Mucosal Immunology

Article	Citations
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	249
Memorial for Nils Lycke	210
Editorial Board	196
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	188
Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection	149
Editorial Board	140
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	124
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	103
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy	100
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	96
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	91
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	89
α4β7 expression guides B cells to front lines of defense in the gut	80
The fellowship of regulatory and tissue-resident memory cells	80
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	70
Response to Lauro and Zorzetti	69
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	65
Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction	64
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	64
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	63
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	60
Role of the humoral immune response during COVID-19: guilty or not guilty?	58
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	55
Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue	53
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	53

“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	50
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	50
Tissue resident memory T cells in the respiratory tract	49
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	46
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	45
Microbial regulation of intestinal motility provides resistance against helminth infection	43
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	43
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	42
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	41
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	40
COVID-19—from mucosal immunology to IBD patients	38
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	38
NOD1 signaling regulates early tissue inflammation during helminth infection	38
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	38
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	37
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	36
Mast cells disrupt the function of the esophageal epithelial barrier	36
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	35
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	35
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	35
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	34
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	34
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	33
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	33
Organismal mucosal immunology: A perspective through the eyes of game theory	32
Microbial antigen in human milk: a natural vaccine?	31
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	31
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	30
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	30
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	29
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	28
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	27
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	27
Chronological maturation of the skin immune barrier is topographically different	27
Airway epithelial cells as drivers of severe asthma pathogenesis	27
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	26
Impaired neutrophil migration underpins host susceptibility to infectious colitis	26
HIV-1 subverts the complement system in semen to enhance viral transmission	25
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	25
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	25
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation	25
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	24
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	24
Ileal mucus viscoelastic properties differ in Crohn’s disease	24
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	24
Caution regarding interpretations of intrauterine γ/δ T cells in protection against experimental vaginal candidiasis	24
Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches	24
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	24

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	23
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	23
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	23
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	23
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	23
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	22
NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis	22
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	22
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice	21
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	21
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	21
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	21
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	21
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	20
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation	20
Human mucosal tissue-resident memory T cells in health and disease	20
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	19
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	19
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	19
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	19
Neutrophils in respiratory viral infections	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	19
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	19
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	19
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	19
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	18
Shining the spotlight on urinary tract immunology	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	18
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	18
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	18
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	18
Editorial Board	18
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	17
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	17
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	17
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	17
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	16
The human memory T cell compartment changes across tissues of the female reproductive tract	16
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	16
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	16
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	16
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	16
The role of retinoic acid in the production of immunoglobulin A	15
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	15
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes	15
Tissue-specific immunity in helminth infections	15
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	15
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	15
Editorial Board	15
How the early life microbiome shapes immune programming in childhood asthma and allergies	15
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone	15
KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo	15
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	14
Aiolos: a molecular guardian of type 2 innate immune cell residency and response	14
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life	14
Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD	14
Epithelial regulation of microbiota-immune cell dynamics	14
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ	14
Sensory neuroimmune interactions at the barrier	14
The IL-33-ILC2 pathway protects from amebic colitis	13
The impact of biological sex on diseases of the urinary tract	13
IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation	13
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation	13
Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections	13
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1	13
Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells	13
Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways	12
Editorial Board	12
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity	12
A pregnancy to remember: trained immunity of the uterine mucosae	12
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution	12
Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities	12
IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma	12
Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis	11
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response	11

Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas	11
Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α	11
Editorial Board	11
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity	11
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	10
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	10
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin	10
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity	10
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	10
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice	10
Neuromedin U promotes human type 2 immune responses	10
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD	10
Living on the edge: Mucus-associated microbes in the colon	9
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation	9
Antibiotic-induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice	9
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	9
Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection	9
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	9
Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions	9
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	9
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes	9
Cellular and functional heterogeneity of the airway epithelium	9
IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections	9
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	8
Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2	8
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease	8
Redefining intestinal immunity with single-cell transcriptomics	8
Correction to: Redefining intestinal immunity with single-cell transcriptomics	8
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8	8
Candida vaginitis: the importance of mitochondria and type I interferon signalling	8
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	8
Correction to: Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	8
Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy	8
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum	8
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	8
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights	8
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node	8
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	8
Correction to: Trained immunity in type 2 immune responses	8
MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation	8
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	8
The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection	8
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense	8
Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection	8
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses	8
Stem cell factor inhibition reduces Th2 inflammation and cellular infiltration in a mouse model of eosinophilic esophagitis	7
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in na	7
Microbiome-based interventions to modulate gut ecology and the immune system	7
Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells	7
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium	7
Emc3 maintains intestinal homeostasis by preserving secretory lineages	7
A reappraisal of IL-9 in inflammation and cancer	7
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses	7
PAD4 inhibition impacts immune responses in SARS-CoV-2 infection	7
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity	7
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages	7
Intestinal immunoregulation: lessons from human mendelian diseases	6
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils	6
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	6
Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease	6
Response to: “Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease”	6
Introduction to host microbiome symbiosis in health and disease	6
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	6
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection	6
STAT4 increases the phenotypic and functional heterogeneity of intestinal tissue-resident memory T cells	6
Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation	6
Dendritic cell functions in the inductive and effector sites of intestinal immunity	6
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine	6
Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice	6
Local complement activation and modulation in mucosal immunity	5
Regulation of tissue-resident memory T cells by the Microbiota	5
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	5
Regulation of intestinal immunity by dietary fatty acids	5
MAIT cells, guardians of skin and mucosa?	5
Skin immunity: dissecting the complex biology of our body's outer barrier	5
High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity	5
Atopic dermatitis and food allergy: More than sensitization	5
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism	5
Lung microbial-host interface through the lens of multi-omics	5
Mucosal-associated invariant T cells have therapeutic potential against ocular autoimmunity	5
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	5
Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases	5
RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition	5
The urothelium: a multi-faceted barrier against a harsh environment	5
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	5