Cell Stem Cell

Article	Citations
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	553
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	273
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	220
Regrowing the heart, one TREE at a time	216
Successful organoid-mediated generation of iPSC-derived CAR-T cells	211
Brain organoids restore cortical damage	210
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	200
Prolonged 3D culture unlocks black box of primate embryogenesis	182
Oscillation steers differentiation	177
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	173
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	168
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	168
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	155
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	153
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	144
Cut out that YAPping: Mechanisms to reduce scar formation	143
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	143
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	143
Tissue morphology influences the temporal program of human brain organoid development	139
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	139
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	135
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	132
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	129
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	129
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	129

Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	128
IRF6 hits the sweet spot	128
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	127
Human biliary epithelial cells for regenerative medicine	127
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	127
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	123
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	121
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	121
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	117
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	114
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	114
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	113
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	112
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	111
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	108
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	105
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	105
Perceiving the brain like never before	104
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	104
Enchanted by the earliest stages of human life	103
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	98
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	96
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	93
An oncogenic enhancer encodes selective selenium dependency in AML	93
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	93
Progress in multicellular human cardiac organoids for clinical applications	91
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	90
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	90
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	90
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	89
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	88
Early human development and stem cell-based human embryo models	88
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	86
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	85
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	85
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	85
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	82
A human pluripotent stem cell-based somitogenesis model using microfluidics	82
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	80
Rebuilding and rebooting immunity with stem cells	80
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	80
Human Down syndrome microglia are up for a synaptic feast	79
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	79
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	78
Mini kidney organoids deliver maximal drug screening impact	78
Video, ergo sum: The search for response to natural light	78
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	77
A reference human induced pluripotent stem cell line for large-scale collaborative studies	77
Organ function is preserved despite reorganization of niche architecture in the hair follicle	77
Advancing cell therapy for neurodegenerative diseases	76

Epigenetic regulation of early human embryo development	76
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	76
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	74
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	74
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	74
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	74
iPSC model of congenital heart disease predicts disease outcome	74
Human hematopoietic stem cells expand beyond cytokines	74
The clones have STRACK: Tracing responses to leukemic mutations	73
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	72
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	72
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial	72
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	71
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	71
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	70
Vitamin C conveys geroprotection on primate ovaries	70
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	70
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	70
Face off: Stem cell therapy versus the immune system	69
Space-associated stem cell hallmarks of aging and resilience in astronauts	69
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	69
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	68
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	68
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	68
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	68
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	67
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	67
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	66
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	66
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	66
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	65
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	65
Chemical reprogramming takes the fast lane	64
Rewinding cells to reverse disease	63
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	63
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	62
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	61
Hallmarks of stem cell aging	61
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	61
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	61
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	61
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	60
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	60
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	59
Capybara: A computational tool to measure cell identity and fate transitions	59
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	58
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	57
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	57
Patient-derived micro-organospheres enable clinical precision oncology	55
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	55
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	55
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	55
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	55
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	54
Beyond transplantation: Gene-edited pig liver supports function in a human host	54
Human blastoids 3.0	53
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	53
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	53
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	53
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	53
Unmasking cancer’s hidden nerve route with patient-derived organoids	52
Raising the bar for human post-implantation embryo models	52
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	51
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	51
Lung repair and regeneration: Advanced models and insights into human disease	51
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	51
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	51
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	50
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	50
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	50
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	50
Acetate to the rescue: Acetyl-CoA facilitates placental development	50
MDS/AML with del5q: An acquired “laminopathy”?	49
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages	49
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	49
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	49
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	48
Generation of human alveolar epithelial type I cells from pluripotent stem cells	48

The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	48
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	47
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	47
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	47
Mapping of clonal lineages across developmental stages in human neural differentiation	47
Hallmarks of stemness in mammalian tissues	47
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	47
Setting the stage for embryo segmentation	46
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	46
Anniversary reflections: Inspiring discoveries and the future of the field	46
Hair follicle stem cells feel the pressure	45
Effective regulatory responses to predatory stem cell markets in Australia and Canada	45
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	45
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling	45
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	45
From stem cells to regulatory T cells: A tale of plasticity	45