OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	44
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	42
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	29
Effect of CTMP1 gene on pulmonary fibrosis	17
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	16
Policosanol suppresses tumor progression in a gastric cancer xenograft model	15
Exposure and health effects follow-up study of residents near a former smelter site	14
Efficiency of pharmaceutical toxicity prediction in computational toxicology	13
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	13
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	13
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	12
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	12
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	12
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	10
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	10
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	10
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	10
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	10
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	10
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	10
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	10
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	10
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	9
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	9
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	9

Acute toxicity assessment of nine organic UV filters using a set of biotests	9
In vitro toxicological assessment of PhSeZnCl in human liver cells	9
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	9
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	8
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	8
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	8
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	8
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention	8
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	8
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	8
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	8
Exploring the various functions of PHD finger protein 20: beyond the unknown	8
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	7
Quantification and visualization of metastatic lung tumors in mice	7
Integrative roles of sphingosine kinase in liver pathophysiology	7
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	7
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	7
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	7
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	7
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	7
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	7
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	7
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	7
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	7
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	7
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	6
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	6
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	6
Current status and future prospects of toxicity assessment using organoids	6
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	6
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	6
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	6
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	6
Steroidogenic cytochrome P450 enzymes as drug target	5
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	5
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	5
Mechanism of endoplasmic reticulum stress-induced endothelial cell ferroptosis in trichloroethylene-induced mouse kidney injury	5
In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations	5
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	5
Methylmercury causes pain disorders by disrupting the neuronal function of spinal dorsal horn neurons in mice	5
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma	5
Correction: Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	5
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	5
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	5
Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism and oxidative stress in female mice	5
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection	5
HEBP2 affects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA-MB-231 breast cancer cells	5
Induction of synergistic apoptosis by tetramethoxystilbene and nutlin-3a in human cervical cancer cells	5
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	5
Enhancement of renal fibrosis in PHF20 transgenic mice	5

Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma	4
Changes in gut microbiota and metabolites of mice with intravenous graphene oxide-induced embryo toxicity	4
Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys	4
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	4
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration	4
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	4
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	4
Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane	4
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	4
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro	4
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation	4
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats	4
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential	4
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	4
Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats	4
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	4
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method	4
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	4
Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid	3
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells	3
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes	3
Regulatory frameworks for fragrance safety in cosmetics: a global overview	3
Effect of 3-caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea on endothelial nitric oxide synthase activation via calcium signaling pathway	3
Chitooligosaccharides as a potential immune modulator for reducing particulate matter 10-induced inflammation in pulmonary damage models	3
Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway	3
Investigation of alternative cell models to BALB/c 3T3 for in vitro neutral red uptake phototoxicity test of pharmaceuticals: NIH 3T3 and HaCaT cells	3
Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll	3
Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source	3
Effect of daflon-500®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats	3
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)	3
Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test	2
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	2
Toxicity assessment using neural organoids: innovative approaches and challenges	2
Two weeks dose range-finding and four weeks repeated dose oral toxicity study of a novel reversible monoamine oxidase B inhibitor KDS2010 in cynomolgus monkeys	2
Saline extract of Portulaca elatior leaves with photoprotective and antioxidant activities does not show acute oral and dermal toxicity in mice	2
The impact of manganese on vascular endothelium	2
Deficiency of the voltage‑gated proton channel Hv1 aggravates lung damage induced by exposure to carboxylated carbon black and carboxylated carbon black@lead	2
Bisphenol A and reproductive health: a comprehensive overview of toxicological effect	2
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study	2
Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury	2
Zinc and selenium attenuate quaternary heavy metal mixture-induced testicular damage via amplification of the antioxidant system, reduction in metal accumulation, inflammatory and apoptotic biomarkers	2
Oxidative stress and pancreatic cancer: a dual role in tumorigenesis and drug toxicity	2
N-methylformamide induces multiple organ toxicity in Fischer 344 rats	2
Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells	2
Case study on the evaluation of skin sensitization for 23 selected fragrance ingredients using a defined approach based on OECD Guideline 497	2
Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats	2
Oxidative stress and NRF2 signaling in kidney injury	2
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice	2
Naringenin suppresses aluminum-induced experimental hepato-nephrotoxicity in mice through modulation of oxidative stress and inflammation	2