Science Signaling

Papers
(The TQCC of Science Signaling is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Pathogenic putrescine111
Avoiding conflict with strigolactones84
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target83
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways78
Aging and age-related disorders, cell by cell74
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress74
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function67
Shining a light on rhodopsin signaling64
Editorial expression of concern64
Transporting leptin to its targets62
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function61
Intrapore lipids hydrophobically gate pannexin-1 channels60
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease59
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization59
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition52
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors51
Nuclear pore decoys fool viruses48
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs48
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis45
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney44
Turning a negative into a positive41
A lifeline for immunotherapy41
Insulin and T reg cells40
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses39
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke38
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth38
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment36
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells35
Lipid drops in on Alzheimer’s disease34
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis34
Targeting AML at the intersection of epigenetics and signaling33
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola33
Ring around the mitochondria33
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses33
Metabolic pressure from sensory neurons33
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation33
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response32
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways32
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP31
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity31
Telomeres to go31
cAMPing up cancer immunotherapy31
Modulation by macrocyclic peptides31
Innate depression30
A message for microglia from microbiota29
Gut bugs on drugs29
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury28
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP228
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger28
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β28
A metabolic regulator for parietal cells27
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice27
The fragile state of opioid withdrawal27
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis27
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF327
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer27
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration27
Glia are powerhouses for sleep26
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model26
Themis is indispensable for IL-2 and IL-15 signaling in T cells26
Data-driven design of orthogonal protein-protein interactions25
Sleep and longevity tied to glia24
An ion channel’s high five24
Stressed Hippo kinase turns to autophagy23
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells23
A savory way to gain weight23
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling22
Cloaked by mutant p5322
Tales from the cryptic pocket22
Stress with ketamine tackles depression22
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells22
A spartin approach to lipophagy22
Obesity and antitumor immunity22
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies21
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent21
Fibrous stroma: Driver and passenger in cancer development21
Protein-PAINT: Superresolution microscopy with signaling proteins21
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy21
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation21
A spatiotemporal Notch interaction map from plasma membrane to nucleus20
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach20
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth20
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome20
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals20
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis20
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans20
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease20
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING19
IL-6 drives hepatocyte dedifferentiation19
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis19
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration19
A gut punch for PCOS19
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP118
Remodeling of the Homer-Shank interactome mediates homeostatic plasticity18
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo18
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release18
Restraining neuroinflammation in Alzheimer’s disease18
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries18
Stress granules plug holes17
Exploiting lysosomal advantage in tumors17
Forced into glucose metabolism17
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons17
Brain aging by gut AGE17
Get moving to clear β-amyloid17
TYK2 on tau17
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens17
Compartmentalized prions17
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop16
Retraction16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile16
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes16
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production16
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors16
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP16
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages15
The adrenal stress response is an essential host response against therapy-induced lethal immune activation15
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells15
Short stature and combined immunodeficiency associated with mutations in RGS1015
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling15
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation15
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters14
The lactate wasteland14
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P14
Sleep loss is a metabolic disorder14
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase14
Interferon with ovarian cancer14
Blebby survivors13
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice13
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells13
Neuronal-glioma cross-talk13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition13
Aging from adipose accumulation of antibodies13
Expand, push, break, release, repair: A unique way to secrete macromolecules13
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity13
Charting metastasis13
Stroke of DNA13
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells13
Rebuilding duct work from the gallbladder13
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF213
The cancer risk of repeat RNAs13
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells13
The biology of addiction12
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization12
Taking down tumors takes atypical integrins12
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication12
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT112
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response12
Poor sleep for pass-out drunks12
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity12
Dissecting the biology of mTORC1 beyond rapamycin12
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs12
The polarizing nature of fructose12
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow12
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice12
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