐mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to 26
The mechanism of liver X receptor regulates the balance of glycoFAsynthesis and cholesterol synthesis in clear cell renal cell carcinoma26
Immunomodulation by intravenous omega‐3 fatty acid treatment in older subjects hospitalized for COVID‐19: A single‐blind randomized controlled trial26
Issue Information26
Heavy metals in cigarette smoke strongly inhibit pancreatic ductal function and promote development of chronic pancreatitis25
Molecular heterogeneity of BCL2/MYC double expressor lymphoma underlies sensitivity to histone deacetylase inhibitor25
Somatic genomic mosaicism in the brain during aging: Scratching the surface25
Serum amyloid A promotes emphysema by triggering the reciprocal activation of neutrophils and ILC3s25
Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinoma25
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling25
Non‐m6A RNA modifications in haematological malignancies25
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis‐associated adhesion of ovarian cancer cells25
Integrative analysis identifies three molecular subsets in ovarian cancer25
Glucocorticoid‐induced osteonecrosis in systemic lupus erythematosus patients24
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis24
Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancer24
Immunogenomic alterations of head and neck squamous cell carcinomas stratified by smoking status24
A metastasis‐associated microRNA‐based liquid biopsy signature for risk‐stratification in colorectal cancer: a multicenter cohort study24
Tumor‐infiltrating CD8+ T cell is prognostic and predicts adjuvant chemotherapy benefit in patients with limited‐stage small cell esophageal carcinoma24
Non‐coding RNAs and colitis‐associated cancer: Mechanisms and clinical applications24
Evolution of clonal hematopoiesis24
Post‐transplant cyclophosphamide as sole GHVD prophylaxis after matched reduced‐intensity conditioning allotransplant23
A novel signature based on pairwise PD‐1/PD‐L1 signaling pathway genes for predicting the overall survival in patients with hepatocellular carcinoma23
The human melanoma proteome atlas—Defining the molecular pathology23
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation23
Dystrophin immunogenicity and requirement in myogenic cells: Paradigm shift in gene therapy for DMD23
Clinical implications of EGFR‐associated MAPK/ERK pathway in multiple primary lung cancer23
Identification of a novel therapeutic target underlying atypical manifestation of Gaucher disease23
Serum tsRNA as a novel molecular diagnostic biomarker for lupus nephritis23
Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis23
Defective α‐tectorin may involve tectorial membrane in familial Meniere disease23
Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34‐BECN1‐TRAF6 complex for autophagy induction22
Deep learning‐based multi‐omics study reveals the polymolecular phenotypic of diabetic kidney disease22
Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways22
Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells22
HBV‐integrated local genomic alterations reveal multicentric independent occurrences of multifocal HCC22
A biobanking turning‐point in the use of formalin‐fixed, paraffin tumor blocks to unveil kinase signaling in melanoma22
MicroRNAs affecting the susceptibility of melanoma cells to CD8+ T cell‐mediated cytolysis22
Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis22
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions22
Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality22
Basal cell adhesion molecule promotes metastasis‐associated processes in ovarian cancer22
Dynamic changes in DNA methylation and hydroxymethylation revealed the transformation of advanced adenoma into colorectal carcinoma22
The PPARγ pathway determines electrophysiological remodelling and arrhythmia risks in DSC2 arrhythmogenic cardiomyopathy21
Diagnostic and prognostic potential of the oral and gut microbiome for lung adenocarcinoma21
The generation of a neuronal phase code for space21
Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy21
B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging21
Disentangling the molecular mystery of tumour–microbiota interactions: Microbial metabolites21
Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans21
Selective degradation of the p53‐R175H oncogenic hotspot mutant by an RNA aptamer‐based PROTAC21
Variations of human heat shock proteins in multiple cancers21
Identification of clinically actionable secondary genetic variants from whole‐genome sequencing in a large‐scale Chinese population21
Induced collagen type‐I secretion by hepatocytes of the melanoma liver metastasis is associated with a reduction in tumour‐infiltrating lymphocytes20
A single‐cell atlas of bisphenol A (BPA)‐induced testicular injury in mice20
Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population20
Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single‐cell transcriptomics20
Forward single‐cell sequencing into clinical application: Understanding of cancer microenvironment at single‐cell solution20
Targeting endoplasmic reticulum stress‐induced lymphatic dysfunction for mitigating bisphosphonate‐related osteonecrosis20
Revealing the transcriptional heterogeneity of organ‐specific metastasis in human gastric cancer using single‐cell RNA Sequencing20
Neutrophil to lymphocyte ratio as a predictor for treatment of radiation‐induced brain necrosis with bevacizumab in nasopharyngeal carcinoma patients19
The roles of innate and adaptive immunity in inactivated viral vaccination‐mediated protection against COVID‐1919
Identification and characterization of novel CD274 (PD‐L1) regulating microRNAs and their functional relevance in melanoma19
SCF‐FBXL8 contributes to liver metastasis and stem‐cell‐like features in colorectal cancer cells by mediating ubiquitination and degradation of TP5319
Profiling of host entry factors in adults and fetuses for severe acute respiratory syndrome coronavirus‐2 infection indicates its developmental regulation19
Towards next‐generation TIL therapy: TILs enriched in neoepitope‐specific T cells19
Issue Information19
Revisiting the chaperonin T‐complex protein‐1 ring complex in human health and disease: A proteostasis modulator and beyond19
TFH2 cells associate with enhanced humoral immunity to SARS‐CoV‐2 inactivated vaccine in patients with allergic rhinitis19
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma19
Complete loss of the atrial natriuretic peptide‐converting enzyme Corin and CHAF‐LA syndrome: Implications to natriuretic peptide physiology and left atrium health19
Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience19
Single‐cell sequencing of mouse heart cellular heterogeneity in hypercholesterolemia reveals the mechanism of myocardial damage19
The dual role of CD70 in B‐cell lymphomagenesis19
Hsa_circ_0057105 modulates a balance of epithelial‐mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma19
The juxtaposition of Ilex cornuta fruit and gut microbiota against alcoholic liver disease based on the integrated pharmacology via metabolomics18
Cell‐free RNA and fully convolutional dense network‐based early preeclampsia prediction18
Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple‐negative breast cancers18
Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD‐mediated pyroptosis in colorectal cancer18
Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation18
Cyclin‐dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration‐resistant prostate cancer18
Single‐cell RNA sequencing reveals SERPINE1‐expressing CAFs remodelling tumour microenvironment in recurrent osteosarcoma18
CD155/TIGIT signalling plays a vital role in the regulation of bone marrow mesenchymal stem cell–induced natural killer–cell exhaustion in multiple myeloma18
EEF2K silencing inhibits tumour progression through repressing SPP1 and synergises with BET inhibitors in melanoma18
Polyadenylation ligation‐mediated sequencing (PALM‐Seq) characterizes cell‐free coding and non‐coding RNAs in human biofluids18
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities18
Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs18
Correlation of vaccine‐elicited antibody levels and neutralizing activities against SARS‐CoV‐2 and its variants18
C1q/TNF‐related protein 4 mediates proliferation and migration of vascular smooth muscle cells during vascular remodelling18
Seize the engine: Emerging cell cycle targets in breast cancer18
PD‐L1/TIGIT bispecific antibody showed survival advantage in animal model18
Clinic‐ready inhibitor of MMP‐9/‐12 restores sensory and functional decline in rodent models of spinal cord injury17
N6‐methyladenosine‐RNA methylation promotes expression of solute carrier family 7 member 11, an uptake transporter of cystine for lipid reactive oxygen species scavenger glutathione 17
Adipose tissue‐derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity17
Early postoperative plasma circulating tumour DNA for molecular residue disease detection and recurrence risk evaluation in surgical non‐small cell lung cancer17
New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP‐binding region of EGFR by targeting the molecular motor MYO1D17
Large‐scale genomic sequencing reveals adaptive opportunity of targeting mutated‐PI3Kα in early and advanced HER2‐positive breast cancer17
Multiomics‐based study of amniotic fluid small extracellular vesicles identified Moesin as a biomarker for antenatal hydronephrosis17
Personalised neoantigen‐based therapy in colorectal cancer17
Structural inequality and temporal brain dynamics across diverse samples17
The emerging roles of UFMylation in the modulation of immune responses17
The volatile and heterogeneous gut microbiota shifts of COVID‐19 patients over the course of a probiotics‐assisted therapy17
Integrating proteomic and clinical data to discriminate major psychiatric disorders: Applications for major depressive disorder, bipolar disorder, and schizophrenia17
Integrating single‐cell RNA sequencing with spatial transcriptomics reveals an immune landscape of human myometrium during labour17
Reinventing magnetic resonance imaging for accessible healthcare: Whole‐body imaging at 0.05 Tesla17
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Ecological and evolutionary dynamics to design and improve ovarian cancer treatment16
Clinical significance of spatiotemporal transcriptional bursting and control16
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11‐dependent repression of CDKN2A16
Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway16
Single‐cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing16
Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy16
Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages16
Plasma extrachromosomal circular DNA is a pathophysiological hallmark of short‐term intensive insulin therapy for type 2 diabetes16
CD47‐SIRPα blocking‐based immunotherapy: Current and prospective therapeutic strategies16
Single‐cell multi‐modal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma16
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia16
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA16
The WNK1–ERK5 route plays a pathophysiological role in ovarian cancer and limits therapeutic efficacy of trametinib16
The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis15
Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway15
Identification of IKZF1 genetic mutations as new molecular subtypes in acute myeloid leukaemia15
Extracellular vesicle‐packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction15
Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development15
Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis15
Somatic mutations in homologous recombination pathway predict favourable prognosis after immunotherapy across multiple cancer types15
Multi‐omics predictive model based on clinical, radiomic and genomic features for predicting the response of limited‐stage small cell lung cancer to definitive chemoradiotherapy15
Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF‐beta and AKT/mTOR signaling pathways15
Single‐cell transcriptomics identify TNFRSF1B as a novel T‐cell exhaustion marker for ovarian cancer15
Effect of epigenetic treatment on SST2 expression in neuroendocrine tumour patients15
Impact of restoring male fertility with transplantation of in vitro propagated spermatogonial stem cells on the health of their offspring throughout life15
Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials15
m6A‐dependent upregulation of DDX21 by super‐enhancer‐driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia15
Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single‐cell RNA sequencing15
Vaginal delivery provides skin colonization resistance from environmental microbes in the NICU15
HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice14
Mitochondrial and immune response dysregulation in melanoma recurrence14
Cancer‐associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer14
TLR4 aggravates microglial pyroptosis by promoting DDX3X‐mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury14
RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy14
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology14
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