Science Translational Medicine

Article	Citations
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice	823
IgA dominates the early neutralizing antibody response to SARS-CoV-2	772
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19	471
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples	469
Enhanced SARS-CoV-2 neutralization by dimeric IgA	364
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates	322
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	312
COVID-19 diagnostics in context	286
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients	283
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus	237
Importance of the pig as a human biomedical model	235
Lung transplantation for patients with severe COVID-19	233
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations	217
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma	217
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	197
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection	192
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome	190
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2	187
Prospects for a safe COVID-19 vaccine	187
Advanced bandages for diabetic wound healing	185
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice	180
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys	179
An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates	172
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance	170
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits	168

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice	164
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors	162
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	159
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	153
Sampling interstitial fluid from human skin using a microneedle patch	151
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection	150
Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs	149
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19	149
Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates	143
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy	143
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	141
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	140
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys	138
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors	137
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma	136
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans	135
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	133
The past, present, and future of antibiotics	133
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy	131
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19	130
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice	130
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice	128
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals	127
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs	127
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity	125
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy	123
cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy	122
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome	122
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	120
Acute inflammatory response via neutrophil activation protects against the development of chronic pain	119
Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice	119
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice	119
Reproducibility in machine learning for health research: Still a ways to go	117
ctDNA monitoring using patient-specific sequencing and integration of variant reads	116
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia	116
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy	115
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19	114
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	113
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness	112
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine	111
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases	111
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity	110
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	110
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma	110
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy	110
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease	109
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines	109
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils	108
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease	108
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline	107

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography	107
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer	107
Nicotinamide for the treatment of heart failure with preserved ejection fraction	104
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms	103
A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease	102
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models	101
Toward robust mammography-based models for breast cancer risk	100
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses	100
Predicting the mutational drivers of future SARS-CoV-2 variants of concern	100
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis	99
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy	99
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients	98
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions	98
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States	98
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates	98
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination	97
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation	96
Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans	96
Biology of antimicrobial resistance and approaches to combat it	95
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms	95
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice	95
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension	94
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components	93
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy	92
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses	91
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia	91
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma	91
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade	90
Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses	90
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis	87
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells	87
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits	87
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment	86
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy	85
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles	85
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy	84
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair	83
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits	83
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	83
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases	83
ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC	82
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice	82
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice	82
Targeting cartilage EGFR pathway for osteoarthritis treatment	81
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor	81
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses	81
Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines	81
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease	81
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels	81
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset	80
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence	79
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models	79
Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma	78
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans	77
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function	77
Spontaneous reversal of stenosis in tissue-engineered vascular grafts	76
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images	76
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern	76
Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis	76
Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States	76
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury	75
Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models	75
BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis	74
Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria	74
An oral antisense oligonucleotide for PCSK9 inhibition	74
Granzyme K + CD8 T cells form a core population in inflamed human tissue	74
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity	73
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease	73
COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women	72
Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target	72
Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function	72
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent	72
Cellular senescence impairs the reversibility of pulmonary arterial hypertension	72
In vivo prime editing of a metabolic liver disease in mice	72
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire	72
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice	71
A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates	70
MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation	70
Immunocytokines are a promising immunotherapeutic approach against glioblastoma	69
An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects	69

A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma	69
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals	69
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy	69
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice	69
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity	69
Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management	68
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS	68
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models	68
Academic careers and the COVID-19 pandemic: Reversing the tide	68
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England	68
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans	68
Cardiac ryanodine receptor calcium release deficiency syndrome	67
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes	67
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	67
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip	66
Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration	66
Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19	65
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models	65
SARS-CoV-2 BA.1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies	65
Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development	64
Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction	64
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice	63
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics	63
Brain circuits for pain and its treatment	63
Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair	63
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers	63
Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study	63
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model	62
Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease	62
Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis	62
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia	62
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite	62
Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases	62
Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors	61
Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche	61
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro	61
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease	61
SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376	60
A probiotic yeast-based immunotherapy against Clostridioides difficile infection	60
Druggable cancer phosphatases	60
Citrullinated vimentin mediates development and progression of lung fibrosis	60
Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition	59
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations	58
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	58
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease	58
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies	58
Platelets release mitochondrial antigens in systemic lupus erythematosus	58
Development and deployment of COVID-19 vaccines for those most vulnerable	57
AMELIE speeds Mendelian diagnosis by matching patient phenotype and genotype to primary literature	57
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia	57
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma	57
Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy	57
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis	57
Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice	57
De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection	56
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling	56
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults	56
Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats	56
Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy	56
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models	55
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters	55
Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep	55
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA	55
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice	55
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy	55
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling	55
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum	55
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents	54
Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium	54
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption	54
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade	54
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression	54
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis	53
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia	53
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models	53
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests	53
Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis	52
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	52
AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation	52
IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia	51
Mechanism and reversal of drug-induced nephrotoxicity on a chip	51
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	51
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses	51
Risk assessment with gut microbiome and metabolite markers in NAFLD development	51
Plasma neurofilament light predicts mortality in patients with stroke	51
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies	51
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice	51
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients	51
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages	51
Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice	51
Systemic cancer therapy with engineered adenovirus that evades innate immunity	50
Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus	50
Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer	50
Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors	50
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence	50