OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	187
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	139
Fisher's Geometric Model as a Tool to Study Speciation	110
Leukocyte Chemotaxis and the Elusive Negative Signals that Make It Work	95
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	84
Fibroblast Heterogeneity in Healthy and Wounded Skin	75
Post-Translational Regulation of HMG CoA Reductase	68
The Role of Membrane Lipids in the Formation and Function of Caveolae	67
Angiogenesis in Wound Repair: Too Much of a Good Thing?	66
A History of Cancer Research: Retroviral Insertional Mutagenesis	64
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	64
Telomere Dynamics in Human Health and Disease	62
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	61
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	61
A Mechanometabolism Toolbox for Studying Cell Migration	58
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	57
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	54
Petabase-Scale Homology Search for Structure Prediction	54
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	52
Diversity of Fibroblasts and Their Roles in Wound Healing	52
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	50
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	49
Mapping the Retina onto the Brain	48
Blastocrithidia —A Genetic Alien from the Planet Earth	48
Roles and Regulation of the Hippo Signaling Pathway in Mammalian Preimplantation Development	47

Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	40
Interneuron Diversity: How Form Becomes Function	39
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	39
The Biology of Lipids	38
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	38
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	36
Neotropics as a Cradle for Adaptive Radiations	36
Machine Learning for Protein Science and Engineering	35
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca²⁺- and Membrane-Binding Proteins	35
Variability in Neural Circuit Formation	32
Regulators of Oligodendrocyte Differentiation	31
Chromosome Ends in Motion: Telomeres as Hazards and Hubs in Meiosis	31
A History of Cancer Research: Oncogenic Transcription Factors	31
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	31
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	30
Growth Factor and Cytokine Delivery Systems for Wound Healing	30
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	30
Glial Cell Development and Function in the Zebrafish Central Nervous System	30
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications	29
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	29
Quantitative Analyses of Coupling in Hybrid Zones	29
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	29
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	28
Genetically Encoded Ca ²⁺ Sensors	28
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	27
Calcium Signaling and Pathogenesis of Neurodegenerative Disorders: Potential Therapeutic Opportunities	27
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	26
Developmental Control of Cell Cycle and Signaling	25
Telomeres and Telomerase	25
Calcium Signaling in Migrating Neutrophils	24
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	23
Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments	23
Mechanobiology of the Hippo–YAP Signaling Network	22
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	21
Glia at Transition Zones	21
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	21
Ca²⁺ Fluxes across Membrane Contact Sites	21
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	20
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	20
The Sensory Ecology of Speciation	19
Development of Prefrontal Circuits and Cognitive Abilities	19
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	18
Remyelination in the Central Nervous System	18
Glia Development and Function in the NematodeCaenorhabditis elegans	17
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	17
Lipid Sorting and Organelle Identity	17
The Unusual Effectiveness of Evolution in Systems Neuroscience	16
Artificial Intelligence Learns Protein Prediction	16
Structural Biology of Telomerase and Associated Factors	16
The Wound Microbiome	16

Role of Microglia in Central Nervous System Development and Plasticity	15
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	15
Neutrophil Migration: Using All the Tricks of Mesenchymal and Amoeboid Cells to Navigate Many Environments	15
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	15
Physical Forces in Regeneration of Cells and Tissues	15
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	15
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	15
Anthropogenic Change and the Process of Speciation	14
Caspase Activation and Inhibition	14
Mechanisms of Alternative Lengthening of Telomeres	14
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	14
Endocytic Roles of Glycans on Proteins and Lipids	14
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	14
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	14
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	14
Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe	13
Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions	13
Leading the Way: Molecular Drivers of Single-Cell Migration	13
Traveling in a Pack: The Border Cells’ Collective Journey Guided by Landscapes and Chemical Cues	13
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	12
The Mechanics of Building Functional Organs	12
Intracellular Cholesterol Trafficking	12
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	11
The Role of Hybridization in Species Formation and Persistence	11
Bioinspired Strategies for Wound Regeneration	11
Core Components of the Hippo Pathway	11
Telomere Crisis Shapes Cancer Evolution	11
Recent Developments in (Archaeal) Pyrrolysine and Selenocysteine Specification and Metabolism	11
Mendel's Pea Genes	10
Building, Breaking, and Repairing Neuromuscular Synapses	10
Schwann Cell Development and Myelination	10
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Cellular Senescence in Acute and Chronic Wound Repair	9
Forces Shaping the Blastocyst	9
Modeling and Simulating Single and Collective Cell Motility	9
Inflammasomes and Other Caspase-Activation Platforms	9
Agritech to Tame the Nitrogen Cycle	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Phosphoinositides in New Spaces	8
Autophagy in Skeletal Muscle	8
Epigenetics of Human Telomeres	8
Many Cells Make Light Work: Self-Generated Gradients Organize Dictyostelium Aggregates and Neutrophil Swarms	8
Glial Malignancies	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	8
Building Representation Learning Models for Antibody Comprehension	8
Control of Inositol 1,4,5-Trisphosphate Receptor Activity by Posttranslational Modifications	8
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	8
Astrocyte Calcium Signaling	8
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
The Contribution of Innervation to Tissue Repair and Regeneration	7
Endothelial CRAC Channels	7
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	7
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	7
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	7
The Burial: Clearance and Consequences	6
Plant Breeding and the Origins of Genetics	6
Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?	6
The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases	6
Guiding Cell Migration with Electric Fields: Mechanisms and Applications of Galvanotaxis	6
Mitochondrial Calcium Signaling in Hepatocyte Health and Disease	6
Telomerase in Cancer Therapeutics	6
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
Modulation of Inositol 1,4,5-Trisphosphate Receptors by Their Primary Physiological Ligands, IP ₃ , Ca ²⁺	6
Collective Mesoderm and Endoderm Cell Migration during Vertebrate Gastrulation	6
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	6
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	6
Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration	6
How Does Selfing Affect the Pace and Process of Speciation?	6