Aging-US

Article	Citations
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis	838
Why does COVID-19 disproportionately affect older people?	641
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis	274
ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy	248
Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1	239
Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study	142
Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway	142
Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	131
Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis	125
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary	123
lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis	119
Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019	109
LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis	98
Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19	97
Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis	88
From causes of aging to death from COVID-19	87
Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis	87
Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways	83
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice	83
SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury	82
Global incidence and mortality of breast cancer: a trend analysis	81
Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization	81
De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2	80
MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat	79
Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer	79

Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8	78
PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma	78
Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus	77
Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites	76
Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency	76
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients	75
Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke	74
Shorter telomere lengths in patients with severe COVID-19 disease	74
An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients	73
PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway	71
Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2	70
TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice	69
Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19	68
Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis	67
A novel immune-related genes prognosis biomarker for melanoma: associated with tumor microenvironment	67
Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer	67
Risk factors for 2019 novel coronavirus disease (COVID-19) patients progressing to critical illness: a systematic review and meta-analysis	67
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells	67
Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival	66
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan	66
Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet	66
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer	64
ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19	64
Exosomal miR-183-5p promotes angiogenesis in colorectal cancer by regulation of FOXO1	64
A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma	64
Gut microbiota in patients with Alzheimer’s disease spectrum: a systematic review and meta-analysis	63
Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin	63
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma	63
Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis	61
Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome	60
Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway	60
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders	59
Age-related shifts in gut microbiota contribute to cognitive decline in aged rats	58
The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study	58
CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats	56
Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis	56
Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase	56
Physical activity and successful aging among middle-aged and older adults: a systematic review and meta-analysis of cohort studies	56
Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1	54
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests	54
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin	53
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3	52
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19	52
Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury	52
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT	51
The aging-related risk signature in colorectal cancer	50
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models	49
Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice	49
Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones	49
Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a	49

Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages	49
Age-related DNA methylation changes are sex-specific: a comprehensive assessment	49
Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models	48
Identification of key modules and genes associated with breast cancer prognosis using WGCNA and ceRNA network analysis	48
Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway	48
WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA	48
Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis	48
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans	47
Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer	47
Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats	47
Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer	47
LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer	47
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study	47
Risk of death by age and gender from CoVID-19 in Peru, March-May, 2020	46
Biomarkers of biological age as predictors of COVID-19 disease severity	45
Analysis of METTL3 and METTL14 in hepatocellular carcinoma	45
Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients	45
A qualitative study of the vocational and psychological perceptions and issues of transdisciplinary nurses during the COVID-19 outbreak	45
Comprehensive analysis of m6A regulators prognostic value in prostate cancer	44
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States	44
Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury	44
Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway	43
Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling	43
Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer	43
Exploring diagnostic m6A regulators in endometriosis	43
PANoptosis components, regulation, and implications	42
Short telomeres increase the risk of severe COVID-19	42
HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification	42
PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia	41
Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2	41
miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke	41
COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians	41
ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants	40
Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma	40
Ovulation and ovarian wound healing are impaired with advanced reproductive age	40
Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling	40
p21 can be a barrier to ferroptosis independent of p53	39
The <i>slc4a2b</i> gene is required for hair cell development in zebrafish	39
Fungal co-infection in COVID-19 patients: evidence from a systematic review and meta-analysis	39
Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure	38
MicroRNA-29a-3p delivery via exosomes derived from engineered human mesenchymal stem cells exerts tumour suppressive effects by inhibiting migration and vasculogenic mimicry in glioma	38
LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability	38
Factors influencing serum neurofilament light chain levels in normal aging	38
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime	38
Serum exosomal long noncoding RNAs lnc-FAM72D-3 and lnc-EPC1-4 as diagnostic biomarkers for hepatocellular carcinoma	37
Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair	37
Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma	37
Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B	37
Effect of lncRNA WT1-AS regulating WT1 on oxidative stress injury and apoptosis of neurons in Alzheimer's disease via inhibition of the miR-375/SIX4 axis	37
Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells	37
Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway	37
lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration	37
Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis	37
Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α	37
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway	37
Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues	36
LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22	36
Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo	36
Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis	36
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence	36
circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis	36
Plasma acylcarnitine levels increase with healthy aging	36
Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway	36
Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway	36
Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions	36
High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study	36
Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells	36
Global variability of the human IgG glycome	36
Infection with SARS-CoV-2 causes abnormal laboratory results of multiple organs in patients	36
Activated CD4+ T cells-derived exosomal miR-142-3p boosts post-ischemic ventricular remodeling by activating myofibroblast	35
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine	35
circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway	35
In search of preventative strategies: novel high-CBD <i>cannabis sativa</i> extracts modulate ACE2 expression in COVID-19 gateway tissues	35
Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers	34
Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1	34
Long non-coding RNA MALAT1 exacerbates acute respiratory distress syndrome by upregulating ICAM-1 expression via microRNA-150-5p downregulation	34
Cellular senescence in lymphoid organs and immunosenescence	34
An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis	34
Immune infiltration and a ferroptosis-associated gene signature for predicting the prognosis of patients with endometrial cancer	34
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome	34

Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19	34
Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation	34
Suppression of p16 alleviates the senescence-associated secretory phenotype	34
Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile	34
Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response	34
Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemoki	34
MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B	33
lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p	33
Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation	33
Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment	33
Age-dependent remodeling of gut microbiome and host serum metabolome in mice	33
Exosomal miR-222 from adriamycin-resistant MCF-7 breast cancer cells promote macrophages M2 polarization via PTEN/Akt to induce tumor progression	33
Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice	33
CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway	33
Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis	33
Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma	33
HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation	33
Identification and validation of an immune-related gene signature predictive of overall survival in colon cancer	33
Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass	32
CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis	32
GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway	32
Mental awareness improved mild cognitive impairment and modulated gut microbiome	32
Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality	32
Long non-coding RNA SNHG12 promotes immune escape of ovarian cancer cells through their crosstalk with M2 macrophages	32
Knockdown of <i>Foxg1</i> in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle	32
ARDD 2020: from aging mechanisms to interventions	32
Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors	32
Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury	32
miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis	32
Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals	32
Perioperative neurocognitive dysfunction: thinking from the gut?	32
Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression	32
Alterations in fecal short chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) in men with benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS)	32
HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 via miR-221-3p binding	32
Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China	32
Clinical course and risk factors for recurrence of positive SARS-CoV-2 RNA: a retrospective cohort study from Wuhan, China	32
PDIA3 correlates with clinical malignant features and immune signature in human gliomas	32
Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway	31
Fusobacterium nucleatum promotes liver metastasis in colorectal cancer by regulating the hepatic immune niche and altering gut microbiota	31
Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories	31
Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster	31
Circ-0001068 is a novel biomarker for ovarian cancer and inducer of PD1 expression in T cells	31
Pompe disease: pathogenesis, molecular genetics and diagnosis	31
LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway	31
LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA	31
LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway	31
Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer	31
Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice	31
BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake	31
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages	31
Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling	31
Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease	31
Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS	31
ATP synthase and Alzheimer’s disease: putting a spin on the mitochondrial hypothesis	31
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy	31
LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression	31
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression	31
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence	30
Long non-coding RNA TPT1-AS1 promotes angiogenesis and metastasis of colorectal cancer through TPT1-AS1/NF90/VEGFA signaling pathway	30
Emerging roles of nucleotide metabolism in cancer development: progress and prospect	30
SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice	30
ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19	30
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the	30
Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition	30
Physical activity, a modulator of aging through effects on telomere biology	30
Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement	30
MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA	30
Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways	30
lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy	30
Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis	30
β cell aging and age-related diabetes	30
Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p	30
Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53	30
Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27kip1 signaling pathway	30
A novel 3’,5’-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer	30
Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2	30
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy	29
Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer’s disease: a pre-clinical study	29
Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage	29
Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis	29
Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis	29
Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging	29
Repetitive transcranial magnetic stimulation of the cerebellum improves ataxia and cerebello-fronto plasticity in multiple system atrophy: a randomized, double-blind, sham-controlled and TMS-EEG study	29
Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade	29
Effects of enriched branched-chain amino acid supplementation on sarcopenia	29
Radiomics-based prediction of survival in patients with head and neck squamous cell carcinoma based on pre- and post-treatment 18F-PET/CT	29
A glycolysis-related gene expression signature in predicting recurrence of breast cancer	29
Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)	29
Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database	29
Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice	29
A DNA methylation age predictor for zebrafish	29
Long non-coding RNA CCAT1 promotes colorectal cancer progression by regulating miR-181a-5p expression	29
The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis	29
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration	29
ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma	29