Cell Stem Cell

Article	Citations
Releasing the brake on protein synthesis in hematopoietic stem cells	265
Know thy neighbor: Modeling spatiotemporal cell-fate patterns in a neural stem cell niche	234
Human blastoids 3.0	216
Can’t touch this: Stromal-mediated ductal proliferation	216
Early-career researchers in the time of COVID-19: Adapting to uncertainty	196
Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism	195
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	195
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	189
Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation	186
Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals	175
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	173
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	169
Advances and challenges toward developing kidney organoids for clinical applications	169
New dog, old tricks: Developmental programs resurface in inflammation	164
Introductions to the community: Early-career researchers in the time of COVID-19	150
Cultivating mentorship, cooperation, and community during COVID-19 and beyond	148
Taking Heart Development to the Next Level	147
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	146
Successful organoid-mediated generation of iPSC-derived CAR-T cells	140
Uncovering the origins and lineage markers of human heart fields	139
Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets	132
Oscillation steers differentiation	129
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	128
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease	122
Regulation of advanced therapies in Europe: Are we on the right track?	122

Human 8-cell-like cells discovered	120
New guidelines for stem cell and embryo research from the ISSCR	119
Having a blast(oid): Modeling human embryo peri-implantation development with blastoids	118
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	117
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery	114
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	113
Lymphatic endothelia stakeout cryptic stem cells	109
New York Stem Cell Foundation Robertson Investigators	108
Unlocking the secrets of cancer stem cells: Immune checkpoint inhibitors face their formidable foes	107
Addressing challenges for repairing adult spinal cord with insights from neonates	106
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation	106
Genetic and non-genetic mechanisms of inflammation may promote transformation in leukemia	105
A deep learning platform to assess drug proarrhythmia risk	104
Membrane Tension Locks In Pluripotency	104
Acetate to the rescue: Acetyl-CoA facilitates placental development	101
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	100
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	99
Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development	98
Cut out that YAPping: Mechanisms to reduce scar formation	97
Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment	95
Regrowing the heart, one TREE at a time	94
Development, maturation, and maintenance of human prostate inferred from somatic mutations	94
The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions	94
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	93
Pervasive donor DNA integration defies precision gene editing of hematopoietic stem cells	93
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	92
Brain organoids restore cortical damage	91
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	91
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	90
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function	90
CAR macrophages tuning the immune symphony of anti-cancer therapies	90
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity	89
A mechanical niche promotes the rejuvenation of blood stem cells	89
Multipotent stromal cells: One name, multiple identities	87
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells	86
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	86
Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy	86
New monkey embryo models—it’s getting complicated	85
Prolonged 3D culture unlocks black box of primate embryogenesis	85
New readers and writers of RNA modifications unique to leukemia stem cells	85
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors	83
Hematopoietic Stem Cell-Targeted Gene-Addition and Gene-Editing Strategies for β-hemoglobinopathies	82
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation	82
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	82
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	82
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	81
A one-way street recognition approach to mediate allogeneic immune cell therapies	79
Mini-colons predict drug toxicity in vitro	78
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	78
Bioengineered human colon organoids with in vivo-like cellular complexity and function	78

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells	78
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models	77
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	77
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	76
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption	76
Tissue morphology influences the temporal program of human brain organoid development	76
Lung repair and regeneration: Advanced models and insights into human disease	74
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	73
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	71
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation	71
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	70
Glioblastoma stem cell HISTArionics	70
A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1	67
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	65
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow	65
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	64
An iron rheostat controls hematopoietic stem cell fate	64
Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids	64
Forward steps in organoid-based forward screening	63
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	63
Amniogenesis occurs in two independent waves in primates	62
An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells	61
Generating high-fidelity cochlear organoids from human pluripotent stem cells	61
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	61
Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia	60
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	60
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	60
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	60
Cell competition and the regulative nature of early mammalian development	59
Exploring the human lacrimal gland using organoids and single-cell sequencing	59
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	58
Early stem cell aging in the mature brain	58
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease	57
Multimodal characterization of murine gastruloid development	57
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes	56
Inflation comes before the fall: How epithelial stretch drives crypt fission	56
Human brain organoids assemble functionally integrated bilateral optic vesicles	55
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing	55
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	55
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease	55
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response	54
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms	53
Capturing Cardiogenesis in Gastruloids	53
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury	52
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01	52
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk	51
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	50
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	50
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion	50
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	50
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	50
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion	50
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea	49
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	48
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	48
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	47
Apart and back again: Reestablished neuronal connections restore walking after paralysis	47
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	47
Hallmarks of stemness in mammalian tissues	46
Seizing hope: Advancing cell therapy for pharmaco-resistant epilepsy toward the clinic	46
Functional renal collecting ducts from human PSCs	46
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	46
Dawn of development: Exploring early human embryogenesis using stem cells	46
The next generation of endothelial differentiation: Tissue-specific ECs	46
The eyeball’s connected to the brain ball	45
MDS/AML with del5q: An acquired “laminopathy”?	45
Taking the guesswork out of journal submission with Community Review	45
Modeling Stem Cell Fates using Non-Markov Processes	44
Androgens increase excitement in brain organoid research	44
Human biliary epithelial cells for regenerative medicine	44
Seeing is believing: Representation as a powerful tool in the fight against racism in science	44
c-Maf: The magic wand that turns on LSEC fate	44
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids	43
A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis	43
Stem cell-derived β cells go in monkeys	43
Bioenergetics matter to metabolic health—from a fat progenitor view	43
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use	42
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation	42
Refined transcriptional blueprint of human preimplantation embryos	41
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	41

Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	41
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis	41
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	40
Paul S. Frenette (1965–2021)	40
IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy	40
Multicellular dynamics of zonal liver regeneration mapped in space and time	40
Replacing microglia to treat Alzheimer’s disease	40
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	40
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	40
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin	40
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration	39
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing	39
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk	39
Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease	38
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy	38
Pancreatic plasticity: Unlocking exocrine lineage specification	38
T cell development made EZ	38
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	38
A step closer to autologous cell therapy for Parkinson’s disease	37
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP	37
The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids	37
Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis	37
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	37
Breathing-induced forces influence lung cell fate	37