Science Signaling

Article	Citations
Pathogenic putrescine	111
Avoiding conflict with strigolactones	84
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	83
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	78
Aging and age-related disorders, cell by cell	74
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	74
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	67
Shining a light on rhodopsin signaling	64
Editorial expression of concern	64
Transporting leptin to its targets	62
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function	61
Intrapore lipids hydrophobically gate pannexin-1 channels	60
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	59
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	59
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	52
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	51
Nuclear pore decoys fool viruses	48
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	48
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	45
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	44
Turning a negative into a positive	41
A lifeline for immunotherapy	41
Insulin and T reg cells	40
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	39
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	38

Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	38
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	36
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	35
Lipid drops in on Alzheimer’s disease	34
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	34
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	33
Targeting AML at the intersection of epigenetics and signaling	33
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	33
Ring around the mitochondria	33
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	33
Metabolic pressure from sensory neurons	33
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	32
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	32
cAMPing up cancer immunotherapy	31
Modulation by macrocyclic peptides	31
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	31
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	31
Telomeres to go	31
Innate depression	30
Gut bugs on drugs	29
A message for microglia from microbiota	29
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	28
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	28
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	28
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	28
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	27
A metabolic regulator for parietal cells	27
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	27
The fragile state of opioid withdrawal	27
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	27
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	27
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	27
Glia are powerhouses for sleep	26
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	26
Themis is indispensable for IL-2 and IL-15 signaling in T cells	26
Data-driven design of orthogonal protein-protein interactions	25
Sleep and longevity tied to glia	24
An ion channel’s high five	24
Stressed Hippo kinase turns to autophagy	23
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	23
A savory way to gain weight	23
A spartin approach to lipophagy	22
Obesity and antitumor immunity	22
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	22
Cloaked by mutant p53	22
Tales from the cryptic pocket	22
Stress with ketamine tackles depression	22
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	22
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	21
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	21

Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	21
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	21
Fibrous stroma: Driver and passenger in cancer development	21
Protein-PAINT: Superresolution microscopy with signaling proteins	21
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	20
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	20
A spatiotemporal Notch interaction map from plasma membrane to nucleus	20
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	20
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	20
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	20
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	20
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	19
A gut punch for PCOS	19
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	19
IL-6 drives hepatocyte dedifferentiation	19
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	19
Restraining neuroinflammation in Alzheimer’s disease	18
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	18
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	18
Remodeling of the Homer-Shank interactome mediates homeostatic plasticity	18
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	18
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	18
TYK2 on tau	17
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	17
Compartmentalized prions	17
Stress granules plug holes	17
Exploiting lysosomal advantage in tumors	17
Forced into glucose metabolism	17
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	17
Brain aging by gut AGE	17
Get moving to clear β-amyloid	17
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	16
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	16
Retraction	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	16
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	16
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	16
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	15
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	15
Short stature and combined immunodeficiency associated with mutations in RGS10	15
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling	15
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	14
Interferon with ovarian cancer	14
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	14
The lactate wasteland	14
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	14
Sleep loss is a metabolic disorder	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
The cancer risk of repeat RNAs	13
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	13
Blebby survivors	13
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	13
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	13
Neuronal-glioma cross-talk	13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	13
Aging from adipose accumulation of antibodies	13
Expand, push, break, release, repair: A unique way to secrete macromolecules	13
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	13
Charting metastasis	13
Stroke of DNA	13
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	13
Rebuilding duct work from the gallbladder	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	12
The polarizing nature of fructose	12
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	12
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	12
The biology of addiction	12
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	12
Taking down tumors takes atypical integrins	12
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	12

The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	12
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	12
Poor sleep for pass-out drunks	12
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	12
Dissecting the biology of mTORC1 beyond rapamycin	12
RAP1 moonlights to activate NF-κB and Notch in ALT	11
Complement-ary immunity to lung cancer	11
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	11
Improving IL-2 for T cell therapy	11
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	11
A twist in β-arrestin’s tail	11
STING and arthritis	11
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	11
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	11
Catalytic site mutations confer multiple states of G protein activation	10
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	10
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	10
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	10
In lonely mice, astrocytes turn inhibitory	10
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	10
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	10
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	10
Stress signaling boosts interferon-induced gene transcription in macrophages	10
A pancreatic pause in breast cancer	10
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	10
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	10
JMJD8 reduces cancer’s STING	10
Acetylation makes a drug-resistant BRAF	9
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	9
Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons	9
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	9
Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1	9
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	9
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	9
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	9
Formate for tumor progression	9
Exploring protein-protein interactions for the development of new analgesics	9
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	9
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	9
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
Cholesterol sensing goes vegetarian	8
Macrophages de liver growth	8
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
Cleanup on IL-2	8
The dimeric form of CXCL12 binds to atypical chemokine receptor 1	8
The GABA B receptor mediates neuroprotection by coupling to G 13	8
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	8
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	8
Nanobody pharmacology	8
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	8
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	8
Neural control of gut repair	8
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	8
Extracellular vesicles as central regulators of blood vessel function in cancer	8
Stressful memories	8
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	8
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	8
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	7
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	7
Lymph node colonization and metastasis	7
Keeping brown fat brown	7
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	7
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	7
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics	7
Rewiring the logic board of IFN signaling	7
RHOA drivers take alternate routes in gastric cancer	7
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	7
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	7
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	7
Waking up melanoma	6
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	6
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	6
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	6
Bacteria benefit tumor cells	6
Bring in the B team	6
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
Paving the way for metastasis	6
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	6
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	6
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	6
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	5
A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF	5
Protein rings are critical to the remarkable signaling properties of bacterial chemotaxis nanoarrays	5
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	5
Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice	5
Stimulation of phospholipase Cβ1 by Gαqpromotes the assembly of stress granule proteins	5
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis	5
Dopamine suppresses ILC2s	5
Polycystin goes with the flow	5