Science Translational Medicine

Article	Citations
IgA dominates the early neutralizing antibody response to SARS-CoV-2	829
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19	496
Enhanced SARS-CoV-2 neutralization by dimeric IgA	385
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates	342
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	338
Importance of the pig as a human biomedical model	315
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma	262
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus	259
Lung transplantation for patients with severe COVID-19	252
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	247
Advanced bandages for diabetic wound healing	236
The past, present, and future of antibiotics	224
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors	204
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection	204
Prospects for a safe COVID-19 vaccine	198
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2	187
Sampling interstitial fluid from human skin using a microneedle patch	182
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	175
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	174
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma	173
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	171
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19	166
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	165
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity	164
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	164

Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection	163
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans	161
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome	156
Acute inflammatory response via neutrophil activation protects against the development of chronic pain	152
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy	151
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19	150
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	149
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys	146
Reproducibility in machine learning for health research: Still a ways to go	143
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases	141
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy	134
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms	134
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals	133
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline	132
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease	132
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	131
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma	131
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines	130
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	129
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease	129
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models	128
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography	126
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy	126
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms	126
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils	125
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits	125
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19	124
Nicotinamide for the treatment of heart failure with preserved ejection fraction	123
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses	119
Toward robust mammography-based models for breast cancer risk	119
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia	116
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis	114
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade	113
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy	113
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment	113
Predicting the mutational drivers of future SARS-CoV-2 variants of concern	112
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy	108
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models	107
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates	107
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy	107
Granzyme K + CD8 T cells form a core population in inflamed human tissue	106
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions	105
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States	105
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles	104
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases	104
Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses	104
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair	103
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma	102
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	102
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury	99

Targeting cartilage EGFR pathway for osteoarthritis treatment	99
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease	98
Brain circuits for pain and its treatment	98
Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines	97
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses	96
An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects	95
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses	95
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy	95
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease	94
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor	94
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images	94
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice	94
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice	92
In vivo prime editing of a metabolic liver disease in mice	92
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset	91
Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria	90
MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation	89
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence	89
A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates	88
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models	88
Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models	88
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern	87
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes	87
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma	86
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models	86
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function	86
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans	85
Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis	84
Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management	83
An oral antisense oligonucleotide for PCSK9 inhibition	83
SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376	83
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	83
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent	82
Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration	81
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England	81
Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade	81
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire	80
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity	80
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease	80
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity	80
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due toTTNmutations	79
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS	79
COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women	79
Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition	78
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	78
Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors	78
Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium	77
Cardiac ryanodine receptor calcium release deficiency syndrome	76
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers	75
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals	75
Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction	75
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models	75
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice	75
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies	74
TRIB3 reduces CD8 + T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer	74
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis	74
Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice	74
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum	74
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia	73
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia	73
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia	73
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies	72
Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy	72
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model	72
Academic careers and the COVID-19 pandemic: Reversing the tide	72
Platelets release mitochondrial antigens in systemic lupus erythematosus	72
SARS-CoV-2 BA.1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies	71
A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma	70
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression	69
Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease	69
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice	69
Druggable cancer phosphatases	69
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	69
Citrullinated vimentin mediates development and progression of lung fibrosis	68
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro	68
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease	68
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA	67
AD-linked R47H-TREM2mutation induces disease-enhancing microglial states via AKT hyperactivation	67
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages	67
Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19	67

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis	66
Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin	66
Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel	65
Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep	65
Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy	64
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults	64
Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models	64
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis	63
Development and deployment of COVID-19 vaccines for those most vulnerable	63
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	63
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression	63
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice	63
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice	63
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models	62
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade	62
Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis	62
Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response	62
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics	62
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair	62
scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function	62
Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy	61
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests	61
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models	61
Risk assessment with gut microbiome and metabolite markers in NAFLD development	61
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses	60
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters	60
Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype	60
Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice	59
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy	59
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species	59
Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair	59
Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus	59
Plasma neurofilament light predicts mortality in patients with stroke	59
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption	58
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis	57
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence	57
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts	57
Mechanism and reversal of drug-induced nephrotoxicity on a chip	57
Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer	57
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	57
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease	57
Treatment of a genetic brain disease by CNS-wide microglia replacement	57
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae	56
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates	56
A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity	56
Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function	55
Mechanism of praziquantel action at a parasitic flatworm ion channel	55
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients	55
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy	55
Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell–cold solid tumors	54
Association of a common genetic variant with Parkinson’s disease is mediated by microglia	54
Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain	54
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers	53
Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant	53
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice	53
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates	53
CD4 + T cells are essential for the development of destructive thyroiditis induced by anti–PD-1 antibody in thyroglobulin-immunized mice	53
Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography	53
Systemic cancer therapy with engineered adenovirus that evades innate immunity	52
Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device	52
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel	52
Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neurons	52
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes	52
Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel in combination with α-PD1 induces tumor remission of breast cancer in mice	51
Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts	51
Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State	51
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity	51
NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling	51
The microbiota in pneumonia: From protection to predisposition	51
Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents	50
Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease	50
Analysis of recurrently protected genomic regions in cell-free DNA found in urine	50
A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease	50
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer	50
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q	50
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters	50
Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol	50
Prosaposin mediates inflammation in atherosclerosis	50
Proinflammatory CD20 + T cells contribute to CNS-directed autoimmunity	49
MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration	49
A decision algorithm to promote outpatient antimicrobial stewardship for uncomplicated urinary tract infection	49
A shift in lung macrophage composition is associated with COVID-19 severity and recovery	49
4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy	49
Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice	49
Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions	49
Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice	49
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models	49
APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia	48
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	48
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease	48
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration	48
Skeletal muscle regeneration with robotic actuation–mediated clearance of neutrophils	48
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS	48
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice	48
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models	48