Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	355
Early-career researchers in the time of COVID-19: Adapting to uncertainty	261
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	235
Brain organoids restore cortical damage	230
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	217
Cut out that YAPping: Mechanisms to reduce scar formation	217
Regrowing the heart, one TREE at a time	215
Prolonged 3D culture unlocks black box of primate embryogenesis	201
Successful organoid-mediated generation of iPSC-derived CAR-T cells	187
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	171
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	170
Oscillation steers differentiation	165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	156
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	155
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	151
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	149
Exploring the human lacrimal gland using organoids and single-cell sequencing	146
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	145
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	143
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	143
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	136
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	136
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	134
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	134
Tissue morphology influences the temporal program of human brain organoid development	129

Human biliary epithelial cells for regenerative medicine	128
Refined transcriptional blueprint of human preimplantation embryos	121
Paul S. Frenette (1965–2021)	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	119
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	117
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	116
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	116
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	115
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	113
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	111
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	109
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	109
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	108
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	106
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	106
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	105
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	105
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	103
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	103
Perceiving the brain like never before	102
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	102
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	102
Naive stem cell blastocyst model captures human embryo lineage segregation	102
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	101
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	101
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	101
Progress in multicellular human cardiac organoids for clinical applications	101
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	100
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	100
Human-monkey chimeras: Monkey see, monkey do	99
Enchanted by the earliest stages of human life	99
Early human development and stem cell-based human embryo models	98
Healing takes nerve	97
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	97
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	96
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	95
An oncogenic enhancer encodes selective selenium dependency in AML	95
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	95
Stem cells and origins of cancer in the upper gastrointestinal tract	94
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	92
Organ function is preserved despite reorganization of niche architecture in the hair follicle	91
Rebuilding and rebooting immunity with stem cells	89
Stem cell models help crack regional oncohistone codes driving childhood gliomas	88
Video, ergo sum: The search for response to natural light	87
Human Down syndrome microglia are up for a synaptic feast	86
Mini kidney organoids deliver maximal drug screening impact	85
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	83
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	83
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	82
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	80

Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	79
Planarian stem cells specify fate yet retain potency during the cell cycle	77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	77
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	76
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	75
Epigenetic regulation of early human embryo development	75
A reference human induced pluripotent stem cell line for large-scale collaborative studies	74
Advancing cell therapy for neurodegenerative diseases	74
Human naive epiblast cells possess unrestricted lineage potential	73
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	72
A human pluripotent stem cell-based somitogenesis model using microfluidics	72
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	71
Maturation for regeneration	70
iPSC model of congenital heart disease predicts disease outcome	70
Human hematopoietic stem cells expand beyond cytokines	69
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	68
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	67
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	67
The clones have STRACK: Tracing responses to leukemic mutations	67
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	67
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	65
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	65
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	65
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	65
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	65
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	64
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	63
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	63
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	63
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	62
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing	62
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	61
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	61
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	60
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	59
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	59
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	59
Rewinding cells to reverse disease	58
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	58
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	57
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	57
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	57
Chemical reprogramming takes the fast lane	57
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	56
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	56
New evidence for adult beta cell neogenesis	56
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	56
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	55
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	55
Capybara: A computational tool to measure cell identity and fate transitions	55
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	55
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	55
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	55
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	55
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	54
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	54
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	54
Patient-derived micro-organospheres enable clinical precision oncology	53
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	53
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	53
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	53
Can’t touch this: Stromal-mediated ductal proliferation	53
Human blastoids 3.0	52
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	52
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	52
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	51
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	51
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	51
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	51
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	50
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	50
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	49
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	48
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	48
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	46
Acetate to the rescue: Acetyl-CoA facilitates placental development	46
Lung repair and regeneration: Advanced models and insights into human disease	46
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	46
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	45

PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	45
Human brain organoids assemble functionally integrated bilateral optic vesicles	45
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	45
MDS/AML with del5q: An acquired “laminopathy”?	45
Hallmarks of stemness in mammalian tissues	44
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	44
The eyeball’s connected to the brain ball	44
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	44
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	44
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	43
Generation of human alveolar epithelial type I cells from pluripotent stem cells	43
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	43
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	43
Mapping of clonal lineages across developmental stages in human neural differentiation	42
Hair follicle stem cells feel the pressure	42
Anniversary reflections: Inspiring discoveries and the future of the field	42
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	42
Setting the stage for embryo segmentation	42