OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	192
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	143
Fisher's Geometric Model as a Tool to Study Speciation	113
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	88
Leukocyte Chemotaxis and the Elusive Negative Signals that Make It Work	76
Post-Translational Regulation of HMG CoA Reductase	73
Fibroblast Heterogeneity in Healthy and Wounded Skin	69
Angiogenesis in Wound Repair: Too Much of a Good Thing?	69
The Role of Membrane Lipids in the Formation and Function of Caveolae	69
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	67
Telomere Dynamics in Human Health and Disease	63
A History of Cancer Research: Retroviral Insertional Mutagenesis	63
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	62
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	61
Petabase-Scale Homology Search for Structure Prediction	60
A Mechanometabolism Toolbox for Studying Cell Migration	57
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	57
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	53
Diversity of Fibroblasts and Their Roles in Wound Healing	53
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	51
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	51
Mapping the Retina onto the Brain	51
Roles and Regulation of the Hippo Signaling Pathway in Mammalian Preimplantation Development	49
Blastocrithidia —A Genetic Alien from the Planet Earth	48
Interneuron Diversity: How Form Becomes Function	42

Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	42
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	42
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	40
Neotropics as a Cradle for Adaptive Radiations	39
The Biology of Lipids	39
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	38
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	36
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca²⁺- and Membrane-Binding Proteins	35
Machine Learning for Protein Science and Engineering	34
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	33
Variability in Neural Circuit Formation	33
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	32
Glial Cell Development and Function in the Zebrafish Central Nervous System	32
Chromosome Ends in Motion: Telomeres as Hazards and Hubs in Meiosis	32
A History of Cancer Research: Oncogenic Transcription Factors	31
Regulators of Oligodendrocyte Differentiation	31
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	31
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	30
Structural Studies of Core Hippo Pathway Components	30
Growth Factor and Cytokine Delivery Systems for Wound Healing	30
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	29
Calcium Signaling and Pathogenesis of Neurodegenerative Disorders: Potential Therapeutic Opportunities	29
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications	29
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	29
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	28
Genetically Encoded Ca ²⁺ Sensors	27
Quantitative Analyses of Coupling in Hybrid Zones	26
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	26
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	25
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	25
Telomeres and Telomerase	25
Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments	24
Developmental Control of Cell Cycle and Signaling	23
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	22
Mechanobiology of the Hippo–YAP Signaling Network	22
Calcium Signaling in Migrating Neutrophils	22
Glia at Transition Zones	21
Ca²⁺ Fluxes across Membrane Contact Sites	21
Lipid Sorting and Organelle Identity	19
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	19
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	19
Remyelination in the Central Nervous System	18
The Sensory Ecology of Speciation	18
Development of Prefrontal Circuits and Cognitive Abilities	18
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	17
Glia Development and Function in the NematodeCaenorhabditis elegans	17
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	16
The Unusual Effectiveness of Evolution in Systems Neuroscience	16
Neutrophil Migration: Using All the Tricks of Mesenchymal and Amoeboid Cells to Navigate Many Environments	16
Structural Biology of Telomerase and Associated Factors	16

Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	16
The Wound Microbiome	16
Artificial Intelligence Learns Protein Prediction	16
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	15
Physical Forces in Regeneration of Cells and Tissues	15
Role of Microglia in Central Nervous System Development and Plasticity	15
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	15
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	15
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	15
Anthropogenic Change and the Process of Speciation	15
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	14
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	14
Caspase Activation and Inhibition	14
Mechanisms of Alternative Lengthening of Telomeres	14
Endocytic Roles of Glycans on Proteins and Lipids	14
Leading the Way: Molecular Drivers of Single-Cell Migration	13
Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions	13
Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe	13
Traveling in a Pack: The Border Cells’ Collective Journey Guided by Landscapes and Chemical Cues	13
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	13
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	13
Bioinspired Strategies for Wound Regeneration	12
The Mechanics of Building Functional Organs	12
Building, Breaking, and Repairing Neuromuscular Synapses	11
Intracellular Cholesterol Trafficking	11
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	11
Inflammasomes and Other Caspase-Activation Platforms	11
Telomere Crisis Shapes Cancer Evolution	11
Core Components of the Hippo Pathway	10
Mendel's Pea Genes	10
Recent Developments in (Archaeal) Pyrrolysine and Selenocysteine Specification and Metabolism	10
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Schwann Cell Development and Myelination	9
Cellular Senescence in Acute and Chronic Wound Repair	9
Forces Shaping the Blastocyst	9
Modeling and Simulating Single and Collective Cell Motility	9
The Role of Hybridization in Species Formation and Persistence	9
Astrocyte Calcium Signaling	9
Agritech to Tame the Nitrogen Cycle	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Phosphoinositides in New Spaces	8
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	8
Many Cells Make Light Work: Self-Generated Gradients Organize Dictyostelium Aggregates and Neutrophil Swarms	8
Glial Malignancies	8
Building Representation Learning Models for Antibody Comprehension	8
Epigenetics of Human Telomeres	8
Autophagy in Skeletal Muscle	8
Mitochondrial Calcium Signaling in Hepatocyte Health and Disease	7
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	7
Endothelial CRAC Channels	7
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	7
The Contribution of Innervation to Tissue Repair and Regeneration	7
Control of Inositol 1,4,5-Trisphosphate Receptor Activity by Posttranslational Modifications	7
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	7
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	7
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	6
Telomerase in Cancer Therapeutics	6
The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases	6
Modulation of Inositol 1,4,5-Trisphosphate Receptors by Their Primary Physiological Ligands, IP ₃ , Ca ²⁺	6
Collective Mesoderm and Endoderm Cell Migration during Vertebrate Gastrulation	6
How Does Selfing Affect the Pace and Process of Speciation?	6
Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration	6
Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?	6
The Burial: Clearance and Consequences	6
Plant Breeding and the Origins of Genetics	6
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
Guiding Cell Migration with Electric Fields: Mechanisms and Applications of Galvanotaxis	6