Translational Research

Article	Citations
Macrophage polarization and diabetic wound healing	253
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome	248
TMAO: how gut microbiota contributes to heart failure	129
miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer	96
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients	92
Immune responses to injury and their links to eye disease	81
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort	77
New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter	76
Oral wound healing models and emerging regenerative therapies	74
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	73
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	66
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease	66
Pathogenesis of heparin-induced thrombocytopenia	64
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet	62
Frailty and cognitive decline	62
Microvascular thrombosis: experimental and clinical implications	61
Frailty and aging in cancer survivors	56
Mechanisms and biomarkers of cancer-associated thrombosis	55
Cutaneous innervation in impaired diabetic wound healing	52
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	51
Targeting T-type/CaV3.2 channels for chronic pain	48
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?	48
Antiphospholipid syndrome	48
Diabetic wound healing in soft and hard oral tissues	44
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study	41

Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF	39
Cellular senescence in age-related disorders	37
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease	36
Sex related differences in the pathogenesis of organ fibrosis	36
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	36
Long and short non-coding RNA and radiation response: a review	36
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy	35
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host	35
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms	34
Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers	33
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future	32
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions	32
Development of oncolytic viruses for cancer therapy	32
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	31
Vascular contributions to Alzheimer's disease	30
NLRP3 inflammasome in neurodegenerative disease	30
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	30
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	29
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	29
Inflammasome signaling in colorectal cancer	28
Gene therapy for bone healing: lessons learned and new approaches	28
Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury	28
RETRACTED: Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation	28
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury	28
The use of fecal microbiota transplant in sepsis	27
Brain mechanisms of chronic pain: critical role of translational approach	27
Form follows function: The endothelial glycocalyx	26
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	25
Biphasic effect of metformin on human cardiac energetics	25
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	25
Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients	25
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	25
Inflammasome activation in traumatic brain injury and Alzheimer's disease	24
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	24
COVID-19 Survival and its impact on chronic kidney disease	24
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	24
Transcription factor HIF1α promotes proliferation, migration, and invasion of cholangiocarcinoma via long noncoding RNA H19/microRNA-612/Bcl-2 axis	23
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy	23
The gut microbiome and frailty	23
Role of senescence in the chronic health consequences of COVID-19	23
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	22
Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition	22
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	22
Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases	22
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	22
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients	21
Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease	21
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis	21
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier	21
Antisense antibacterial compounds	20

Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients	20
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	20
Central nervous system outcomes of COVID-19	20
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats	20
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection	20
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	20
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis	18
Inflammatory arthritis in patients with COVID-19	18
IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung	18
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	18
The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility	18
Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases	18
Influence of immunomodulatory drugs on the gut microbiota	17
Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome	17
An mRNA vaccine to prevent genital herpes	17
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	17
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats	17
Genetics of frailty: A longevity perspective	17
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis	16
Therapeutic Vaccines for the Treatment of HIV	16
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	16
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	16
Advances in mRNA and other vaccines against MERS-CoV	16
Kidney organoids: a pioneering model for kidney diseases	16
A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer	16
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer	16
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors	16
Pathobiology of frailty in lung disease	15
Pain in sickle cell disease: current and potential translational therapies	15
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	15
Back and neck pain: in support of routine delivery of non-pharmacologic treatments as a way to improve individual and population health	15
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional	15
Engineering approaches for cardiac organoid formation and their characterization	15
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions	15
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge	15
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice	15
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	15
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene	15
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	14
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	14
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	14
Trehalose as quantitative biomarker for in vivo diagnosis and treatment follow-up in cryptococcomas	14
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	14
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	14
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	14
Serum levels of the soluble urokinase plasminogen activator receptor (suPAR) correlates with disease activity in early rheumatoid arthritis and reflects joint damage over time	13
Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study	13
Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea	13
Methodological approaches for the prediction of opioid use-related epidemics in the United States: a narrative review and cross-disciplinary call to action	13
Post-COVID-19 patients show an increased endothelial progenitor cell production	13
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	13
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo	13
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen	13
Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: A five-year follow-up of the AChPOL registry, with special focus on patients	12
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls	12
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway	12
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type	12
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	12
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota	12
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	12
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	12
Inflammasomes as mediators of inflammation in HIV-1 infection	12
Venous thrombosis of the liver: current and emerging concepts in management	12
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling	12
MicroRNA expression profiling in acute kidney injury	12
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis	12
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis	12
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	12
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	11
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease	11
Venous thromboembolism in people living with HIV infection (PWH)	11
Emerging molecular mediators and targets for age-related skeletal muscle atrophy	11
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway	11
Current opinion and emerging trends on the treatment, diagnosis, and prevention of pregnancy-associated venous thromboembolic disease: a review	11
MicroRNA Expression Profiling in Diabetic Kidney Disease	11
Immunity, immunotherapy, and rectal cancer: A clinical and translational science review	11
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	11
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	11
CD11b agonists offer a novel approach for treating lupus nephritis	11
Fibrinolytics for the treatment of pulmonary embolism	11

Intertwined pathways of complement activation command the pathogenesis of lupus nephritis	11
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	11
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies	11
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	11
Innovative highlights of clinical drug trial design	11
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	11
Skeletal muscle MiR-210 expression is associated with mitochondrial function in peripheral artery disease patients	10
PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity	10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge	10
Protein glycosylation in urine as a biomarker of diseases	10
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage	10
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia	10
Gender-sex differences in autoimmune atrophic gastritis	10
Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors	10
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	9
The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology	9
Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors	9
Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes	9
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis	9
Retinal organoid light responsivity: current status and future opportunities	9
Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and α7 nicotinic receptor expression	9
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)	9
New mechanistic insights to PLOD1-mediated human vascular disease	9
Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease	9
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors	9
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions	9
Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study)	9
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease	9
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity	8
Novel treatments for chronic pain: moving beyond opioids	8
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	8
Metformin and myocardial ischemia and reperfusion injury: Moving toward “prime time” human use?	8
Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease	8
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	8
Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells	8
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	8
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles	8
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	8
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	8
Cytokine signature of inflammation mediated by autoreactive Th-cells, in calf muscle of claudicating patients with Fontaine stage II peripheral artery disease	8
Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function	8
PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4	8
Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori	8
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy	8
Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities	8
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	8
Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold	8
Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pi	8
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models	8
Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems	7
Hormones and thrombosis: risk across the reproductive years and beyond	7
The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome	7
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	7
Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis	7
CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling	7
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	7
Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer	7
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	7
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells	7
Targeting DAMPs with nucleic acid scavengers to treat lupus	7
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	7
CD71 mesangial IgA1 receptor and the progression of IgA nephropathy	7
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	7
Effects of estrogen receptor signaling on prostate cancer carcinogenesis	7
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex	7
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	7
Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis	7
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway	7
Aldosterone suppresses cardiac mitochondria	7
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta	7
Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons	7
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-1	7
Pin1 and Alzheimer's disease	7
Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy	7
Next generation patient derived tumor organoids	7
Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation	7
The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats	7
Targeted inhibition of ZAK ameliorates renal interstitial fibrosis	7
The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1	6
MicroRNA and protein-coding gene expression analysis in idiopathic pulmonary fibrosis yields novel biomarker signatures associated to survival	6
Spectrins and human diseases	6
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects	6
Insights from experimental post-thrombotic syndrome and potential for novel therapies	6
Differential expression of members of SOX family of transcription factors in failing human hearts	6
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets	6
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	6
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	6
Topical captopril: a promising treatment for secondary lymphedema	6
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2	6
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling	6
Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma	6
Understanding the adipose tissue acetylome in obesity and insulin resistance	6
Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like phenotype	6
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	6