Science Translational Medicine

Article	Citations
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	464
Stronger regulation of AI in biomedicine	357
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	304
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	266
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	245
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 + T cells	237
Advancing beyond the twists and turns of T cell exhaustion in cancer	224
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	215
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	212
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	212
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	210
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	206
Evolution of inflammation and immunity in a dengue virus 1 human infection model	203
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	202
Point-of-care diagnostic tests for tuberculosis disease	191
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	185
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	174
Antigenic distance between primary and secondary dengue infections correlates with disease risk	173
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	167
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	160
In vivo gene immunotherapy for cancer	155
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	155
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	154
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	153
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	151

AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	150
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	148
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	145
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	138
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	136
Engineering CAR-T therapies for autoimmune disease and beyond	134
Transcriptome-based identification of tumor-reactive and bystander CD8 + T cell receptor clonotypes in human pancreatic cancer	130
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	127
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	126
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	125
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	124
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	121
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	121
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	120
Translating insights into therapies for Long Covid	119
Development and preclinical validation of 2-deoxy 2-[ 18 F]fluorocellobiose as an Aspergillus -specific PET tracer	119
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	119
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	118
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	115
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	113
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	113
Molecular hallmarks of hydrocephalus	112
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	112
Next-generation CAR T cell therapies for glioblastoma	112
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	110
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	110
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	110
NAD + precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	110
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	110
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	110
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	110
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	107
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	106
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	106
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	106
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	104
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	104
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	103
TREM1 activation of myeloid cells promotes antitumor immunity	103
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	103
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	102
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	99
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	99
Generating functionally stable and antigen-specific T reg cells from effector T cells for cell therapy of inflammatory diseases	98
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	98
A nose for tau	97
Integrating the gut microbiome and pharmacology	97
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	97
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models	96
Short-course combination treatment for experimental chronic Chagas disease	96

Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice	96
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	95
The m 6 A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus	95
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis	95
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis	93
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	93
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers	93
Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	93
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	91
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration	91
Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity	90
T cell receptor precision editing of regulatory T cells for celiac disease	90
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	89
Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial	89
Harnessing regulatory T cells to establish immune tolerance	88
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses	88
CD23 + IgG1 + memory B cells are poised to switch to pathogenic IgE production in food allergy	87
Astrocytic α2-Na + /K + ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model	86
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	85
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria	84
Obesity and lifespan, a complex tango	84
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	84
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	83
Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months	83
Assessment of cholesterol homeostasis in the living human brain	82
Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors	82
Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes	81
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	81
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire	81
Cationic nanogel–based nasal therapeutic HPV vaccine prevents the development of cervical cancer	81
Wastewater surveillance facilitates climate change–resilient pathogen monitoring	81
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders	80
SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis	80
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19	79
Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice	78
Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice	78
Erratum for the Research Article “A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer” by A. M. Miller et al<	78
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia	78
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis	77
Immune responses to gut bacteria associated with time to diagnosis and clinical response to T cell–directed therapy for type 1 diabetes prevention	77
Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension	76
A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice	76
A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria	76
Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection	76
Metabolic surgery reduces CRC disease progression through circulating bile acid diversion	76
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis	75
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair	75
Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neurons	75
Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus	74
Synthetic biology–driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer	73
A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins	73
Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection	72
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non–small cell lung cancer	72
Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice	72
T STEM -like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models	72
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases	71
Targeting cytokines in inflammatory bowel disease	71
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor	71
Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection	71
MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis	70
Sex, lean body mass, and cardiac performance	69
Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel in combination with α-PD1 induces tumor remission of breast cancer in mice	69
Clonal hematopoiesis detection in patients with cancer using cell-free DNA sequencing	69
Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis	69
Translating the evolving molecular landscape of tumors to biomarkers of response for cancer immunotherapy	69
Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice	69
Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation	69
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis	68
IgE in allergy: It takes two	68
Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice	68
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans	68
Comment on “A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk”	67
Blocking common γ chain cytokine signaling ameliorates T cell–mediated pathogenesis in disease models	67
Erratum for the Research Article “Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4” by Y. Ren et al .	67
Erratum for the Research Article “Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy” by W. Lu et al .	67
Genetic and structural aspects of amyloid diseases	67
Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration	66
Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets	66
Resident microbes shape the vaginal epithelial glycan landscape	66
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans	65

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma	65
Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice	64
A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge	64
Expression of the excitatory opsin ChRERα can be traced longitudinally in rat and nonhuman primate brains with PET imaging	64
Spatial genomics: Mapping the landscape of fibrosis	63
Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age–related tauopathy and Alzheimer’s disease	63
A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos	63
Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6	63
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology	63
Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models	63
NF-κB perturbation reveals unique immunomodulatory functions in Prx1 + fibroblasts that promote development of atopic dermatitis	62
Antibody-mediated protection against symptomatic COVID-19 can be achieved at low serum neutralizing titers	62
Repeated Omicron exposures redirect SARS-CoV-2–specific memory B cell evolution toward the latest variants	62
Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease	61
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	61
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease	60
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases	60
Seeking satiety: From signals to solutions	60
Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit	60
Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer	60
Human OX40L–CAR-T regs target activated antigen-presenting cells and control T cell alloreactivity	58
Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant–associated infections	58
New government drug repurposing programs: Opportunities and uncertainties	58
An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice	58
In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis	58
Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics	57
Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer	57
Interleukin-2–based therapies in cancer	56
Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models	56
Neuroinflammation: An astrocyte perspective	56
Delivery of therapeutic carbon monoxide by gas-entrapping materials	56
Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device	56
Allergy: Mechanistic insights into new methods of prevention and therapy	56
An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques	55
Predicting the next round of drugs for Medicare price negotiation	55
Triple knockdown of CD11a , CD49d , and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity	55
Cholesterol desensitizes the response of endometrial cancer to progestin by attenuating progestin signaling	55
Where do the pathogens that cause surgical site infections come from?	55
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease	55
Targeting SIRT2 induces MLH1 deficiency and boosts antitumor immunity in preclinical colorectal cancer models	55
Erratum for the Research Article “Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch,” by Z. Luo et al .	55
Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease	55
Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression	54
A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes	54
A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2–specific immune responses in rhesus macaques	54
Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets	54
Provocateurs of autoimmunity within the gut microbiota	53
Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase	53
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human	52
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model	52
Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients	52
Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy	52
Donor-derived regulatory dendritic cell infusion modulates effector CD8+T cell and NK cell responses after liver transplantation	52
A mouse model of chronic primary pain that integrates clinically relevant genetic vulnerability, stress, and minor injury	52
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses	51
Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy	51
Protein kinase Cι mediates immunosuppression in lung adenocarcinoma	51
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis	50
GABABreceptor modulation of visual sensory processing in adults with and without autism spectrum disorder	50
Learning CNS immunopathology from therapeutic interventions	50
Response to Comment on “Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases”	50
Response to comment on “Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics”	50
T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19	50
Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria	49
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer	49
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy	49
Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem–specific human B cells	49
An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus	48
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson’s disease	48
Modeling lesion transition dynamics to clinically characterize patients with clade I mpox in the Democratic Republic of the Congo	48
Activation and antitumor immunity of CD8 + T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acid	48
DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis	47
Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis	47
Keratinocytes: From passive targets to active mediators of systemic autoimmunity	47
Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”	47
Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation	46
Erratum for the Research Article “Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia” by R. Sartori et al .	46
A new chapter in lipid signaling and kidney fibrosis	46
An identity crisis for lung cancer cells	46
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination	45
Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis	45
The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells	45
Pathophysiology of Dyt1- Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction	45
Hemodynamic evaluation of biomaterial-based surgery for Tetralogy of Fallot using a biorobotic heart, in silico, and ovine models	45
Vaccines for a sustainable planet	45
Bruton’s tyrosine kinase inhibitors rescue neuronal impairment caused by B cell–mediated lymphotoxin-α release	45
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure	45
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency	44
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis	44
Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss	44
Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness	44
Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease	44
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice	44
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity	44
Population-level implications of the Israeli booster campaign to curtail COVID-19 resurgence	44