ACS Medicinal Chemistry Letters

Article	Citations
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	143
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	138
Issue Editorial Masthead	132
Issue Publication Information	83
Issue Publication Information	69
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	63
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	58
Clozapine as an E3 Ligand for PROTAC Technology	50
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	49
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket	47
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	46
Design and Synthesis of a Structurally Stabilized B-Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3)	46
Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids	44
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	42
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	40
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	40
In This Issue, Volume 14, Issue 5	37
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	36
Novel Phosphorylpurinone Compounds for Treating Cancer	35
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	35
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain	35
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	34
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	34
Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6	33
Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity	32

Modulation of Cancer Networks through Protein Degradation, DNA Repair Inhibition, and Quantitative Interactomics	32
Multimodal Control of STAT6 Signaling through Small-Molecule Modulation and Targeted Degradation	31
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	31
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	31
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	31
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	31
Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	31
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	29
Structure–Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region	29
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	28
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	27
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	27
Contemporary Computational Applications and Tools in Drug Discovery	26
Targeting the “Undruggable” Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer	26
Discovery of Quinazolinone Derivatives as Potent PARP1 Inhibitors	24
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	23
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	22
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	22
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	22
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	22
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	22
Issue Editorial Masthead	21
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	21
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	20
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	20
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	20
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	20
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	20
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	20
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	20
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	20
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	20
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	19
N -Myristoyltransferase Inhibitors as a Potential Starting Point for the Development of Antischistosomal Agents	19
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	19
Novel Indazole Compounds as PKMYT1 Kinase Inhibitors for Treating Cancer	19
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	19
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	19
Novel Compounds as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity	19
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	19
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	19
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	19
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	19
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	18
Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group	18
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	18
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	18
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	18
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	18
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	18

Advancing New Chemical Modalities into Clinical Studies	18
Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase	18
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	17
N -Alkyl and N -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable P	17
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	17
Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics	17
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	17
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	17
Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na V 1.8 Inhibitors	17
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	17
Synthesis and Biochemical Characterization of Investigational Pyrazolopyrimidine-Based Allosteric KRAS Modulators	16
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	16
A Novel Peptide-Based PD-L1 PET Tracer: Design, Synthesis, and Preclinical Imaging Validation	16
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	16
Fragment Ligands of the m6A-RNA Reader YTHDF2	16
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	16
Mechanistic Insights from Differences in the Aggregate Morphologies of Amphotericin B and Its Less Toxic Variant Am-2-19 (Turletricin)	16
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	16
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	15
Synthesis and Preclinical Evaluation of Novel 68Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	15
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents	15
Issue Publication Information	15
6,7-Dihalo-Benzothiadiazines as Potent and Selective AMPA Receptor Modulators for Cognitive Enhancement and Neuroprotection	15
Synthesis and Biological Evaluation of 3,5-Diaryl-Substituted 1,2,4-Oxadiazole Sulfamates as Potent Steroid Sulfatase Inhibitors	15
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	14
Issue Publication Information	14
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	14
Issue Editorial Masthead	14
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	14
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	14
Issue Editorial Masthead	14
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	14
Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2	14
Issue Editorial Masthead	14
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry	14
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	14
Issue Publication Information	14
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	14
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics	14
Chemical Design and Pharmacokinetics Enable Precision Psychedelic Therapeutics	13
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	13
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	13
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D 2 Receptors	13
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist	13
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	13
From Solid-State Control to Predictive Precision: Building a Deployable Ecosystem for Psychedelic Therapeutics	13
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	13
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	13
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	12
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	12
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	12
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	12
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	12
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	12
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	12
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	12
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	12
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	12
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	12
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	12
Novel Compounds for Treating Huntington’s Disease	12
Targeting the Glucokinase–Glucokinase Regulatory Protein Axis: Pharmacophore-Based Identification of Novel Antidiabetic Small Molecules	12
Novel Substituted Aryl Sulfonamides and Sulfuric Diamides As Transglutaminase 2 Inhibitors	11
Tambjamines as Promising Leads for the Development of Next-Generation Antifungals against Candida auris	11
Issue Publication Information	11
Discovery of Small-Molecule GLP-1 Receptor Agonists with Improved Oral Pharmacokinetics Based on Orforglipron	11
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	11
Targeted Degradation of EGFR and PKC Isoforms: Emerging Bifunctional and Peptidic Modalities in Oncology and Immune Regulation	11
In this Issue, Volume 16, Issue 5	11
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	11
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	11
DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site	11
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	11
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	11
Call for Papers: Allosteric Modulators in Drug Discovery	11
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	11
Issue Editorial Masthead	11
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	11

Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Novel Nonpeptide as Oxytocin Receptor Agonist	11
Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	11
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	10
Issue Publication Information	10
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	10
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	10
Fentanyl-Rewired: A 2-Azaspiro[3.3]heptane Core Preserves μ-Opioid Function	10
Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide	10
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	10
Novel 2 H -Pyrazolo[3,4- d ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Dise	10
Novel Compounds as MALT1 Inhibitors for Treating Cancer	10
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	10
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	10
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	10
Issue Editorial Masthead	10
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	10
Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer	10
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	10
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	10
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	10
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	10
Fragment-Based Discovery of Drug-like LRH-1 Agonists	10
Novel Compounds for Treating Hemoglobinopathies, Namely, Anemia, Sickle Cell Disease, or Thalassemia	10
Issue Editorial Masthead	10
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	10
Next-Generation GLUT Inhibitors: Lactone to Lactam Conversion in Rapaglutin A Confers Resistance to Plasma Esterases	10
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	10
Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist	10
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	10
5-Nitrofuran-Semicarbazone Hybrids as Antitrypanosomal Agents: Structure–Activity Relationship and Nitroreductase Activation	10
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	10
Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	10
Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	10
The Value of Academic and Industrial Collaborations in Drug Discovery	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	9
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	9
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	9
Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid)	9
Novel Substituted Spiro-Ureas as Monoacylglycerol Lipase Inhibitors	9
Design, Synthesis, and Biological Evaluation of Tetrazol-2-yl-acetamides as Novel Antitubercular Agents	9
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	9
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	9
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	9
Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	9
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	9
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	9
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	9
Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Issue Publication Information	9
Synthesis and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological Recognition	8
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	8
Issue Publication Information	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Novel AHR Agonists for Treating Psoriasis	8
In This Issue, Volume 15, Issue 4	8
Issue Editorial Masthead	8
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	8
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement	8
4-Aminoalkylquinolines as Potent Antitubercular Agents Targeting the Cytochrome bc 1 Complex	8
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	8
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Novel 6-Substituted-3-Phenylisoindolin-1-ones as Cbl-B Inhibitors for Treating Cancer	8
Integrated Advancements in Neuroplasticity, Psychedelic Therapeutics, and AI-Driven Innovations for Precision Medicine	8
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode	8
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	8
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	8
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	8
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders	8
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	8
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging	8
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy	8
Issue Publication Information	8
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	8
Biological Effects of Modifications of the Englerin A Glycolate	8
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	8