Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	355
Early-career researchers in the time of COVID-19: Adapting to uncertainty	261
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	235
Brain organoids restore cortical damage	230
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	217
Cut out that YAPping: Mechanisms to reduce scar formation	217
Regrowing the heart, one TREE at a time	215
Prolonged 3D culture unlocks black box of primate embryogenesis	201
Successful organoid-mediated generation of iPSC-derived CAR-T cells	187
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	171
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	170
Oscillation steers differentiation	165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	156
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	155
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	151
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	149
Exploring the human lacrimal gland using organoids and single-cell sequencing	146
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	145
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	143
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	143
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	136
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	136
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	134
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	134
Tissue morphology influences the temporal program of human brain organoid development	129

Human biliary epithelial cells for regenerative medicine	128
Refined transcriptional blueprint of human preimplantation embryos	121
Paul S. Frenette (1965–2021)	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	119
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	117
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	116
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	116
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	115
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	113
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	111
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	109
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	109
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	108
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	106
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	106
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	105
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	105
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	103
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	103
Perceiving the brain like never before	102
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	102
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	102
Naive stem cell blastocyst model captures human embryo lineage segregation	102
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	101
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	101
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	101
Progress in multicellular human cardiac organoids for clinical applications	101
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	100
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	100
Human-monkey chimeras: Monkey see, monkey do	99
Enchanted by the earliest stages of human life	99
Early human development and stem cell-based human embryo models	98
Healing takes nerve	97
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	97
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	96
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	95
An oncogenic enhancer encodes selective selenium dependency in AML	95
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	95
Stem cells and origins of cancer in the upper gastrointestinal tract	94
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	92
Organ function is preserved despite reorganization of niche architecture in the hair follicle	91
Rebuilding and rebooting immunity with stem cells	89
Stem cell models help crack regional oncohistone codes driving childhood gliomas	88
Video, ergo sum: The search for response to natural light	87
Human Down syndrome microglia are up for a synaptic feast	86
Mini kidney organoids deliver maximal drug screening impact	85
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	83
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	83
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	82
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	80

Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	79
Planarian stem cells specify fate yet retain potency during the cell cycle	77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	77
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	76
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	75
Epigenetic regulation of early human embryo development	75
A reference human induced pluripotent stem cell line for large-scale collaborative studies	74
Advancing cell therapy for neurodegenerative diseases	74
Human naive epiblast cells possess unrestricted lineage potential	73
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	72
A human pluripotent stem cell-based somitogenesis model using microfluidics	72
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	71
Maturation for regeneration	70
iPSC model of congenital heart disease predicts disease outcome	70
Human hematopoietic stem cells expand beyond cytokines	69
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	68
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	67
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	67
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	67
The clones have STRACK: Tracing responses to leukemic mutations	67
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	65
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	65
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	65
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	65
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	65
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	64
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	63
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	63
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	63
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	62
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing	62
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	61
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	61
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	60
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	59
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	59
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	59
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	58
Rewinding cells to reverse disease	58
Chemical reprogramming takes the fast lane	57
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	57
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	57
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	57
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	56
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	56
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	56
New evidence for adult beta cell neogenesis	56
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	55
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	55
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	55
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	55
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	55
Capybara: A computational tool to measure cell identity and fate transitions	55
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	55
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	54
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	54
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	54
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	53
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	53
Can’t touch this: Stromal-mediated ductal proliferation	53
Patient-derived micro-organospheres enable clinical precision oncology	53
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	53
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	52
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	52
Human blastoids 3.0	52
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	51
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	51
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	51
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	51
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	50
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	50
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	49
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	48
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	48
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	46
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	46
Acetate to the rescue: Acetyl-CoA facilitates placental development	46
Lung repair and regeneration: Advanced models and insights into human disease	46
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	45

MDS/AML with del5q: An acquired “laminopathy”?	45
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	45
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	45
Human brain organoids assemble functionally integrated bilateral optic vesicles	45
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	44
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	44
Hallmarks of stemness in mammalian tissues	44
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	44
The eyeball’s connected to the brain ball	44
Generation of human alveolar epithelial type I cells from pluripotent stem cells	43
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	43
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	43
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	43
Anniversary reflections: Inspiring discoveries and the future of the field	42
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	42
Setting the stage for embryo segmentation	42
Mapping of clonal lineages across developmental stages in human neural differentiation	42
Hair follicle stem cells feel the pressure	42
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	41
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	41
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	41
Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain	41
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling	41
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	41
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	41
From stem cells to regulatory T cells: A tale of plasticity	41
Hallmarks of regeneration	40
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	40
Effective regulatory responses to predatory stem cell markets in Australia and Canada	40
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	39
The treasure inside human naive pluripotency, generation of trophectoderm and blastoids	39
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	39
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	39
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	39
Generating human neural diversity with a multiplexed morphogen screen in organoids	39
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	38
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis	38
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	37
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	37
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	36
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	36
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	36
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	36
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	36
Capturing human trophoblast development with naive pluripotent stem cells in vitro	35
3D ECM-rich environment sustains the identity of naive human iPSCs	35
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	35
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	35
Establishment, maintenance, and recall of inflammatory memory	35
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	34
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	34
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	34
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	34
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	34
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche	34
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	34
The difficult translational pathway from animal models to patients	34
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification	33
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	33
Spatiotemporal single-cell roadmap of human skin wound healing	33
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	33
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	33
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	33
Quickly moving too slowly: Interneuron migration in Timothy Syndrome	32
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	32
Early-career researchers in the time of COVID-19: Benefits of structural support	32
“Eyeing” corneal stem cell identity, dynamics, and compartmentalization	32
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	32
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	31
Empowering human lung development	31
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	30
Maternal gut microbiota influence stem cell function in offspring	30
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	30
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	30
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	29
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling	28
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	28
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	28
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	28
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	28
Inflation comes before the fall: How epithelial stretch drives crypt fission	28
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	28
Forward steps in organoid-based forward screening	28
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	28
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	27
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	27
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	27
Generating high-fidelity cochlear organoids from human pluripotent stem cells	26
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	26
Amniogenesis occurs in two independent waves in primates	26
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	26
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	25
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	25
Multipotent stromal cells: One name, multiple identities	25
Bioprinted platform for parallelized screening of engineered microtissues in vivo	25