Science Translational Medicine

(The H4-Index of Science Translational Medicine is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice823
IgA dominates the early neutralizing antibody response to SARS-CoV-2772
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19471
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples469
Enhanced SARS-CoV-2 neutralization by dimeric IgA364
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates322
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters312
COVID-19 diagnostics in context286
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients283
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus237
Importance of the pig as a human biomedical model235
Lung transplantation for patients with severe COVID-19233
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma217
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations217
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis197
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection192
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome190
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2187
Prospects for a safe COVID-19 vaccine187
Advanced bandages for diabetic wound healing185
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice180
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys179
An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates172
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance170
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits168
Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice164
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors162
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models159
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages153
Sampling interstitial fluid from human skin using a microneedle patch151
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection150
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19149
Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs149
Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates143
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy143
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals141
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia140
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys138
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors137
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma136
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans135
The past, present, and future of antibiotics133
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide133
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy131
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice130
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19130
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice128
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs127
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals127
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity125
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy123
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome122
cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy122
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery120
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice119
Acute inflammatory response via neutrophil activation protects against the development of chronic pain119
Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice119
Reproducibility in machine learning for health research: Still a ways to go117
ctDNA monitoring using patient-specific sequencing and integration of variant reads116
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia116
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy115
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19114
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection113
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness112
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases111
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine111
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models110
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma110
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy110
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity110
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines109
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease109
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease108
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils108
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer107
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline107
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography107
Nicotinamide for the treatment of heart failure with preserved ejection fraction104
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms103
A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease102
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models101
Predicting the mutational drivers of future SARS-CoV-2 variants of concern100
Toward robust mammography-based models for breast cancer risk100
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses100
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis99
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy99
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients98
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States98
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates98
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions98
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination97
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation96
Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans96
Biology of antimicrobial resistance and approaches to combat it95
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms95
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice95