Science Signaling

Article	Citations
Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration	143
High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design	139
The hallmarks of cancer are also the hallmarks of wound healing	98
The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps	84
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease	77
Two glutamate- and pH-regulated Ca 2+ channels are required for systemic wound signaling in Arabidopsis	74
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling	70
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function	69
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity	65
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif	64
Plasmodesmata-localized proteins and ROS orchestrate light-induced rapid systemic signaling in Arabidopsis	64
Cytoplasmic short linear motifs in ACE2 and integrin β 3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy	63
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer	61
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation	61
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis	59
Biased ligands at opioid receptors: Current status and future directions	58
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications	56
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	54
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	53
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling	50
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	50
Kynurenic acid may underlie sex-specific immune responses to COVID-19	50
The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells	49
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity	47
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses	47

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner	46
Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics	45
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca 2+ transfer for survival	44
2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila	44
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation	44
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	44
High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors	42
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival	41
The extracellular matrix protein TasA is a developmental cue that maintains a motile subpopulation within Bacillus subtilis biofilms	39
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke	39
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior	38
Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome	38
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling	37
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes	36
Select hyperactivating NLRP3 ligands enhance the T H 1- and T H 17-inducing potential of human type 2 conventional dendritic cells	35
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis	35
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	35
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability	35
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	34
Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells	34
The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes	34
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	33
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	33
Activation of PPARα enhances astroglial uptake and degradation of β-amyloid	33
A novel TNFR2 agonist antibody expands highly potent regulatory T cells	33
The ER chaperone calnexin controls mitochondrial positioning and respiration	32
The injury response to DNA damage in live tumor cells promotes antitumor immunity	32
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner	32
NF-κB responds to absolute differences in cytokine concentrations	31
Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation	30
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability	30
A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets	30
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation	29
The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors	29
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	29
A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers	28
Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis	28
Neuroligin-2 as a central organizer of inhibitory synapses in health and disease	27
Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells	27
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α	27
Interclass GPCR heteromerization affects localization and trafficking	27
Long-chain polyphosphates impair SARS-CoV-2 infection and replication	26
Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation	26
p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators	25
Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies	25
SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function	24
Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis	24
TRPML1 channels initiate Ca 2+ sparks in vascular smooth muscle cells	24
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption	24
Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice	24

Metabolic adaptation to calorie restriction	24
Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance	24
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication	24
Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates	24
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	24
Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases	23
Local Ca 2+ signals couple activation of TRPV1 and ANO1 sensory ion channels	23
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells	22
IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice	22
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity	21
NET formation is independent of gasdermin D and pyroptotic cell death	21
BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1	21
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation	21
IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr 1250 and Tyr 1251	21
The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse	21
A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis	20
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis	20
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	20
EGF promotes DKK1 transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3	20
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	20
Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death	20
ETV7 limits antiviral gene expression and control of influenza viruses	19
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils	19
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway	19
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites	19
β-Arrestin–dependent ERK signaling reduces anxiety-like and conditioned fear–related behaviors in mice	19
14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban	19
The dimeric form of CXCL12 binds to atypical chemokine receptor 1	18
Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse	18
Balancing energy and protein homeostasis at ER-mitochondria contact sites	18
GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma	18
Redox priming promotes Aurora A activation during mitosis	18
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells	18
An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease	18
Phenotypic variability, not noise, accounts for most of the cell-to-cell heterogeneity in IFN-γ and oncostatin M signaling responses	18
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	18
Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state	18
Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells	18
Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression	17
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation	17
Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation	17
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	17
The omega-3 hydroxy fatty acid 7( S )-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology	17
Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools	17
MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation	17
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function	17
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING	16
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	16
Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16	16
Modulation of PKM activity affects the differentiation of T H 17 cells	16
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin	16
ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells	16
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome	16
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling	16
The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines	16
Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis	16
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways	16
DDAH2 suppresses RLR-MAVS–mediated innate antiviral immunity by stimulating nitric oxide–activated, Drp1-induced mitochondrial fission	15
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport	15
PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor	15
Structural insights into the signal transduction mechanism of the K + -sensing two-component system KdpDE	15
The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid	15
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity	15
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	15
Tissue-specific adrenergic regulation of the L-type Ca 2+ channel Ca V 1.2	15
Fibrous stroma: Driver and passenger in cancer development	15
Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca 2+ mobilization and the inflammatory activity of dendritic cells	15
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor hetero	15
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	15
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca 2+ signaling	15
Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry	15
PhoQ is an unsaturated fatty acid receptor that fine-tunes Salmonella pathogenic traits	15
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway	15
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	15
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17	15
Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK	14
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment	14
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	14
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	14
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice	14

Interleukin-7 protects CD8 + T cells from adenosine-mediated immunosuppression	14
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation	14
Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1	14
Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model	13
Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway	13
Functional and biological heterogeneity of KRAS Q61 mutations	13
Ubiquitination and functional modification of GluN2B subunit–containing NMDA receptors by Cbl-b in the spinal cord dorsal horn	13
Emerging roles of PLCγ1 in endothelial biology	13
Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice	13
A protein kinase A–regulated network encodes short- and long-lived cellular memories	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation	13
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	13
PI(4,5)P 2 -stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt–β-catenin signaling	13
Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance	13
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα i :β-arrestin complexes	13
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion	13