OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 84. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
A population of c-kit ⁺ IL-17A ⁺ ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation	362
Hypoxia as a medicine	359
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	358
Translating diagnostics and drug delivery technologies to low-resource settings	307
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke	284
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis	268
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation	265
Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes	239
Vaccines for a sustainable planet	216
Hemodynamic evaluation of biomaterial-based surgery for Tetralogy of Fallot using a biorobotic heart, in silico, and ovine models	212
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	210
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	191
Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition	185
Stronger regulation of AI in biomedicine	183
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	178
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection	177
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes	175
Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis	172
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	161
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	158
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer	157
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice	155
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	155
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer	155
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model	150

Pandemic preparedness strategies must go beyond vaccines	149
An identity crisis for lung cancer cells	148
Targeting electrochemical communication between neurons and cancer	147
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	146
Next-generation RSV vaccines avoid flipping out	145
Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function	142
Increased β ₂ -adrenergic signaling promotes fracture healing through callus neovascularization in mice	141
Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration	138
Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”	136
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure	131
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose	129
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	128
Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges	126
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	122
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer	121
In-line miniature 3D-printed pressure-cycled ventilator maintains respiratory homeostasis in swine with induced acute pulmonary injury	121
Erratum for the Research Article: “Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis” by M. Scherlinger, V. Guillotin, I. Douchet, P. Vacher, A. B	118
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	117
Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation	113
FcγRIIB expressed on CD8⁺T cells limits responsiveness to PD-1 checkpoint inhibition in cancer	112
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency	109
Advancing beyond the twists and turns of T cell exhaustion in cancer	109
Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell–dependent regression of glioblastoma	109
What keeps me up at night	108
Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants	107
Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial	106
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	105
Pathophysiology of Dyt1- Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction	105
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	105
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis	102
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	100
Erratum for the Research Article “Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer” by H.-H. Wu et al	99
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	99
A new chapter in lipid signaling and kidney fibrosis	98
Drug discovery in Africa tackles zoonotic and related infections	98
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19	96
Closing the loop on adrenal health, dysfunction, and disease	96
High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury	95
Sexual dimorphism in functional pain syndromes	94
Keratinocytes: From passive targets to active mediators of systemic autoimmunity	93
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections	92
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia	92
Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents	92
Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy	92
CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis	92
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models	91
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q	91
Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy	90
Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity	89
Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor	89

The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells	88
BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML	88
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	87
The trillion dollar vaccine gap	87
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	87
cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes	86
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes	85
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	84
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	84
Formyl peptide receptor 1 signaling potentiates inflammatory brain injury	84