OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	58
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	56
Policosanol suppresses tumor progression in a gastric cancer xenograft model	31
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	23
Effect of CTMP1 gene on pulmonary fibrosis	18
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	18
Punicalagin mitigates benzo[α]pyrene induced epithelial-mesenchymal transition and migration in triple‑negative breast cancer cells	16
Exposure and health effects follow-up study of residents near a former smelter site	16
Esculetin alleviates IgA nephropathy in rats by improving intestinal mucosal function through the IL-17/NF-κB signaling	15
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	14
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	13
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	13
Efficiency of pharmaceutical toxicity prediction in computational toxicology	13
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	13
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	12
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	12
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	12
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	11
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	11
In vitro toxicological assessment of PhSeZnCl in human liver cells	11
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	11
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	11
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	11
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	11
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	11

15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	11
Acute toxicity assessment of nine organic UV filters using a set of biotests	11
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	11
Exploring the various functions of PHD finger protein 20: beyond the unknown	10
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	10
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	10
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	10
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	10
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention	10
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	10
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	9
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	9
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	9
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	9
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	8
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	8
Integrative roles of sphingosine kinase in liver pathophysiology	8
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	8
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	8
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	8
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	8
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	8
Disinfection’s impact on the environment, molecular cross-resistance with antibiotics, and modern reduction approaches	7
In silico cardiac safety assessment using a multi-biomarker approach based on an electrophysiological model of hiPSC-derived cardiomyocytes	7
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	7
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	7
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	7
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	7
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	7
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	6
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	6
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	6
Enhancement of renal fibrosis in PHF20 transgenic mice	6
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	6
The resveratrol-induced apoptosis and/or necroptosis of lung cancer cells is dependent on the activation status of PARP-1 and MLKL under oxidative stress	6
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	6
Methylmercury causes pain disorders by disrupting the neuronal function of spinal dorsal horn neurons in mice	6
Current status and future prospects of toxicity assessment using organoids	6
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	6
Steroidogenic cytochrome P450 enzymes as drug target	6
Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism and oxidative stress in female mice	6
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	5
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	5
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	5
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	5
Correction: Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	5
Mechanism of endoplasmic reticulum stress-induced endothelial cell ferroptosis in trichloroethylene-induced mouse kidney injury	5
In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations	5
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection	5
Induction of synergistic apoptosis by tetramethoxystilbene and nutlin-3a in human cervical cancer cells	5

Changes in gut microbiota and metabolites of mice with intravenous graphene oxide-induced embryo toxicity	5
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	5
HEBP2 affects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA-MB-231 breast cancer cells	5
Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys	4
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	4
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation	4
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	4
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	4
Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane	4
Sperm analysis for reproductive toxicology studies in common marmosets (Callithrix jacchus)	4
Publisher Correction: Sex-dependent neurotoxicity of environmental toxicants: a narrative review	4
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method	4
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	4
Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T	4
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro	4
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential	4
Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source	3
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats	3
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	3
Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid	3
Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury	3
Investigation of alternative cell models to BALB/c 3T3 for in vitro neutral red uptake phototoxicity test of pharmaceuticals: NIH 3T3 and HaCaT cells	3
Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway	3
Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll	3
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration	3
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes	3
Regulatory frameworks for fragrance safety in cosmetics: a global overview	3
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)	3
Development of in vitro skin corrosion test using KeraSkin™	3
Chitooligosaccharides as a potential immune modulator for reducing particulate matter 10-induced inflammation in pulmonary damage models	3
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	3
A 13-week repeated oral toxicity study of Mycoleptodonoides aitchisonii (Agaricomycetes) in Sprague–Dawley rats	3
Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells	3
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells	3
Transferability and reproducibility of IMMUNOTOX-T assay, an in vitro method for evaluation of chemical-mediated immunotoxicity	3