OOIR: Observatory of International Research

Papers

(The median citation count of Biochip Journal is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A Laser-Micromachined PCB Electrolytic Micropump Using an Oil-Based Electrolyte Separation Barrier	85
Microfabricated Stretching Devices for Studying the Effects of Tensile Stress on Cells and Tissues	83
Recent Advances of Concentration Gradient Microfluidic Chips for Drug Screening	55
A Review of Microfluidic Chip-Based Strategies for Extracellular Vesicle Isolation: Bridging Traditional Methods and Clinical Translation	55
Ligand-Driven Enzyme-Accelerated Signal Enhancement via Polydopamine Deposition for Visualizing Cell Receptors	53
Advancing Blood–Brain Barrier-on-a-Chip Models Through Numerical Simulations	50
Recent Advances in Electrochemical and Optical Biosensors for Cancer Biomarker Detection	47
Numerical-Simulation-Based Buffer Design for Microchip Electrophoresis with Capacitively Coupled Contactless Conductivity Detection	42
Enhancement of Overlimiting Current in a Three-Dimensional Hierarchical Micro/Nanofluidic System by Non-uniform Compartmentalization	41
Microfluidic Platform for On-site Simultaneous Analysis of Ketamine and MDMA in Urine	38
In Vitro Assays of Neurite Outgrowth and Synapse Formation Using Thermoplasmonic Ablation Technique	37
Tandem Invasive Signal Amplification for Sensitive, Fluorescence Polarization-Based Terminal Transferase Activity Assay	32
Single-Shot Light-Field Microscopy: An Emerging Tool for 3D Biomedical Imaging	31
Deep Learning-Assisted Droplet Digital PCR for Quantitative Detection of Human Coronavirus	29
Polymerase Elongation onto Patterned DNA for Random Accessed DNA Data Storage	26
Recent Advances in Aptasensor Technologies for the Detection of Lung Diseases: A Comprehensive Review	25
Modelling Cardiovascular Diseases Using Human Microphysiological Systems	24
Engineered Blood Clots for Embolization in a 3D Microfluidic Chip Model Mimicking Vascular Structures	22
Thermoplasmonic Scaffold Design for the Modulation of Neural Activity in Three-Dimensional Neuronal Cultures	21
Helicobacter pylori-Vacuolating Cytotoxin A Induces Neurotoxic Neuroinflammation in Human Multicellular Models	21
Electrokinetic Paper-Based Ion Pre-concentrator for On-Site Detection of Ionic Water Contaminants	21
Organ-On-A-Chip Technology: An In-depth Review of Recent Advancements and Future of Whole Body-on-chip	20
Development of a 3D Vascularized Skeletal Muscle Model Using Bi-Layered Seeding Methods	20
DNA-Wrapped CNT Sensor for Small Nucleic Acid Detection: Influence of Short Complementary Sequence	20
Current Advances in Paper-Based Biosensor Technologies for Rapid COVID-19 Diagnosis	20

Label-free Electrochemical Biosensor for Glycated Hemoglobin (HbA1c) and Glycated Albumin (GA) Measurement Using 4-mercapto-phenyl Boronic Acid Embedded Affinity	20
Non-Invasive, Non-Enzymatic Glucose Sensor Using Phenylboronic Acid with Reversible Glucose Interaction	20
Nitrogen-Containing Bisphosphonate Carbon Dots with High Affinity to Calcium-Based Biomaterials for Suppression of Osteoclasts	20
One-Step Immunoassay of Influenza Virus Using Screened Fv-Antibodies and Switching Peptides	20
Integrating the Blood–Brain Barrier and Blood-CSF Barrier Organ-on-Chip Models: Development and Future Directions	19
Establishment and Evaluation of Immunocolloidal Gold Chromatography Method in the Sandwich Mode for Novel Coronavirus Double-Antibody Detection	19
Plasmonic-Multichromatic Sensor for Gallic Acid Assay Utilizing Ag-Coated Au Nanobipyramids	19
Sensitive Detection of SARS-CoV-2 Spike Protein Using an Aptamer Sandwich Assay-Based Electrochemical Biosensor	19
Enhancement of Maturation and Functionality of Human Fabry Disease Kidney Organoids in a Microfluidic Gradient Chip	18
M13 Bacteriophage-Based Bio-nano Systems for Bioapplication	18
Organ-on-a-Chip Models for Studying Gut–Brain Axis and Appetite Regulation	18
Detection and Real-Time Monitoring of LDL-Cholesterol by Redox-Free Impedimetric Biosensors	18
A Lateral Flow Assay for Nucleic Acid Detection Based on Rolling Circle Amplification Using Capture Ligand-Modified Oligonucleotides	17
Polydopamine Nanoparticle-Incorporated Fluorescent Hydrogel for Fluorescence Imaging-Guided Photothermal Therapy of Cancers	17
Classification of DNA Mixtures by Nanoelectrokinetic Driftless Preconcentration	17
Erratum: Brain Endothelial Cells Regulate Neural Stem Cell Maintenance by Consuming Growth Factors in a Reconstituted Vascular Neural Stem Cell Niche	17
Non-invasive Thermohydrodynamic Approach for Fast Cell Manipulation at the Microscale	17
Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling	16
Real-Time Detection of SARS-CoV-2 Nucleocapsid Antigen Using Data Analysis Software and IoT-Based Portable Reader with Single-Walled Carbon Nanotube Field Effect Transistor	16
Recording Fast Ion Channel Kinetics Using Non-invasive Electrical Impedance Spectroscopy	16
Acoustofluidic Microbioreactor Using Surface Acoustic Wave-induced Acoustic Streaming Flow	16
Recent Strategies in Nanomaterials-Based Signal Amplification of Electrochemical Biosensors	15
Surface Modification Strategies for Biomedical Applications: Enhancing Cell–Biomaterial Interfaces and Biochip Performances	15
Recent Advances in Electrochemical and Optical Point-of-Care Testing for Marine Biotoxin Detection	15
One-Step Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein Using Screened Fv-Antibodies	15
Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies	15
Towards Nanomaterial-Incorporated Soft Actuators: from Inorganic/Organic Material-Based Soft Robot to Biomaterial-Based Biohybrid Robot	14
Recent Progress in Rapid Biosensor Fabrication Methods: Focus on Electrical Potential Application	14
SARS-CoV-2 S1-Inducing Reactive Astrocyte and Proteinopathies via TANK-Binding Kinase 1 in Human Neuroglia Model	14
Recent Advances in 3D-Cultured Brain Tissue Models Derived from Human iPSCs	14
Critical Challenges and Future Direction in Extracellular Vesicle Research and Commercialization	14
Spheroid-Matrix Kidney-on-a-Chip Model for Predicting Drug-Induced Nephrotoxicity	13
Synergetic Chemo-Mechano Antimicrobial Puncturable Nanostructures for Efficient Bioaerosol Removal	13
Low-Powered pH-Stable Nano-electrokinetically Enhanced Lateral Flow Assay for COVID-19 Antigen Test	13
Advancements in Kidney-on-Chip: Antibiotic-Induced Kidney Injury and Future Directions	13
Miniaturized and Automated Optical-Switch Raman Spectroscopy Enabling Multiwell Surface-Enhanced Raman Spectroscopy Screening More than 26,000 Wells per Day	13
A Gut–Liver–Kidney (GLK) Multi-Organ Chip for Physiologically Modeling the Renal Filtration and Reabsorption of Oral Drugs	12
Matrix–Matrix Interfaces Orchestrate Early Mechanosensitive Transition from Attractor To Track	12
Erratum: A 3D Microfluidic Model of Initial Lymphatic Vessels for Investigating Dendritic Cell Chemotaxis Under Inflammatory Condition	12
Simultaneous Triplex Detection in a Single-Test-Line Lateral Flow Immunoassay Utilizing Distinct Nanoparticle Colorimetry	12
Functionalized Carbon Quantum Dots Derived from Zelkova serrata Plant Leaves for the Detection of Normetanephrine in Geriatric Plasma Samples and ROS-Induced Antibacterial Applications Using a Plausib	12
Continuous Isolation of Stem-Cell-Derived Extracellular Vesicles (SC-EVs) by Recycled Magnetic Beads in Microfluidic Channels	12
Fabrication of Nephrotoxic Model by Kidney-on-a-Chip Implementing Renal Proximal Tubular Function In Vitro	11
High-Performance Graphene FET Integrated Front-End Amplifier Using Pseudo-resistor Technique for Neuro-prosthetic Diagnosis	11
Oxygen-Terminated Silicon Carbide (SiC) Particle-Coated Electrodes for Highly Sensitive Electrochemical Immunoassays	11
One-Step Homogeneous Immunoassay for the Detection of Influenza Virus Using Switching Peptide and Graphene Quencher	11
A Label-Free, One-Step Isothermal Assay for Sensitive Detection of Telomerase Activity Using Light-Up Aptamer	11
Rapid and Cost-Effective On-site Detection of Plant Viruses Using Personal Glucose Meters Integrated with LAMP and Cascade Enzymatic Reactions	11
Surface Plasmon Resonance (SPR) Biosensor for the Detection of SARS-CoV-2 Using Autodisplyaed FV-antibodies on Outer Membrane of E. coli	11
Advanced Microfluidic Platform for Tumor Spheroid Formation and Cultivation Fabricated from OSTE+ Polymer	11

Microtubule WGM Sensor: Applications and Key Technologies	10
Lateral Flow Assay System Using Glycerol-Stabilized Fluorescent Copper Nanoclusters as Detection Labels	10
Development of Gut-Mucus Chip for Intestinal Absorption Study	10
Modular Microfluidics: A Systematic Review of Assembly-Based Categorization and Biological Applications	9
Target-Responsive Template Structure Switching-Mediated Exponential Rolling Circle Amplification for the Direct and Sensitive Detection of MicroRNA	9
Recent Advances in Electrochemical and Nanophotonic Biosensors for SARS-CoV-2 Detection	9
Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review	9
Mechanically Flexible Polymeric Nanoneedle Arrays for Promoting Differentiation and Functional Activity of Neural Progenitor Cells	8
Fluorescent Lateral Flow Assay with Carbon Nanodot Conjugates for Carcinoembryonic Antigen	8
A Robust, Solvent-Resistant Paper-Based Platform for Discriminative Detection of Organic Solvents	8
Immunogenicity Monitoring Cell Chip Incorporating Finger-Actuated Microfluidic and Colorimetric Paper-Based Analytical Functions	8
Nanomaterials-Based Exosomes for the Diagnostics and Drug Deliveries of Central Nervous System Diseases	8
Multiplex Magnetic Biosensor Microarrays Facilitate Personalized Vaccination Schedules for SARS-CoV-2 Variants	7
Engineering Myocardial Anisotropy to Model Electrical Dysfunction and Pharmacological Responsiveness in Arrhythmogenic Cardiomyopathy	7
3D Artificial Cell Membranes as Versatile Platforms for Biological Applications	7
Advanced Organotypic In Vitro Model Systems for Host–Microbial Coculture	6
Micro-injection Molded Droplet Generation System for Digital PCR Application	6
Integration of Machine Learning in Surface-Enhanced Raman Spectroscopy Biosensor for Biomedical Applications	6
Voltammetric Aptamer-Based Biochip Featuring Poly Gallic Acid/SnO2–MoO3 Nanocomposite for Selective Tryptophan Detection: Potential Application in Alzheimer's Diagnosis	6
Fabrication of Biomimetic Cell Culture Membranes Using Robust and Reusable Nickel Micropillar Molds	6
Exploring the Role of Shape and Size in Metal–Organic Framework–Mediated Ferroptosis	6
Investigation of Collagen Network Microstructure and Vascular Sprouting On-Chip Using Non-enzymatic Glycation	6
Vertical Droplet-Squeezing Platform for Highly Efficient Biomolecular Delivery	6
Highly Efficient DNA Reporter for CRISPR/Cas12a-Based Specific and Sensitive Biosensor	6
Point-of-Care Diagnostic Modular Device for Detection of VHSV with Reverse Transcription Loop-Mediated Isothermal Amplification	6
Paper-Based Radial Flow Assay Integrated to Portable Isothermal Amplification Chip Platform for Colorimetric Detection of Target DNA	6
Effect of Periodical Tensile Stimulation on the Human Skin Equivalents by Magnetic Stretching Skin-on-a-Chip (MSSC)	6
Label-Free Impedance Monitoring of the Protective Effect of Salviae Miltiorrhizae Radix on Glutamate-Induced Neurotoxicity	6
Stabilized Exfoliated Black Phosphorus Nanosheets for Fungal DNA-Extraction Assay	5
Fabrication of Cell Spheroids for 3D Cell Culture and Biomedical Applications	5
Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip	5
Flexible Capillary Microfluidic Devices Based on Surface-Energy Modified Polydimethylsiloxane and Polymethylmethacrylate with Room-Temperature Chemical Bonding	5
Comparison and Analysis of Polymer-Functionalized Carbon Nanotubes for Enhancement of the Quantitative Detection of Procalcitonin Levels in Human Plasma	5
Optical-Switch Raman Spectroscopy for High Throughput Screening	5
Intensity Histogram-Based Reliable Image Analysis Method for Bead-Based Fluorescence Immunoassay	5
One-Step Immunoassay for the Detection of Influenza Virus Based on Screened Nucleoprotein (NP)-like Mimotopes from Fv-Antibody Library	5
Gut-Liver-Immune Modular Multi-organ Chip for Non-alcoholic Fatty Liver Disease (NAFLD) Model	5
Toxicity Assessment of Humidifier Disinfectant Component CMIT/MIT Using Bioprinted Thin-Layer Human Alveolar Model	5