OOIR: Observatory of International Research

Papers

(The H4-Index of Aging-US is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Challenges in targeting the tryptophan metabolism in cancer immunotherapy	216
Advanced age is not the decisive factor in chemotherapy of small cell lung cancer: a population-based study	129
Serum adenosine deaminase activity and acute cerebral infarction: a retrospective case-control study based on 7913 participants	78
DNA methylation entropy is a biomarker for aging	77
Clinical characterization and therapeutic targets of vitamin A in patients with hepatocholangiocarcinoma and coronavirus disease	72
Vascular function in the aging human brain during muscle exertion	70
AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy	68
PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma	67
Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder	67
CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction	66
ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function	64
Identification and validation of oxeiptosis-associated lncRNAs and prognosis-related signature genes to predict the immune status in uterine corpus endometrial carcinoma	64
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis	60
Correction for: LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis	59
Correction for: Circular RNA Plek promotes fibrogenic activation by regulating the miR-135b-5p/TGF-βR1 axis after spinal cord injury	59
Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma	58
Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study	58
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats	57
Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence	57
	56
Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer	55
Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses	54
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies	53
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway	52
S100A9, as a potential predictor of prognosis and immunotherapy response for GBM, promotes the malignant progression of GBM cells and migration of M2 macrophages	52

Multilevel data integration and molecular docking approach to systematically elucidate the underlying pharmacological mechanisms of Er-Zhi-Wan against hepatocellular carcinoma	52
Investigating causal associations among gut microbiota, gut microbiota-derived metabolites, and gestational diabetes mellitus: a bidirectional Mendelian randomization study	51
	50
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer	50
BMAL1 modulates senescence programming via AP-1	50
Development and validation of a combined cuproptosis and immunogenic cell death prognostic model for diffuse large B-cell lymphoma	47
In vivo tau staging in Alzheimer’s disease	46
Identification and external validation of the hub genes associated with cardiorenal syndrome through time-series and network analyses	45
THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)	45
Two lncRNA signatures with cuproptosis as a novel prognostic model and clinicopathological value for endometrioid endometrial adenocarcinoma	44
Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis	43
Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	43
Staying fit and the obese aging heart condition	42
Clinicopathological and prognostic value of long noncoding RNA SNHG7 in cancers: a meta-analysis and bioinformatics	42
Pan-cancer analysis of disulfidptosis with potential implications in prognosis, immune microenvironment, and drug resistance in human cancer	42
Association between dipeptidyl peptidase-4 inhibitor use and risk of Parkinson’s disease among patients with diabetes mellitus: a retrospective cohort study	42
Bisphosphonates and breast cancer survival: a meta-analysis and trial sequential analysis of 81508 participants from 23 prospective epidemiological studies	41
Metastasis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma	41
An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis	41