Science Signaling

Article	Citations
Aging and age-related disorders, cell by cell	113
Nuclear pore decoys fool viruses	105
Shining a light on rhodopsin signaling	97
Pathogenic putrescine	94
Intrapore lipids hydrophobically gate pannexin-1 channels	81
Avoiding conflict with strigolactones	80
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	79
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	70
Editorial expression of concern	70
Estrogen-powered kidney protection	68
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	65
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	63
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	63
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	62
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	51
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	48
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	46
APOE ε4 on immunity	45
Turning a negative into a positive	45
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	44
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	44
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	44
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	42
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	42
Metabolic pressure from sensory neurons	40

Targeting AML at the intersection of epigenetics and signaling	40
Lipid drops in on Alzheimer’s disease	40
Ring around the mitochondria	39
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	38
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	38
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	38
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	38
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	37
cAMPing up cancer immunotherapy	35
A metabolic regulator for parietal cells	35
Telomeres to go	35
Gut bugs on drugs	35
The fragile state of opioid withdrawal	35
Modulation by macrocyclic peptides	35
Innate depression	33
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	33
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	32
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	32
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	31
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	31
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	30
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	30
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	30
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	30
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	30
Protein-PAINT: Superresolution microscopy with signaling proteins	29
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H +	29
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	29
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	29
Obesity and antitumor immunity	28
Stressed Hippo kinase turns to autophagy	28
A spatiotemporal Notch interaction map from plasma membrane to nucleus	28
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	28
An ion channel’s high five	27
Tales from the cryptic pocket	27
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	27
Sleep and longevity tied to glia	27
Stress with ketamine tackles depression	27
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	26
Glia are powerhouses for sleep	26
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	24
Data-driven design of orthogonal protein-protein interactions	24
Themis is indispensable for IL-2 and IL-15 signaling in T cells	24
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	24
Fibrous stroma: Driver and passenger in cancer development	24
Jump-starting IFN-I responses and epithelial regeneration	24
A spartin approach to lipophagy	24
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	23
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	23

Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	22
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	21
A gut punch for PCOS	21
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	21
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	21
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	20
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	20
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	20
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	20
IL-6 drives hepatocyte dedifferentiation	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	19
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	19
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	19
Compartmentalized prions	18
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
Brain aging by gut AGE	18
Restraining neuroinflammation in Alzheimer’s disease	18
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	18
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	18
Stress granules plug holes	17
Retraction	17
TYK2 on tau	17
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	17
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	17
Get moving to clear β-amyloid	17
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	17
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	17
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	16
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
Sleep loss is a metabolic disorder	16
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling	16
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	16
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	16
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	15
Expand, push, break, release, repair: A unique way to secrete macromolecules	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	15
Blebby survivors	15
Aging from adipose accumulation of antibodies	15
The lactate wasteland	15
Rebuilding duct work from the gallbladder	14
Charting metastasis	14
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	14
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	14
Interferon with ovarian cancer	14
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
Taking down tumors takes atypical integrins	14
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	14
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK –driven lung cancer by concurrent integrin and MET signaling	14
Poor sleep for pass-out drunks	13
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation	13
Stroke of DNA	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
Neuronal-glioma cross-talk	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
The cancer risk of repeat RNAs	13
The polarizing nature of fructose	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
Senataxin promotes recombination fidelity during antigen receptor gene diversification	12
A twist in β-arrestin’s tail	12
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells	12
Catalytic site mutations confer multiple states of G protein activation	12
The biology of addiction	12

The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	12
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	12
Complement-ary immunity to lung cancer	12
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation	11
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	11
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	11
Stress signaling boosts interferon-induced gene transcription in macrophages	11
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	11
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	11
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	11
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	11
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	11
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	11
A pancreatic pause in breast cancer	10
JMJD8 reduces cancer’s STING	10
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	10
Acetylation makes a drug-resistant BRAF	10
In lonely mice, astrocytes turn inhibitory	10
Formate for tumor progression	10
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	10
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	10
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	10
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	10
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	10
Exploring protein-protein interactions for the development of new analgesics	10
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment	9
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	9
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	9
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	9
Neural control of gut repair	9
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	9
Cholesterol sensing goes vegetarian	9
Skewing p53 to tumor-suppressor targets	8
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	8
Nanobody pharmacology	8
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	8
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
Cleanup on IL-2	8
Extracellular vesicles as central regulators of blood vessel function in cancer	8
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	8
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
Macrophages de liver growth	8
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	8
Lymph node colonization and metastasis	8
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	8
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	8
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	8
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	7
Rewiring the logic board of IFN signaling	7
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	7
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	7
Keeping brown fat brown	7
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	7
Bacteria benefit tumor cells	7
Waking up melanoma	7
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
Bring in the B team	7
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	7
RHOA drivers take alternate routes in gastric cancer	7
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	7
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	7
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	6
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	6
The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD	6
Extracellular WNT conveyors	6
The TMEM16A anion channel as a versatile regulator of vascular tone	6
Bypassing ACE2	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
TIM3 is a context-dependent coregulator of cytotoxic T cell function	6
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells	6
Poachers turned gamekeepers in T cells	6
The long-lasting effects of NO	6
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	6
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	6
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis	6
Get up and sweat to treat cancer	6
Treating neuroinflammation through the nose	6
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells	5
Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling	5
CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation	5
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells	5
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	5
p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers	5
Enhancing naloxone	5
Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR	5
The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function	5
Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice	5