Mucosal Immunology

Article	Citations
Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation	212
The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes	162
The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection	162
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function	153
Animal and translational models of SARS-CoV-2 infection and COVID-19	142
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection	142
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes	131
Cellular and functional heterogeneity of the airway epithelium	112
Introduction to host microbiome symbiosis in health and disease	95
Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression	89
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	83
Dietary fiber metabolites regulate innate lymphoid cell responses	78
The NLRP6 inflammasome in health and disease	76
Tissue resident memory T cells in the respiratory tract	74
MAIT cells, guardians of skin and mucosa?	63
Neutrophils in respiratory viral infections	63
Long-term maintenance of lung resident memory T cells is mediated by persistent antigen	62
IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia	60
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	54
Macrophage metabolic reprogramming during chronic lung disease	54
MAIT cell-directed therapy of Mycobacterium tuberculosis infection	54
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation	53
Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation	51
Seasonal and pandemic influenza: 100 years of progress, still much to learn	51
The emerging roles of eosinophils in mucosal homeostasis	51

Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	50
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	50
The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD	44
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice	44
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	44
Microbiome-based interventions to modulate gut ecology and the immune system	44
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	42
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile	42
Granulocytes act as a niche for Mycobacterium tuberculosis growth	41
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	40
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity	39
Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation	38
Host responses to mucosal biofilms in the lung and gut	38
IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection	38
Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis	37
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	36
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils	36
Intestinal epithelial cell metabolism at the interface of microbial dysbiosis and tissue injury	36
The development of colitis in Il10 mice is dependent on IL-22	36
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	35
The role of innate lymphoid cells in response to microbes at mucosal surfaces	35
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis	34
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa	34
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation	34
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis	33
The microbiome and host mucosal interactions in urinary tract diseases	32
Genetic influences on viral-induced cytokine responses in the lung	32
EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice	31
Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue	31
Dendritic cell functions in the inductive and effector sites of intestinal immunity	31
Mechanisms of activation of innate-like intraepithelial T lymphocytes	31
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	30
Mucosal immunity to poliovirus	30
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation	30
Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation	29
IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation	29
Human mucosal tissue-resident memory T cells in health and disease	28
PPARγ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2	27
Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection	27
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	26
The impact of biological sex on diseases of the urinary tract	26
Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease	26
Resistance of children to Covid-19. How?	26
MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice	26
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	25
Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity	25
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance	25
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	25
Mucosal immunology of the ocular surface	24
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus	24

NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis	24
Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection	23
Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium	23
Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-λ response in vivo and in enteroid cultures	23
Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment	23
Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation	23
Microbial modulation of intestinal T helper cell responses and implications for disease and therapy	23
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	22
Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection	22
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	22
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy	22
Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming	22
The urothelium: a multi-faceted barrier against a harsh environment	22
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa	21
Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice	21
LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus	21
Tissue-specific immunity in helminth infections	20
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation	20
Role of the humoral immune response during COVID-19: guilty or not guilty?	20
Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis	20
Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state	20
Maternal natural killer cells at the intersection between reproduction and mucosal immunity	19
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo	19
A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection	19
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD	19
A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA	19
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β	19
Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques	19
Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling	19
Self and microbiota-derived epitopes induce CD4+ T cell anergy and conversion into CD4+Foxp3+ regulatory cells	19
Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation	18
The human memory T cell compartment changes across tissues of the female reproductive tract	18
Plectin ensures intestinal epithelial integrity and protects colon against colitis	18
Skin immunity: dissecting the complex biology of our body's outer barrier	18
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection	18
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity	18
Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder	18
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	18
Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection	18
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	18
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation	17
The fellowship of regulatory and tissue-resident memory cells	17
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen	17
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	17
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity	17
Immunosurveillance of Candida albicans commensalism by the adaptive immune system	17
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone	17
Regulation of tissue-resident memory T cells by the Microbiota	17
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	17
A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins	17
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity	16
Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis	16
Effects of helminths on the human immune response and the microbiome	16
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	16
ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation	16
Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils	16
Intestinal epithelium in early life	16
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses	16
Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss	15
The CTA1-DD adjuvant strongly potentiates follicular dendritic cell function and germinal center formation, which results in improved neonatal immunization	15
Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis	15
The dialogue between unconventional T cells and the microbiota	15
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease	15
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	15
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients	15
The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15	15
Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance	15
A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cells	15
Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution	14
Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes	14
Immune interventions in COVID-19: a matter of time?	14
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	14
The role of retinoic acid in the production of immunoglobulin A	14
Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis	14
The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease	14
Plasma concentration of injectable contraceptive correlates with reduced cervicovaginal growth factor expression in South African women	14
mTOR signaling mediates ILC3-driven immunopathology	14
Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11blo to CD11bhi status during lung injury process	14
Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity	13
Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes	13

Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells	13
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	13
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin	13
Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids	13
Lung microbial-host interface through the lens of multi-omics	13
Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities	12
Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae	12
Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	12
T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet	12
The IL-33-ILC2 pathway protects from amebic colitis	12
Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection	12
Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma	12
“Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease	12
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8	12
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	12
Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response	11
TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge	11
Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation	11
B cells and the microbiota: a missing connection in food allergy	11
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	11
Redefining intestinal immunity with single-cell transcriptomics	11
Microbial regulation of intestinal motility provides resistance against helminth infection	11
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ	11
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	11
The rise to power of the microbiome: power and sample size calculation for microbiome studies	11
Infection with the enteric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node	10
The interplay between innate lymphoid cells and T cells	10
Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets	10
A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection	10
R848 or influenza virus can induce potent innate immune responses in the lungs of neonatal mice	10
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	10
NMP4 regulates the innate immune response to influenza A virus infection	10
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability	10
Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition	10
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation	9
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	9
Trained immunity in type 2 immune responses	9
Emc3 maintains intestinal homeostasis by preserving secretory lineages	9
DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-α-induced immunopathology	9
Liver X receptor regulates Th17 and RORγt+ Treg cells by distinct mechanisms	9
MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells	9
Intestinal immunoregulation: lessons from human mendelian diseases	9
Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease	9
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium	9
Adrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy	9
Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation	9
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	9
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils	9
Aiolos regulates eosinophil migration into tissues	9
Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice	9
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine	9
HIV-1 subverts the complement system in semen to enhance viral transmission	8
Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11	8
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	8
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	8
Stromal regulation of the intestinal barrier	8
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life	8
Mast cells disrupt the function of the esophageal epithelial barrier	8
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection	8
Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction	8
Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals	8
HIV transmitting mononuclear phagocytes; integrating the old and new	8
COVID-19—from mucosal immunology to IBD patients	8
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation	8
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	7
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	7
Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium	7
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	7
IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue	7
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	7
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses	7
PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota	7
Niche rather than origin dysregulates mucosal Langerhans cells development in aged mice	7
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	7
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations	7
A ligand-independent fast function of RARα promotes exit from metabolic quiescence upon T cell activation and controls T cell differentiation	7