Science Translational Medicine

Papers
(The median citation count of Science Translational Medicine is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice823
IgA dominates the early neutralizing antibody response to SARS-CoV-2772
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19471
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples469
Enhanced SARS-CoV-2 neutralization by dimeric IgA364
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates322
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters312
COVID-19 diagnostics in context286
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients283
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus237
Importance of the pig as a human biomedical model235
Lung transplantation for patients with severe COVID-19233
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma217
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations217
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis197
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection192
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome190
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2187
Prospects for a safe COVID-19 vaccine187
Advanced bandages for diabetic wound healing185
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice180
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys179
An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates172
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance170
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits168
Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice164
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors162
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models159
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages153
Sampling interstitial fluid from human skin using a microneedle patch151
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection150
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19149
Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs149
Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates143
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy143
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals141
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia140
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys138
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors137
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma136
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans135
The past, present, and future of antibiotics133
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide133
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy131
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice130
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19130
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice128
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs127
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals127
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity125
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy123
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome122
cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy122
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery120
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice119
Acute inflammatory response via neutrophil activation protects against the development of chronic pain119
Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice119
Reproducibility in machine learning for health research: Still a ways to go117
ctDNA monitoring using patient-specific sequencing and integration of variant reads116
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia116
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy115
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19114
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection113
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness112
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases111
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine111
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models110
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma110
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy110
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity110
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines109
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease109
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease108
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils108
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer107
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline107
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography107
Nicotinamide for the treatment of heart failure with preserved ejection fraction104
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms103
A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease102
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models101
Predicting the mutational drivers of future SARS-CoV-2 variants of concern100
Toward robust mammography-based models for breast cancer risk100
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses100
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis99
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy99
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States98
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates98
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients98
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions98
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination97
Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans96
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation96
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms95
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice95
Biology of antimicrobial resistance and approaches to combat it95
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension94
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components93
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy92
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma91
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses91
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia91
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade90
Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses90
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits87
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis87
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells87
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment86
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy85
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles85
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy84
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases83
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair83
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits83
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates83
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice82
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice82
ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC82
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses81
Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines81
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease81
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels81
Targeting cartilage EGFR pathway for osteoarthritis treatment81
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor81
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset80
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models79
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence79
Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma78
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function77
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans77
Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis76
Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States76
Spontaneous reversal of stenosis in tissue-engineered vascular grafts76
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images76
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern76
Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models75
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury75
Granzyme K + CD8 T cells form a core population in inflamed human tissue74
BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis74
Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria74
An oral antisense oligonucleotide for PCSK9 inhibition74
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease73
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity73
Cellular senescence impairs the reversibility of pulmonary arterial hypertension72
In vivo prime editing of a metabolic liver disease in mice72
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire72
COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women72
Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target72
Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function72
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent72
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice71
MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation70
A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates70
A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma69
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals69
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy69
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice69
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity69
Immunocytokines are a promising immunotherapeutic approach against glioblastoma69
An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects69
Academic careers and the COVID-19 pandemic: Reversing the tide68
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England68
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans68
Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management68
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS68
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models68
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort67
Cardiac ryanodine receptor calcium release deficiency syndrome67
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes67
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip66
Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration66
SARS-CoV-2 BA.1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies65
Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-1965
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models65
Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction64
Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development64
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers63
Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study63
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice63
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics63
Brain circuits for pain and its treatment63
Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair63
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite62
Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases62
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model62
Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease62
Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis62
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia62
Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors61
Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche61
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro61
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease61
SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC37660
A probiotic yeast-based immunotherapy against Clostridioides difficile infection60
Druggable cancer phosphatases60
Citrullinated vimentin mediates development and progression of lung fibrosis60
Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition59
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations58
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment58
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease58
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies58
Platelets release mitochondrial antigens in systemic lupus erythematosus58
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis57
Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice57
Development and deployment of COVID-19 vaccines for those most vulnerable57
AMELIE speeds Mendelian diagnosis by matching patient phenotype and genotype to primary literature57
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia57
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma57
Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy57
Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats56
Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy56
De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection56
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling56
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults56
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling55
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum55
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models55
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters55
Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep55
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA55
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice55
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy55
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents54
Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium54
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption54
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade54
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression54
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis53
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia53
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models53
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests53
Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis52
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation52
AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation52
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice51
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients51
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages51
Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice51
IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia51
Mechanism and reversal of drug-induced nephrotoxicity on a chip51
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia51
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses51
Risk assessment with gut microbiome and metabolite markers in NAFLD development51
Plasma neurofilament light predicts mortality in patients with stroke51
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies51
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence50
Systemic cancer therapy with engineered adenovirus that evades innate immunity50
Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus50
Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer50
Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors50
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