OOIR: Observatory of International Research

Papers

(The H4-Index of Aging-US is 34. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
	278
Vascular function in the aging human brain during muscle exertion	150
Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	118
Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses	88
LncRNA DANCR suppresses acute myocardial infarction in mice via mediating p-RXRA/TRAF2/NIK/IKK/NF-κB signaling pathway	65
Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma	52
The impact of ALDH7A1 variants in oral cancer development and prognosis	50
PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma	49
Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder	46
Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence	45
Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer	45
ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function	45
In vivo tau staging in Alzheimer’s disease	44
An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis	44
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer	44
Epigenetic aging signatures and age prediction in human skeletal muscle	43
AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy	42
Mapping the core senescence phenotype of primary human colon fibroblasts	41
Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation	41
S100A9, as a potential predictor of prognosis and immunotherapy response for GBM, promotes the malignant progression of GBM cells and migration of M2 macrophages	41
Association between dipeptidyl peptidase-4 inhibitor use and risk of Parkinson’s disease among patients with diabetes mellitus: a retrospective cohort study	40
CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction	40
Organotypic cultures as aging associated disease models	39
Investigating causal associations among gut microbiota, gut microbiota-derived metabolites, and gestational diabetes mellitus: a bidirectional Mendelian randomization study	39
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer	38

BMAL1 modulates senescence programming via AP-1	38
Pan-cancer analysis of disulfidptosis with potential implications in prognosis, immune microenvironment, and drug resistance in human cancer	38
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway	38
Identification and validation of immunogenic cell death-related score in uveal melanoma to improve prediction of prognosis and response to immunotherapy	37
The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study	37
Advanced age is not the decisive factor in chemotherapy of small cell lung cancer: a population-based study	37
THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)	37
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats	36
Development and validation of a combined cuproptosis and immunogenic cell death prognostic model for diffuse large B-cell lymphoma	36
Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study	34
Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series	34