Mucosal Immunology

Article	Citations
Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation	245
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function	191
The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes	187
The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection	179
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection	175
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes	162
Animal and translational models of SARS-CoV-2 infection and COVID-19	146
Cellular and functional heterogeneity of the airway epithelium	145
Introduction to host microbiome symbiosis in health and disease	115
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	110
Tissue resident memory T cells in the respiratory tract	98
Dietary fiber metabolites regulate innate lymphoid cell responses	89
MAIT cells, guardians of skin and mucosa?	74
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	73
Neutrophils in respiratory viral infections	71
Long-term maintenance of lung resident memory T cells is mediated by persistent antigen	69
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	64
Microbiome-based interventions to modulate gut ecology and the immune system	63
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	63
Macrophage metabolic reprogramming during chronic lung disease	62
MAIT cell-directed therapy of Mycobacterium tuberculosis infection	61
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	57
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation	56
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	56
Intestinal epithelial cell metabolism at the interface of microbial dysbiosis and tissue injury	54

Granulocytes act as a niche for Mycobacterium tuberculosis growth	53
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice	51
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile	48
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity	48
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils	47
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	45
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	43
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation	41
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	40
Skin immunity: dissecting the complex biology of our body's outer barrier	39
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis	39
IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection	39
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	38
Dendritic cell functions in the inductive and effector sites of intestinal immunity	38
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	38
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis	38
The urothelium: a multi-faceted barrier against a harsh environment	38
The impact of biological sex on diseases of the urinary tract	37
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa	37
The microbiome and host mucosal interactions in urinary tract diseases	36
Genetic influences on viral-induced cytokine responses in the lung	36
Mucosal immunology of the ocular surface	36
EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice	35
Mucosal immunity to poliovirus	35
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation	35
IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation	34
Human mucosal tissue-resident memory T cells in health and disease	33
Tissue-specific immunity in helminth infections	33
Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease	33
Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue	32
NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis	31
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	30
PPARγ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2	30
Microbial modulation of intestinal T helper cell responses and implications for disease and therapy	30
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	29
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	29
Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium	29
Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection	29
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa	29
Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation	28
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus	28
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance	28
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	28
Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-λ response in vivo and in enteroid cultures	27
Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming	26
Role of the humoral immune response during COVID-19: guilty or not guilty?	26
Maternal natural killer cells at the intersection between reproduction and mucosal immunity	25
Self and microbiota-derived epitopes induce CD4+ T cell anergy and conversion into CD4+Foxp3+ regulatory cells	25
Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment	25
Immunosurveillance of Candida albicans commensalism by the adaptive immune system	25

Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection	25
Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice	24
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation	24
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β	23
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy	23
A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins	23
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	23
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease	22
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	22
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity	22
Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis	22
The human memory T cell compartment changes across tissues of the female reproductive tract	22
Intestinal epithelium in early life	22
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD	22
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen	21
Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes	21
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity	21
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	21
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	21
A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection	21
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	21
Microbial regulation of intestinal motility provides resistance against helminth infection	21
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo	20
Regulation of tissue-resident memory T cells by the Microbiota	20
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity	20
Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss	20
Effects of helminths on the human immune response and the microbiome	20
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	20
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection	20
Plectin ensures intestinal epithelial integrity and protects colon against colitis	20
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	20
The fellowship of regulatory and tissue-resident memory cells	20
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation	20
The role of retinoic acid in the production of immunoglobulin A	19
Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis	19
Trained immunity in type 2 immune responses	19
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	19
Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection	18
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses	18
The rise to power of the microbiome: power and sample size calculation for microbiome studies	18
Lung microbial-host interface through the lens of multi-omics	18
Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution	18
Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis	18
IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma	17
TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge	17
The dialogue between unconventional T cells and the microbiota	17
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients	17
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone	17
Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells	16
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	16
Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids	16
ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation	16
The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15	16
A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cells	16
Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity	16
Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation	15
The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease	15
Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities	15
mTOR signaling mediates ILC3-driven immunopathology	15
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin	15
“Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease	15
Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11blo to CD11bhi status during lung injury process	15
Redefining intestinal immunity with single-cell transcriptomics	14
Immune interventions in COVID-19: a matter of time?	14
Stromal regulation of the intestinal barrier	14
Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae	14
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	14
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ	14
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8	14
Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes	14
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life	13
Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	13
Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response	13
Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets	13
Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease	13
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	13
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	13
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	13
B cells and the microbiota: a missing connection in food allergy	13
T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet	13

HIV transmitting mononuclear phagocytes; integrating the old and new	12
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	12
The IL-33-ILC2 pathway protects from amebic colitis	12
Skin barrier immunology from early life to adulthood	12
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	12
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses	12
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability	12
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine	12
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	11
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	11
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	11
Emc3 maintains intestinal homeostasis by preserving secretory lineages	11
MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells	11
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	11
Intestinal immunoregulation: lessons from human mendelian diseases	11
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	11
Mast cells disrupt the function of the esophageal epithelial barrier	11
Neuromedin U promotes human type 2 immune responses	11
R848 or influenza virus can induce potent innate immune responses in the lungs of neonatal mice	11
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils	11
Infection with the enteric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node	11
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	11
Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium	10
HIV-1 subverts the complement system in semen to enhance viral transmission	10
COVID-19—from mucosal immunology to IBD patients	10
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation	10
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation	10
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium	10
A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection	10
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	10
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	10
NMP4 regulates the innate immune response to influenza A virus infection	10
DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-α-induced immunopathology	10
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	10
Liver X receptor regulates Th17 and RORγt+ Treg cells by distinct mechanisms	10
The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection	9
Regulation of intestinal immunity by dietary fatty acids	9
Glutaminolysis is required in maintaining immune regulatory functions in B cells	9
Staphylococcus aureus specific lung resident memory CD4+ Th1 cells attenuate the severity of influenza virus induced secondary bacterial pneumonia	9
Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation	9
Aiolos regulates eosinophil migration into tissues	9
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	9
Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction	9
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation	8
Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals	8
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations	8
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection	8
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	8
Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice	8
Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance	8
Expansion of MAIT cells in the combined absence of NKT and γδ-T cells	8
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	8
Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11	8
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	8
Intestinal helminth infection transforms the CD4+ T cell composition of the skin	8
iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis	7
Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches	7
The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis	7
A ligand-independent fast function of RARα promotes exit from metabolic quiescence upon T cell activation and controls T cell differentiation	7
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy	7
ATG16L1 protects from interferon-γ-induced cell death in the small intestinal crypt	7
Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation	7
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum	7
FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression	7
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	7
Rhinovirus C causes heterogeneous infection and gene expression in airway epithelial cell subsets	7
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	7
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	7
PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota	7
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	7
Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation	7
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	7
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation	7
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	6
Helios+ and RORγt+ Treg populations are differentially regulated by MHCII, CD28, and ICOS to shape the intestinal Treg pool	6
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	6
Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection	6
A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice	6
A pregnancy to remember: trained immunity of the uterine mucosae	6
CGRP inhibits human Langerhans cells infection with HSV by differentially modulating specific HSV-1 and HSV-2 entry mechanisms	6
Expanded ILC2s in human infant intestines promote tissue growth	6
Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling	6
Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis	6
Harnessing murine models of Crohn's disease ileitis to advance concepts of pathophysiology and treatment	6
Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections	6
Microbial antigen in human milk: a natural vaccine?	6