Cell Stem Cell

Article	Citations
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	520
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	268
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	206
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	206
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	205
Regrowing the heart, one TREE at a time	193
Cut out that YAPping: Mechanisms to reduce scar formation	192
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	174
Successful organoid-mediated generation of iPSC-derived CAR-T cells	173
Brain organoids restore cortical damage	169
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	162
Tissue morphology influences the temporal program of human brain organoid development	151
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	147
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	147
Prolonged 3D culture unlocks black box of primate embryogenesis	142
Oscillation steers differentiation	141
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	140
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	135
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	134
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	132
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	129
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	128
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	127
IRF6 hits the sweet spot	125
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	125

Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	125
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	125
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	124
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	123
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	121
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	120
Human biliary epithelial cells for regenerative medicine	120
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	115
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	115
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	110
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	110
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	108
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	108
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	108
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	104
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	104
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	103
Perceiving the brain like never before	103
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	102
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	101
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	99
Enchanted by the earliest stages of human life	94
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	93
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	92
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	92
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	91
An oncogenic enhancer encodes selective selenium dependency in AML	90
Early human development and stem cell-based human embryo models	88
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	88
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	87
Progress in multicellular human cardiac organoids for clinical applications	87
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	85
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	82
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	82
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	82
Rebuilding and rebooting immunity with stem cells	81
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	81
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	80
A human pluripotent stem cell-based somitogenesis model using microfluidics	80
Human Down syndrome microglia are up for a synaptic feast	79
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	79
Mini kidney organoids deliver maximal drug screening impact	79
Video, ergo sum: The search for response to natural light	78
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	78
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	78
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	76
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	76
Organ function is preserved despite reorganization of niche architecture in the hair follicle	76
A reference human induced pluripotent stem cell line for large-scale collaborative studies	75
Advancing cell therapy for neurodegenerative diseases	75

Epigenetic regulation of early human embryo development	75
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	74
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	74
iPSC model of congenital heart disease predicts disease outcome	73
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	73
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	73
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	73
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	72
Human hematopoietic stem cells expand beyond cytokines	72
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	71
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	71
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	70
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	69
Face off: Stem cell therapy versus the immune system	69
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	69
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	69
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	68
The clones have STRACK: Tracing responses to leukemic mutations	68
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	68
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	66
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	66
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	66
Vitamin C conveys geroprotection on primate ovaries	66
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	66
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	66
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	65
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	65
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	65
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	64
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	64
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	64
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	64
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	63
Hallmarks of stem cell aging	63
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	61
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	61
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	61
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	60
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	60
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	60
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	60
New evidence for adult beta cell neogenesis	58
Rewinding cells to reverse disease	58
Chemical reprogramming takes the fast lane	58
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	57
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	57
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	56
Patient-derived micro-organospheres enable clinical precision oncology	56
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	55
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	54
Beyond transplantation: Gene-edited pig liver supports function in a human host	54
Capybara: A computational tool to measure cell identity and fate transitions	54
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	53
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	53
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	53
Acetate to the rescue: Acetyl-CoA facilitates placental development	53
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	53
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	52
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	52
Can’t touch this: Stromal-mediated ductal proliferation	52
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	51
Human blastoids 3.0	51
Unmasking cancer’s hidden nerve route with patient-derived organoids	50
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	50
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	50
Raising the bar for human post-implantation embryo models	50
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	50
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	50
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	49
Lung repair and regeneration: Advanced models and insights into human disease	48
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	48
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	48
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	48
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	48
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	47
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	47
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	47

Hallmarks of stemness in mammalian tissues	47
MDS/AML with del5q: An acquired “laminopathy”?	47
Generation of human alveolar epithelial type I cells from pluripotent stem cells	46
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	46
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	46
Mapping of clonal lineages across developmental stages in human neural differentiation	46
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	46
Anniversary reflections: Inspiring discoveries and the future of the field	45
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	45
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	45
Setting the stage for embryo segmentation	45
Effective regulatory responses to predatory stem cell markets in Australia and Canada	44
Hair follicle stem cells feel the pressure	44
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	44
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	44
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	44
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	44