World Journal of Stem Cells

Article	Citations
Stem cells and pain	66
Clinical trials using dental stem cells: 2022 update	61
Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation	47
Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model	43
Emerging role of mesenchymal stem cell-derived exosomes in the repair of acute kidney injury	35
Dental mesenchymal stromal/stem cells in different microenvironments— implications in regenerative therapy	35
Stem cell-derived neural organoids as platforms to investigate glioblastoma invasion and migration: A systematic review	33
Bone marrow mesenchymal stem cell therapy regulates gut microbiota to improve post-stroke neurological function recovery in rats	32
Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study	30
Recombinant human thrombopoietin safety and efficacy in pediatric allogeneic hematopoietic stem cell transplantation: A cohort study	29
Human retinal secretome: A cross-link between mesenchymal and retinal cells	27
Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury: First results of a phase I study	26
MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells	26
Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury	26
Application and prospects of high-throughput screening for in vitro neurogenesis	23
Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells	23
Harnessing and honing mesenchymal stem/stromal cells for the amelioration of graft-versus-host disease	22
Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications	21
Priming strategies for controlling stem cell fate: Applications and challenges in dental tissue regeneration	21
Comparison of therapeutic potential of macrophage- or mesenchymal stem cell-derived exosomes in pancreatic cancer: An updated review	20
Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications	20
Collagen III combined with autologous adipose-derived mesenchymal stem cells accelerates burn wound healing in a rat model	20
Gut microbiota modulating intestinal stem cell differentiation	20
MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model	20
Fibro-adipogenic progenitors prevent skeletal muscle degeneration at acute phase upon tendon rupture in a murine tibialis anterior tenotomy model	20

Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation	20
Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance	18
Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing	18
Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain	17
Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model	17
Understanding and controlling the variables for advanced cell therapy	16
Tumor necrosis factor-α inhibition restores matrix formation by human adipose-derived stem cells in the late stage of chondrogenic differentiation	16
Multiroute administration of Wharton’s jelly mesenchymal stem cells in chronic complete spinal cord injury: A phase I safety and feasibility study	16
Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome	15
Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia	15
Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature	15
Advancing mechanistic insights and clinical translation of exosomal miR-137-3p in endometrial regeneration	14
Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia	14
Application of adipose-derived stem cells in treating fibrosis	13
Extracellular vesicles: Emerged as a promising strategy for regenerative medicine	13
Mesenchymal stem/stromal cells as adjuvant therapy in COVID-19-associated acute lung injury and cytokine storm: Importance of cell identification	13
MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells	13
Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential	13
Repetitive administration of cultured human CD34+ cells improve adenine-induced kidney injury in mice	12
ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells	12
Potential of ginsenoside Rg1 to treat aplastic anemia via mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model	12
Banking of perinatal mesenchymal stem/stromal cells for stem cell-based personalized medicine over lifetime: Matters arising	12
Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications	12
Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing	12
Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases	12
O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells	12
Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model	11
Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations	11
Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells	11
Barriers to mesenchymal stromal cells for low back pain	11
Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes	11
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro	11
Recent progress in hair follicle stem cell markers and their regulatory roles	11
Refining adipose-derived stem cell isolation for optimal regenerative therapy	11
Inhibition of glutathione metabolism can limit the development of pancreatic cancer	11
Advances of nanotechnology applied to cancer stem cells	10
Living bio-drug therapies using mesenchymal stem cells and exosomes for mechanically ventilated patients with acute respiratory distress syndrome: A systematic review and meta-analysis	10
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction	10
Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities	10
Adipokines regulate mesenchymal stem cell osteogenic differentiation	10
Molecular mechanism of therapeutic approaches for human gastric cancer stem cells	10
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis	10
Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis	10
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation	10
Expression of cancer stem cell markers and their prognostic significance in stage IIIA non-small cell lung cancer	10
Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury: First results of a phase I study	9
Applications of artificial intelligence in stem cell therapy	9
Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells	9
High glucose microenvironment and human mesenchymal stem cell behavior	9
Innovative mesenchymal stem cell treatments for fatty liver disease	9

Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars	9
Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential	9
Exploring the critical therapeutic window: Dose-frequency optimization of human umbilical cord mesenchymal stem cells for preclinical asthma treatment	9
Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging	9
Application of dental stem cells in three-dimensional tissue regeneration	9
Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation	9
Bone marrow mesenchymal stem cell treatment improves post-stroke cerebral function recovery by regulating gut microbiota in rats	9
Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction	9
Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis	9
Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease	9
Stem cell transplantation in cerebrovascular accidents: A global bibliometric analysis (2000-2023)	8
Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells	8
Human umbilical cord mesenchymal stromal cell-derived extracellular vesicles alleviate radiation induced pulmonary fibrosis	8
Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization	8
Engineering ligament tissues: Synergistic power of aligned nanofibers and cyclic stretch	8
Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy	8
MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway	8
Strategies to improve regenerative potential of mesenchymal stem cells	8
How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration	8
Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated para	8
Skinny people serum factors promote the differentiation of multipotent stem cells into brown adipose tissue	8
Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients	8
Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis	8
Preliminary evidence of renal function improvement in chronic progressive kidney disease using autologous CD34+ cell therapy: A clinical trial	8
Human dental pulp stem/stromal cells in clinical practice	8
Potential plausible role of Wharton’s jelly mesenchymal stem cells for diabetic bone regeneration	8
Correction to “ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors”	8
Silent saboteurs: How microplastics disrupt stem cells and tissue regeneration	7
Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells	7
Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: A comparative analysis with mesenchymal stem cells	7
Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors, and their in vivo implantation regenerated the intervertebral disc degeneration	7
Mesenchymal stem cell-derived exosomes and the Wnt/β-catenin pathway: Unifying mechanisms of multi-organ regeneration and the path to precision clinical translation	7
Stem cell therapy for intervertebral disc degeneration: Clinical progress with exosomes and gene vectors	7
WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells	7
Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging	7
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway	7
Advances in human umbilical cord mesenchymal stem cells-derived extracellular vesicles and biomaterial assemblies for endometrial injury treatment	7
Stromal vascular fraction: Mechanisms and application in reproductive disorders	7
Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders	7
Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures	7
Priming strategies for controlling stem cell fate: Applications and challenges in dental tissue regeneration	7
Umbilical cord mesenchymal stem cell exosomes alleviate necrotizing enterocolitis in neonatal mice by regulating intestinal epithelial cells autophagy	7
Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics	7
Effects of immune cells on mesenchymal stem cells during fracture healing	7
Generation of a human haploid neural stem cell line for genome-wide genetic screening	6
Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy	6
Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation	6
Molecular signaling in cancer stem cells of tongue squamous cell carcinoma: Therapeutic implications and challenges	6
Bibliometrics of trends in global research on the roles of stem cells in myocardial fibrosis therapy	6
Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles	6
Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation	6
Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling	6
Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure	6
Emergence of the stromal vascular fraction and secretome in regenerative medicine	6
Long noncoding ribonucleic acid ENST00000517482 enhances mesenchymal stem cell therapy against acute lung injury	6
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators	5
Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives	5
Long noncoding RNAs in mesenchymal stromal/stem cells osteogenic differentiation: Implications in osteoarthritis pathogenesis	5
Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease	5
Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells	5
Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway	5
First-ever stem cell therapy restores insulin independence in type 1 diabetes: A medical milestone	5
Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia	5
Stem cell therapy applied for digestive anastomosis: Current state and future perspectives	5
Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft	5
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling	5
Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats	5
Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation	5
Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing	5
Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases	5
L-arginine: A promising metabolite in enhancing the protective effects of adipose-derived stem cells against ischemic pathologies	4
X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury	4
Optimal good manufacturing practice-compliant production of dental follicle stem cell sheet and its application in Sprague-Dawley rat periodontitis	4
Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway	4
Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque	4
Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance	4
When hematology meets ophthalmology: Cytomegalovirus retinitis in pediatric stem cell recipients	4
Pretreatment can alleviate programmed cell death in mesenchymal stem cells	4
Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health	4
Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells	4

Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy	4
Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia	4
MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells	4
Culture and identification of neonatal rat brain-derived neural stem cells	4
L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases	4
Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy	4
Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing	3
Stem cell therapy for insulin-dependent diabetes: Are we still on the road?	3
Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives	3
Dual role of extracellular vesicles in neurodegenerative diseases	3
Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke	3
Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances	3
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis	3
Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice	3
Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression	3
Stem cell-derived biofactors fight against coronavirus infection	3
Quercetin pretreated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease via IL-10 /Janus kinase 2/STAT3 signaling	3
Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases	3
Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages	3
Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial	3
Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy	3
Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche	3
Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositis via Lactobacillus reuteri - dependent modulation of the gut microbiota	2
Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis	2
Adipose-derived regenerative therapies for the treatment of knee osteoarthritis	2
Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment	2
Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells	2
Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China	2
ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells	2
Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology	2
Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes	2
Entering the era of living biopharmaceuticals for treating knee osteoarthritis: A systematic review and network meta-analysis	2
Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review	2
Engineering the future of nanomedicine: Strategic approaches to extracellular vesicle-based drug administration regimens	2
Adult neural stem cells and schizophrenia	2
Dual role and clinical application of extracellular vesicles in acute respiratory distress syndrome: Mechanism analysis and translational challenges	2
Melatonin-based priming of stem cells to alleviate oxidative stress	2
Disagreements in the therapeutic use of mesenchymal stem cell-derived secretome	2
Interplay between mesenchymal stem cells and macrophages: Promoting bone tissue repair	2
Perspectives on Schwann-like cells derived from bone marrow-mesenchymal stem cells: Advancing peripheral nerve injury therapies	2
ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells	2
Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy	2
Cardiac stem cells: Current knowledge and future prospects	2
Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges	2
Effects of immune cells on mesenchymal stem cells during fracture healing	2
Epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics	2
Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages	2
Advances in mesenchymal stem cell therapy for lupus nephritis	2
Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway	2
Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine	2
Human pluripotent stem cell-derived kidney organoids: Current progress and challenges	2
Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor	2
GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines	2
Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment	2