Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	706
Prolonged 3D culture unlocks black box of primate embryogenesis	297
Oscillation steers differentiation	276
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	266
A sculptor of modern regenerative medicine	257
Regrowing the heart, one TREE at a time	253
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	208
Rebuilding the bridge: Functional AVN cells for cardiac repair	200
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches	188
eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation	184
Brain organoids restore cortical damage	177
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	175
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	175
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	170
Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation	165
A peripheral glial niche orchestrates the early stages of skin wound healing	156
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	156
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	153
Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids	149
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	138
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	136
Tissue morphology influences the temporal program of human brain organoid development	135
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	134
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	129
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	129

From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	126
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	124
Transcriptional code for circuit integration in the injured brain by transplanted human neurons	123
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	121
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	121
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	120
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	118
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	116
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	116
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	116
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	115
IRF6 hits the sweet spot	112
Cradles for maturation: Turning progenitor cells into functional intestinal epithelium	111
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	108
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	106
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	106
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	106
Enchanted by the earliest stages of human life	105
Unlocking human brain networks by assembling circuits in vitro and in vivo	105
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	104
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	102
Perceiving the brain like never before	97
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	96
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	95
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	95
Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells	94
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	94
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	93
Early human development and stem cell-based human embryo models	93
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience	93
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	92
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	92
Mini kidney organoids deliver maximal drug screening impact	91
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	91
Endogenous aldehydes: A driver of clonal hematopoiesis from within?	89
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	89
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	89
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	89
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	88
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	87
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	86
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	84
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	84
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	83
Organ function is preserved despite reorganization of niche architecture in the hair follicle	83
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis	82
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	82
A human pluripotent stem cell-based somitogenesis model using microfluidics	81
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo	81
Human Down syndrome microglia are up for a synaptic feast	81

Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	81
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification	81
Rebuilding and rebooting immunity with stem cells	80
Advancing cell therapy for neurodegenerative diseases	80
Epigenetic regulation of early human embryo development	79
The clones have STRACK: Tracing responses to leukemic mutations	78
A reference human induced pluripotent stem cell line for large-scale collaborative studies	78
Human hematopoietic stem cells expand beyond cytokines	77
Face off: Stem cell therapy versus the immune system	75
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	75
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	75
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial	75
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	74
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	74
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	73
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	72
Tissues assemble! Rebuilding the human periportal liver in a dish	70
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	70
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	70
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	69
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	69
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	68
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	68
Space-associated stem cell hallmarks of aging and resilience in astronauts	67
Vitamin C conveys geroprotection on primate ovaries	66
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	66
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	66
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	66
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	66
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	66
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	65
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	64
Chemical reprogramming takes the fast lane	64
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	63
Rewinding cells to reverse disease	63
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells	63
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	62
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	62
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	62
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	62
Hallmarks of stem cell aging	62
SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments	61
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	60
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	59
Patient-derived micro-organospheres enable clinical precision oncology	59
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	59
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity	58
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	58
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	57
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	57
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	57
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	57
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	57
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	56
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	56
Acetate to the rescue: Acetyl-CoA facilitates placental development	56
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	55
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	55
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	54
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	51
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	51
Unmasking cancer’s hidden nerve route with patient-derived organoids	51
Raising the bar for human post-implantation embryo models	51
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	50
Lung repair and regeneration: Advanced models and insights into human disease	49
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	49
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	49
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	49
Beyond transplantation: Gene-edited pig liver supports function in a human host	49
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages	47
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	46
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	46
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration	45
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	44
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	44
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	44
Mapping of clonal lineages across developmental stages in human neural differentiation	43
Generation of human alveolar epithelial type I cells from pluripotent stem cells	43
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	42

Hallmarks of stemness in mammalian tissues	42
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	42
Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines	42
Anniversary reflections: Inspiring discoveries and the future of the field	41
Effective regulatory responses to predatory stem cell markets in Australia and Canada	41
Setting the stage for embryo segmentation	41
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	41
From stem cells to regulatory T cells: A tale of plasticity	41
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	41
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	40
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression	40
Generating human neural diversity with a multiplexed morphogen screen in organoids	40
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	39
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	39
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	39
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	39
Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models	39
Hallmarks of regeneration	38
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	38
Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats	37
MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells	37
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	37
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis	36
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	36
Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories	36
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	35
Pineal gland organoids illuminate human melatonin and circadian regulation	35
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	35
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders	34
3D ECM-rich environment sustains the identity of naive human iPSCs	34
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems	34
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	33
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	33
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	33
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	32
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	32
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	32
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	32
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	32
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	31
CAR-A astrocytes for Alzheimer’s: Promise and challenge	31
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	30
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	30
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	30
The difficult translational pathway from animal models to patients	30
Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries	30
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	29
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	29
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP	29
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	29
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	28
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	28
Spatiotemporal single-cell roadmap of human skin wound healing	28
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	28
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models	28
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	28
The evolution of microglia replacement: A new paradigm for CNS disease therapy	27
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	27
Empowering human lung development	27
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	27
Maternal gut microbiota influence stem cell function in offspring	27
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	27
Human retinal organoids functionally bridge a transected optic nerve in a rat model	27
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	26
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	26
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier	26
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	26
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	25
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer	25
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease	25
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	25
From form to function: New heights in kidney organoids	25
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells	24
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	24
Bioprinted platform for parallelized screening of engineered microtissues in vivo	24
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	24
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches	24
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	24
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	24
Prevention of transgene silencing during human pluripotent stem cell differentiation	24
Generating high-fidelity cochlear organoids from human pluripotent stem cells	24
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	23
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	23
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	23
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP	23
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	23
T cell development made EZ	22
A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells	22
Breathing-induced forces influence lung cell fate	22
Greasing the machinery toward maturation of stem cell-derived β cells	21
Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy	21
Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids	21
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis	20
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration	20
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis	20