OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Stem Cell is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	355
Early-career researchers in the time of COVID-19: Adapting to uncertainty	261
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	235
Brain organoids restore cortical damage	230
Cut out that YAPping: Mechanisms to reduce scar formation	217
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	217
Regrowing the heart, one TREE at a time	215
Prolonged 3D culture unlocks black box of primate embryogenesis	201
Successful organoid-mediated generation of iPSC-derived CAR-T cells	187
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	171
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	170
Oscillation steers differentiation	165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	156
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	155
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	151
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	149
Exploring the human lacrimal gland using organoids and single-cell sequencing	146
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	145
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	143
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	143
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	136
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	136
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	134
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	134
Tissue morphology influences the temporal program of human brain organoid development	129

Human biliary epithelial cells for regenerative medicine	128
Refined transcriptional blueprint of human preimplantation embryos	121
Paul S. Frenette (1965–2021)	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	119
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	117
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	116
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	116
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	115
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	113
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	111
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	109
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	109
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	108
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	106
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	106
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	105
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	105
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	103
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	103
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	102
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	102
Naive stem cell blastocyst model captures human embryo lineage segregation	102
Perceiving the brain like never before	102
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	101
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	101
Progress in multicellular human cardiac organoids for clinical applications	101
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	101
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	100
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	100
Human-monkey chimeras: Monkey see, monkey do	99
Enchanted by the earliest stages of human life	99
Early human development and stem cell-based human embryo models	98
Healing takes nerve	97
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	97
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	96
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	95
An oncogenic enhancer encodes selective selenium dependency in AML	95
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population	95
Stem cells and origins of cancer in the upper gastrointestinal tract	94
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	92
Organ function is preserved despite reorganization of niche architecture in the hair follicle	91
Rebuilding and rebooting immunity with stem cells	89
Stem cell models help crack regional oncohistone codes driving childhood gliomas	88
Video, ergo sum: The search for response to natural light	87
Human Down syndrome microglia are up for a synaptic feast	86
Mini kidney organoids deliver maximal drug screening impact	85
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	83
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	83
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	82
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	80

Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	79
Planarian stem cells specify fate yet retain potency during the cell cycle	77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	77