OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
IgA dominates the early neutralizing antibody response to SARS-CoV-2	802
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19	488
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples	487
Enhanced SARS-CoV-2 neutralization by dimeric IgA	371
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates	335
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	334
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients	291
Importance of the pig as a human biomedical model	286
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus	250
Lung transplantation for patients with severe COVID-19	240
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma	237
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	222
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations	221
Advanced bandages for diabetic wound healing	215
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome	197
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection	196
Prospects for a safe COVID-19 vaccine	193
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2	188
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice	185
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance	184
Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice	181
The past, present, and future of antibiotics	181
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors	181
An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates	177
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits	170

Sampling interstitial fluid from human skin using a microneedle patch	168
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	164
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19	161
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	158
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection	157
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	156
Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs	154
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma	154
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	154
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy	153
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	152
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans	148
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity	144
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice	144
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors	143
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19	143
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome	142
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy	141
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice	141
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys	139
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	135
Acute inflammatory response via neutrophil activation protects against the development of chronic pain	134
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy	132
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals	130
Reproducibility in machine learning for health research: Still a ways to go	128
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy	125
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine	124
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma	122
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline	122
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases	121
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	121
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms	121
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines	121
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity	119
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease	119
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	119
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils	118
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease	117
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography	116
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19	116
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models	115
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy	114
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms	113
Nicotinamide for the treatment of heart failure with preserved ejection fraction	113
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy	111
A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease	110
Predicting the mutational drivers of future SARS-CoV-2 variants of concern	109
Toward robust mammography-based models for breast cancer risk	109
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses	109
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis	107

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation	107
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade	105
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice	104
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy	104
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates	104
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia	104
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States	103
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits	103
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions	102
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment	101
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients	101
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination	101
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components	99
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles	98
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models	96
Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma	96
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy	95
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	95
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair	94
Granzyme K ⁺ CD8 T cells form a core population in inflamed human tissue	94
Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses	94
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy	94
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells	94