Cell Stem Cell

Article	Citations
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids	409
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium	321
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction	297
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response	262
Human naive epiblast cells possess unrestricted lineage potential	225
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis	212
Wound healing, fibroblast heterogeneity, and fibrosis	210
Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate	203
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2	201
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling	189
Capturing human trophoblast development with naive pluripotent stem cells in vitro	187
Naive stem cell blastocyst model captures human embryo lineage segregation	185
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes	184
Capturing Cardiogenesis in Gastruloids	181
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response	166
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids	166
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance	163
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids	162
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency	153
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men	151
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells	142
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms	141
Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01	141
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	139
Establishment, maintenance, and recall of inflammatory memory	135

Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification	133
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	133
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells	132
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment	128
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use	122
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification	121
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate	120
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging	119
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	118
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids	117
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq	115
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer	114
Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder	111
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids	107
Mapping Development of the Human Intestinal Niche at Single-Cell Resolution	106
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging	106
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	105
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury	103
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity	102
Reciprocal regulation of mesenchymal stem cells and immune responses	100
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis	99
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function	98
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration	97
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function	97
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy	97
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo	97
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation	95
Human brain organoids assemble functionally integrated bilateral optic vesicles	95
Tracing the skeletal progenitor transition during postnatal bone formation	94
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	94
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	93
Hydrogel Network Dynamics Regulate Vascular Morphogenesis	93
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders	91
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells	91
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging	90
Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling	90
The spatiotemporal program of zonal liver regeneration following acute injury	89
Decoding Human Megakaryocyte Development	87
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease	87
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	86
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	86
A reference human induced pluripotent stem cell line for large-scale collaborative studies	86
8C-like cells capture the human zygotic genome activation program in vitro	85
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation	85
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly	85
Early stem cell aging in the mature brain	84
Multipotent stromal cells: One name, multiple identities	83
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	82
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis	82
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids	82

Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions	81
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors	80
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling	79
Human embryonic genome activation initiates at the one-cell stage	79
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk	79
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing	79
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens	78
Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues	78
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	77
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome	77
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes	77
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	76
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	76
Patient-derived micro-organospheres enable clinical precision oncology	74
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response	73
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells	73
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	73
Enteric glial cell heterogeneity regulates intestinal stem cell niches	72
Exploring the human lacrimal gland using organoids and single-cell sequencing	71
Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells	70
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	70
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	69
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease	68
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	67
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy	66
ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence	64
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	64
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity	63
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	63
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation	63
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth	63
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease	62
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	61
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	61
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes	61
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow	60
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas	60
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	60
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	59
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development	59
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia	59
Progress in multicellular human cardiac organoids for clinical applications	58
Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function	58
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization	58
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models	57
Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer	57
Amniogenesis occurs in two independent waves in primates	56
Planarian stem cells specify fate yet retain potency during the cell cycle	55
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	55
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation	55
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging	55
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal	54
EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity	54
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	53
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	52
Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis	52
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	52
Biomaterials to enhance stem cell transplantation	52
Structural and functional integration of human forebrain organoids with the injured adult rat visual system	51
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	51
BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors	51
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration	50
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium	50
Clonal hematopoiesis: Mutation-specific adaptation to environmental change	50
Stem cells and origins of cancer in the upper gastrointestinal tract	50
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	49
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration	49
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex	49
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling	48
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation	48
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	47
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development	47
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance	46
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	46
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals	46
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	46
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism	46
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs	45
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	45
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	44

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load	44
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	44
RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy	44
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	44
Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury	43
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis	43
Programming hydrogels to probe spatiotemporal cell biology	43
Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension	43
Cynomolgus monkey embryo model captures gastrulation and early pregnancy	43
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	42
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	42
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation	42
Advancing cell therapy for neurodegenerative diseases	41
Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease	41
Biomanufacturing human tissues via organ building blocks	41
Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma	40
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity	40
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	40
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion	40
Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells	40
Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells	40
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool	40
Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue	40
Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers	39
Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras	39
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	38
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis	38
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	38
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	38
Decoding the temporal and regional specification of microglia in the developing human brain	38
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea	38
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis	38
The next generation of endothelial differentiation: Tissue-specific ECs	38
Two-photon live imaging of single corneal stem cells reveals compartmentalized organization of the limbal niche	37
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms	37
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling	37
Harnessing organs-on-a-chip to model tissue regeneration	37
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation	37
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity	36
Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells	36
Modeling human multi-lineage heart field development with pluripotent stem cells	36
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration	35
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption	35
MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing	35
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	35
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation	35
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation	35
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration	34
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia	34
Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury	33
3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages	33
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	33
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia	32
Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia	32
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients	32
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	32
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity	31
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells	31
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	31
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease	31
Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain	31
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	30
Development, maturation, and maintenance of human prostate inferred from somatic mutations	30
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation	30
Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function	30
Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development	30
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	30
Engineering multiscale structural orders for high-fidelity embryoids and organoids	29
Multimodal characterization of murine gastruloid development	29
The frontier of live tissue imaging across space and time	29
Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology	29
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	29
The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions	29
Cascade diversification directs generation of neuronal diversity in the hypothalamus	28
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing	28
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	28
Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease	28
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy	28
Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells	27
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	27
Advancing cell-based cancer immunotherapy through stem cell engineering	27
Capybara: A computational tool to measure cell identity and fate transitions	27
A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan	26
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons	26
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy	26
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	26
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib	26
hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease	26
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery	26
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery	25
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	25
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	25
Computational Stem Cell Biology: Open Questions and Guiding Principles	25
Human branching cholangiocyte organoids recapitulate functional bile duct formation	25
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	24