Mucosal Immunology

Article	Citations
Mucosal-associated invariant T cells have therapeutic potential against ocular autoimmunity	237
Memorial for Nils Lycke	206
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity	191
Editorial Board	178
Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Crohn’s disease	141
Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases	138
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice	122
Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation	97
The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells	93
RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut	91
Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection	89
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	89
Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α	79
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	76
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	67
Neuromedin U promotes human type 2 immune responses	67
Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection	61
Effects of helminths on the human immune response and the microbiome	61
Editorial Board	60
α4β7 expression guides B cells to front lines of defense in the gut	57
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response	54
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution	52
T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet	51
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy	50
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine	50

Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	49
Editorial Board	47
Response to Lauro and Zorzetti	47
Editorial Board	44
Extracellular vesicles of Bacteroides uniformis induce M1 macrophage polarization and aggravate gut inflammation during weaning	43
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	41
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	40
Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas	39
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine	38
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	37
Mucosal immunity to poliovirus	35
Human mucosal tissue-resident memory T cells in health and disease	35
The fellowship of regulatory and tissue-resident memory cells	35
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD	34
Skin immunity: dissecting the complex biology of our body's outer barrier	34
Regulation of intestinal immunity by dietary fatty acids	33
ATG16L1 protects from interferon-γ-induced cell death in the small intestinal crypt	33
Editorial Board	31
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	31
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	31
Regulation of tissue-resident memory T cells by the Microbiota	31
Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn’s disease patients with a severe disease course	30
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	29
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	29
Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation	29
Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract	29
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	29
High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity	29
Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells	28
A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice	28
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation	28
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection	26
B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation	25
Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice	25
Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases	25
Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease	25
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	24
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	24
Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis	24
Atopic dermatitis and food allergy: More than sensitization	23
Dietary influence and immune balance: Regulating CD4+ IEL responses and MHCII in the gut	22
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	22
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	22
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity	22
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	22
Spatially separated epithelium-associated and lamina propria neutrophils present distinct functional identities in the inflamed colon mucosa	22
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	21
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	21
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients	21
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	21

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin	21
Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction	21
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity	21
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	21
Nur77 as a novel regulator of Paneth cell differentiation and function	20
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	20
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	20
MAIT cells, guardians of skin and mucosa?	20
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	20
Stress systems exacerbate the inflammatory response after corneal abrasion in sleep-deprived mice via the IL-17 signaling pathway	20
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation	20
Local complement activation and modulation in mucosal immunity	19
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism	19
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	19
Lung microbial-host interface through the lens of multi-omics	19
The urothelium: a multi-faceted barrier against a harsh environment	19
Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis	18
Sex-associated early-life viral innate immune response is transcriptionally associated with chromatin remodeling of type-I IFN-inducible genes	18
Neutrophils in respiratory viral infections	18
Role of the humoral immune response during COVID-19: guilty or not guilty?	18
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation	18
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	17
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs	17
Increased ocular plasma cells induce damaging α-synuclein+ microglia in autoimmune uveitis	17
Editorial Board	17
Cellular and functional heterogeneity of the airway epithelium	17
Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions	16
Correction: Cellular and functional heterogeneity of the airway epithelium	16
Antibiotic-induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice	16
IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections	16
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses	16
John Bienenstock Obituary	15
Editorial Board	15
Editorial Board	15
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	15
Guardians of the epithelium: macrophages protect against toxic fungal derivatives	15
Intestinal helminth infection transforms the CD4+ T cell composition of the skin	15
Microbial regulation of intestinal motility provides resistance against helminth infection	14
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	14
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy	14
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	14
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	14
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	14
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	14
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	14
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	14
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation	14
Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia	13
TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge	13
Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells	13
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	13
Editorial Board	13
Rhinovirus C causes heterogeneous infection and gene expression in airway epithelial cell subsets	13
Staphylococcus aureus specific lung resident memory CD4+ Th1 cells attenuate the severity of influenza virus induced secondary bacterial pneumonia	13
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	13
Western diet reduces small intestinal intraepithelial lymphocytes via FXR-Interferon pathway	13
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	12
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	12
Pulmonary immune profiling reveals common inflammatory endotypes of childhood wheeze and suppurative lung disease	12
Lung influenza virus-specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells	12
The kynurenine pathway regulated by intestinal innate lymphoid cells mediates postoperative cognitive dysfunction	12
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	12
Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses	11
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	11
Microbiota-derived butyrate inhibits cDC development via HDAC inhibition, diminishing their ability to prime T cells	11
Local antigen encounter promotes generation of tissue-resident memory T cells in the large intestine	11
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	11
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	11
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	11
Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin	11
Tissue resident memory T cells in the respiratory tract	11
A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection	11
Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue	11
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β	11
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	11
Exposure to environmental microbiota may modulate gut microbial ecology and the immune system	11
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	11
Bi-directional signaling between the intestinal epithelium and type-3 innate lymphoid cells regulates secretory dynamics and interleukin-22	10
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	10
A spotlight on heightened T cell complexity and relevance in mucosal tissues	10

Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease	10
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	10
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	10
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	10
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	10
mTOR signaling mediates ILC3-driven immunopathology	9
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	9
Expanded ILC2s in human infant intestines promote tissue growth	9
Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection	9
Systemically inoculated adjuvants stimulate pDC-dependent IgA response in local site	9
Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response	9
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	9
NOD1 signaling regulates early tissue inflammation during helminth infection	8
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	8
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	8
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	8
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses	8
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	8
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	8
Highly multiplexed cytokine analysis of bronchoalveolar lavage and plasma reveals age-related dynamics and correlates of inflammation in children	8
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection	8
Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn’s disease in a retinoic acid–deficient manner	8
Immune interventions in COVID-19: a matter of time?	7
Letter to the Editor on “CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile”	7
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	7
Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis	7
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	7
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node	7
The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis	7
Candida vaginitis: the importance of mitochondria and type I interferon signalling	7
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	7
Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection	7
Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling	7
Organismal mucosal immunology: A perspective through the eyes of game theory	7
Microbial antigen in human milk: a natural vaccine?	7
Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis	7
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	7
Editorial Board	7
Shining the spotlight on urinary tract immunology	7
It’s getting hot in here: The interface between obesity, influenza, and thermoneutrality	6
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	6
Inducible pluripotent stem cells to study human mast cell trajectories	6
A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cells	6
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	6
Salivary IgA and vimentin differentiate in vitro SARS-CoV-2 infection: A study of 290 convalescent COVID-19 patients	6
Bite-sized immunology; damage and microbes educating immunity at the gingiva	6
Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis	6
Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance	6
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8	6
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights	6
RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes	6
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	6
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	5
Corrigendum to “High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia” [Mucosal Immunol. 11(5) (2018) 1306–1315]	5
COVID-19—from mucosal immunology to IBD patients	5
Intestinal epithelium in early life	5
LAIR-1 limits macrophage activation in acute inflammatory lung injury	5
Mast cells disrupt the function of the esophageal epithelial barrier	5
Correction to: “Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease	5
Plectin ensures intestinal epithelial integrity and protects colon against colitis	5
A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation	5
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	5
Expansion of MAIT cells in the combined absence of NKT and γδ-T cells	5
FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression	5
Correction to: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	5
Dynamic regulation of innate lymphoid cell development during ontogeny	5
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	5
Correction to: Plectin ensures intestinal epithelial integrity and protects colon against colitis	5
Correction: Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	5
Controlling functional homeostasis of ileal resident macrophages by vitamin B12 during steady state and Salmonella infection in mice	5
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability	4
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	4
Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice	4
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes	4
Initiation of type 2 immunity at barrier surfaces	4
Glial-immune interactions in barrier organs	4
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation	4
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	4
Unfolded protein response factor ATF6 augments T helper cell responses and promotes mixed granulocytic airway inflammation	4
Maternal obesity associates with altered humoral immunity in blood and colostrum	4
Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation	4
The rise to power of the microbiome: power and sample size calculation for microbiome studies	4
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	4
Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium	4
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	4
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense	4
IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease	4
Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids	4
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	4
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice	4
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis	4
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	4
Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection	4
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	4
Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	4