OOIR: Observatory of International Research

Papers

(The TQCC of Cold Spring Harbor Perspectives in Biology is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	123
Post-Translational Regulation of HMG CoA Reductase	93
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	89
Angiogenesis in Wound Repair: Too Much of a Good Thing?	88
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	88
Fisher's Geometric Model as a Tool to Study Speciation	88
Fibroblast Heterogeneity in Healthy and Wounded Skin	88
The Role of Membrane Lipids in the Formation and Function of Caveolae	80
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	71
Telomere Dynamics in Human Health and Disease	67
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	64
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	59
Petabase-Scale Homology Search for Structure Prediction	55
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	51
A History of Cancer Research: Retroviral Insertional Mutagenesis	51
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	49
Diversity of Fibroblasts and Their Roles in Wound Healing	47
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	42
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	41
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	38
Mapping the Retina onto the Brain	38
Blastocrithidia—A Genetic Alien from the Planet Earth	38
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	37
Interneuron Diversity: How Form Becomes Function	36
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	35

The Nuclear Lamina	34
The Biology of Lipids	34
Building and Maintaining the Skin	32
Neotropics as a Cradle for Adaptive Radiations	30
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	30
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	30
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration	30
Machine Learning for Protein Science and Engineering	29
Variability in Neural Circuit Formation	28
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	27
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	27
A History of Cancer Research: Oncogenic Transcription Factors	27
Regulators of Oligodendrocyte Differentiation	27
Glial Cell Development and Function in the Zebrafish Central Nervous System	27
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook	26
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	26
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	24
Essential Roles for RNA in Shaping Nuclear Organization	24
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	23
Quantitative Analyses of Coupling in Hybrid Zones	22
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture	22
Lipid Metabolism	22
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	22
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	21
The Diverse Manifestations of Regeneration and Why We Need to Study Them	21
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions	21
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	21
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	21
Caspases and Their Substrates	20
Developmental Control of Cell Cycle and Signaling	20
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	20
Glia at Transition Zones	19
Pancreatic β-Cell Development and Regeneration	19
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	19
Development of Prefrontal Circuits and Cognitive Abilities	19
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	19
Lipid Sorting and Organelle Identity	18
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	17
Remyelination in the Central Nervous System	17
The Sensory Ecology of Speciation	17
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	17