OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	559
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	326
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	311
In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis	269
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	255
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	245
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	236
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	225
Resilient nanostructured bioanalytic microneedle longitudinally monitors preclinical renal and hepatic drug clearance and dysfunction	223
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	220
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	206
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	205
Evolution of inflammation and immunity in a dengue virus 1 human infection model	190
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	177
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	171
Stronger regulation of AI in biomedicine	168
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	167
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	156
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	154
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	153
Engineering CAR-T therapies for autoimmune disease and beyond	149
In vivo gene immunotherapy for cancer	148
Advancing beyond the twists and turns of T cell exhaustion in cancer	146
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	141
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	135

Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	135
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	134
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	133
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	131
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	131
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	130
Antigenic distance between primary and secondary dengue infections correlates with disease risk	129
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	128
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	128
Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2 -related neurodevelopmental disorder	121
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	121
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	120
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	119
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	117
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	116
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	115
Molecular hallmarks of hydrocephalus	112
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	112
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	112
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	111
TREM1 activation of myeloid cells promotes antitumor immunity	111
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy	111
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	110
Integrating the gut microbiome and pharmacology	110
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	109
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma	108
Generating functionally stable and antigen-specific T _reg cells from effector T cells for cell therapy of inflammatory diseases	108
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	105
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	104
Next-generation CAR T cell therapies for glioblastoma	103
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	101
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	100
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	100
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	100
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	99
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection	97
Translating insights into therapies for Long Covid	97
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	97
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	95
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	94
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	94
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	94
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis	93
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	93
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis	93
Assessment of cholesterol homeostasis in the living human brain	91
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	90
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	90
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models	90
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	90

Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	90
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models	89
Extracellular BRICK1 drives heart repair after myocardial infarction in mice	89
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	88
BDNF Val ⁶⁶ Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer	88
T cell receptor precision editing of regulatory T cells for celiac disease	88
Obesity and lifespan, a complex tango	87
Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial	87
Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months	87
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	85
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria	85