OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	206
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	105
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	103
The Role of Membrane Lipids in the Formation and Function of Caveolae	85
Fisher's Geometric Model as a Tool to Study Speciation	81
Fibroblast Heterogeneity in Healthy and Wounded Skin	79
Nucleotide Metabolism	78
Post-Translational Regulation of HMG CoA Reductase	76
Angiogenesis in Wound Repair: Too Much of a Good Thing?	74
A History of Cancer Research: Retroviral Insertional Mutagenesis	73
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	68
Petabase-Scale Homology Search for Structure Prediction	65
Telomere Dynamics in Human Health and Disease	64
The Impact of Space and Time on the Functional Output of the Genome	62
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	58
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	58
Diversity of Fibroblasts and Their Roles in Wound Healing	56
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	50
Mapping the Retina onto the Brain	49
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	49
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	45
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	43
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	42
Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism	41
Interneuron Diversity: How Form Becomes Function	41

The Biology of Lipids	41
3D or Not 3D: Shaping the Genome during Development	37
The Nuclear Lamina	37
Building and Maintaining the Skin	37
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	37
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	34
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	34
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration	33
Neotropics as a Cradle for Adaptive Radiations	33
A History of Cancer Research: Oncogenic Transcription Factors	31
Auxin in Root Development	31
Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome	31
Glial Cell Development and Function in the Zebrafish Central Nervous System	29
Variability in Neural Circuit Formation	28
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	27
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	27
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	27
Regulators of Oligodendrocyte Differentiation	26
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook	26
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Essential Roles for RNA in Shaping Nuclear Organization	25
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	25
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	25
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	24
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	22
Quantitative Analyses of Coupling in Hybrid Zones	21
Polyploidy in Tissue Repair and Regeneration	21
Lipid Metabolism	21
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions	21
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	21
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture	21
Developmental Control of Cell Cycle and Signaling	20
The Diverse Manifestations of Regeneration and Why We Need to Study Them	20
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory	19
Caspases and Their Substrates	19
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	19
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	18
All for One and One for All: Regenerating Skeletal Muscle	18
Motility Matters: How CD8⁺ T-Cell Trafficking Influences Effector and Memory Cell Differentiation	18
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	18
Glia Development and Function in the NematodeCaenorhabditis elegans	18
Glia at Transition Zones	18
Development of Prefrontal Circuits and Cognitive Abilities	18
Pancreatic β-Cell Development and Regeneration	17
Remyelination in the Central Nervous System	17
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	17
The Sensory Ecology of Speciation	17
Innate Mechanisms of Heart Regeneration	16
Lipid Sorting and Organelle Identity	16
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	15

The Wound Microbiome	15
Artificial Intelligence Learns Protein Prediction	15
Structural Biology of Telomerase and Associated Factors	15
Genetic and Cellular Contributions to Liver Regeneration	14
Physical Forces in Regeneration of Cells and Tissues	14
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	14
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	14
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	14
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation	14
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	14
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	13
Mechanisms of Alternative Lengthening of Telomeres	13
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	13
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	13
Anthropogenic Change and the Process of Speciation	13
Role of Microglia in Central Nervous System Development and Plasticity	13
Imaginal Disc Regeneration: Something Old, Something New	13
Caspase Activation and Inhibition	12
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	12
Shedding Light on Telomere Replication, Insights from the Fission YeastSchizosaccharomyces pombe	12
Endocytic Roles of Glycans on Proteins and Lipids	12
Auxin Transporters—A Biochemical View	12
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration	11
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	11
Bioinspired Strategies for Wound Regeneration	11
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
Insect Gut Regeneration	11
Sex Differences in Circadian Rhythms	11
Basics of Metabolic Reactions	11
The Mechanics of Building Functional Organs	11
Intracellular Cholesterol Trafficking	11
Lung Regeneration: Cells, Models, and Mechanisms	10
Forces Shaping the Blastocyst	10
Building, Breaking, and Repairing Neuromuscular Synapses	10
Schwann Cell Development and Myelination	10
Modeling and Simulating Single and Collective Cell Motility	10
Epigenetics of Human Telomeres	10
The Role of Hybridization in Species Formation and Persistence	10
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	10
Agritech to Tame the Nitrogen Cycle	10
Chromatin Mechanisms Driving Cancer	10
Inflammasomes and Other Caspase-Activation Platforms	10
Cellular Senescence in Acute and Chronic Wound Repair	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Astrocyte Calcium Signaling	9
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	9
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	9
Building Representation Learning Models for Antibody Comprehension	8
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	8
Autophagy in Skeletal Muscle	8
Glial Malignancies	8
Evidence for Perinatal Steroid Influence on Human Sexual Orientation and Gendered Behavior	8
Quantifying Sex Differences in Behavior in the Era of “Big” Data	8
Phosphoinositides in New Spaces	8
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	7
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	7
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	7
The Contribution of Innervation to Tissue Repair and Regeneration	7
Plant Breeding and the Origins of Genetics	7
NADPH—The Forgotten Reducing Equivalent	7