OOIR: Observatory of International Research

Papers

(The TQCC of Science Translational Medicine is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
IgA dominates the early neutralizing antibody response to SARS-CoV-2	609
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance	494
Advances in therapeutic applications of extracellular vesicles	430
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade	410
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF ^V600E melanoma	399
Immunological mechanisms of the antitumor effects of supplemental oxygenation	371
Aggregatibacter actinomycetemcomitans –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis	332
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells	326
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients	312
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials	307
Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients	305
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism	280
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy	266
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism	248
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells	244
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome	234
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming	223
Reproducing human and cross-species drug toxicities using a Liver-Chip	214
Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy	203
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	200
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia	186
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations	186
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans	180
The gut microbiota influences skeletal muscle mass and function in mice	177
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data	177
Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier	169
HIV latency in isolated patient CD4⁺T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing	168
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies	166
The vermiform appendix impacts the risk of developing Parkinson’s disease	165
Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation	161
GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells	160
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis	155
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer	155
Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs	149
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases	149
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs	146
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease	146
Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease	146
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility	139
Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1	138
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis	137
Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer	134
Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis	131
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state	130
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans	129
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response	129
Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction	125
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis	125
A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice	124
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus	124
Engineering precision biomaterials for personalized medicine	123
Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge	123
Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial	123
On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation	122
Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer	121
Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma	121
Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia	119
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier	119
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizesp53-deficient cancers to mTOR inhibition	119
Companion animals: Translational scientist’s new best friends	118
Hurdles in therapy with regulatory T cells	117
Applications of liquid biopsies for cancer	116
Multiple roles for HIV broadly neutralizing antibodies	115
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy	115
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	114
Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation	114
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment	114
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer	113
Illusory movement perception improves motor control for prosthetic hands	113
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk	113
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs	112
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype	112
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay	111
HBEGF ⁺ macrophages in rheumatoid arthritis induce fibroblast invasiveness	108
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy	107
Structure-based drug design identifies polythiophenes as antiprion compounds	106
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies	106
Astrocyte molecular signatures in Huntington’s disease	105
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	105
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis	105
Challenges for mesenchymal stromal cell therapies	104
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy	104
Development of a stress response therapy targeting aggressive prostate cancer	103
Enhancing functional abilities and cognitive integration of the lower limb prosthesis	102
Targeted antibody and cytokine cancer immunotherapies through collagen affinity	102
Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction	102
Tuberculosis following PD-1 blockade for cancer immunotherapy	101
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma	101
Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration	101
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin	100
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation	99
The 1918 influenza pandemic: 100 years of questions answered and unanswered	98
Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm	98
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response	97
Patients with autism spectrum disorders display reproducible functional connectivity alterations	96
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain	95
Big data and black-box medical algorithms	94
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice	90
The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing	89
Mixed-effects association of single cells identifies an expanded effector CD4 ⁺ T cell subset in rheumatoid arthritis	89
Rapamycin and Alzheimer’s disease: Time for a clinical trial?	88
Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion	88
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis	88
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics	86
Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy	85
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus	85
A multimodality test to guide the management of patients with a pancreatic cyst	85
A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy	84
Challenges and strategies for developing efficacious and long-lasting malaria vaccines	84
Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants	82
In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma	82
In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis	82
Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression	81
CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity	81
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening	81
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model	80
A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism	80
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa	79
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice	79
Neoantigen quality, not quantity	78
Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina	78
Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain	78
Targeting the NF-κB signaling pathway in chronic tendon disease	77
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51	77
Cyclin G1 and TASCC regulate kidney epithelial cell G ₂ -M arrest and fibrotic maladaptive repair	77
Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma	76
An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis	76
An innate-like Vδ1 ⁺ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer	76
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma	75
An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis	75
Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects	75
Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors	74
Advanced bandages for diabetic wound healing	74
Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation	74
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells	74
High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides	73
Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α	73
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	73
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer	72
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension	71
Two-mAb cocktail protects macaques against the Makona variant of Ebola virus	70
Production and transplantation of bioengineered lung into a large-animal model	70
The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders	70
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	69
Therapeutically relevant engraftment of a CRISPR-Cas9–edited HSC-enriched population with HbF reactivation in nonhuman primates	68
A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy	68
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development	67
Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination	67
Activin type II receptor signaling in cardiac aging and heart failure	67