Science Translational Medicine

(The TQCC of Science Translational Medicine is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
IgA dominates the early neutralizing antibody response to SARS-CoV-2609
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance494
Advances in therapeutic applications of extracellular vesicles430
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade410
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF V600E melanoma399
Immunological mechanisms of the antitumor effects of supplemental oxygenation371
Aggregatibacter actinomycetemcomitans –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis332
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells326
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients312
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials307
Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients305
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism280
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy266
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism248
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells244
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome234
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming223
Reproducing human and cross-species drug toxicities using a Liver-Chip214
Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy203
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters200
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia186
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations186
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans180
The gut microbiota influences skeletal muscle mass and function in mice177
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data177
Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier169
HIV latency in isolated patient CD4+T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing168
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies166
The vermiform appendix impacts the risk of developing Parkinson’s disease165
Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation161
GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells160
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis155
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer155
Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs149
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases149
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs146
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease146
Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease146
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility139
Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1138
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis137
Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer134
Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis131
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state130
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans129
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response129
Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction125
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis125
A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice124
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus124
Engineering precision biomaterials for personalized medicine123
Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge123
Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial123
On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation122
Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer121
Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma121
Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia119
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier119
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizesp53-deficient cancers to mTOR inhibition119
Companion animals: Translational scientist’s new best friends118
Hurdles in therapy with regulatory T cells117
Applications of liquid biopsies for cancer116
Multiple roles for HIV broadly neutralizing antibodies115
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy115
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models114
Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation114
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment114
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer113
Illusory movement perception improves motor control for prosthetic hands113
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk113
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs112
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype112
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay111
HBEGF + macrophages in rheumatoid arthritis induce fibroblast invasiveness108
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy107
Structure-based drug design identifies polythiophenes as antiprion compounds106
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies106
Astrocyte molecular signatures in Huntington’s disease105
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages105
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis105
Challenges for mesenchymal stromal cell therapies104
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy104
Development of a stress response therapy targeting aggressive prostate cancer103
Enhancing functional abilities and cognitive integration of the lower limb prosthesis102
Targeted antibody and cytokine cancer immunotherapies through collagen affinity102
Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction102
Tuberculosis following PD-1 blockade for cancer immunotherapy101
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma101
Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration101
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin100
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation99
The 1918 influenza pandemic: 100 years of questions answered and unanswered98
Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm98
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response97
Patients with autism spectrum disorders display reproducible functional connectivity alterations96
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain95
Big data and black-box medical algorithms94
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice90
The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing89
Mixed-effects association of single cells identifies an expanded effector CD4 + T cell subset in rheumatoid arthritis89
Rapamycin and Alzheimer’s disease: Time for a clinical trial?88
Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion88
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis88
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics86
Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy85
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus85
A multimodality test to guide the management of patients with a pancreatic cyst85
A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy84
Challenges and strategies for developing efficacious and long-lasting malaria vaccines84
Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants82
In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma82
In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis82
Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression81
CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity81
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening81
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model80
A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism80
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa79
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice79
Neoantigen quality, not quantity78
Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina78
Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain78
Targeting the NF-κB signaling pathway in chronic tendon disease77
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD5177
Cyclin G1 and TASCC regulate kidney epithelial cell G 2 -M arrest and fibrotic maladaptive repair77
Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma76
An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis76
An innate-like Vδ1 + γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer76
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma75
An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis75
Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects75
Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors74
Advanced bandages for diabetic wound healing74
Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation74
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells74
High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides73
Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α73
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals73
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer72
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension71
Two-mAb cocktail protects macaques against the Makona variant of Ebola virus70
Production and transplantation of bioengineered lung into a large-animal model70
The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders70
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia69
Therapeutically relevant engraftment of a CRISPR-Cas9–edited HSC-enriched population with HbF reactivation in nonhuman primates68
A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy68
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development67
Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination67
Activin type II receptor signaling in cardiac aging and heart failure67