Science Signaling

Article	Citations
Bring in the B team	102
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	96
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	90
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	76
Making MAVS better	75
A Siah3 of relief: A role for mitophagy as a fail-safe during developmental axon pruning	70
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity	70
Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling	69
TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis	68
Rewiring the logic board of IFN signaling	65
The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells	62
Growth factor–dependent phosphorylation of Gα i shapes canonical signaling by G protein–coupled receptors	61
Bacteria-induced BBB breakdown	58
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	57
A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo	56
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling	56
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	52
Short stature and combined immunodeficiency associated with mutations in RGS10	52
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	50
Promoting DNA repair to prevent fibrosis	48
Intrapore lipids hydrophobically gate pannexin-1 channels	44
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	44
ARC unleashes elastase	43
Connect-the-DOT from early stress to depression	41
Autophagy chokes on SARS-CoV-2	40

Bile acids for immune tolerance	37
Transporting leptin to its targets	37
Activating T cells with asparagine	36
Interfacing with a receptor	36
Pathogenic putrescine	35
Hungry in the sun	34
Paving the way for metastasis	32
Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α 2a -adrenergic receptors	30
Keeping brown fat brown	29
Patching up B cells	29
Missing signals from Fragile astrocytes	29
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	28
Distributing apoptosis protects epithelia	28
Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes	28
Aging and age-related disorders, cell by cell	27
Emerging roles of PLCγ1 in endothelial biology	27
Editorial expression of concern	27
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	27
Waking up melanoma	26
Taking the STING out of aging?	26
Shining a light on rhodopsin signaling	25
Pathogen-associated grooming	25
Bacteria benefit tumor cells	25
Stressing the gut-brain axis	25
An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis	24
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	24
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function	24
RNAs create a sticky situation	24
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	24
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	24
Avoiding conflict with strigolactones	24
Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells	23
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis	23
The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury	23
The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse	23
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	23
Bile acid–induced metabolic changes in the colon promote Enterobacteriaceae expansion and associate with dysbiosis in Crohn’s disease	22
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	22
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice	22
Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons	21
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	21
Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling	21
Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs	21
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	21
RHOA drivers take alternate routes in gastric cancer	20
Nuclear pore decoys fool viruses	20
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	20
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	20
TheBacillus cereustoxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100	20
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	20

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	20
Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes	20
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	19
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	19
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	19
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis	19
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	19
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	18
Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice	18
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation	18
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	18
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	18
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	18
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease	18
Alarmin’ lymphoid developments	17
Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states	17
Sensing stretch to suppress appetite	17
Lipid drops in on Alzheimer’s disease	17
Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells	17
Aging from adipose accumulation of antibodies	17
Protecting the liver with PKD1	17
Hypoxia protects the gut	16
Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery	16
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor hetero	16
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	16
Blebby survivors	16
Respiratory syncytial virus induces β 2 -adrenergic receptor dysfunction in human airway smooth muscle cells	16
Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning	16
Turning a negative into a positive	16
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	15
Poachers turned gamekeepers in T cells	15
An evolutionarily conserved coronin-dependent pathway defines cell population size	15
Extracellular WNT conveyors	15
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	15
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	15
Arrestins lie in wait	14
Lysine lactylation regulates metabolic pathways and biofilm formation in Streptococcus mutans	14
A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure	14
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling	14
ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation	14
To B or not to B	14
Hitching a ride in macrophages	13
Get up and sweat to treat cancer	13
Legionella takes aim at mitochondria	13
Cleaved to keep dying cells alive	13
Piquing our interest: Insights into the role of PEAK3 in signaling and disease	13
Bypassing ACE2	12
New connections: The selectivity and subversion of SLiMs	12
Metastatic dormancy needs STING	12
Charting metastasis	12
The expanding footprint of basic biology research in India	12
A check on the immunological synapse	12
Actin’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse	12
Targeting AML at the intersection of epigenetics and signaling	11
A lifeline for immunotherapy	11
A role for lipid transporters in PDAC	11
A cancerous connection for creatine	11
A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF	11
Uncloaking tumors	11
The long-lasting effects of NO	11
An alternative to mitophagy	11
Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells	11
Insulin and T reg cells	11
Interferon with ovarian cancer	11
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines	10
Expand, push, break, release, repair: A unique way to secrete macromolecules	10
G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling	10
Hepatic stellate cells: From bad reputation to mediators of liver homeostasis	10
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	10
HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling	10
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites	10
Mind over asthma	10
The TMEM16A anion channel as a versatile regulator of vascular tone	10
The lactate wasteland	10
SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages	10
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	10
Ring around the mitochondria	10
Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism	10
Balancing act of small GTPases downstream of plexin-A4 signaling motifs promotes dendrite elaboration in mammalian cortical neurons	10
Sleep to fight tumors	9

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17	9
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	9
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	9
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING	9
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	9
The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression	9
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	9
Anxiety from the gut	9
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication	9
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	9
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	9
Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy	9
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	9
Goblet cell stress management	9
The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING	9
Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability	8
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation	8
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion	8
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	8
TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22	8
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression	8
CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans	8
Neurons go antiviral	8
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation	8
Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in Escherichia coli chemoreceptor arrays	8
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	8
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	8
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1	8
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α	8
Balancing energy and protein homeostasis at ER-mitochondria contact sites	8
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	8
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation	8
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	8
The transcription factor XBP1 in dendritic cells promotes the T H 2 cell response in airway allergy	8
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	8
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	8
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	7
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	7
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	7
Erratum for the Research Article “Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells” by T. Rosenlehner et al	7
Innate depression	7
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	7
Polycystin goes with the flow	7
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection	7
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation	7
The polarizing nature of fructose	7
Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast	7
The fragile state of opioid withdrawal	7
Protein rings are critical to the remarkable signaling properties of bacterial chemotaxis nanoarrays	7
Eliminating infection by promoting bacterial growth	7
Dopamine suppresses ILC2s	7
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	7
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	7
Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration	7
Microbes help honeybees learn	7
Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders	7
Systemic inflammation from the brain	7
Mitochondrial fission fueled by fasting	7
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape	7
A metabolic regulator for parietal cells	6
Telomeres to go	6
ATDC KEAPs NRF2 active	6
Drugging mutant p53	6
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling inDrosophilawing development	6
Phosphorylated Gβ is a directional cue during yeast gradient tracking	6
Neuronal-glioma cross-talk	6
Beige is the color of keeping weight off	6
A TRAIL from gut to brain	6
CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism	6
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	6
Stress exhausts T cells	6
The gliogenic switch takes teamwork	6
The type II TGF-β receptor phosphorylates Tyr 182 in the type I receptor to activate downstream Src signaling	6
Stroke of DNA	5
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling	5
A plasma membrane–associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells	5
cAMPing up cancer immunotherapy	5
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS	5
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome	5
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	5
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice	5
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1	5
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function	5
Modulation by macrocyclic peptides	5
CMTM4 makes IL-17 signaling more complex	5
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	5
Intercellular cross-talk curbs Alzheimer’s disease	5
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	5
A noncanonical IRAK4-IRAK1 pathway counters DNA damage–induced apoptosis independently of TLR/IL-1R signaling	5
Gut bugs on drugs	5
M 1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease	5
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP	5
Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance	5
A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1–DCC	5
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	5