OOIR: Observatory of International Research

Papers

(The TQCC of Mucosal Immunology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	249
Memorial for Nils Lycke	210
Editorial Board	196
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	188
Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection	149
Editorial Board	140
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	124
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	103
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy	100
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	96
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	91
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	89
α4β7 expression guides B cells to front lines of defense in the gut	80
The fellowship of regulatory and tissue-resident memory cells	80
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	70
Response to Lauro and Zorzetti	69
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	65
Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction	64
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	64
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	63
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	60
Role of the humoral immune response during COVID-19: guilty or not guilty?	58
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	55
Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue	53
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	53

“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	50
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	50
Tissue resident memory T cells in the respiratory tract	49
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	46
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	45
Microbial regulation of intestinal motility provides resistance against helminth infection	43
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	43
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	42
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	41
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	40
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	38
NOD1 signaling regulates early tissue inflammation during helminth infection	38
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	38
COVID-19—from mucosal immunology to IBD patients	38
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	37
Mast cells disrupt the function of the esophageal epithelial barrier	36
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	36
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	35
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	35
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	35
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	34
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	34
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	33
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	33
Organismal mucosal immunology: A perspective through the eyes of game theory	32
Microbial antigen in human milk: a natural vaccine?	31
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	31
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	30
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	30
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	29
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	28
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	27
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	27
Chronological maturation of the skin immune barrier is topographically different	27
Airway epithelial cells as drivers of severe asthma pathogenesis	27
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	26
Impaired neutrophil migration underpins host susceptibility to infectious colitis	26
HIV-1 subverts the complement system in semen to enhance viral transmission	25
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	25
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	25
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation	25
Ileal mucus viscoelastic properties differ in Crohn’s disease	24
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	24
Caution regarding interpretations of intrauterine γ/δ T cells in protection against experimental vaginal candidiasis	24
Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches	24
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	24
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	24
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	24

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	23
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	23
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	23
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	23
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	23
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	22
NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis	22
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	22
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice	21
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	21
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	21
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	21
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	21
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation	20
Human mucosal tissue-resident memory T cells in health and disease	20
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	20
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	19
Neutrophils in respiratory viral infections	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	19
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	19
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	19
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	19
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	19
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	19
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	19
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	18
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	18
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	18
Editorial Board	18
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	18
Shining the spotlight on urinary tract immunology	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	18
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	17
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	17
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	17
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	17
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	16
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	16
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	16
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	16
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	16
The human memory T cell compartment changes across tissues of the female reproductive tract	16