OOIR: Observatory of International Research

Papers

(The H4-Index of Aging-US is 34. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
	292
Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses	179
Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma	128
PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma	98
Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder	67
Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer	59
In vivo tau staging in Alzheimer’s disease	57
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer	55
CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction	50
S100A9, as a potential predictor of prognosis and immunotherapy response for GBM, promotes the malignant progression of GBM cells and migration of M2 macrophages	50
Association between dipeptidyl peptidase-4 inhibitor use and risk of Parkinson’s disease among patients with diabetes mellitus: a retrospective cohort study	48
DNA methylation entropy is a biomarker for aging	47
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies	47
Metastasis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma	47
THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)	46
Identification and validation of immunogenic cell death-related score in uveal melanoma to improve prediction of prognosis and response to immunotherapy	46
AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy	45
Development and validation of a combined cuproptosis and immunogenic cell death prognostic model for diffuse large B-cell lymphoma	45
The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study	44
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer	44
Two lncRNA signatures with cuproptosis as a novel prognostic model and clinicopathological value for endometrioid endometrial adenocarcinoma	43
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC	43
Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study	42
Multilevel data integration and molecular docking approach to systematically elucidate the underlying pharmacological mechanisms of Er-Zhi-Wan against hepatocellular carcinoma	42
Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence	42

Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats	40
Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series	39
Serum adenosine deaminase activity and acute cerebral infarction: a retrospective case-control study based on 7913 participants	39
Organotypic cultures as aging associated disease models	38
Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial	37
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway	37
An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis	36
Identification and validation of oxeiptosis-associated lncRNAs and prognosis-related signature genes to predict the immune status in uterine corpus endometrial carcinoma	35
Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation	35
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results	34
Mapping the core senescence phenotype of primary human colon fibroblasts	34
LncRNA DANCR suppresses acute myocardial infarction in mice via mediating p-RXRA/TRAF2/NIK/IKK/NF-κB signaling pathway	34
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis	34