Cell Stem Cell

Article	Citations
Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges	677
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids	521
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids	393
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration	335
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium	308
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction	289
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response	260
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia	227
Human naive epiblast cells possess unrestricted lineage potential	213
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2	196
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis	194
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity	179
Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate	178
Capturing human trophoblast development with naive pluripotent stem cells in vitro	177
Capturing Cardiogenesis in Gastruloids	175
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling	175
Naive stem cell blastocyst model captures human embryo lineage segregation	175
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes	169
Wound healing, fibroblast heterogeneity, and fibrosis	169
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response	161
Tissue Stem Cells: Architects of Their Niches	155
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids	155
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids	148
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance	147
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis	146

Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency	146
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men	144
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells	137
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms	133
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	133
Aging and Rejuvenation of Neural Stem Cells and Their Niches	131
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells	125
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	124
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes	122
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01	122
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification	122
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer	121
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing	121
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment	119
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification	117
Establishment, maintenance, and recall of inflammatory memory	116
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury	113
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate	112
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids	112
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	112
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use	110
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq	108
Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder	105
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging	103
Mapping Development of the Human Intestinal Niche at Single-Cell Resolution	100
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer	99
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids	99
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury	97
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding	97
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome	96
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis	95
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells	93
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo	93
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells	93
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function	92
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration	92
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function	92
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse	92
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	89
Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling	89
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging	89
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation	87
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy	87
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	87
Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium	85
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging	85
Human brain organoids assemble functionally integrated bilateral optic vesicles	84
Tracing the skeletal progenitor transition during postnatal bone formation	84
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	84
Decoding Human Megakaryocyte Development	84

Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells	83
A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury	83
Hydrogel Network Dynamics Regulate Vascular Morphogenesis	82
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity	81
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation	81
Reciprocal regulation of mesenchymal stem cells and immune responses	80
Early stem cell aging in the mature brain	80
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	80
Multipotent stromal cells: One name, multiple identities	80
The spatiotemporal program of zonal liver regeneration following acute injury	80
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders	80
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids	79
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	79
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease	78
8C-like cells capture the human zygotic genome activation program in vitro	78
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly	77
Epithelial Plasticity during Liver Injury and Regeneration	76
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors	75
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	75
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	75
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions	74
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome	74
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes	73
Human embryonic genome activation initiates at the one-cell stage	73
A reference human induced pluripotent stem cell line for large-scale collaborative studies	72
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	72
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk	72
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens	72
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis	72
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response	71
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing	71
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling	70
Patient-derived micro-organospheres enable clinical precision oncology	66
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	66
Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues	65
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits	65
Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells	65
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	64
Enteric glial cell heterogeneity regulates intestinal stem cell niches	63
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	63
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells	62
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes	62
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity	61
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy	60
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	59
Exploring the human lacrimal gland using organoids and single-cell sequencing	59
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	59
ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence	57
Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer	57
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation	57
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	57
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	57
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	56
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease	56
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	55
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia	55
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	54
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization	54
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth	54
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow	54
Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts	54
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models	53
Amniogenesis occurs in two independent waves in primates	53
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development	53
Planarian stem cells specify fate yet retain potency during the cell cycle	52
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas	52
Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function	51
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche	51
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease	51
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	51
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium	50
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	50
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal	50
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	49
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation	49
Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis	49
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging	49
BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors	49
Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer	48
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	48

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex	48
Stem cells and origins of cancer in the upper gastrointestinal tract	47
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	47
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	47
Progress in multicellular human cardiac organoids for clinical applications	47
The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis	47
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	46
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration	46
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	46
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes	45
EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity	45
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development	44
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling	43
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	43
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation	42
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	42
Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load	42
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation	42
RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy	41
Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease	41
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	41
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation	41
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration	41
Structural and functional integration of human forebrain organoids with the injured adult rat visual system	41
Clonal hematopoiesis: Mutation-specific adaptation to environmental change	41
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs	41
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	41