OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Flavonoids: structure–function and mechanisms of action and opportunities for drug development	68
No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period	23
Heavy metals in hair and nails as markers of occupational hazard among welders working in United Arab Emirates	15
Distribution of organochlorine pesticide pollution in water, sediment, mollusk, and fish at Saguling Dam, West Java, Indonesia	14
Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging	13
A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells	13
Evaluation of the skin sensitization potential of metal oxide nanoparticles using the ARE-Nrf2 Luciferase KeratinoSensTM assay	13
In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice	11
Grading criteria of histopathological evaluation in BCOP assay by various staining methods	11
Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn® through the augmentation of cellular antioxidant defense machineries	11
Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer	10
Analysis of organochlorine pesticides residues in fish from Edko Lake (North of Egypt) using eco-friendly method and their health implications for humans	10
Regulation of cardiovascular biology by microsomal epoxide hydrolase	9
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	9
Urinary 1-aminopyrene level in Koreans as a biomarker for the amount of exposure to atmospheric 1-nitropyrene	8
RETRACTED ARTICLE: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	8
Neurotoxicity of anthracene and benz[a]anthracene involves oxidative stress-induced neuronal damage, cholinergic dysfunction and disruption of monoaminergic and purinergic enzymes	8
Fimbristylis ovata and Artemisia vulgaris extracts inhibited AGE-mediated RAGE expression, ROS generation, and inflammation in THP-1 cells	8
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	7
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	7
Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation	7
Policosanol suppresses tumor progression in a gastric cancer xenograft model	6
Acute toxicity assessment of nine organic UV filters using a set of biotests	6
Evaluation of the acute, sub-chronic and chronic oral toxicity, genetic toxicity, and safety of a Lomens-P0	6
Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats	6

Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma	6
Characterisation of changes in global genes expression in the lung of ICR mice in response to the inflammation and fibrosis induced by polystyrene nanoplastics inhalation	6
Trade‐offs between male fertility reduction and selected growth factors or the klotho response in a lipopolysaccharide-dependent mouse model	6
In vitro toxicological assessment of PhSeZnCl in human liver cells	6
Advantages of omics technology for evaluating cadmium toxicity in zebrafish	6
A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies	5
Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice	5
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	5
Melanocytotoxic chemicals and their toxic mechanisms	5
Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice	5
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin	5
Recent insights into autophagy and metals/nanoparticles exposure	5
Acute toxicity of aqueous extract of Ambrosia arborescens Mill. on biochemical and histopathological parameters in rats	4
Flow cytometric evaluation of the potential of metal oxide nanoparticles for skin sensitization using 5-Bromo-2-deoxyuridine	4
Sub-acute toxicity study on hydromethanolic leaves extract of Combretum hypopilinum (Combretaceae) Diels in Wistar rats	4
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	4
A review on the pharmacokinetic properties and toxicity considerations for chloroquine and hydroxychloroquine to potentially treat coronavirus patients	4
Sub-lethal effects of organophosphates and synthetic pyrethroid insecticides on muscle tissue transaminases of Oreochromis niloticus in vivo	4
Ameliorative effects of Dictyota dichotoma on hepatotoxicity induced by gibberellic acid in albino rats	4
Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats	4
Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice	4
Antiphotoaging properties of Zingiber montanum essential oil isolated by solvent-free microwave extraction against ultraviolet B-irradiated human dermal fibroblasts	4
Anti-inflammatory effects of Athyrium yokoscense extract via inhibition of the Erk1/2 and NF-κB pathways in bisphenol A-stimulated A549 cells	4
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	4
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	4
Ruthenium biochanin-A complex ameliorates lung carcinoma through the downregulation of the TGF-β/PPARγ/PI3K/TNF-α pathway in association with caspase-3-mediated apoptosis	4
Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats	4
Acute toxicity and antimalarial studies of extract of Allophylus spicatus in animals	4
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	4
Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice	4
Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague–Dawley rats	3
Toxicity of a 90-day repeated oral dose of a collagen peptide derived from skate (Raja kenojei) skin: a rat model study	3
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	3
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	3
Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells	3
Efficiency of pharmaceutical toxicity prediction in computational toxicology	3
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice	3
Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells	3
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	3
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	3
Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y	3
Naringenin suppresses aluminum-induced experimental hepato-nephrotoxicity in mice through modulation of oxidative stress and inflammation	3
Hemorrhagic changes and microglia activation induced by Macrovipera lebetina obtusa venom with the inhibited enzymatic activity in rat brain	3
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	3
Machine-learning based prediction models for assessing skin irritation and corrosion potential of liquid chemicals using physicochemical properties by XGBoost	3
Protective effects of cardamom aqueous extract against tamoxifen-induced pancreatic injury in female rats	3
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss	3
Explanation of difenoconazole removal by chitosan with Langmuir adsorption isotherm and kinetic modeling	3
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	3
Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay	3

Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	3
Evaluation of the in vitro and in vivo genotoxicity of a Dioscorea Rhizome water extract	3
Assessment of toxicity and genotoxic safety profile of novel fisetin ruthenium-p-cymene complex in mice	3
Integrative roles of sphingosine kinase in liver pathophysiology	3
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	2
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	2
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	2
Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats	2
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	2
Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity	2
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	2
n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats	2
Repeated oral dose toxicity and genotoxicity of a standardized Quisqualis indica extract	2
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	2
Zinc and selenium attenuate quaternary heavy metal mixture-induced testicular damage via amplification of the antioxidant system, reduction in metal accumulation, inflammatory and apoptotic biomarkers	2
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	2
Protective role of selenium on structural change of human hemoglobin in the presence of vinyl chloride	2
Publication trends in South Korean research on particulate matter and health effects during two decades (2000–2019)	2
Defining the reactivity of nanoparticles to peptides through direct peptide reactivity assay (DPRA) using a high pressure liquid chromatography system with a diode array detector	2
The toxic effects of spent crankcase oil exposures; systematic review and meta-analysis	2
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	2
Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity	2
Rapid and simultaneous purification of aflatoxin B1, zearalenone and deoxynivalenol using their monoclonal antibodies and magnetic nanoparticles	2
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma	2
Effects of diesel exhaust particles and urban particles on brain endothelial cells	2
Catalytic enhancements in cytochrome P450 2C19 by cytochrome b5	2
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	2