Science Signaling

Article	Citations
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	98
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	90
Transporting leptin to its targets	88
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	86
Editorial expression of concern	84
Intrapore lipids hydrophobically gate pannexin-1 channels	72
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	72
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	71
Avoiding conflict with strigolactones	69
Aging and age-related disorders, cell by cell	66
Shining a light on rhodopsin signaling	64
Nuclear pore decoys fool viruses	64
Pathogenic putrescine	60
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	58
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	58
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	57
Estrogen-powered kidney protection	55
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	53
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	48
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	47
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	46
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	44
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	44
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	43
Targeting AML at the intersection of epigenetics and signaling	42

Turning a negative into a positive	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	40
Insulin and T reg cells	40
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	39
Ring around the mitochondria	38
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	38
Metabolic pressure from sensory neurons	37
Lipid drops in on Alzheimer’s disease	37
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	37
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	36
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	36
Telomeres to go	35
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	35
Gut bugs on drugs	34
A metabolic regulator for parietal cells	33
cAMPing up cancer immunotherapy	33
The fragile state of opioid withdrawal	33
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	31
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	31
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	31
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	31
Modulation by macrocyclic peptides	31
A message for microglia from microbiota	30
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	29
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	29
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	28
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	28
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	28
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	28
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	28
Innate depression	27
Protein-PAINT: Superresolution microscopy with signaling proteins	27
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	27
Obesity and antitumor immunity	27
A savory way to gain weight	26
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	26
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	26
A spatiotemporal Notch interaction map from plasma membrane to nucleus	26
An ion channel’s high five	25
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	25
A spartin approach to lipophagy	25
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	25
Sleep and longevity tied to glia	24
Tales from the cryptic pocket	24
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	23
Themis is indispensable for IL-2 and IL-15 signaling in T cells	23
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	23
Stressed Hippo kinase turns to autophagy	23
Glia are powerhouses for sleep	22
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	22

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	22
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	22
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	22
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	22
Stress with ketamine tackles depression	22
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	22
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	21
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	21
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	21
Fibrous stroma: Driver and passenger in cancer development	21
IL-6 drives hepatocyte dedifferentiation	21
Data-driven design of orthogonal protein-protein interactions	21
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	19
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	19
A gut punch for PCOS	19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	19
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	19
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	18
Get moving to clear β-amyloid	18
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	18
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	18
Stress granules plug holes	18
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	17
Exploiting lysosomal advantage in tumors	17
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling	17
TYK2 on tau	17
Compartmentalized prions	17
Restraining neuroinflammation in Alzheimer’s disease	17
Brain aging by gut AGE	17
Retraction	17
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	16
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	16
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	16
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	16
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	15
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	15
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	15
Sleep loss is a metabolic disorder	15
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	15
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	14
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	14
The lactate wasteland	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Aging from adipose accumulation of antibodies	14
Charting metastasis	14
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
Rebuilding duct work from the gallbladder	14
Blebby survivors	14
Interferon with ovarian cancer	13
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	13
Dissecting the biology of mTORC1 beyond rapamycin	13
The biology of addiction	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
Taking down tumors takes atypical integrins	13
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	13
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	13
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	12
Improving IL-2 for T cell therapy	12
A twist in β-arrestin’s tail	12
The cancer risk of repeat RNAs	12
Neuronal-glioma cross-talk	12
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	12

Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	12
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	12
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	12
Poor sleep for pass-out drunks	12
The polarizing nature of fructose	12
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	12
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	12
Stroke of DNA	12
STING and arthritis	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	11
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	11
Catalytic site mutations confer multiple states of G protein activation	11
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	11
Complement-ary immunity to lung cancer	11
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	10
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	10
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	10
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	10
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	10
Stress signaling boosts interferon-induced gene transcription in macrophages	10
Acetylation makes a drug-resistant BRAF	10
Formate for tumor progression	10
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	10
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	10
A pancreatic pause in breast cancer	10
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	10
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	9
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	9
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	9
Extracellular vesicles as central regulators of blood vessel function in cancer	9
Nanobody pharmacology	9
JMJD8 reduces cancer’s STING	9
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	9
In lonely mice, astrocytes turn inhibitory	9
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	9
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	9
Exploring protein-protein interactions for the development of new analgesics	9
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	9
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	9
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	9
The GABA B receptor mediates neuroprotection by coupling to G 13	9
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	9
Cholesterol sensing goes vegetarian	8
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	8
Stressful memories	8
Cleanup on IL-2	8
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	8
Neural control of gut repair	8
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	8
Macrophages de liver growth	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	8
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	8
Lymph node colonization and metastasis	7
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	7
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	7
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	7
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment	7
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	7
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	7
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	7
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	7
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	7
Waking up melanoma	6
Paving the way for metastasis	6
Bring in the B team	6
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer	6
The TMEM16A anion channel as a versatile regulator of vascular tone	6
Bacteria benefit tumor cells	6
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	6
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	6
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	6
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	6
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells	6
RHOA drivers take alternate routes in gastric cancer	6
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	6
Keeping brown fat brown	6
Rewiring the logic board of IFN signaling	6
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	6
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	6
Protecting the liver with PKD1	6
Polycystin goes with the flow	5
Protein rings are critical to the remarkable signaling properties of bacterial chemotaxis nanoarrays	5
Dopamine suppresses ILC2s	5
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	5
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells	5
Stimulation of phospholipase Cβ1 by Gαqpromotes the assembly of stress granule proteins	5