Science Signaling

Article	Citations
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	132
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons	127
Cholinergic signals and antibodies	121
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	97
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	86
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα i1/3 to reduce depressive-like behaviors in mice	81
Aging and age-related disorders, cell by cell	79
Nuclear pore decoys fool viruses	75
Avoiding conflict with strigolactones	68
Editorial expression of concern	60
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	56
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	54
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	53
Estrogen-powered kidney protection	52
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	52
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	49
Pathogenic putrescine	47
Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice	47
Turning a negative into a positive	45
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	44
APOE ε4 on immunity	44
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	43
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	43
Metabolic pressure from sensory neurons	42
Lipid drops in on Alzheimer’s disease	41

Ring around the mitochondria	41
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	40
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	40
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	39
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	39
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	39
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	39
Telomeres to go	37
Gut bugs on drugs	37
The fragile state of opioid withdrawal	36
A metabolic regulator for parietal cells	36
cAMPing up cancer immunotherapy	36
Modulation by macrocyclic peptides	35
Innate depression	34
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	34
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	34
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	34
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	34
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	34
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	32
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	32
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	31
Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia	31
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H +	31
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	31
Stressed Hippo kinase turns to autophagy	30
Jump-starting IFN-I responses and epithelial regeneration	30
Stress with ketamine tackles depression	29
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	29
An ion channel’s high five	28
Glia are powerhouses for sleep	27
Sleep and longevity tied to glia	27
EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer	27
Tales from the cryptic pocket	27
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	26
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	26
A spartin approach to lipophagy	25
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	25
A spatiotemporal Notch interaction map from plasma membrane to nucleus	25
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	25
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	25
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	24
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	24
Data-driven design of orthogonal protein-protein interactions	24
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	24
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	23
A gut punch for PCOS	23
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	23
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	23

IL-6 drives hepatocyte dedifferentiation	23
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	22
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	22
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	22
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	21
Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration	21
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	21
Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca 2+ influx	21
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	21
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	20
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	20
Stress granules plug holes	19
Get moving to clear β-amyloid	19
TYK2 on tau	19
Retraction	19
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	19
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	18
Restraining neuroinflammation in Alzheimer’s disease	18
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	18
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	18
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	18
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	18
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	18
Sleep loss is a metabolic disorder	17
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	17
Fungi facilitate gut healing	17
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	17
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling	17
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	17
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	17
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	17
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	17
Rebuilding duct work from the gallbladder	16
The lactate wasteland	16
Aging from adipose accumulation of antibodies	16
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	16
Blebby survivors	16
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK –driven lung cancer by concurrent integrin and MET signaling	16
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	15
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	15
Charting metastasis	15
Antimuscarinic drugs exert β-arrestin–biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis	15
Expand, push, break, release, repair: A unique way to secrete macromolecules	15
Interferon with ovarian cancer	15
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	15
The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells	15
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	14
The polarizing nature of fructose	14
Neuronal-glioma cross-talk	14
Taking down tumors takes atypical integrins	14
Stroke of DNA	14
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation	14
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	14
The cancer risk of repeat RNAs	14
Poor sleep for pass-out drunks	14
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
The biology of addiction	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
Keeping inflammasomes in check during bone resorption	13
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	12
A twist in β-arrestin’s tail	12
Senataxin promotes recombination fidelity during antigen receptor gene diversification	12
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	12
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	12
SIRT2 versus Lck	12
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	12
Complement-ary immunity to lung cancer	12

Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	12
Catalytic site mutations confer multiple states of G protein activation	12
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	12
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
Stress signaling boosts interferon-induced gene transcription in macrophages	12
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	11
In lonely mice, astrocytes turn inhibitory	11
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	11
JMJD8 reduces cancer’s STING	11
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	11
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation	11
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells	11
Formate for tumor progression	11
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	11
A pancreatic pause in breast cancer	11
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	11
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	11
Neural control of gut repair	10
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	10
Exploring protein-protein interactions for the development of new analgesics	10
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	10
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	10
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	10
Cholesterol sensing goes vegetarian	10
Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization	10
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	10
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	10
Cleanup on IL-2	9
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	9
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	9
Nanobody pharmacology	9
Macrophages de liver growth	9
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	9
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	9
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	9
Skewing p53 to tumor-suppressor targets	9
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	9
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	9
Extracellular vesicles as central regulators of blood vessel function in cancer	8
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	8
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	8
Keeping brown fat brown	8
Antigen affinity modulates ERK pulsing frequency during T cell activation	8
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	8
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	8
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment	8
Waking up melanoma	8
Lymph node colonization and metastasis	8
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD	7
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	7
RHOA drivers take alternate routes in gastric cancer	7
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	7
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	7
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	7
Rewiring the logic board of IFN signaling	7
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	7
Bypassing ACE2	7
Bring in the B team	7
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	7
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	7
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	7
Extracellular WNT conveyors	7
The long-lasting effects of NO	6
Protecting the liver with PKD1	6
The TMEM16A anion channel as a versatile regulator of vascular tone	6
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells	6
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	6
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer	6
Poachers turned gamekeepers in T cells	6
Treating neuroinflammation through the nose	6
Hitching a ride in macrophages	6
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	6
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	6
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins	6
The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification	6
Actin’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse	6
The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice	6
Get up and sweat to treat cancer	6
TIM3 is a context-dependent coregulator of cytotoxic T cell function	6
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis	6
Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR	5
Switching off the bat signal	5
CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation	5
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP	5
Immunogenic Lncs to cancer therapy	5
p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers	5
Free cGAS	5
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	5
A cholinergic signaling pathway underlying cortical circuit activation of quiescent neural stem cells in the lateral ventricle	5