OOIR: Observatory of International Research

Papers

(The H4-Index of ACS Medicinal Chemistry Letters is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Novel Histone Acetyltransferase (HAT) Inhibitors for Treating Diseases	87
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	87
In This Issue, Volume 14, Issue 5	74
Issue Publication Information	56
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	49
Issue Editorial Masthead	49
Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain	48
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	48
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	47
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	39
Issue Publication Information	39
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	38
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	36
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	35
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	34
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	34
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	34
Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules	33
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	32
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	32
Clozapine as an E3 Ligand for PROTAC Technology	32
Novel Phosphorylpurinone Compounds for Treating Cancer	31
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	30
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	28
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	28

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers	27
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	27
Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs	27