OOIR: Observatory of International Research

Papers

(The H4-Index of ACS Medicinal Chemistry Letters is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2	165
Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment	137
Solution Conformations Shed Light on PROTAC Cell Permeability	95
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs	77
The Advent of Generative Chemistry	64
Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity	64
Structural Impact of Mutation D614G in SARS-CoV-2 Spike Protein: Enhanced Infectivity and Therapeutic Opportunity	61
PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases	53
A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin	52
Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space	51
Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry	47
Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies	46
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors	45
Biotransformation: Impact and Application of Metabolism in Drug Discovery	44
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	44
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor	43
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	41
Risdiplam, the First Approved Small Molecule Splicing Modifier Drug as a Blueprint for Future Transformative Medicines	41
Systematic Investigation of the Permeability of Androgen Receptor PROTACs	40
Evaluation of 3-Dimensionality in Approved and Experimental Drug Space	39
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency	37
The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID	36
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate	36
Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors	35
Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists	31

Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging	31
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)	30
Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy	29
Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia	28
Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain	28