OOIR: Observatory of International Research

Papers

(The H4-Index of Aging-US is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Advanced age is not the decisive factor in chemotherapy of small cell lung cancer: a population-based study	241
Serum adenosine deaminase activity and acute cerebral infarction: a retrospective case-control study based on 7913 participants	149
DNA methylation entropy is a biomarker for aging	91
Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder	83
Vascular function in the aging human brain during muscle exertion	83
CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction	79
Correction for: LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis	77
Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma	75
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats	72
	70
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway	69
Multilevel data integration and molecular docking approach to systematically elucidate the underlying pharmacological mechanisms of Er-Zhi-Wan against hepatocellular carcinoma	66
S100A9, as a potential predictor of prognosis and immunotherapy response for GBM, promotes the malignant progression of GBM cells and migration of M2 macrophages	65
Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses	61
Clinicopathological and prognostic value of long noncoding RNA SNHG7 in cancers: a meta-analysis and bioinformatics	60
LncRNA DANCR suppresses acute myocardial infarction in mice via mediating p-RXRA/TRAF2/NIK/IKK/NF-κB signaling pathway	60
In vivo tau staging in Alzheimer’s disease	60
Identification and external validation of the hub genes associated with cardiorenal syndrome through time-series and network analyses	57
THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)	56
Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	53
Two lncRNA signatures with cuproptosis as a novel prognostic model and clinicopathological value for endometrioid endometrial adenocarcinoma	53
Pan-cancer analysis of disulfidptosis with potential implications in prognosis, immune microenvironment, and drug resistance in human cancer	49
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis	45
Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma	44
Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based stud	43

An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis	43
Identification and validation of oxeiptosis-associated lncRNAs and prognosis-related signature genes to predict the immune status in uterine corpus endometrial carcinoma	43
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer	42
Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation	41
The impact of ALDH7A1 variants in oral cancer development and prognosis	41
Mapping the core senescence phenotype of primary human colon fibroblasts	40
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer	40
Metastasis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma	40
F12 as a reliable diagnostic and prognostic biomarker associated with immune infiltration in papillary thyroid cancer	40
AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy	39
Organotypic cultures as aging associated disease models	39
Association between dipeptidyl peptidase-4 inhibitor use and risk of Parkinson’s disease among patients with diabetes mellitus: a retrospective cohort study	39
PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma	39
LINC02362 attenuates hepatocellular carcinoma progression through the miR-516b-5p/SOSC2 axis	38
Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence	38
Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner	38