Cell Stem Cell

(The TQCC of Cell Stem Cell is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges603
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids516
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids374
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease331
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration307
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium292
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction274
Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation264
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response250
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future228
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia216
Human naive epiblast cells possess unrestricted lineage potential194
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2190
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis181
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer174
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity173
Capturing Cardiogenesis in Gastruloids164
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling163
Capturing human trophoblast development with naive pluripotent stem cells in vitro162
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells159
Naive stem cell blastocyst model captures human embryo lineage segregation159
Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate154
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response152
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair148
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes147
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids144
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men140
Tissue Stem Cells: Architects of Their Niches138
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis136
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency136
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids132
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank132
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells129
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance128
Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids127
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms125
Wound healing, fibroblast heterogeneity, and fibrosis121
Aging and Rejuvenation of Neural Stem Cells and Their Niches119
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients117
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells116
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma116
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy115
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01114
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes111
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer110
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing110
Smooth Muscle Cell Reprogramming in Aortic Aneurysms109
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription109
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification108
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification108
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors108
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury105
Establishment, maintenance, and recall of inflammatory memory104
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment103
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population103
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids101
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use101
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate100
Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder99
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq95
Mapping Development of the Human Intestinal Niche at Single-Cell Resolution92
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids91
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding89
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging89
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome89
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer87
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis87
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury86
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function85
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells85
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse83
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo83
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells83
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function82
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration81
Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling81
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy81
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging80
Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium80
Principles of signaling pathway modulation for enhancing human naive pluripotency induction79
A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury78
Decoding Human Megakaryocyte Development77
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging76
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting76
Hydrogel Network Dynamics Regulate Vascular Morphogenesis75
Multipotent stromal cells: One name, multiple identities75
Human brain organoids assemble functionally integrated bilateral optic vesicles75
Early stem cell aging in the mature brain75
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells74
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit74
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation74
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells74
Tracing the skeletal progenitor transition during postnatal bone formation73
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation72
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids72
Epithelial Plasticity during Liver Injury and Regeneration72
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders71
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease71
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response70
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk70
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing69
Human embryonic genome activation initiates at the one-cell stage68
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction68
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate68
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions67
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing66
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors66
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis66
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells66
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly66
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens64
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome64
Reciprocal regulation of mesenchymal stem cells and immune responses64
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity64
The spatiotemporal program of zonal liver regeneration following acute injury62
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling62
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing62
8C-like cells capture the human zygotic genome activation program in vitro62
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes61
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits61
A reference human induced pluripotent stem cell line for large-scale collaborative studies60
Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells59
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases59
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells58
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity58
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids58
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes57
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells57
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease57
Exploring the human lacrimal gland using organoids and single-cell sequencing55
Patient-derived micro-organospheres enable clinical precision oncology55
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells55
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells54
Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues54
Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer54
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development53
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer53
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy52
Lymphatics act as a signaling hub to regulate intestinal stem cell activity52
ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence51
Amniogenesis occurs in two independent waves in primates51
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth51
Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts50
Enteric glial cell heterogeneity regulates intestinal stem cell niches50
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia50
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization49
Planarian stem cells specify fate yet retain potency during the cell cycle48
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models48
GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells48
Circadian Regulation of Adult Stem Cell Homeostasis and Aging48
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy48
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging48
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche47
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells47
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium47
The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis47
Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function46
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair45
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development45
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease45
Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer45
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation45
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas44
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow44
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells44
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex44
Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis44
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization44
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids43
BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors43
Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis43
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease43
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants42
Stem cells and origins of cancer in the upper gastrointestinal tract41
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity41
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors41
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration40
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation40
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development40
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs40
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal39
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling39
Progress in multicellular human cardiac organoids for clinical applications39
Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension38
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity38
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation38
Preying on Public Fears and Anxieties in a Pandemic: Businesses Selling Unproven and Unlicensed “Stem Cell Treatments” for COVID-1938
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis38
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation38
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery38