OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	434
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer	371
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	367
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	345
Erratum for the Research Article: “Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis” by M. Scherlinger, V. Guillotin, I. Douchet, P. Vacher, A. B	284
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	283
Stronger regulation of AI in biomedicine	223
Advancing beyond the twists and turns of T cell exhaustion in cancer	205
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	204
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	201
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	194
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	191
Antigenic distance between primary and secondary dengue infections correlates with disease risk	187
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	185
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	182
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	179
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	178
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia	177
Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease	175
Engineering CAR-T therapies for autoimmune disease and beyond	169
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	165
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	163
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	163
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	162
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	159

A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification	158
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	155
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	153
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	152
Evolution of inflammation and immunity in a dengue virus 1 human infection model	151
Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy	150
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	134
In vivo gene immunotherapy for cancer	134
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	134
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	133
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	132
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	132
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	127
Point-of-care diagnostic tests for tuberculosis disease	126
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	125
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	122
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	122
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	118
Translating insights into therapies for Long Covid	118
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	117
Integrating the gut microbiome and pharmacology	115
Next-generation CAR T cell therapies for glioblastoma	114
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors	113
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	113
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	112
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	112
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	110
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	109
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	108
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	106
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	105
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	105
TREM1 activation of myeloid cells promotes antitumor immunity	105
A portable magnetofluidic platform for detecting sexually transmitted infections and antimicrobial susceptibility	105
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	105
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	105
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	101
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	100
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	100
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	100
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	99
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	99
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	98
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer	98
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	97
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	97
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	97
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	97
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	96
4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy	95

The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	95
Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	94
Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors	94
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T _H 1 response with a diverse TCR repertoire	94
Na _v 1.7 target modulation and efficacy can be measured in nonhuman primate assays	93
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	93
Wastewater surveillance facilitates climate change–resilient pathogen monitoring	92
Assessment of cholesterol homeostasis in the living human brain	92
A nose for tau	91
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	91
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	91
An oral antisense oligonucleotide for PCSK9 inhibition	91
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis	90
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	90
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration	90