Translational Research

Article	Citations
Information for Readers	151
Contents	130
Author Guidelines	81
Contents	76
Information for Readers	71
Information for Readers	62
Editorial Advisory Board	62
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	61
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	55
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	51
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	47
Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury: An integrative RNA-Seq and network analysis	46
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	45
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	42
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	41
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	40
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	39
Clonal hematopoiesis and bone marrow inflammation	39
Masthead	37
Masthead	36
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	35
Understanding the adipose tissue acetylome in obesity and insulin resistance	35
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	34
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	34
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	33

GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	32
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	32
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	31
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	31
Kidney organoids: a pioneering model for kidney diseases	31
SynNotch-iNOS CAR-Macrophages Remodel the Tumor Immune Microenvironment and Exhibit Antitumor Efficacy via a CD4+ T Cell-Dependent Mechanism	31
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	30
Information for Readers	30
Editorial Advisory Board	29
Masthead	29
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	29
Editorial Advisory Board	28
Information for Readers	27
Contents	27
Contents	27
Editorial Advisory Board	27
Editorial Advisory Board	27
Masthead	26
Contents	26
Editorial Advisory Board	25
STIM1 deletion in regulatory T cells restores redox balance and protects against hypertension-induced cardiovascular complications	25
Angiogenic and reparative potency of a human cardiac CD90− mesenchymal subpopulation in heart ischemic model	25
FAK-TRIM25 promotes HSC activation and glycolysis by inhibiting c-Myc ubiquitination via FBXW7	25
Contents	25
Author Guidelines	24
Contents	24
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	24
Editorial Advisory Board	24
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	24
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	24
Masthead	23
Information for Readers	23
Information for Readers	23
Contents	23
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	22
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	22
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	22
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	22
Masthead	21
Author Guidelines	21
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	21
Author Guidelines	21
Contents	21
Contents	21
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	21
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	20
Contents	20
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	20
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	20
Effectiveness of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid for predicting metachronous peritoneal metastasis of gastric cancer	19

Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	19
Masthead	19
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	19
Author Guidelines	19
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	19
Contents	19
Inhibiting CCR3 expands cancer stem cells via c-Myc–NTSR1 axis and associates with tumor innervation features	19
Information for Readers	18
Information for Readers	18
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	18
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	18
Contents	18
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	18
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	17
Contents	17
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	17
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	17
Contents	17
Author Guidelines	17
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	17
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	17
Editorial Advisory Board	17
Intranasal application of adeno-associated viruses: a systematic review	17
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	16
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	16
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	16
Contents	16
Information for Readers	16
Contents	16
Contents	15
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	15
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	15
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	15
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	15
Contents	15
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	15
Masthead	14
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	14
Information for Readers	14
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	14
Masthead	14
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	14
Trimethylamine N-oxide exacerbates myocardial ischemia-reperfusion injury by sustaining PERK/eIF2α activation and impairing ferredoxin reductase-dependent mitochondrial function	14
Information for Readers	13
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	13
Contents	13
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	13
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	13
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	13
Author Guidelines	13
Masthead	13
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	13
Contents	13
Masthead	13
Topical captopril: a promising treatment for secondary lymphedema	12
Bronchoscopy-guided synergistic pulsed irreversible electroporation ablation as a novel intervention therapy for lung lesions: A pilot study in a preclinical model	12
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	12
Contents	12
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	12
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	12
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	12
Masthead	12
IgG from anti-MDA5⁺ CADM patients impairs NK cell function via CD16 in RP-ILD	12
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	12
Kv1.3 Modulates Macrophage M2 Polarization via the STAT3 Pathway: A Novel Mechanism and Therapeutic Target for Steroid-Resistant Asthma	12
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	12
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	12
Masthead	12
Gender-sex differences in autoimmune atrophic gastritis	12
Editorial Advisory Board	11
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	11
Editorial Advisory Board	11
Contents	11
Masthead	11
Contents	11
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	11
Immune cell distribution and DNA methylation signatures differ between tumor and stroma enriched compartment in pancreatic ductal adenocarcinoma	10
Masthead	10
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	10
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	10

The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway	10
Contents	10
The key role of cellular plasticity in the development of colorectal cancer	10
Single-cell and spatial transcriptomic colocalization analysis reveals the roles of histone deacetylation in lung adenocarcinoma progression and microenvironment	10
Contents	10
Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypes	10
Information for Readers	10
Unraveling PANoptosis a key player in acute kidney injury and its clinical implications	10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease	10