OOIR: Observatory of International Research

Papers

(The H4-Index of Science Signaling is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps	102
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease	88
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function	79
Essential requirement for JPT2 in NAADP-evoked Ca ²⁺ signaling	76
Plasmodesmata-localized proteins and ROS orchestrate light-induced rapid systemic signaling in Arabidopsis	73
Biased ligands at opioid receptors: Current status and future directions	70
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	69
Cytoplasmic short linear motifs in ACE2 and integrin β ₃ link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy	67
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif	66
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca ²⁺ microdomain formation	65
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer	64
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	63
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	62
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	61
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications	60
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling	58
Kynurenic acid may underlie sex-specific immune responses to COVID-19	57
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	56
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling	52
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis	52
2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila	50
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation	50
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner	50
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes	47
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival	45

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	44
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	42
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner	42
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication	41
Adenosine signaling activates ATP-sensitive K ⁺ channels in endothelial cells and pericytes in CNS capillaries	40
Select hyperactivating NLRP3 ligands enhance the T _H 1- and T _H 17-inducing potential of human type 2 conventional dendritic cells	40
A novel TNFR2 agonist antibody expands highly potent regulatory T cells	39
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	37
Activation of PPARα enhances astroglial uptake and degradation of β-amyloid	37
NF-κB responds to absolute differences in cytokine concentrations	37
A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets	36