OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 89. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	480
Stronger regulation of AI in biomedicine	365
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	305
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	272
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	256
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	249
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	230
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	224
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	224
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	217
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	213
Evolution of inflammation and immunity in a dengue virus 1 human infection model	210
Engineering CAR-T therapies for autoimmune disease and beyond	205
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	205
In vivo gene immunotherapy for cancer	196
Point-of-care diagnostic tests for tuberculosis disease	185
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	179
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	174
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	172
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	162
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	160
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	160
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	160
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	159
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	154

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	153
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	150
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	141
Advancing beyond the twists and turns of T cell exhaustion in cancer	141
Antigenic distance between primary and secondary dengue infections correlates with disease risk	137
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	137
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	134
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	133
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	131
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	128
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	126
Generating functionally stable and antigen-specific T _reg cells from effector T cells for cell therapy of inflammatory diseases	123
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	123
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	122
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	121
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	120
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	119
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	117
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	117
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	117
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection	116
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	114
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	114
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	114
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	114
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	111
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	110
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	110
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	110
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	109
Molecular hallmarks of hydrocephalus	107
Next-generation CAR T cell therapies for glioblastoma	107
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	106
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	106
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	106
Integrating the gut microbiome and pharmacology	105
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	105
TREM1 activation of myeloid cells promotes antitumor immunity	105
Translating insights into therapies for Long Covid	104
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	102
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	101
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	101
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	100
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	100
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	100
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	99
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	99
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis	98
A nose for tau	98
Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice	97

Short-course combination treatment for experimental chronic Chagas disease	97
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	96
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models	96
The m ⁶ A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus	95
Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity	93
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses	93
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	92
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	92
Astrocytic α2-Na ⁺ /K ⁺ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model	92
CD23 ⁺ IgG1 ⁺ memory B cells are poised to switch to pathogenic IgE production in food allergy	91
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	91
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	91
T cell receptor precision editing of regulatory T cells for celiac disease	90
Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial	89