OOIR: Observatory of International Research

Papers

(The TQCC of Biomolecules & Therapeutics is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Lipid Metabolism, Disorders and Therapeutic Drugs - Review	66
Diabetic Nephropathy - a Review of Risk Factors, Progression, Mechanism, and Dietary Management	60
Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection	40
COVID-19 Vaccine: Critical Questions with Complicated Answers	39
The Role of Leptin in the Association between Obesity and Psoriasis	33
Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit	32
Chronicles of EGFR Tyrosine Kinase Inhibitors: Targeting EGFR C797S Containing Triple Mutations	32
Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells	31
Inhibition of Cytochrome P450 Enzymes by Drugs-Molecular Basis and Practical Applications	29
Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders	26
Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease	24
Bioactive Lipids and Their Derivatives in Biomedical Applications	24
Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae	21
Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation	20
Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma	20
Topical Application of S1P₂ Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice	19
Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway	19
Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology	19
Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science	18
AR-mTOR-SRF Axis Regulates HMMR Expression in Human Prostate Cancer Cells	17
Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics	17
Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers	17
Enhancing Anti-Cancer Therapy with Selective Autophagy Inhibitors by Targeting Protective Autophagy	17
Drug Discovery Perspectives of Antisense Oligonucleotides	16
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption	15

Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model	15
Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis- Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models	15
Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives	15
Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation	15
Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance	15
Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression	15
Immune Responses to Plant-Derived Recombinant Colorectal Cancer Glycoprotein EpCAM-FcK Fusion Protein in Mice	14
Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress	14
Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells	14
Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling	14
Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine	14
Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells	14
Metabolic Bone Diseases and New Drug Developments	13
Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging	13
Autophagy and Digestive Disorders: Advances in Understanding and Therapeutic Approaches	12
Transcriptome Analysis of Long-Term Exposure to Blue Light in Retinal Pigment Epithelial Cells	12
Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3	12
Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells	12
Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis	12
Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS	12
High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells	12
Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes	12
Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation	12
Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways	11
Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice	11
Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells	11
Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo	11
Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction	11
4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice	10
Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases	10
Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder	10
Senotherapeutics and Their Molecular Mechanism for Improving Aging	10
Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease	10
KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells	10
A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment	10
KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice	10
Cell Autonomous Circadian Systems and Their Relation to Inflammation	10
Luteolin Promotes Apoptosis of Endometriotic Cells and Inhibits the Alternative Activation of Endometriosis-Associated Macrophages	10
The Endoplasmic Reticulum Stress Response Mediates Shikonin-Induced Apoptosis of 5-Fluorouracil-Resistant Colorectal Cancer Cells	10
Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson's Disease Models	10
The Role of Mitochondrial Biogenesis Dysfunction in Diabetic Cardiomyopathy	9
Suppression of Foxo3-Gatm by miR-132-3p Accelerates Cyst Formation by Up-Regulating ROS in Autosomal Dominant Polycystic Kidney Disease	9
A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity	9
Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene	9
Licochalcone H Induces Cell Cycle Arrest and Apoptosis in Human Skin Cancer Cells by Modulating JAK2/STAT3 Signaling	9
Thymoquinone Suppresses Migration of Human Renal Carcinoma Caki-1 Cells through Inhibition of the PGE₂-Mediated Activation of the EP2 Receptor Pathway	8
MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells	8
The Trend of Organic Based Nanoparticles in the Treatment of Diabetes and Its Perspectives	8
Antiviral Efficacy of Pralatrexate against SARS-CoV-2	8
NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases	8

C-Reactive Protein Signaling Pathways in Tumor Progression	8
Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway	8
Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients	7
Gene Expression Profiling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine	7
Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Disease	7
Nitric Oxide Signal Transduction and Its Role in Skin Sensitization	7
Abiraterone Acetate Attenuates SARS-CoV-2 Replication by Interfering with the Structural Nucleocapsid Protein	7
Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment	7
8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells	7
MeBib Suppressed Methamphetamine Self-Administration Response via Inhibition of BDNF/ERK/CREB Signal Pathway in the Hippocampus	7
The Role of Adiponectin in the Skin	7
5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson’s Disease	7
Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways	7
Suppressive Effect of CYM50358 S1P₄ Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice	7
Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy	7