OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	70
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	65
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	39
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	24
Effect of CTMP1 gene on pulmonary fibrosis	23
Punicalagin mitigates benzo[α]pyrene induced epithelial-mesenchymal transition and migration in triple‑negative breast cancer cells	22
Exposure and health effects follow-up study of residents near a former smelter site	21
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	20
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	19
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	18
Mammalian target of rapamycin is required for insulin secretion in pancreatic β-cells via NeuroD1 in vitro and in vivo	17
Efficiency of pharmaceutical toxicity prediction in computational toxicology	17
Evaluation of acute neurotoxic effects induced by Gelsemium elegans in rats	16
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	15
Esculetin alleviates IgA nephropathy in rats by improving intestinal mucosal function through the IL-17/NF-κB signaling	15
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	15
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	14
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	14
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	13
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	13
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	13
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	13
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	13
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	13
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	13

Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	12
Acute toxicity assessment of nine organic UV filters using a set of biotests	12
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	11
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	11
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	11
Exploring the various functions of PHD finger protein 20: beyond the unknown	11
In vitro toxicological assessment of PhSeZnCl in human liver cells	11
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention	11
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	11
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	11
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	10
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	10
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	10
Risk assessment of diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as a UV filter in cosmetics	10
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	10
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	10
Integrative roles of sphingosine kinase in liver pathophysiology	9
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	9
Disinfection’s impact on the environment, molecular cross-resistance with antibiotics, and modern reduction approaches	9
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	9
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	9
Current status and future prospects of toxicity assessment using organoids	8
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	8
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	8
In silico cardiac safety assessment using a multi-biomarker approach based on an electrophysiological model of hiPSC-derived cardiomyocytes	8
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	8
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	8
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	8
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	8
Steroidogenic cytochrome P450 enzymes as drug target	7
Methylmercury causes pain disorders by disrupting the neuronal function of spinal dorsal horn neurons in mice	7
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	7
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	7
Evaluation of local and acute toxicity, and skin absorption of cannabidiol isolated from Cannabis sativa cultivated in Korea	7
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	7
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	7
The resveratrol-induced apoptosis and/or necroptosis of lung cancer cells is dependent on the activation status of PARP-1 and MLKL under oxidative stress	7
Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism and oxidative stress in female mice	6
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	6
Safety assessment of xylitol used in cosmetic products	6
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	6
Enhancement of renal fibrosis in PHF20 transgenic mice	6
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	6
HEBP2 affects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA-MB-231 breast cancer cells	5
Mechanism of endoplasmic reticulum stress-induced endothelial cell ferroptosis in trichloroethylene-induced mouse kidney injury	5
Induction of synergistic apoptosis by tetramethoxystilbene and nutlin-3a in human cervical cancer cells	5
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	5
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection	5
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	5
Microphysiological system-based respiratory toxicity assessment: recent advances and regulatory perspectives	5

Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys	5
Safety assessment of biotin used in cosmetics	5
In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations	5
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	5
Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane	5
Correction: Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	5
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro	4
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation	4
Occupational risk assessment of p-tert-butylphenol: toxicity reference values and worker exposure evaluation	4
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	4
Sperm analysis for reproductive toxicology studies in common marmosets (Callithrix jacchus)	4
Publisher Correction: Sex-dependent neurotoxicity of environmental toxicants: a narrative review	4
Changes in gut microbiota and metabolites of mice with intravenous graphene oxide-induced embryo toxicity	4
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	4
Safety assessment of methylene bis-benzotriazolyl tetramethylbutylphenol, a UV filter in cosmetics	4
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration	3
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential	3
Interactive effects of combination antiretroviral therapy (cART) and alcohol on the cerebellum of diabetic male Sprague Dawley rats	3
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method	3
Chitooligosaccharides as a potential immune modulator for reducing particulate matter 10-induced inflammation in pulmonary damage models	3
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes	3
Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T	3
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	3
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	3
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	3
Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway	3
Transferability and reproducibility of IMMUNOTOX-T assay, an in vitro method for evaluation of chemical-mediated immunotoxicity	3
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	3
Drug repositioning of amiodarone on the progression of thyroid cancer cells via the induction of apoptosis and autophagy	3
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats	3
Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll	3
A 13-week repeated oral toxicity study of Mycoleptodonoides aitchisonii (Agaricomycetes) in Sprague–Dawley rats	3
Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats	2
Case study on the evaluation of skin sensitization for 23 selected fragrance ingredients using a defined approach based on OECD Guideline 497	2
Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid	2
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells	2
Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells	2
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)	2
Toxicity assessment using neural organoids: innovative approaches and challenges	2
Bisphenol A and reproductive health: a comprehensive overview of toxicological effect	2
Deficiency of the voltage‑gated proton channel Hv1 aggravates lung damage induced by exposure to carboxylated carbon black and carboxylated carbon black@lead	2
Co-exposure to lead and hypertension exacerbates social impairment in mice through TREM2/IGF-1 mediated microglial polarization in the PVN	2
Regulatory frameworks for fragrance safety in cosmetics: a global overview	2
Hydramethylnon induces synergistic toxicity of pyrethroid mixtures in human lung epithelial cells	2
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	2
CALN1 regulates calcium–redox homeostasis and apoptotic responses to 5-fluorouracil in colorectal cancer cells	2
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study	2
Tris(2-chloroethyl) phosphate (TCEP) modulates hyperuricemia by regulating the expression of renal urate transporters OAT1, URAT1, and GLUT9	2
Investigation of alternative cell models to BALB/c 3T3 for in vitro neutral red uptake phototoxicity test of pharmaceuticals: NIH 3T3 and HaCaT cells	2
Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source	2
Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury	2
Development of in vitro skin corrosion test using KeraSkin™	2
The impact of manganese on vascular endothelium	2