OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
IgA dominates the early neutralizing antibody response to SARS-CoV-2	829
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19	496
Enhanced SARS-CoV-2 neutralization by dimeric IgA	385
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates	342
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	338
Importance of the pig as a human biomedical model	315
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma	262
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus	259
Lung transplantation for patients with severe COVID-19	252
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	247
Advanced bandages for diabetic wound healing	236
The past, present, and future of antibiotics	224
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors	204
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection	204
Prospects for a safe COVID-19 vaccine	198
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2	187
Sampling interstitial fluid from human skin using a microneedle patch	182
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	175
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	174
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma	173
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	171
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19	166
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	165
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	164
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity	164

Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection	163
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans	161
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome	156
Acute inflammatory response via neutrophil activation protects against the development of chronic pain	152
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy	151
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19	150
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	149
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys	146
Reproducibility in machine learning for health research: Still a ways to go	143
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases	141
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy	134
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms	134
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals	133
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline	132
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease	132
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma	131
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	131
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines	130
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease	129
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	129
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models	128
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms	126
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography	126
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy	126
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits	125
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils	125
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19	124
Nicotinamide for the treatment of heart failure with preserved ejection fraction	123
Toward robust mammography-based models for breast cancer risk	119
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses	119
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia	116
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis	114
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy	113
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment	113
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade	113
Predicting the mutational drivers of future SARS-CoV-2 variants of concern	112
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy	108
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy	107
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models	107
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates	107
Granzyme K ⁺ CD8 T cells form a core population in inflamed human tissue	106
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States	105
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions	105
Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses	104
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles	104
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases	104
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair	103
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	102
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma	102
Targeting cartilage EGFR pathway for osteoarthritis treatment	99

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury	99
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease	98
Brain circuits for pain and its treatment	98
Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines	97
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses	96
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy	95
An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects	95
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses	95
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor	94
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images	94
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice	94
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease	94
In vivo prime editing of a metabolic liver disease in mice	92
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice	92
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset	91
Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria	90