Science Signaling

Article	Citations
The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps	102
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease	88
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function	79
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling	76
Plasmodesmata-localized proteins and ROS orchestrate light-induced rapid systemic signaling in Arabidopsis	73
Biased ligands at opioid receptors: Current status and future directions	70
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	69
Cytoplasmic short linear motifs in ACE2 and integrin β 3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy	67
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif	66
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation	65
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer	64
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	63
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	62
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	61
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications	60
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling	58
Kynurenic acid may underlie sex-specific immune responses to COVID-19	57
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	56
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling	52
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis	52
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner	50
2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila	50
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation	50
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes	47
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival	45

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	44
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner	42
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	42
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication	41
Select hyperactivating NLRP3 ligands enhance the T H 1- and T H 17-inducing potential of human type 2 conventional dendritic cells	40
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	40
A novel TNFR2 agonist antibody expands highly potent regulatory T cells	39
NF-κB responds to absolute differences in cytokine concentrations	37
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	37
Activation of PPARα enhances astroglial uptake and degradation of β-amyloid	37
A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets	36
The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors	34
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation	34
The injury response to DNA damage in live tumor cells promotes antitumor immunity	34
Neuroligin-2 as a central organizer of inhibitory synapses in health and disease	33
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability	32
Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis	32
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	30
Long-chain polyphosphates impair SARS-CoV-2 infection and replication	29
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α	29
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	29
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells	29
EGF promotes DKK1 transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3	28
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	28
Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation	28
The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse	28
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity	27
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption	26
Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice	26
NET formation is independent of gasdermin D and pyroptotic cell death	26
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome	26
MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation	25
SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function	25
Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases	25
Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK	24
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17	24
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways	24
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	24
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	24
IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice	24
Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates	24
The dimeric form of CXCL12 binds to atypical chemokine receptor 1	23
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity	23
ETV7 limits antiviral gene expression and control of influenza viruses	23
Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death	23
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	23
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	23
The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS	22
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils	22
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	22

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport	22
Balancing energy and protein homeostasis at ER-mitochondria contact sites	22
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	21
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation	21
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	21
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites	21
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling	21
The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines	21
Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis	20
β-Arrestin–dependent ERK signaling reduces anxiety-like and conditioned fear–related behaviors in mice	20
PI(4,5)P 2 -stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt–β-catenin signaling	20
Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16	20
DDAH2 suppresses RLR-MAVS–mediated innate antiviral immunity by stimulating nitric oxide–activated, Drp1-induced mitochondrial fission	20
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor hetero	20
The omega-3 hydroxy fatty acid 7( S )-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology	20
Phenotypic variability, not noise, accounts for most of the cell-to-cell heterogeneity in IFN-γ and oncostatin M signaling responses	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	19
Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca 2+ mobilization and the inflammatory activity of dendritic cells	19
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice	19
Fibrous stroma: Driver and passenger in cancer development	19
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function	19
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	19
Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state	19
Functional and biological heterogeneity of KRASQ61mutations	18
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation	18
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	18
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway	18
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	18
Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools	18
Tissue-specific adrenergic regulation of the L-type Ca 2+ channel Ca V 1.2	17
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling	17
Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model	17
Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation	17
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	17
Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression	17
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING	17
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	16
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation	16
Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells	16
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	16
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	16
ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells	16
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation	16
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	16
Interleukin-7 protects CD8 + T cells from adenosine-mediated immunosuppression	16
Palmitoylation of the Parkinson’s disease–associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis	16
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	16
Emerging roles of PLCγ1 in endothelial biology	16
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics	15
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts	15
Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in Escherichia coli chemoreceptor arrays	15
Remodeling of the Homer-Shank interactome mediates homeostatic plasticity	15
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα i :β-arrestin complexes	15
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells	15
Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration	15
Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance	14
Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1	14
Protein-PAINT: Superresolution microscopy with signaling proteins	14
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion	14
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	14
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment	14
Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling	14
NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C hi monocytes in pressure-overloaded hearts	14
Themis is indispensable for IL-2 and IL-15 signaling in T cells	13
Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine	13
Stress signaling boosts interferon-induced gene transcription in macrophages	13
Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling	13
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1	13
NK cells integrate signals over large areas when building immune synapses but require local stimuli for degranulation	12
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape	12
Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes	12
Synaptic activity–dependent changes in the hippocampal palmitoylome	12
TheBacillus cereustoxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100	12
The GABA B receptor mediates neuroprotection by coupling to G 13	12
Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex	12
PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation	12
Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1	11
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	11
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	11
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	11

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	11
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	11
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	11
Dissecting the biology of mTORC1 beyond rapamycin	11
The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING	11
Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability	10
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	10
The perception and response of T cells to a changing environment are based on the law of initial value	10
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	10
Engineered chemotaxis core signaling units indicate a constrained kinase-off state	10
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome	10
Stimulation of phospholipase Cβ1 by Gαqpromotes the assembly of stress granule proteins	10
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1	10
Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells	10
A cholesterol analog stabilizes the human β 2 -adrenergic receptor nonlinearly with temperature	10
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	10
The transcription factor XBP1 in dendritic cells promotes the T H 2 cell response in airway allergy	10
Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors	10
SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages	10
Uveal melanoma–associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis	10
Signaling by the tyrosine kinase Yes promotes liver cancer development	10
Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension	10