OOIR: Observatory of International Research

Papers

(The median citation count of Clinical and Translational Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Single‐cell RNA sequencing technologies and applications: A brief overview	398
Cytosolic DNA‐STING‐NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide	154
Pyroptosis, metabolism, and tumor immune microenvironment	143
Anti‐inflammatory hydrogel dressings and skin wound healing	143
CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling	135
Emerging roles of exosomal miRNAs in diabetes mellitus	126
Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway	112
METTL1‐m⁷G‐EGFR/EFEMP1 axis promotes the bladder cancer development	108
METTL1 promotes hepatocarcinogenesis via m⁷G tRNA modification‐dependent translation control	107
m⁶A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2‐mediated IGF1R mRNA stabilization	94
The potential impact of ChatGPT in clinical and translational medicine	91
Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin	90
Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfun	90
Revealing the transcriptional heterogeneity of organ‐specific metastasis in human gastric cancer using single‐cell RNA Sequencing	90
Evaluation of the safety and efficacy of using human menstrual blood‐derived mesenchymal stromal cells in treating severe and critically ill COVID‐19 patients: An exploratory clinical trial	90
Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis	89
FTO modifies the m6A level of MALAT and promotes bladder cancer progression	84
Lactobacillus lactis and Pediococcus pentosaceus‐driven reprogramming of gut microbiome and metabolome ameliorates the progression of non‐alcoholic fatty liver disease	78
Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment	72
Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity	72
Spatial omics: Navigating to the golden era of cancer research	72
EMT‐cancer cells‐derived exosomal miR‐27b‐3p promotes circulating tumour cells‐mediated metastasis by modulating vascular permeability in colorectal cancer	71
Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics	68
Research trends in pharmacological modulation of tumor‐associated macrophages	67
LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c‐Myc mRNA stability	66

Cancer‐associated fibroblast‐derived exosomal microRNA‐20a suppresses the PTEN/PI3K‐AKT pathway to promote the progression and chemoresistance of non‐small cell lung cancer	65
NAT10‐mediated mRNA N4‐acetylcytidine modification promotes bladder cancer progression	64
The opportunities and pitfalls of ChatGPT in clinical and translational medicine	64
Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A	62
The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer	61
The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis	60
The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma	60
Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinoma	60
Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1–Wnt/β‐catenin–TFE3 feedback loop signalling	60
Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer	57
Apolipoprotein C‐II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway	57
The roles of exosomes in cancer drug resistance and its therapeutic application	56
Long noncoding RNA CASC11 promotes hepatocarcinogenesis and HCC progression through EIF4A3‐mediated E2F1 activation	56
Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR‐576‐5p/PCDH10 axis	56
Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer	55
Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B‐cell lymphoma	55
Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer	55
The role of cell‐penetrating peptides in potential anti‐cancer therapy	53
Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis	51
CD13 promotes hepatocellular carcinogenesis and sorafenib resistance by activating HDAC5‐LSD1‐NF‐κB oncogenic signaling	50
The future of ChatGPT in academic research and publishing: A commentary for clinical and translational medicine	49
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation	48
Interplay of m⁶A and histone modifications contributes to temozolomide resistance in glioblastoma	47
The omicron variant of SARS‐CoV‐2: Understanding the known and living with unknowns	47
Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis	46
EASY‐APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis	46
Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α	45
Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head	44
Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis	44
A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species	43
A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia	42
Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3β	42
Circle‐Seq reveals genomic and disease‐specific hallmarks in urinary cell‐free extrachromosomal circular DNAs	42
Time course of endothelial dysfunction markers and mortality in COVID‐19 patients: A pilot study	41
Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression	41
Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma	41
Circulating tumor cell characterization of lung cancer brain metastases in the cerebrospinal fluid through single‐cell transcriptome analysis	41
Integrative multiomics analysis of human atherosclerosis reveals a serum response factor‐driven network associated with intraplaque hemorrhage	41
The roles of E3 ubiquitin ligases in cancer progression and targeted therapy	40
T_reg deficiency‐mediated T_H1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells	40
Patient‐derived renal cell carcinoma organoids for personalized cancer therapy	39
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A	39
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression	38
LncRNA nuclear‐enriched abundant transcript 1 shuttled by prostate cancer cells‐secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR‐205‐5p/runt‐related	37
Keeping an eye on circadian time in clinical research and medicine	37
TLR4 aggravates microglial pyroptosis by promoting DDX3X‐mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury	37
LAG3 and its emerging role in cancer immunotherapy	37
Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway	37
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA	36
Role of endothelial cells in tumor microenvironment	36

A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2‐mediated epigenetic modulation in esophag	35
YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation	35
Blood biomarkers associated to complete pathological response on NSCLC patients treated with neoadjuvant chemoimmunotherapy included in NADIM clinical trial	35
Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2	35
MAFG‐AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma	34
CD47‐SIRPα blocking‐based immunotherapy: Current and prospective therapeutic strategies	34
S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis	34
VEGF‐C/VEGFR‐3 axis protects against pressure‐overload induced cardiac dysfunction through regulation of lymphangiogenesis	34
Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway	33
Exosome‐transmitted miR‐769‐5p confers cisplatin resistance and progression in gastric cancer by targeting CASP9 and promoting the ubiquitination degradation of p53	33
m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency	33
Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF‐kB signaling pathways synergistically	33
Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single‐cell RNA sequencing	33
Multi‐omics consensus ensemble refines the classification of muscle‐invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies	33
Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagy	32
Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo	32
Multiplex immunofluorescence and single‐cell transcriptomic profiling reveal the spatial cell interaction networks in the non‐small cell lung cancer microenvironment	32
Potential of peptide‐engineered exosomes with overexpressed miR‐92b‐3p in anti‐angiogenic therapy of ovarian cancer	32
Integrated biomarker profiling of the metabolome associated with impaired fasting glucose and type 2 diabetes mellitus in large‐scale Chinese patients	32
The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma	32
Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR‐141‐3p/MYPT1/p‐MLC2 axis in prostate cancer	32
LINC01133 promotes hepatocellular carcinoma progression by sponging miR‐199a‐5p and activating annexin A2	32
Patient‐derived organoids for personalized gallbladder cancer modelling and drug screening	32
Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury	32
BRD4‐IRF1 axis regulates chemoradiotherapy‐induced PD‐L1 expression and immune evasion in non‐small cell lung cancer	31
Baicalein is a novel TLR4‐targeting therapeutics agent that inhibits TLR4/HIF‐1α/VEGF signaling pathway in colorectal cancer	31
The application of ChatGPT in healthcare progress notes: A commentary from a clinical and research perspective	31
Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR‐302a	31
Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer	31
Somatic mutations in homologous recombination pathway predict favourable prognosis after immunotherapy across multiple cancer types	31
Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1	29
Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19	29
Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription	29
Hypoxic colorectal cancer‐derived extracellular vesicles deliver microRNA‐361‐3p to facilitate cell proliferation by targeting TRAF3 via the noncanonical NF‐κB pathways	29
Identification of tumor‐associated macrophage subsets that are associated with breast cancer prognosis	29
A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6	28
Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids	28
Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study	28
Definition of erythroid cell‐positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection	27
Reiterative infusions of MSCs improve pediatric osteogenesis imperfecta eliciting a pro‐osteogenic paracrine response: TERCELOI clinical trial	27
Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer	27
Emerging roles of the solute carrier family in pancreatic cancer	27
Multi‐omic landscaping of human midbrains identifies disease‐relevant molecular targets and pathways in advanced‐stage Parkinson's disease	27
TGF‐β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation	27
The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis	27
Spatiotemporal molecular medicine: A new era of clinical and translational medicine	26
Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies	26
Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis	26
Clinical implications of plasma ctDNA features and dynamics in gastric cancer treated with HER2‐targeted therapies	26
MiRNA‐516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis	26
TGF‐β signaling in liver metastasis	26
Integrated microbiome, metabolome, and proteome analysis identifies a novel interplay among commensal bacteria, metabolites and candidate targets in non‐small cell lung cancer	26
Mechanisms of interactions between lung‐origin telocytes and mesenchymal stem cells to treat experimental acute lung injury	26
Vaccine‐breakthrough infection by the SARS‐CoV‐2 omicron variant elicits broadly cross‐reactive immune responses	25
Therapeutic targeting of SPIB/SPI1‐facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression	25
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2	25
Potential biomarkers and targets of mitochondrial dynamics	25
FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression	25
Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation	25
N⁶‐methyladenosine‐modified lncRNA ARHGAP5‐AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma	25
Glioma glycolipid metabolism: MSI2–SNORD12B–FIP1L1–ZBTB4 feedback loop as a potential treatment target	25
Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de‐palmitoylation	25
A multi‐omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma	25
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1	24
Challenges of microRNA‐based biomarkers in clinical application for cardiovascular diseases	24
NAT10: An RNA cytidine transferase regulates fatty acid metabolism in cancer cells	24
Single‐cell and spatial transcriptomics reveal the fibrosis‐related immune landscape of biliary atresia	24
The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease	24
Serum extracellular vesicles containing MIAT induces atrial fibrosis, inflammation and oxidative stress to promote atrial remodeling and atrial fibrillation via blockade of miR‐485‐5p‐mediated CXCL10	24
Persistent high glucose induced EPB41L4A‐AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non‐histones	24
A comprehensive and universal approach for embryo testing in patients with different genetic disorders	23
Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases	23
Combined treatment with anti‐PSMA CAR NK‐92 cell and anti‐PD‐L1 monoclonal antibody enhances the antitumour efficacy against castration‐resistant prostate cancer	23
Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target	23
LncRNA PCAT1 activates SOX2 and suppresses radioimmune responses via regulating cGAS/STING signalling in non‐small cell lung cancer	23
Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology	23
A novel potential target of IL‐35‐regulated JAK/STAT signaling pathway in lupus nephritis	23
Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population	23
How to translate the knowledge of COVID‐19 into the prevention of Omicron variants	23
Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin	23

Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein	23
ZNF677 suppresses renal cell carcinoma progression through N6‐methyladenosine and transcriptional repression of CDKN3	23
The volatile and heterogeneous gut microbiota shifts of COVID‐19 patients over the course of a probiotics‐assisted therapy	23
METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung injury	23
FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1	22
CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations	22
The central role of a two‐way positive feedback pathway in molecular targeted therapies‐mediated pyroptosis in anaplastic thyroid cancer	22
Single‐cell transcriptome sequencing of B‐cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy	22
Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT3	22
Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating s	22
Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling	22
Engineering chimeric antigen receptor T cells for solid tumour therapy	22
Protective function of interleukin‐22 in pulmonary fibrosis	22
Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodelling	22
4‐phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR‐α	22
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma	22
Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials	22
Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy	21
Knockdown of lactate dehydrogenase by adeno‐associated virus‐delivered CRISPR/Cas9 system alleviates primary hyperoxaluria type 1	21
Spatiotemporal molecular imaging is a critical part of spatiotemporal molecular medicine	21
circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR‐520c‐3p/methyl‐DNA‐binding domain protein 2 axis	21
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives	21
mRNA vaccine in cancer therapy: Current advance and future outlook	21
Tumour cells are sensitised to ferroptosis via RB1CC1‐mediated transcriptional reprogramming	21
Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2⁺ γδ T cell can be a promising complement	21
Intratumoural microbiome can predict the prognosis of hepatocellular carcinoma after surgery	21
Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma	21
Activation of Toll‐like receptor 7 provides cardioprotection in septic cardiomyopathy‐induced systolic dysfunction	21
A cellular census of human peripheral immune cells identifies novel cell states in lung diseases	21
RNA N⁶‐methyladenosine modification in the lethal teamwork of cancer stem cells and the tumor immune microenvironment: Current landscape and therapeutic potential	21
CTHRC1+ fibroblasts are stimulated by macrophage‐secreted SPP1 to induce excessive collagen deposition in keloids	20
ALKBH5‐mediated m⁶A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma	20
IL‐22‐mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury	20
The Human Melanoma Proteome Atlas—Complementing the melanoma transcriptome	20
Preclinical platforms to study therapeutic efficacy of human γδ T cells	20
Macrophage‐derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment	20
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double‐blind, place	19
LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m⁶A‐YTHDF2‐dependent manner	19
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification	19
Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma	19
Immunomodulation by intravenous omega‐3 fatty acid treatment in older subjects hospitalized for COVID‐19: A single‐blind randomized controlled trial	19
Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide	19
CB₁R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome	19
NOX5 mediates the crosstalk between tumor cells and cancer‐associated fibroblasts via regulating cytokine network	19
Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis	19
N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation	19
Whole‐genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer	19
Clinical challenges of tissue preparation for spatial transcriptome	19
Decoding of exosome heterogeneity for cancer theranostics	19
Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling	19
Identification of BGN and THBS2 as metastasis‐specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis	19
The CTCF/LncRNA‐PACERR complex recruits E1A binding protein p300 to induce pro‐tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression	19
Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple‐negative breast cancers	19
CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis	19
MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment	18
Single‐cell RNA‐seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma	18
The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission	18
Regulatory roles of osteopontin in human lung cancer cell epithelial‐to‐mesenchymal transitions and responses	18
Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development	18
Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets	18
Targeting integrin αvβ3 with indomethacin inhibits patient‐derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma	18
An activity‐based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti‐fibrotic therapeutic strategies	18
Intraoperative near‐infrared II window fluorescence imaging‐assisted nephron‐sparing surgery for complete resection of cystic renal masses	18
Decidual CXCR4⁺CD56^brightNK cells as a novel NK subset in maternal–foetal immune tolerance to alleviate early pregnancy failure	18
SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases	18
Exosome‐derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase‐3‐dependent cleavage	18
Adipose‐specific ATGL ablation reduces burn injury‐induced metabolic derangements in mice	18
PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron	17
Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids	17
Activated neutrophils polarize protumorigenic interleukin‐17A‐producing T helper subsets through TNF‐α‐B7‐H2‐dependent pathway in human gastric cancer	17
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma	17
Functional biomarkers that distinguish between tinnitus with and without hyperacusis	17
Destabilization of macrophage migration inhibitory factor by 4‐IPP reduces NF‐κB/P‐TEFb complex‐mediated c‐Myb transcription to suppress osteosarcoma tumourigenesis	17
FL118, acting as a ‘molecular glue degrader’, binds to, dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer wit	17
Epicardial and endothelial cell activation concurs with extracellular matrix remodeling in atrial fibrillation	17
Lipid metabolism–related lncRNA SLC25A21‐AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c‐Myc axis and SLC25A21 expression	17
A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma	17
Altered nitric oxide induced by gut microbiota reveals the connection between central precocious puberty and obesity	17
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma	17
Small molecule inhibitors from organoid‐based drug screen induce concurrent apoptosis and gasdermin E‐dependent pyroptosis in colorectal cancer	17
NSUN2‐mediated m⁵C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression	17
Accurate classification of COVID‐19 patients with different severity via machine learning	17
Plasma levels of hsa‐miR‐3158‐3p microRNA on admission correlate with MRI findings and predict outcome in cerebral malaria	17
MiR‐378a‐3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation	17
Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression	17
Dynamic modulations of sphingolipids and glycerophospholipids in COVID‐19	17
Preparation for the challenge of heavily mutated Omicron variant	17
C/EBPδ drives key endocrine signals in the human amnion at parturition	16
Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis	16
CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease	16
Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells	16
Glucocorticoid‐induced osteonecrosis in systemic lupus erythematosus patients	16
Abrogation of graft ischemia‐reperfusion injury in ischemia‐free liver transplantation	16
LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis	16
Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells	16