Neurotherapeutics

Article	Citations
FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson’s Disease	153
Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain	125
Septic-Associated Encephalopathy: a Comprehensive Review	113
Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease	73
Matrix Metalloproteinases in Acute Intracerebral Hemorrhage	66
Cell Death and Recovery in Traumatic Brain Injury	64
Neuropathology of Alzheimer’s Disease	60
From Genetic Testing to Precision Medicine in Epilepsy	54
Availability of Medications for the Treatment of Alcohol and Opioid Use Disorder in the USA	54
Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments	52
Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis	48
Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease	48
Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord	47
Restless Legs Syndrome: Contemporary Diagnosis and Treatment	46
Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson’s Disease	45
Vascular Cognitive Impairment (VCI)	45
Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin	44
The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development	44
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease	42
Aneurysmal Subarachnoid Hemorrhage: an Overview of Inflammation-Induced Cellular Changes	41
CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice	41
Iron and Ferroptosis as Therapeutic Targets in Alzheimer’s Disease	40
Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis	40
Effects of Cannabinoids on Sleep and their Therapeutic Potential for Sleep Disorders	38
Therapy of Parkinson’s Disease Subtypes	38

Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study	38
Therapeutic Update on Huntington’s Disease: Symptomatic Treatments and Emerging Disease-Modifying Therapies	37
Targeted Perfusion Therapy in Spinal Cord Trauma	34
An Update on Psychopharmacological Treatment of Autism Spectrum Disorder	34
Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia–Reperfusion Injury	34
Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets	33
Medical Management and Prevention of Motor Complications in Parkinson’s Disease	33
FG-4592 Improves Depressive-Like Behaviors through HIF-1-Mediated Neurogenesis and Synapse Plasticity in Rats	33
Proactive Motor Functional Recovery Following Immersive Virtual Reality–Based Limb Mirroring Therapy in Patients with Subacute Stroke	32
Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain	32
NonREM Disorders of Arousal and Related Parasomnias: an Updated Review	31
Sleep Issues in Parkinson’s Disease and Their Management	31
Interactions Among lncRNAs/circRNAs, miRNAs, and mRNAs in Neuropathic Pain	31
Update on Intravenous Immunoglobulin in Neurology: Modulating Neuro-autoimmunity, Evolving Factors on Efficacy and Dosing and Challenges on Stopping Chronic IVIg Therapy	29
Advances in Therapeutic Approaches for Spontaneous Intracerebral Hemorrhage	29
Neurodevelopmental Disorders Commonly Presenting with Sleep Disturbances	29
Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood–Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats	29
Crosstalk Among NLRP3 Inflammasome, ETBR Signaling, and miRNAs in Stress-Induced Depression-Like Behavior: a Modulatory Role for SGLT2 Inhibitors	28
Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice	28
Nightmare Disorder and Isolated Sleep Paralysis	28
RETRACTED ARTICLE: The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial	28
Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases	28
P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain	27
Induction Versus Escalation in Multiple Sclerosis: A 10-Year Real World Study	27
Pharmacological Management of Insomnia	27
Deep Brain Stimulation for Depression	27
Autonomic Dysfunction in Parkinson’s Disease	27
Sleep and Epilepsy: a Focused Review of Pathophysiology, Clinical Syndromes, Co-morbidities, and Therapy	27
Circadian Rhythm Sleep–Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease	27
The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models	27
In Vivo Wireless Brain Stimulation via Non-invasive and Targeted Delivery of Magnetoelectric Nanoparticles	27
Benzodiazepines, z-Hypnotics, and Risk of Dementia: Special Considerations of Half-Lives and Concomitant Use	27
Ferulic Acid Ameliorates Alzheimer’s Disease-like Pathology and Repairs Cognitive Decline by Preventing Capillary Hypofunction in APP/PS1 Mice	27
Decreased Level of Exosomal miR-5121 Released from Microglia Suppresses Neurite Outgrowth and Synapse Recovery of Neurons Following Traumatic Brain Injury	26
HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window	26
Immunogenicity and safety of mRNA COVID-19 vaccines in people with multiple sclerosis treated with different disease-modifying therapies	26
Donepezil Protects Against Doxorubicin-Induced Chemobrain in Rats via Attenuation of Inflammation and Oxidative Stress Without Interfering With Doxorubicin Efficacy	25
Upregulation of AQP4 Improves Blood–Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage	25
Culture, Ethnicity, and Level of Education in Alzheimer’s Disease	24
Disease-Modifying Therapies for Alzheimer’s Disease: More Questions than Answers	24
Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats	24
Approach to Cognitive Impairment in Parkinson’s Disease	24
Genomics and Functional Genomics of Alzheimer’s Disease	23
ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia	23
Managing Essential Tremor	23
Four-Repeat Tauopathies: Current Management and Future Treatments	23
Overcoming Barriers to Parkinson Disease Trial Participation: Increasing Diversity and Novel Designs for Recruitment and Retention	23
Stiff-person Syndrome and GAD Antibody-spectrum Disorders: GABAergic Neuronal Excitability, Immunopathogenesis and Update on Antibody Therapies	23
Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy	22
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer’s Disease Pathogenesis in Cell and Animal Models	22

Axonal Charcot-Marie-Tooth Disease: from Common Pathogenic Mechanisms to Emerging Treatment Opportunities	22
Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology	22
The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect	22
Reldesemtiv in Patients with Spinal Muscular Atrophy: a Phase 2 Hypothesis-Generating Study	22
Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study	21
Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases	21
Effect of Capsaicinoids on Neurophysiological, Biochemical, and Mechanical Parameters of Swallowing Function	20
Major Features of the 2021 WHO Classification of CNS Tumors	20
Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism	20
Therapeutic Approaches to the Neurologic Manifestations of COVID-19	20
Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy	20
Targeting Gys1 with AAV‐SaCas9 Decreases Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models	19
The Treatment of Sleep Dysfunction in Neurodegenerative Disorders	19
Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis	19
Recent Advances in Neuroimaging of Epilepsy	19
Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain	19
Heterogeneity in Alzheimer’s Disease Diagnosis and Progression Rates: Implications for Therapeutic Trials	19
IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy	19
Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients	18
Mesenchymal Stem Cell (MSC)–Derived Extracellular Vesicles Protect from Neonatal Stroke by Interacting with Microglial Cells	18
A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas	18
Antisense Oligonucleotides for the Study and Treatment of ALS	18
Transcutaneous Spinal Neuromodulation Reorganizes Neural Networks in Patients with Cerebral Palsy	18
Natural History Studies and Clinical Trial Readiness for Genetic Developmental and Epileptic Encephalopathies	18
Surgical Treatment of Parkinson’s Disease: Devices and Lesion Approaches	18
Noninvasive Neuroprosthesis Promotes Cardiovascular Recovery After Spinal Cord Injury	18
Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial	18
Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain	17
Pipeline Embolization Device for Intracranial Aneurysms in a Large Chinese Cohort: Complication Risk Factor Analysis	17
Management of psychiatric disorders in Parkinson’s disease	17
Gene and Cell-Based Therapies for Parkinson’s Disease: Where Are We?	17
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice	17
Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome	17
Treatment and Evaluation Advances in Leprosy Neuropathy	17
Poly-Arginine Peptide-18 (R18) Reduces Brain Injury and Improves Functional Outcomes in a Nonhuman Primate Stroke Model	17
Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation	17
CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons	16
Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice	16
Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development	16
Antibody Therapies in Autoimmune Encephalitis	16
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies	16
RETRACTED ARTICLE: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology	16
Spreading Depolarizations and Subarachnoid Hemorrhage	16
Approaches to Disease Modification for Parkinson’s Disease: Clinical Trials and Lessons Learned	16
Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues	16
Current Concepts and Controversies in the Management of REM Sleep Behavior Disorder	16
Implementation of Mobile Health Technologies in Clinical Trials of Movement Disorders: Underutilized Potential	16
Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP	16
CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy	16
The Use, Standardization, and Interpretation of Brain Imaging Data in Clinical Trials of Neurodegenerative Disorders	16
Antidepressant Monotherapy and Combination Therapy with Acupuncture in Depressed Patients: A Resting-State Functional Near-Infrared Spectroscopy (fNIRS) Study	16
Updates in IDH-Wildtype Glioblastoma	16
Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31	15
Management of Tardive Syndrome: Medications and Surgical Treatments	15
Hypoglossal Nerve Stimulation Therapy for the Treatment of Obstructive Sleep Apnea	15
Non-pharmacological Approaches for Management of Insomnia	15
REM Sleep Deprivation Impairs Learning and Memory by Decreasing Brain O-GlcNAc Cycling in Mouse	15
Withaferin-A Treatment Alleviates TAR DNA-Binding Protein-43 Pathology and Improves Cognitive Function in a Mouse Model of FTLD	15
L-Serine Treatment is Associated with Improvements in Behavior, EEG, and Seizure Frequency in Individuals with GRIN-Related Disorders Due to Null Variants	15
A practical guide to the pharmacological and behavioral therapy of Narcolepsy	15
The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies	15
Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal	15
Central Nervous System Targets: Supraspinal Mechanisms of Analgesia	15
Microglia in Alzheimer’s Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis	14
A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats	14
The Pharmacogenetics of Rituximab: Potential Implications for Anti-CD20 Therapies in Multiple Sclerosis	14
Idiopathic Hypersomnia and Other Hypersomnia Syndromes	14
Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial	14
Precision Therapy for Epilepsy Related to Brain Malformations	14
Galantamine Inhibits Aβ1–42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ1–42 Engulfment During Autophagic Degradation	14
Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy	14
DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats	14
Physiology-Based Treatment of Myoclonus	13
Lentiviral Interleukin-10 Gene Therapy Preserves Fine Motor Circuitry and Function After a Cervical Spinal Cord Injury in Male and Female Mice	13
Overlapping Molecular Pathways Leading to Autism Spectrum Disorders, Fragile X Syndrome, and Targeted Treatments	13
Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine	13
Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury	13
Treating Post-traumatic Stress Disorder with Neuromodulation Therapies: Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, and Deep Brain Stimulation	13
Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study	13
Assessing Cannabis Demand: A Comprehensive Review of the Marijuana Purchase Task	13

Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy	13
Autoimmune Neurological Disorders with IgG4 Antibodies: a Distinct Disease Spectrum with Unique IgG4 Functions Responding to Anti-B Cell Therapies	13
Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation	13
Modulation of the Microbiome in Parkinson’s Disease: Diet, Drug, Stool Transplant, and Beyond	13
Structural Neuroimaging Findings Related to Adult Non-CNS Cancer and Treatment: Review, Integration, and Implications for Treatment of Cognitive Dysfunction	13
Emerging Clinical Technology: Application of Machine Learning to Chronic Pain Assessments Based on Emotional Body Maps	13
KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease	13
Treatment of Progressive Multifocal Leukoencephalopathy Using Immune Restoration	13