Translational Research

Article	Citations
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases	1678
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome	241
Macrophage polarization and diabetic wound healing	203
TMAO: how gut microbiota contributes to heart failure	112
New tuberculosis drug targets, their inhibitors, and potential therapeutic impact	96
Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model	89
miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer	86
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients	85
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort	73
New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter	71
Immune responses to injury and their links to eye disease	69
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	67
Oral wound healing models and emerging regenerative therapies	64
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease	64
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	63
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet	60
Pathogenesis of heparin-induced thrombocytopenia	60
Microvascular thrombosis: experimental and clinical implications	59
Frailty and cognitive decline	55
Frailty and aging in cancer survivors	51
Mechanisms and biomarkers of cancer-associated thrombosis	48
Topical application of bacteriophages for treatment of wound infections	48
Cutaneous innervation in impaired diabetic wound healing	46
Antiphospholipid syndrome	45
Targeting T-type/CaV3.2 channels for chronic pain	43

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?	43
Next-generation direct-acting influenza therapeutics	42
Diabetic wound healing in soft and hard oral tissues	41
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	40
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study	39
Long and short non-coding RNA and radiation response: a review	35
Cellular senescence in age-related disorders	34
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease	34
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome	33
Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers	32
Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF	31
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future	31
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host	31
Sex related differences in the pathogenesis of organ fibrosis	31
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms	31
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	31
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy	30
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions	30
Development of oncolytic viruses for cancer therapy	30
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	30
Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury	28
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	27
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	27
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury	27
NLRP3 inflammasome in neurodegenerative disease	26
Inflammasome signaling in colorectal cancer	26
RETRACTED: Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation	26
Vascular contributions to Alzheimer's disease	26
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	26
Evaluating for-profit public benefit corporations as an additional structure for antibiotic development and commercialization	26
The use of fecal microbiota transplant in sepsis	26
Form follows function: The endothelial glycocalyx	25
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	25
Gene therapy for bone healing: lessons learned and new approaches	24
Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients	24
Biphasic effect of metformin on human cardiac energetics	23
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	23
Transcription factor HIF1α promotes proliferation, migration, and invasion of cholangiocarcinoma via long noncoding RNA H19/microRNA-612/Bcl-2 axis	22
Role of senescence in the chronic health consequences of COVID-19	22
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	22
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	21
COVID-19 Survival and its impact on chronic kidney disease	21
The gut microbiome and frailty	21
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	21
Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition	21
Brain mechanisms of chronic pain: critical role of translational approach	21
Vaccines to prevent genital herpes	21
Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases	20
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients	20
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients	20

Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	20
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae	20
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats	19
Antisense antibacterial compounds	19
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis	19
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier	19
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	19
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	18
IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung	18
Central nervous system outcomes of COVID-19	18
Inflammatory arthritis in patients with COVID-19	18
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection	18
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	18
Inflammasome activation in traumatic brain injury and Alzheimer's disease	18
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis	17
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	17
Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome	17
The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility	17
Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases	17
Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease	17
Role of placental fibrinogen-like protein 1 in gestational diabetes	17
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	16
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats	16
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	16
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	15
Genetics of frailty: A longevity perspective	15
A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer	15
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional	15
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions	15
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy	15
Influence of immunomodulatory drugs on the gut microbiota	14
Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy	14
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	14
Pathobiology of frailty in lung disease	14
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	14
Back and neck pain: in support of routine delivery of non-pharmacologic treatments as a way to improve individual and population health	14
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer	14
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	14
Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study	13
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice	13
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis	13
New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae	13
Therapeutic Vaccines for the Treatment of HIV	13
Methodological approaches for the prediction of opioid use-related epidemics in the United States: a narrative review and cross-disciplinary call to action	13
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	13
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	12
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo	12
Trehalose as quantitative biomarker for in vivo diagnosis and treatment follow-up in cryptococcomas	12
An mRNA vaccine to prevent genital herpes	12
Venous thrombosis of the liver: current and emerging concepts in management	12
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge	12
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway	12
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	12
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen	12
Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea	12
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls	12
Formulation of host-targeted therapeutics against bacterial infections	12
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	12
Serum levels of the soluble urokinase plasminogen activator receptor (suPAR) correlates with disease activity in early rheumatoid arthritis and reflects joint damage over time	11
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene	11
Immunity, immunotherapy, and rectal cancer: A clinical and translational science review	11
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis	11
Inflammasomes as mediators of inflammation in HIV-1 infection	11
Innovative highlights of clinical drug trial design	11
Pathogenic implications of dysregulated miRNAs in propionic acidemia related cardiomyopathy	11
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota	11
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling	11
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease	11
MicroRNA expression profiling in acute kidney injury	11
Post-COVID-19 patients show an increased endothelial progenitor cell production	11
Kidney organoids: a pioneering model for kidney diseases	11
Pain in sickle cell disease: current and potential translational therapies	11
Fibrinolytics for the treatment of pulmonary embolism	11
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	11
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	11
Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: A five-year follow-up of the AChPOL registry, with special focus on patients	11
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies	11
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	11
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors	11
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type	11

MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	11
MicroRNA Expression Profiling in Diabetic Kidney Disease	10
Intertwined pathways of complement activation command the pathogenesis of lupus nephritis	10
Emerging molecular mediators and targets for age-related skeletal muscle atrophy	10
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis	10
Current opinion and emerging trends on the treatment, diagnosis, and prevention of pregnancy-associated venous thromboembolic disease: a review	10
Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors	10
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	10
PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity	10
The embedded researcher model in Australian healthcare settings: comparison by degree of “embeddedness”	10
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	10
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	10
Engineering approaches for cardiac organoid formation and their characterization	10
Advances in mRNA and other vaccines against MERS-CoV	10
Venous thromboembolism in people living with HIV infection (PWH)	10
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	10
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	10
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	10
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia	9
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	9
Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia	9
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge	9
CD11b agonists offer a novel approach for treating lupus nephritis	9
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	9
Retinal organoid light responsivity: current status and future opportunities	9