OOIR: Observatory of International Research

Papers

(The TQCC of Mucosal Immunology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Editorial Board	256
Editorial Board	202
Memorial for Nils Lycke	183
Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis	126
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	112
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	100
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	100
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	90
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	78
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	73
Role of the humoral immune response during COVID-19: guilty or not guilty?	61
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	61
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	49
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	47
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	47
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	46
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	44
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	43
Fibroblasts sense commensal-derived metabolites and regulate group 2 innate lymphoid cells-dependent defense in the stomach	42
The neuroendocrine peptide catestatin promotes clearance of cutaneous Staphylococcus aureus through mast cell Mrgpr activation	40
Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control	40
Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and macrophages on lung immunopathology and antiviral responses	40
Microbial regulation of intestinal motility provides resistance against helminth infection	39
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	39
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	38

Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	38
Microbial antigen in human milk: a natural vaccine?	37
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	35
Mast cells disrupt the function of the esophageal epithelial barrier	34
NOD1 signaling regulates early tissue inflammation during helminth infection	33
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	32
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	31
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	30
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	30
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	30
Organismal mucosal immunology: A perspective through the eyes of game theory	29
Chronological maturation of the skin immune barrier is topographically different	28
Inhaled Acinetobacter lwoffii exposure promotes lung PD-L1+ neutrophils and dampens viral-induced type 2 immunity	28
The gut-liver axis modulates intestinal immune homeostasis	27
Impaired neutrophil migration underpins host susceptibility to infectious colitis	27
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	27
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity	27
Airway epithelial cells as drivers of severe asthma pathogenesis	27
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	26
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	26
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	26
Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming	25
Role of IL-10 signaling in the circadian control of host response to influenza infection	25
Metabolic regulation of macrophage-tissue interactions in the lung	25
Ileal mucus viscoelastic properties differ in Crohn’s disease	25
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	24
Neuronal VIP wires the intestinal epithelial cell function	24
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	24
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	24
Optimized hookworm-derived biologic, AIP-2NTQ48 restores mucosal tolerance and down-regulates colon cancer-associated gene expression in TNBS-induced colitis	24
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	23
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	23
Editorial Board	23
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	22
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	21
Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages	20
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	19
Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis	19
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	19
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	18
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	18
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	17
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	17
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	17
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	17
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	17
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	17
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	17
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	16
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	16

Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	16
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury	16
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	16
Seminal fluid expands the uterine gamma/delta T cell pool during early pregnancy in mice	16
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	16
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	15
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	15
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	15
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	15
Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling	15
Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism	15
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	15
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	14
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	14
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	14
Editorial Board	14
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	14
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	14
Shining the spotlight on urinary tract immunology	14
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	14
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma	13
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	13
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	13
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	13
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	13
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	13
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	13
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	13
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	13
CD39 regulates P2RX7-mediated lung necrotic lesions in severe experimental tuberculosis	12
Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss	12
Tissue-specific immunity in helminth infections	12
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	12
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	12
Short-course intranasal LAT9997 therapy limits post-influenza bacterial pneumonia by recalibrating lung immunity	12
Editorial Board	12
How the early life microbiome shapes immune programming in childhood asthma and allergies	12
Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction	12
Sensory neuroimmune interactions at the barrier	12