OOIR: Observatory of International Research

Papers

(The TQCC of Toxicological Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	62
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	57
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	32
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	23
Effect of CTMP1 gene on pulmonary fibrosis	19
Punicalagin mitigates benzo[α]pyrene induced epithelial-mesenchymal transition and migration in triple‑negative breast cancer cells	19
Policosanol suppresses tumor progression in a gastric cancer xenograft model	17
Exposure and health effects follow-up study of residents near a former smelter site	16
Esculetin alleviates IgA nephropathy in rats by improving intestinal mucosal function through the IL-17/NF-κB signaling	16
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	14
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	14
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	14
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	13
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	13
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	13
Efficiency of pharmaceutical toxicity prediction in computational toxicology	13
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	13
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	13
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	13
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	12
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	12
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	12
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	11
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	11
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	11

Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	11
In vitro toxicological assessment of PhSeZnCl in human liver cells	11
Exploring the various functions of PHD finger protein 20: beyond the unknown	11
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	11
Acute toxicity assessment of nine organic UV filters using a set of biotests	11
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	11
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	10
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	10
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	10
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention	10
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	10
Integrative roles of sphingosine kinase in liver pathophysiology	9
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	9
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	9
Risk assessment of diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as a UV filter in cosmetics	9
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	9
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	9
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	8
Disinfection’s impact on the environment, molecular cross-resistance with antibiotics, and modern reduction approaches	8
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	8
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	8
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	8
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	8
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	8
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	8
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	7
Current status and future prospects of toxicity assessment using organoids	7
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	7
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	7
Steroidogenic cytochrome P450 enzymes as drug target	7
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	7
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	7
In silico cardiac safety assessment using a multi-biomarker approach based on an electrophysiological model of hiPSC-derived cardiomyocytes	7
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	7