Aging-US

Article	Citations
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis	280
Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	154
Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway	154
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary	138
Global incidence and mortality of breast cancer: a trend analysis	98
Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization	98
Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways	91
SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury	87
MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat	86
Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer	84
Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke	81
Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites	80
TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice	79
Gut microbiota in patients with Alzheimer’s disease spectrum: a systematic review and meta-analysis	77
Shorter telomere lengths in patients with severe COVID-19 disease	77
Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer	75
An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients	73
Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19	71
Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis	70
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer	69
Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin	69
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma	68
Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis	65
A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma	65
Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway	64

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis	63
Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome	63
The aging-related risk signature in colorectal cancer	59
The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study	58
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests	56
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models	56
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19	55
Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1	55
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3	55
Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones	54
Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer	53
Identification of key modules and genes associated with breast cancer prognosis using WGCNA and ceRNA network analysis	53
Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling	52
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans	52
WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA	52
Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway	51
Age-related DNA methylation changes are sex-specific: a comprehensive assessment	50
Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats	49
Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer	49
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study	49
Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis	49
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States	49
Analysis of METTL3 and METTL14 in hepatocellular carcinoma	48
Risk of death by age and gender from CoVID-19 in Peru, March-May, 2020	47
A qualitative study of the vocational and psychological perceptions and issues of transdisciplinary nurses during the COVID-19 outbreak	46
Exploring diagnostic m6A regulators in endometriosis	45
HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification	45
Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling	45
Comprehensive analysis of m6A regulators prognostic value in prostate cancer	45
Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma	44
Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury	44
PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia	44
COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians	44
Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer	44
Short telomeres increase the risk of severe COVID-19	43
Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway	43
LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability	43
Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway	42
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway	42
p21 can be a barrier to ferroptosis independent of p53	42
Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure	42
Factors influencing serum neurofilament light chain levels in normal aging	42
Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues	41
Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis	41
MicroRNA-29a-3p delivery via exosomes derived from engineered human mesenchymal stem cells exerts tumour suppressive effects by inhibiting migration and vasculogenic mimicry in glioma	41
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime	40
Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment	40
lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration	40
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence	40
Pompe disease: pathogenesis, molecular genetics and diagnosis	39

Suppression of p16 alleviates the senescence-associated secretory phenotype	39
Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells	39
The <i>slc4a2b</i> gene is required for hair cell development in zebrafish	39
Immune infiltration and a ferroptosis-associated gene signature for predicting the prognosis of patients with endometrial cancer	39
Fungal co-infection in COVID-19 patients: evidence from a systematic review and meta-analysis	39
Effect of lncRNA WT1-AS regulating WT1 on oxidative stress injury and apoptosis of neurons in Alzheimer's disease via inhibition of the miR-375/SIX4 axis	39
Fusobacterium nucleatum promotes liver metastasis in colorectal cancer by regulating the hepatic immune niche and altering gut microbiota	39
Global variability of the human IgG glycome	38
High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study	38
Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells	38
Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1	38
Cellular senescence in lymphoid organs and immunosenescence	38
Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation	37
Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemoki	37
circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis	37
Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression	37
Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile	37
In search of preventative strategies: novel high-CBD <i>cannabis sativa</i> extracts modulate ACE2 expression in COVID-19 gateway tissues	37
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine	37
circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway	36
Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice	36
Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis	36
Circ-0001068 is a novel biomarker for ovarian cancer and inducer of PD1 expression in T cells	36
Age-dependent remodeling of gut microbiome and host serum metabolome in mice	36
HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation	36
Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer	36
LncRNA-SNHG1 promotes macrophage M2-like polarization and contributes to breast cancer growth and metastasis	36
Effects of exercise on cellular and tissue aging	36
miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis	36
Emerging roles of nucleotide metabolism in cancer development: progress and prospect	36
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome	36
Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions	36
GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway	35
Perioperative neurocognitive dysfunction: thinking from the gut?	35
Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition	35
Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis	35
Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway	35
Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice	35
CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis	35
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression	35
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the	35
Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories	34
CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway	34
LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression	34
Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling	34
Mental awareness improved mild cognitive impairment and modulated gut microbiome	34
Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database	34
An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis	34
ARDD 2020: from aging mechanisms to interventions	34
β cell aging and age-related diabetes	34
Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma	34
Identification and validation of an immune-related gene signature predictive of overall survival in colon cancer	34
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages	34
Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers	34
Exosomal miR-222 from adriamycin-resistant MCF-7 breast cancer cells promote macrophages M2 polarization via PTEN/Akt to induce tumor progression	34
Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China	33
Comparison of exosomes derived from induced pluripotent stem cells and mesenchymal stem cells as therapeutic nanoparticles for treatment of corneal epithelial defects	33
Early diagnosis of lung cancer: which is the optimal choice?	33
Alzheimer’s disease as a chronic maladaptive polyamine stress response	33
LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA	33
Clinical course and risk factors for recurrence of positive SARS-CoV-2 RNA: a retrospective cohort study from Wuhan, China	33
Long non-coding RNA SNHG12 promotes immune escape of ovarian cancer cells through their crosstalk with M2 macrophages	33
Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade	33
rTMS modulates precuneus-hippocampal subregion circuit in patients with subjective cognitive decline	33
PDIA3 correlates with clinical malignant features and immune signature in human gliomas	33
Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease	33
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy	33
Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury	32
Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis	32
ATP synthase and Alzheimer’s disease: putting a spin on the mitochondrial hypothesis	32
Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3	32
Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors	32
Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis	32
Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS	32
Knockdown of <i>Foxg1</i> in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle	32
A DNA methylation age predictor for zebrafish	32
LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway	32
Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement	32
Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice	32
Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis	32

Alterations in fecal short chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) in men with benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS)	32
Effects of enriched branched-chain amino acid supplementation on sarcopenia	31
Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)	31
Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson’s disease patients with type 2 diabetes mellitus	31
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy	31
Repetitive transcranial magnetic stimulation of the cerebellum improves ataxia and cerebello-fronto plasticity in multiple system atrophy: a randomized, double-blind, sham-controlled and TMS-EEG study	31
Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1	31
Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)	31
SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice	31
Exosomes derived from microRNA-512-5p-transfected bone mesenchymal stem cells inhibit glioblastoma progression by targeting JAG1	31
Glioblastoma cell differentiation trajectory predicts the immunotherapy response and overall survival of patients	31
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence	31
A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism	31
Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury	31
lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy	31
Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice	31
Identification and prognostic value of metabolism-related genes in gastric cancer	30
TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway	30
DNA methylation-based lung adenocarcinoma subtypes can predict prognosis, recurrence, and immunotherapeutic implications	30
Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis	30
Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p	30
GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells	30
Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway	30
Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis	30
Cancer-associated fibroblasts secreted miR-103a-3p suppresses apoptosis and promotes cisplatin resistance in non-small cell lung cancer	30
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration	30
LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes	30
Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy	30
ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma	30
Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes	29
Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease	29
Radiomics-based prediction of survival in patients with head and neck squamous cell carcinoma based on pre- and post-treatment 18F-PET/CT	29
Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion	29
The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017	29
A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer	29
RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation	29
CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis	29
Comprehensive analysis of ferritin subunits expression and positive correlations with tumor-associated macrophages and T regulatory cells infiltration in most solid tumors	29
Global, regional, and national burden of blindness and vision loss due to common eye diseases along with its attributable risk factors from 1990 to 2019: a systematic analysis from the global burden o	29
Inhibition of Exo-miR-19a-3p derived from cardiomyocytes promotes angiogenesis and improves heart function in mice with myocardial infarction via targeting HIF-1α	29
Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer’s disease: a pre-clinical study	29
miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt/β-catenin axis	29
A glycolysis-related gene expression signature in predicting recurrence of breast cancer	29
A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer	29
Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging	29
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment	29
The construction and analysis of a ferroptosis-related gene prognostic signature for pancreatic cancer	29
Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults	28
lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury	28
ASNEO: Identification of personalized alternative splicing based neoantigens with RNA-seq	28
Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer	28
Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis	28
circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA	28
The long noncoding RNA LINC01140/miR-140-5p/FGF9 axis modulates bladder cancer cell aggressiveness and macrophage M2 polarization	28
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice	28
lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis	28
Matrix stiffness promotes glioma cell stemness by activating BCL9L/Wnt/β-catenin signaling	28
Screening of Alzheimer’s disease by facial complexion using artificial intelligence	28
Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression	28
PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury	27
CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3β/β-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer	27
Analysis of plasma metabolic profile, characteristics and enzymes in the progression from chronic hepatitis B to hepatocellular carcinoma	27
Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19	27
MiR-16-5p suppresses myofibroblast activation in systemic sclerosis by inhibiting NOTCH signaling	27
Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome	27
CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis–angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF	27
Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma	27
Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome	27
Neutrophil extracellular traps, released from neutrophil, promote microglia inflammation and contribute to poor outcome in subarachnoid hemorrhage	27
Global, regional, and national burdens of leukemia from 1990 to 2017: a systematic analysis of the global burden of disease 2017 study	27
S100A gene family: immune-related prognostic biomarkers and therapeutic targets for low-grade glioma	27
Carbon nanotubes (CNT)-loaded ginsenosides Rb3 suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer	27
Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis	27
miRNA-122-5p stimulates the proliferation and DNA synthesis and inhibits the early apoptosis of human spermatogonial stem cells by targeting CBL and competing with lncRNA CASC7	27
Low expression of NLRP1 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients	27
Development of a susceptibility gene based novel predictive model for the diagnosis of ulcerative colitis using random forest and artificial neural network	27
GPR43 regulation of mitochondrial damage to alleviate inflammatory reaction in sepsis	26
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression	26
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway	26
Cross-talk between the ER pathway and the lncRNA MAFG-AS1/miR-339-5p/ CDK2 axis promotes progression of ER+ breast cancer and confers tamoxifen resistance	26
Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling	26
miR-140-3p inhibits bladder cancer cell proliferation and invasion by targeting FOXQ1	26
miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts	26
miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling	26
Radiation-induced skin injury: pathogenesis, treatment, and management	26
TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin	26
Epigenetic age prediction in semen – marker selection and model development	26
LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis	26
Retrospective study of gene signatures and prognostic value of m6A regulatory factor in non-small cell lung cancer using TCGA database and the verification of FTO	26
Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis	26
Differentially expressed immune response genes in COVID-19 patients based on disease severity	26
LncRNA HAND2-AS1 suppressed the growth of triple negative breast cancer via reducing secretion of MSCs derived exosomal miR-106a-5p	26
Dietary inflammatory potential and risk of sarcopenia: data from national health and nutrition examination surveys	25
Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG	25
Expression and molecular profiles of the AlkB family in ovarian serous carcinoma	25