Translational Research

Article	Citations
Information for Readers	107
Contents	106
Author Guidelines	106
Clonal hematopoiesis and bone marrow inflammation	86
Contents	62
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	59
Editorial Advisory Board	57
Information for Readers	56
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	56
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	53
Editorial Advisory Board	53
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	51
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	49
Information for Readers	49
Contents	48
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	46
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	46
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	45
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	45
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	38
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	35
Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury: An integrative RNA-Seq and network analysis	33
Masthead	32
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	31
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	31

Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	30
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	29
COVID-19 Survival and its impact on chronic kidney disease	29
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	29
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	29
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	29
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	28
Author Guidelines	28
Kidney organoids: a pioneering model for kidney diseases	28
Understanding the adipose tissue acetylome in obesity and insulin resistance	27
Contents	27
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	27
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	26
Information for Readers	26
Editorial Advisory Board	25
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	25
Information for Readers	25
Masthead	25
Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery	25
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	25
Angiogenic and reparative potency of a human cardiac CD90− mesenchymal subpopulation in heart ischemic model	24
Editorial Advisory Board	24
Editorial Advisory Board	24
Contents	24
Contents	24
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	24
Contents	22
Editorial Advisory Board	22
Post-COVID-19 patients show an increased endothelial progenitor cell production	22
Information for Readers	22
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	22
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	21
Masthead	21
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	20
Author Guidelines	20
Information for Readers	20
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	20
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	20
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	20
Contents	19
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	19
Information for Readers	19
Contents	19
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	19
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	19
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	19
Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 (“CRS-1”)	19
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	19
Masthead	19
Information for Readers	19

Masthead	18
Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin	18
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	18
Masthead	18
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	18
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	18
Contents	17
Author Guidelines	17
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	17
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	17
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	17
Author Guidelines	17
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	17
Contents	16
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	16
Contents	16
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	16
Contents	16
Effectiveness of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid for predicting metachronous peritoneal metastasis of gastric cancer	16
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	16
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	15
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	15
Author Guidelines	15
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	15
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	15
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	15
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	15
Masthead	15
Intranasal application of adeno-associated viruses: a systematic review	14
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	14
Contents	14
Contents	14
Author Guidelines	14
Contents	14
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	14
Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use – an exploratory study	14
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	14
Information for Readers	14
Contents	14
Editorial Advisory Board	14
Contents	14
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	14
Information for Readers	13
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	13
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	13
Contents	13
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	13
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	13
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	12
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	12
Information for Readers	12
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	12
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	12
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	12
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	12
Information for Readers	12
Contents	12
Information for Readers	12
Masthead	12
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	12
Contents	12
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	12
Editorial Advisory Board	11
Contents	11
Masthead	11
Masthead	11
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	11
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	11
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	11
Author Guidelines	11
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	11
Masthead	11
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	11
Topical captopril: a promising treatment for secondary lymphedema	11
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	11
Contents	11
Contents	11
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	11
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	11
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	10

SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	10
Gender-sex differences in autoimmune atrophic gastritis	10
Masthead	10
Masthead	10
Editorial Advisory Board	10
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	10
Editorial Advisory Board	10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10