Translational Research

Article	Citations
Information for Readers	474
Information for Readers	140
Editorial Advisory Board	131
Author Guidelines	112
Contents	103
Editorial Advisory Board	99
Information for Readers	98
Contents	98
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	92
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	80
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	74
Author Guidelines	54
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	53
Contents	53
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	53
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	53
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	51
Clonal hematopoiesis and bone marrow inflammation	50
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	49
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	48
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	46
Diabetic wound healing in soft and hard oral tissues	45
Masthead	44
Author Guidelines	44
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	44

COVID-19 Survival and its impact on chronic kidney disease	43
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	43
Kidney organoids: a pioneering model for kidney diseases	41
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	34
Understanding the adipose tissue acetylome in obesity and insulin resistance	33
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	32
Contents	31
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	31
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	31
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	28
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	28
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	27
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	27
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	26
Post-COVID-19 patients show an increased endothelial progenitor cell production	26
Information for Readers	26
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	25
Contents	25
Masthead	25
Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery	25
Masthead	25
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	25
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	25
Editorial Advisory Board	25
Editorial Advisory Board	24
Information for Readers	24
Information for Readers	24
Editorial Advisory Board	23
Editorial Advisory Board	23
Contents	23
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	23
Contents	23
Contents	22
Angiogenic and reparative potency of a human cardiac CD90− mesenchymal subpopulation in heart ischemic model	22
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	22
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	22
Masthead	22
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	22
Information for Readers	21
Information for Readers	21
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	20
Author Guidelines	20
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	20
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	20
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	20
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	19
Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 (“CRS-1”)	19
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	19
Information for Readers	18
Masthead	18

Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	18
Contents	18
Author Guidelines	18
Contents	18
Masthead	18
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	18
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	18
Author Guidelines	18
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	18
Contents	18
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	17
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	17
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	17
Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin	17
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	17
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	17
Effectiveness of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid for predicting metachronous peritoneal metastasis of gastric cancer	17
Information for Readers	16
Author Guidelines	16
Contents	16
Editorial Advisory Board	16
Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use – an exploratory study	15
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	15
Contents	15
Contents	15
Masthead	15
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	15
Contents	15
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	15
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	15
Contents	15
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	14
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	14
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	14
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	14
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	14
Author Guidelines	14
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	14
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	13
Contents	13
Editorial Advisory Board	13
Intranasal application of adeno-associated viruses: a systematic review	13
Contents	13
Information for Readers	13
Contents	13
Contents	13
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	12
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	12
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	12
Information for Readers	12
Information for Readers	12
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	12
Contents	12
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	12
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	12
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	12
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	12
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	12
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	12
Masthead	11
Contents	11
Contents	11
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	11
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	11
Author Guidelines	11
Masthead	11
Masthead	11
Contents	11
Topical captopril: a promising treatment for secondary lymphedema	11
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	11
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	11
Masthead	11
Editorial Advisory Board	11
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	11
Information for Readers	11
Editorial Advisory Board	10
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	10
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	10
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	10
Masthead	10

Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	10
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	10
Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells	10
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	10
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	10
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	10
Masthead	9
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	9
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	9
Gender-sex differences in autoimmune atrophic gastritis	9
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	9
Editorial Advisory Board	9
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	9
Editorial Advisory Board	9
Masthead	9
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	9
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	9
Information for Readers	9
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	9
Contents	9
Brain mechanisms of chronic pain: critical role of translational approach	9
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	9
Appreciation to reviewers	9
Gene therapy for bone healing: lessons learned and new approaches	9