Cell Stem Cell

Article	Citations
Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges	603
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids	516
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids	374
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease	331
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration	307
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium	292
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction	274
Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation	264
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response	250
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future	228
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia	216
Human naive epiblast cells possess unrestricted lineage potential	194
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2	190
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis	181
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer	174
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity	173
Capturing Cardiogenesis in Gastruloids	164
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling	163
Capturing human trophoblast development with naive pluripotent stem cells in vitro	162
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	159
Naive stem cell blastocyst model captures human embryo lineage segregation	159
Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate	154
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response	152
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair	148
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes	147

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids	144
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men	140
Tissue Stem Cells: Architects of Their Niches	138
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis	136
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency	136
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids	132
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank	132
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells	129
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance	128
Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids	127
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms	125
Wound healing, fibroblast heterogeneity, and fibrosis	121
Aging and Rejuvenation of Neural Stem Cells and Their Niches	119
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	117
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells	116
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma	116
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	115
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01	114
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes	111
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer	110
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing	110
Smooth Muscle Cell Reprogramming in Aortic Aneurysms	109
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription	109
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification	108
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification	108
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors	108
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury	105
Establishment, maintenance, and recall of inflammatory memory	104
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment	103
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	103
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids	101
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use	101
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate	100
Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder	99
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq	95
Mapping Development of the Human Intestinal Niche at Single-Cell Resolution	92
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids	91
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding	89
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging	89
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome	89
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer	87
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis	87
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury	86
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function	85
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells	85
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells	83
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse	83
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo	83
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function	82
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration	81

Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling	81
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy	81
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging	80
Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium	80
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	79
A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury	78
Decoding Human Megakaryocyte Development	77
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging	76
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	76
Hydrogel Network Dynamics Regulate Vascular Morphogenesis	75
Multipotent stromal cells: One name, multiple identities	75
Human brain organoids assemble functionally integrated bilateral optic vesicles	75
Early stem cell aging in the mature brain	75
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	74
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit	74
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation	74
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells	74
Tracing the skeletal progenitor transition during postnatal bone formation	73
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation	72
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids	72
Epithelial Plasticity during Liver Injury and Regeneration	72
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders	71
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease	71
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response	70
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk	70
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	69
Human embryonic genome activation initiates at the one-cell stage	68
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	68
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	68
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions	67
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors	66
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis	66
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	66
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly	66
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	66
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome	64
Reciprocal regulation of mesenchymal stem cells and immune responses	64
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity	64
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens	64
The spatiotemporal program of zonal liver regeneration following acute injury	62
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling	62
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing	62
8C-like cells capture the human zygotic genome activation program in vitro	62
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes	61
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits	61
A reference human induced pluripotent stem cell line for large-scale collaborative studies	60
Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells	59
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	59
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	58
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity	58
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	58
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes	57
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells	57
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease	57
Exploring the human lacrimal gland using organoids and single-cell sequencing	55
Patient-derived micro-organospheres enable clinical precision oncology	55
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	55
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells	54
Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues	54
Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer	54
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development	53
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer	53
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	52
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	52
Amniogenesis occurs in two independent waves in primates	51
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth	51
ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence	51
Enteric glial cell heterogeneity regulates intestinal stem cell niches	50
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia	50
Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts	50
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization	49
Planarian stem cells specify fate yet retain potency during the cell cycle	48
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models	48
GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells	48
Circadian Regulation of Adult Stem Cell Homeostasis and Aging	48
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy	48
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging	48
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche	47
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	47
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium	47

The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis	47
Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function	46
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	45
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	45
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease	45
Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer	45
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation	45
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas	44
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow	44
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	44
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex	44
Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis	44
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	44
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	43
BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors	43
Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis	43
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease	43
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	42
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	41
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	41
Stem cells and origins of cancer in the upper gastrointestinal tract	41
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration	40
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	40
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development	40
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs	40
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal	39
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling	39
Progress in multicellular human cardiac organoids for clinical applications	39
Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension	38
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity	38
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation	38
Preying on Public Fears and Anxieties in a Pandemic: Businesses Selling Unproven and Unlicensed “Stem Cell Treatments” for COVID-19	38
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis	38
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation	38
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	38