Translational Research

Article	Citations
Macrophage polarization and diabetic wound healing	297
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome	250
TMAO: how gut microbiota contributes to heart failure	143
miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer	100
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients	100
Immune responses to injury and their links to eye disease	85
Oral wound healing models and emerging regenerative therapies	83
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort	83
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	77
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease	70
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	69
Pathogenesis of heparin-induced thrombocytopenia	67
Microvascular thrombosis: experimental and clinical implications	66
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet	65
Cutaneous innervation in impaired diabetic wound healing	60
Targeting T-type/CaV3.2 channels for chronic pain	56
Mechanisms and biomarkers of cancer-associated thrombosis	56
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	55
Antiphospholipid syndrome	54
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?	51
Diabetic wound healing in soft and hard oral tissues	50
Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF	48
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study	42
Cellular senescence in age-related disorders	40
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	39

NLRP3 inflammasome in neurodegenerative disease	38
Long and short non-coding RNA and radiation response: a review	37
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease	37
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy	36
Vascular contributions to Alzheimer's disease	36
Development of oncolytic viruses for cancer therapy	35
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms	34
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	34
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future	33
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	33
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	32
Gene therapy for bone healing: lessons learned and new approaches	32
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions	32
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	32
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	31
Inflammasome activation in traumatic brain injury and Alzheimer's disease	31
Brain mechanisms of chronic pain: critical role of translational approach	31
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	30
Form follows function: The endothelial glycocalyx	30
Inflammasome signaling in colorectal cancer	30
Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury	29
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	29
RETRACTED: Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation	29
The use of fecal microbiota transplant in sepsis	29
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	29
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury	28
Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients	28
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy	27
COVID-19 Survival and its impact on chronic kidney disease	27
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	25
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	25
Biphasic effect of metformin on human cardiac energetics	24
Role of senescence in the chronic health consequences of COVID-19	24
Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases	24
An mRNA vaccine to prevent genital herpes	24
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	24
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	24
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier	23
Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition	22
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients	22
Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease	22
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	22
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients	21
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	21
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats	21
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	21
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis	21
Central nervous system outcomes of COVID-19	20
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection	20
The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility	20

Advances in mRNA and other vaccines against MERS-CoV	19
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional	19
IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung	19
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	19
MicroRNA expression profiling in acute kidney injury	19
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	19
Inflammatory arthritis in patients with COVID-19	18
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats	18
Engineering approaches for cardiac organoid formation and their characterization	18
Influence of immunomodulatory drugs on the gut microbiota	18
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis	17
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice	17
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	17
Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome	17
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene	17
Kidney organoids: a pioneering model for kidney diseases	17
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota	17
Back and neck pain: in support of routine delivery of non-pharmacologic treatments as a way to improve individual and population health	17
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors	17
A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer	16
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	16
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer	16
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	16
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions	16
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	16
Pain in sickle cell disease: current and potential translational therapies	16
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	16
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge	16
Trehalose as quantitative biomarker for in vivo diagnosis and treatment follow-up in cryptococcomas	16
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	16
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	15
Fibrinolytics for the treatment of pulmonary embolism	15
Post-COVID-19 patients show an increased endothelial progenitor cell production	15
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	15
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	15
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	15
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	14
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	14
CD11b agonists offer a novel approach for treating lupus nephritis	14
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	14
Methodological approaches for the prediction of opioid use-related epidemics in the United States: a narrative review and cross-disciplinary call to action	14
Protein glycosylation in urine as a biomarker of diseases	14
Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study	14
MicroRNA Expression Profiling in Diabetic Kidney Disease	13
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis	13
Inflammasomes as mediators of inflammation in HIV-1 infection	13
Serum levels of the soluble urokinase plasminogen activator receptor (suPAR) correlates with disease activity in early rheumatoid arthritis and reflects joint damage over time	13
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen	13
Retinal organoid light responsivity: current status and future opportunities	13
Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea	13
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway	13
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	13
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	13
Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors	12
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	12
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls	12
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway	12
Venous thrombosis of the liver: current and emerging concepts in management	12
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	12
Nf1 heterozygous mice recapitulate the anthropometric and metabolic features of human neurofibromatosis type 1	12
Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: A five-year follow-up of the AChPOL registry, with special focus on patients	12
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies	12
Gender-sex differences in autoimmune atrophic gastritis	12
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis	12
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage	12
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	12
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)	12
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling	12
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	12
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	12
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type	12
Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation	11
Intertwined pathways of complement activation command the pathogenesis of lupus nephritis	11
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	11
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors	11
Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and α7 nicotinic receptor expression	11
Immunity, immunotherapy, and rectal cancer: A clinical and translational science review	11
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis	11
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models	11
Venous thromboembolism in people living with HIV infection (PWH)	11

Current opinion and emerging trends on the treatment, diagnosis, and prevention of pregnancy-associated venous thromboembolic disease: a review	11
Skeletal muscle MiR-210 expression is associated with mitochondrial function in peripheral artery disease patients	10
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway	10
The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1	10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	10
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge	10
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease	10
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta	10
New mechanistic insights to PLOD1-mediated human vascular disease	10
The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology	10
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia	10
Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons	10
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease	10
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	10
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	9
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	9
Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer	9
Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study)	9
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	9
PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4	9
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles	9
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	9
The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats	9
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions	9
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity	9
Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori	9
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	9
Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis	9
Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function	9
Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells	9
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-1	9