OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs	67
Flavonoids: structure–function and mechanisms of action and opportunities for drug development	48
No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period	20
Assessment of acute and repeated pulmonary toxicities of oligo(2-(2-ethoxy)ethoxyethyl guanidium chloride in mice	20
Celecoxib induces apoptosis through Akt inhibition in 5-fluorouracil-resistant gastric cancer cells	17
Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice	13
Distribution of organochlorine pesticide pollution in water, sediment, mollusk, and fish at Saguling Dam, West Java, Indonesia	13
Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole	13
Heavy metals in hair and nails as markers of occupational hazard among welders working in United Arab Emirates	13
Differential mechanisms underlying methotrexate-induced cell death and epithelial-mesenchymal transition in A549 cells	13
The in vitro toxicity evaluation of halloysite nanotubes (HNTs) in human lung cells	12
Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging	12
A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells	11
Grading criteria of histopathological evaluation in BCOP assay by various staining methods	11
Acute toxicity and morphology alterations of glyphosate-based herbicides to Daphnia magna and Cyclops vicinus	11
Testosterone recuperates deteriorated male fertility in cypermethrin intoxicated rats	10
Evaluation of the skin sensitization potential of metal oxide nanoparticles using the ARE-Nrf2 Luciferase KeratinoSensTM assay	10
Effect of low-dose corticosterone pretreatment on the production of inflammatory mediators in super-low-dose LPS-primed immune cells	10
Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn® through the augmentation of cellular antioxidant defense machineries	9
Analysis of organochlorine pesticides residues in fish from Edko Lake (North of Egypt) using eco-friendly method and their health implications for humans	9
Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer	9
Urinary 1-aminopyrene level in Koreans as a biomarker for the amount of exposure to atmospheric 1-nitropyrene	8
β-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats	8
Regulation of cardiovascular biology by microsomal epoxide hydrolase	8
In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice	8

Developmental, behavioral and endocrine alterations in male rats at early and late postnatal life following in utero exposure to low dose di-n-butylphthalate	7
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	7
Protective effect of fisetin against subchronic chlorpyrifos-induced toxicity on oxidative stress biomarkers and neurobehavioral parameters in adult male albino mice	7
Advantages of omics technology for evaluating cadmium toxicity in zebrafish	6
Fimbristylis ovata and Artemisia vulgaris extracts inhibited AGE-mediated RAGE expression, ROS generation, and inflammation in THP-1 cells	6
Evaluation of genetic toxicity, acute and sub-chronic oral toxicity and systemic safety of Agrimonia pilosa and Rhus gall 50% ethanolic extract mixture (APRG64) in vitro and in vivo (rodent and non-ro	6
Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	6
Trade‐offs between male fertility reduction and selected growth factors or the klotho response in a lipopolysaccharide-dependent mouse model	6
Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation	6
Hepatic and renal damage by alcohol and cigarette smoking in rats	6
The effect of streptozotocin induced diabetes on sperm function: a closer look at AGEs, RAGEs, MAPKs and activation of the apoptotic pathway	5
Beneficial effects of Diplectria barbata (Wall. Ex C. B. Clarke) Franken et Roos extract on aging and antioxidants in vitro and in vivo	5
Effects of subacute oral administration of aqueous extract of Macaranga barteri Müll.Arg (Euphorbiaceae) leaf on anthropometric and haematological parameters in rats	5
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	5
Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice	5
Policosanol suppresses tumor progression in a gastric cancer xenograft model	5
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma	4
Sub-acute toxicity study on hydromethanolic leaves extract of Combretum hypopilinum (Combretaceae) Diels in Wistar rats	4
Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice	4
Anti-inflammatory effects of Athyrium yokoscense extract via inhibition of the Erk1/2 and NF-κB pathways in bisphenol A-stimulated A549 cells	4
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	4
The role of noble bumblebee (Bombus terrestris) queen glycosaminoglycan in aged rat and gene expression profile based on DNA microarray	4
Acute toxicity and antimalarial studies of extract of Allophylus spicatus in animals	4
Evaluation of the acute, sub-chronic and chronic oral toxicity, genetic toxicity, and safety of a Lomens-P0	4
Standardization of the first Korean national reference standard for snake (Gloydius brevicaudus) antivenom	4
Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats	4
Neurotoxicity of anthracene and benz[a]anthracene involves oxidative stress-induced neuronal damage, cholinergic dysfunction and disruption of monoaminergic and purinergic enzymes	4
Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats	4
A review on the pharmacokinetic properties and toxicity considerations for chloroquine and hydroxychloroquine to potentially treat coronavirus patients	4
Recent insights into autophagy and metals/nanoparticles exposure	4
Beet root (Beta vulgaris) protects lipopolysaccharide and alcohol-induced liver damage in rat	4
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	4
In vitro toxicological assessment of PhSeZnCl in human liver cells	3
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin	3
Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells	3
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	3
Protective effects of cardamom aqueous extract against tamoxifen-induced pancreatic injury in female rats	3
Explanation of difenoconazole removal by chitosan with Langmuir adsorption isotherm and kinetic modeling	3
Flow cytometric evaluation of the potential of metal oxide nanoparticles for skin sensitization using 5-Bromo-2-deoxyuridine	3
Characterisation of changes in global genes expression in the lung of ICR mice in response to the inflammation and fibrosis induced by polystyrene nanoplastics inhalation	3
Antiphotoaging properties of Zingiber montanum essential oil isolated by solvent-free microwave extraction against ultraviolet B-irradiated human dermal fibroblasts	3
Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells	3
Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague–Dawley rats	3
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	3
Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y	3
Hemorrhagic changes and microglia activation induced by Macrovipera lebetina obtusa venom with the inhibited enzymatic activity in rat brain	3
Evaluation of the in vitro and in vivo genotoxicity of a Dioscorea Rhizome water extract	3
Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice	3
Ameliorative effects of Dictyota dichotoma on hepatotoxicity induced by gibberellic acid in albino rats	3
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	2

Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	2
Rapid and simultaneous purification of aflatoxin B1, zearalenone and deoxynivalenol using their monoclonal antibodies and magnetic nanoparticles	2
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma	2
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	2
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss	2
Protective role of selenium on structural change of human hemoglobin in the presence of vinyl chloride	2
Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay	2
Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice	2
Sub-lethal effects of organophosphates and synthetic pyrethroid insecticides on muscle tissue transaminases of Oreochromis niloticus in vivo	2
Machine-learning based prediction models for assessing skin irritation and corrosion potential of liquid chemicals using physicochemical properties by XGBoost	2
Integrative roles of sphingosine kinase in liver pathophysiology	2
Acute toxicity of aqueous extract of Ambrosia arborescens Mill. on biochemical and histopathological parameters in rats	2
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	2
Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats	2
Assessment of toxicity and genotoxic safety profile of novel fisetin ruthenium-p-cymene complex in mice	2
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	2
Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague–Dawley rats	2
Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity	2