Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	685
Prolonged 3D culture unlocks black box of primate embryogenesis	282
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	269
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches	254
Rebuilding the bridge: Functional AVN cells for cardiac repair	245
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	241
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	198
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	192
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	179
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	178
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	173
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	169
Tissue morphology influences the temporal program of human brain organoid development	168
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	166
Oscillation steers differentiation	158
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	154
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	151
A sculptor of modern regenerative medicine	148
Regrowing the heart, one TREE at a time	148
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	148
Brain organoids restore cortical damage	135
A peripheral glial niche orchestrates the early stages of skin wound healing	134
Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids	128
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	128
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	125

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	123
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	122
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	120
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	119
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	116
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	115
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	115
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	115
IRF6 hits the sweet spot	114
Transcriptional code for circuit integration in the injured brain by transplanted human neurons	112
Cradles for maturation: Turning progenitor cells into functional intestinal epithelium	112
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	110
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	109
Unlocking human brain networks by assembling circuits in vitro and in vivo	106
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	106
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	105
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	103
Enchanted by the earliest stages of human life	103
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	103
Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells	100
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	100
Perceiving the brain like never before	100
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	97
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience	94
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	93
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	93
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	92
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	91
Human Down syndrome microglia are up for a synaptic feast	91
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	91
Early human development and stem cell-based human embryo models	91
Mini kidney organoids deliver maximal drug screening impact	90
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	89
A human pluripotent stem cell-based somitogenesis model using microfluidics	89
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification	88
Endogenous aldehydes: A driver of clonal hematopoiesis from within?	86
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	86
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis	86
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	86
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	86
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	85
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	84
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	84
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	83
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo	83
Epigenetic regulation of early human embryo development	82
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	82
Organ function is preserved despite reorganization of niche architecture in the hair follicle	81
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	80

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	80
Advancing cell therapy for neurodegenerative diseases	79
Face off: Stem cell therapy versus the immune system	78
A reference human induced pluripotent stem cell line for large-scale collaborative studies	78
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	78
Rebuilding and rebooting immunity with stem cells	78
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial	77
Human hematopoietic stem cells expand beyond cytokines	77
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	76
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	76
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	76
iPSC model of congenital heart disease predicts disease outcome	75
The clones have STRACK: Tracing responses to leukemic mutations	75
Tissues assemble! Rebuilding the human periportal liver in a dish	74
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	74
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	73
Vitamin C conveys geroprotection on primate ovaries	72
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	71
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	70
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	70
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	70
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	69
Space-associated stem cell hallmarks of aging and resilience in astronauts	68
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	68
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	68
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	67
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	67
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	66
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	65
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	65
Rewinding cells to reverse disease	65
Chemical reprogramming takes the fast lane	65
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	64
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	63
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	62
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity	62
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	62
SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments	62
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	61
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	61
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	61
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	61
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	60
Hallmarks of stem cell aging	60
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	60
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	60
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells	59
Patient-derived micro-organospheres enable clinical precision oncology	59
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	59
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	58
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	58
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	57
Acetate to the rescue: Acetyl-CoA facilitates placental development	56
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	56
Unmasking cancer’s hidden nerve route with patient-derived organoids	56
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	56
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	55
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	55
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	55
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	54
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	54
Raising the bar for human post-implantation embryo models	54
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	53
Beyond transplantation: Gene-edited pig liver supports function in a human host	52
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	52
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	51
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	50
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	50
Lung repair and regeneration: Advanced models and insights into human disease	49
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	49
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	48
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	47
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	47
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages	47
Generation of human alveolar epithelial type I cells from pluripotent stem cells	47
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	46
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	45
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	45
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration	45
Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines	45

Anniversary reflections: Inspiring discoveries and the future of the field	44
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	44
Hallmarks of stemness in mammalian tissues	44
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	44
Mapping of clonal lineages across developmental stages in human neural differentiation	44
Setting the stage for embryo segmentation	42
From stem cells to regulatory T cells: A tale of plasticity	42
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	41
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	41
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	41
Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models	41
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	41
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	40
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	40
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	40
Generating human neural diversity with a multiplexed morphogen screen in organoids	40
Effective regulatory responses to predatory stem cell markets in Australia and Canada	39
Hallmarks of regeneration	39
Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories	38
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	38
Pineal gland organoids illuminate human melatonin and circadian regulation	38
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	37
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis	37
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	36
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	36
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	36
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	36
MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells	35
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	34
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	34
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	34
3D ECM-rich environment sustains the identity of naive human iPSCs	34
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders	33
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	33
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	33
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP	32
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	32
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	32
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	32
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	32
Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries	31
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models	31
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	31
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	30
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	30
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	30
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	30
The difficult translational pathway from animal models to patients	30
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	30
Empowering human lung development	29
Spatiotemporal single-cell roadmap of human skin wound healing	29
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	29
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	29
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	29
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer	28
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	28
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier	28
The evolution of microglia replacement: A new paradigm for CNS disease therapy	28
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	27
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	27
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	27
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	27
Maternal gut microbiota influence stem cell function in offspring	27
From form to function: New heights in kidney organoids	26
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	26
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	26
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	26
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches	26
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	26
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	25
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	25
Generating high-fidelity cochlear organoids from human pluripotent stem cells	25
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	25
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells	25
Bioprinted platform for parallelized screening of engineered microtissues in vivo	25
Amniogenesis occurs in two independent waves in primates	25
Prevention of transgene silencing during human pluripotent stem cell differentiation	24
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	24
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis	24
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis	24
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	24
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	24
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis	24
Adult neurogenesis: New neurons, new opportunities	24
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease	24
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	24
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration	24
Breathing-induced forces influence lung cell fate	23
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP	23
Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives	23
T cell development made EZ	23
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands	22
A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells	22
Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules	22
Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy	22