ACS Medicinal Chemistry Letters

Article	Citations
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	111
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	107
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	104
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	69
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	56
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	55
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	50
Issue Publication Information	47
Issue Editorial Masthead	47
Issue Publication Information	45
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	43
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain	41
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	41
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	39
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	39
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	38
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	37
In This Issue, Volume 14, Issue 5	36
Targeting the “Undruggable” Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer	36
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	35
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	33
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	32
Novel Phosphorylpurinone Compounds for Treating Cancer	32
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	31
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	31

Clozapine as an E3 Ligand for PROTAC Technology	30
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket	30
Design and Synthesis of a Structurally Stabilized B-Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3)	30
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	29
Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	29
Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids	29
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	28
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	28
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	27
Contemporary Computational Applications and Tools in Drug Discovery	27
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	27
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	26
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	26
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	26
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	25
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	25
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	24
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	24
Issue Editorial Masthead	23
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	23
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	23
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	22
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	22
Thermal Stability and Utility of Dienes as Protecting Groups for Acrylamides	21
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry	21
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	21
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	21
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	20
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	20
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	20
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	20
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	20
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	20
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	19
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	19
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	19
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	19
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	18
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	18
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	18
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	18
Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones	18
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	18
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	18
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	17
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	17
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	17
Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group	17
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	17
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	17

Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	17
Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase	17
Advancing New Chemical Modalities into Clinical Studies	17
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	16
Fragment Ligands of the m6A-RNA Reader YTHDF2	16
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	16
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	16
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	16
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	16
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists	16
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	15
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	15
Issue Editorial Masthead	15
Issue Editorial Masthead	15
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D2 Receptors	15
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	15
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	15
Issue Publication Information	15
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	15
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	15
Synthesis and Preclinical Evaluation of Novel 68Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	15
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	15
Issue Publication Information	15
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	15
Issue Publication Information	15
Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2	14
Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke	14
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics	14
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	14
Issue Editorial Masthead	14
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids	14
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	14
The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate	14
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	14
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	14
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	14
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer	14
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist	14
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	14
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	13
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	13
Identification and In Silico Binding Study of a Highly Potent DENV NS2B-NS3 Covalent Inhibitor	13
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	13
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	13
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	13
In this Issue, Volume 16, Issue 5	13
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	13
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition	13
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	13
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	13
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	13
Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	13
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	13
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	13
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	13
SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity	13
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	13
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	13
Fragment-Based Discovery of Drug-like LRH-1 Agonists	12
Application of Rapidly Accelerating Fibrosarcoma Protein Degraders in Drug Discovery	12
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	12
Issue Publication Information	12
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	12
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	12
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity	12
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	12
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	12
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	12
In This Issue, Volume 13, Issue 1	12
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	12
Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist	11
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	11
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	11
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	11
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	11
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	11

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	11
Issue Editorial Masthead	11
Targeted Degradation of EGFR and PKC Isoforms: Emerging Bifunctional and Peptidic Modalities in Oncology and Immune Regulation	11
Novel 2 H -Pyrazolo[3,4- d ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Dise	10
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	10
Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide	10
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	10
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	10
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants	10
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	10
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	10
Issue Publication Information	10
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups	10
Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	10
Issue Editorial Masthead	10
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	10
Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
Issue Editorial Masthead	10
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	10
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	10
Novel Nonpeptide as Oxytocin Receptor Agonist	10
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	10
Next-Generation GLUT Inhibitors: Lactone to Lactam Conversion in Rapaglutin A Confers Resistance to Plasma Esterases	10
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	10
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	10
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	10
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	10
Issue Publication Information	10
Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes	10
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	9
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	9
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	9
ACS Medicinal Chemistry Letters: An Innovation Ten Years in the Making	9
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control	9
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors	9
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	9
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	9
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	9
How a Blockchain Approach Can Improve Data Reliability in the COVID-19 Pandemic	9
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	9
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	9
Design, Synthesis, and Biological Evaluation of Tetrazol-2-yl-acetamides as Novel Antitubercular Agents	9
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	9
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	9
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	9
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	9
Biological Effects of Modifications of the Englerin A Glycolate	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
Inhibitors of Nav1.7 for the Treatment of Pain	9
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	9
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation	8
Application of Compositions Comprising a KRAS G12C Inhibitor and an EGFR Inhibitor for the Potential Treatment of Cancer	8
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging	8
In This Issue, Volume 15, Issue 4	8
Issue Publication Information	8
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity	8
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors	8
Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors	8
Advances in the Quest for Safe and Effective Drugs That Target the Cannabinoid Receptor Type 1 (CB1)	8
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B	8
Structure–Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors	8
BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis	8
Integrated Advancements in Neuroplasticity, Psychedelic Therapeutics, and AI-Driven Innovations for Precision Medicine	8
Issue Publication Information	8
Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators	8
Total Synthesis as Training for Medicinal Chemistry	8
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases	8
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists	8
Investigation of Isobactin Analogues of Teixobactin	8
Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity	8
Issue Publication Information	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies	8
Novel AHR Agonists for Treating Psoriasis	8
Issue Editorial Masthead	8
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol	8
Novel Cyanotriazole Compounds for Treating Kinetoplastid Diseases, Particularly, Chagas Disease, Leishmaniasis, and Human African Trypanosomiasis	8