Cell Stem Cell

(The TQCC of Cell Stem Cell is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis486
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration392
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development368
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons302
Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications298
Cancer Stem Cells: The Architects of the Tumor Ecosystem297
Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance292
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients285
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling275
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications274
Targeting Cancer Stemness in the Clinic: From Hype to Hope270
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility264
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia237
hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids230
Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation197
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity191
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells171
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain168
Engineering Stem Cell Self-organization to Build Better Organoids165
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration164
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network163
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development163
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response163
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons160
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs160
A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry160
Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling152
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway152
Paneth Cell Multipotency Induced by Notch Activation following Injury148
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2148
Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy147
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging146
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors144
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells140
Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation139
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration135
Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition134
Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells131
YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury128
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression125
Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration122
Targeting Glioma Stem Cell-Derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy121
Reconstruction of the Human Colon Epithelium In Vivo118
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis108
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells105
Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells105
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease105
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids104
The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty104
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration102
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance102
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development101
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes100
Adult Neurogenesis, Glia, and the Extracellular Matrix97
Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow97
Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis96
Cellular Plasticity in Intestinal Homeostasis and Disease95
A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development94