Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	759
Prolonged 3D culture unlocks black box of primate embryogenesis	313
Oscillation steers differentiation	289
A sculptor of modern regenerative medicine	286
Regrowing the heart, one TREE at a time	281
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	272
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	198
Brain organoids restore cortical damage	193
Rebuilding the bridge: Functional AVN cells for cardiac repair	192
eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation	192
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches	191
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	184
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	183
Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids	174
SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues	174
A peripheral glial niche orchestrates the early stages of skin wound healing	165
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	153
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	148
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	147
Tissue morphology influences the temporal program of human brain organoid development	146
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	143
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	142
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	135
Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation	133
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	133

From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	129
Transcriptional code for circuit integration in the injured brain by transplanted human neurons	127
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	127
Cradles for maturation: Turning progenitor cells into functional intestinal epithelium	127
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	124
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	117
IRF6 hits the sweet spot	115
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	114
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	113
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	113
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	112
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	111
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	110
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	108
Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells	107
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	107
Modeling human hypothalamic cell diversity through developmental patterning	103
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience	103
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	102
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	102
Perceiving the brain like never before	102
Enchanted by the earliest stages of human life	101
Unlocking human brain networks by assembling circuits in vitro and in vivo	99
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	98
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	98
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	97
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	97
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	95
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	95
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	94
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	94
Early human development and stem cell-based human embryo models	93
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	91
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	91
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	90
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	89
Rebuilding and rebooting immunity with stem cells	89
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	88
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	88
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	88
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	87
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo	87
Organ function is preserved despite reorganization of niche architecture in the hair follicle	86
A human pluripotent stem cell-based somitogenesis model using microfluidics	86
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis	86
Endogenous aldehydes: A driver of clonal hematopoiesis from within?	85
Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells	84
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	84
Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level	84
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	83

Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	82
Epigenetic regulation of early human embryo development	81
Advancing cell therapy for neurodegenerative diseases	80
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification	78
Tissues assemble! Rebuilding the human periportal liver in a dish	77
The clones have STRACK: Tracing responses to leukemic mutations	77
A reference human induced pluripotent stem cell line for large-scale collaborative studies	77
Human hematopoietic stem cells expand beyond cytokines	76
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	76
Face off: Stem cell therapy versus the immune system	75
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial	74
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	73
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	73
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	73
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	72
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	71
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	70
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	70
Vitamin C conveys geroprotection on primate ovaries	70
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	70
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	70
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	68
Space-associated stem cell hallmarks of aging and resilience in astronauts	68
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	67
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	67
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	66
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	66
Chemical reprogramming takes the fast lane	66
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	64
Rewinding cells to reverse disease	64
SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments	63
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	63
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	62
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	62
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells	62
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	62
Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy	62
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	61
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	61
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	61
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	61
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	61
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	61
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	61
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	60
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity	59
Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis	59
Hallmarks of stem cell aging	57
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	57
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	56
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	56
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	55
Acetate to the rescue: Acetyl-CoA facilitates placental development	54
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	54
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	53
Unmasking cancer’s hidden nerve route with patient-derived organoids	52
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	52
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	51
Raising the bar for human post-implantation embryo models	51
Beyond transplantation: Gene-edited pig liver supports function in a human host	50
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	50
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages	49
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	48
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	48
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	48
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	48
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	48
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	47
Lung repair and regeneration: Advanced models and insights into human disease	47
Mapping of clonal lineages across developmental stages in human neural differentiation	46
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	46
Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities	45
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	45
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration	45
FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function	45
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	45
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	45
Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines	44

From stem cells to regulatory T cells: A tale of plasticity	44
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	44
Hallmarks of stemness in mammalian tissues	44
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	44
Generation of human alveolar epithelial type I cells from pluripotent stem cells	44
Setting the stage for embryo segmentation	44
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression	43
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	43
Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models	42
Effective regulatory responses to predatory stem cell markets in Australia and Canada	41
Generating human neural diversity with a multiplexed morphogen screen in organoids	41
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	40
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	40
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	40
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	40
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	39
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	39
Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats	39
Hallmarks of regeneration	39
Pineal gland organoids illuminate human melatonin and circadian regulation	38
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	38
3D ECM-rich environment sustains the identity of naive human iPSCs	37
Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis	37
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	36
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	35
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	35
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	35
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	35
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	35
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	34
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders	34
Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories	34
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems	34
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	34
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	33
MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells	33
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	33
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	32
Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries	32
CAR-A astrocytes for Alzheimer’s: Promise and challenge	32
ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation	31
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	31
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models	31
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	31
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	30
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	30
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	30
Closing the gap: Toward functional, bioengineered esophageal grafts	30
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	29
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	29
Empowering human lung development	29
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	29
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	29
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	29
The difficult translational pathway from animal models to patients	29
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP	29
Spatiotemporal single-cell roadmap of human skin wound healing	29
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	28
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	28
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier	27
Human retinal organoids functionally bridge a transected optic nerve in a rat model	27
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	27
Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis	27
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	27
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	26
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	26
Maternal gut microbiota influence stem cell function in offspring	26
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	26
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches	26
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer	26
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	26
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	26
Prevention of transgene silencing during human pluripotent stem cell differentiation	26
The evolution of microglia replacement: A new paradigm for CNS disease therapy	26
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	26
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells	25
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	25
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	24
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	24
From form to function: New heights in kidney organoids	24
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	24
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	24
Bioprinted platform for parallelized screening of engineered microtissues in vivo	24
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease	24
Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy	23
Generating high-fidelity cochlear organoids from human pluripotent stem cells	23
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis	23
Ketone bodies as guardians of leukemic stemness through ferroptosis suppression	23
Breathing-induced forces influence lung cell fate	22
Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules	22
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis	22
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum	22
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP	22
Greasing the machinery toward maturation of stem cell-derived β cells	22
T cell development made EZ	22