OOIR: Observatory of International Research

Papers

(The H4-Index of Science Signaling is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	98
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	90
Transporting leptin to its targets	88
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	86
Editorial expression of concern	84
Intrapore lipids hydrophobically gate pannexin-1 channels	72
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	72
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	71
Avoiding conflict with strigolactones	69
Aging and age-related disorders, cell by cell	66
Shining a light on rhodopsin signaling	64
Nuclear pore decoys fool viruses	64
Pathogenic putrescine	60
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	58
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	58
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	57
Estrogen-powered kidney protection	55
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	53
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	48
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	47
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	46
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	44
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	44
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	43
Targeting AML at the intersection of epigenetics and signaling	42

Turning a negative into a positive	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	40
Insulin and T _reg cells	40
A sensitive biosensor of endogenous Gα _i activity enables the accurate characterization of endogenous GPCR agonist responses	39
Ring around the mitochondria	38
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	38
Metabolic pressure from sensory neurons	37
Lipid drops in on Alzheimer’s disease	37
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	37
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	36
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	36