Translational Research

Article	Citations
Serum neurofilament light as a biomarker of vulnerability to a second mild traumatic brain injury	336
Next generation patient derived tumor organoids	108
Retinal organoid light responsivity: current status and future opportunities	108
Information for Readers	104
New Association Announcement - High-Impact Elsevier Journal and Leading Chinese Institute Join Forces	103
Masthead	77
Editorial Advisory Board	73
Information for Readers	71
Editorial Advisory Board	70
Contents	69
Clonal hematopoiesis and bone marrow inflammation	63
Contents	62
Masthead	58
Information for Readers	55
Contents	54
Contents	44
Editorial Advisory Board	42
Information for Readers	41
Contents	41
Author Guidelines	40
Editorial Advisory Board	40
Information for Readers	40
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer	38
Contents	36
Information for Readers	36

Contents	36
Editorial Advisory Board	35
Editorial Advisory Board	35
Masthead	35
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	35
Contents	34
Author Guidelines	34
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	33
Masthead	33
Masthead	32
Author Guidelines	30
Editorial Advisory Board	30
Contents	29
Contents	29
Contents	29
Contents	29
Circulating chaperones in patients with aortic valve stenosis undergoing TAVR: impact of concomitant chronic kidney disease	29
Glyburide confers neuroprotection against age-related macular degeneration (AMD)	28
Hypophosphatemia in acute liver failure of a broad range of etiologies is associated with phosphaturia without kidney damage or phosphatonin elevation	28
Topical delivery of mitogen-activated protein kinase inhibitor binimetinib prevents the development of cutaneous neurofibromas in neurofibromatosis type 1 mutant mice	28
TIR8 protects against nonalcoholic steatohepatitis by antagonizing lipotoxicity-induced PPARα downregulation and reducing the sensitivity of hepatocytes to LPS	26
Contents	25
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	25
PCSK9 inhibition protects mice from food allergy	25
Contents	24
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	24
Editorial Advisory Board	24
Information for Readers	24
The unveiled mosaic of intra-tumor heterogeneity in ovarian cancer through spatial transcriptomic technologies: A systematic review	22
Editorial Advisory Board	22
Chronic kidney disease and pulmonary hypertension: Progress in diagnosis and treatment	22
Contents	22
Assessing the impact of e-cigarettes on human barrier systems: A systematic review	22
Editorial Advisory Board	21
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	21
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	21
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	21
Contents	20
Author Guidelines	20
Author Guidelines	20
Contents	20
Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy	19
Diagnostic molecular markers predicting aggressive potential in low-grade prostate cancer	19
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	19
Author Guidelines	19
Masthead	19
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	19
Contents	19
Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators	18
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	18

Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	18
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors	18
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell	18
Vascular contributions to Alzheimer's disease	18
Engineering approaches for cardiac organoid formation and their characterization	18
Arginine methylation and respiratory disease	18
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex	17
Contents	17
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	17
Corrigendum to Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer [Translational Research 231C (202	17
Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression	16
Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice	16
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2	16
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	16
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	16
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	16
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	16
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	16
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	16
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	15
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	15
The effect of macrophage-targeted interventions on blood pressure – a systematic review and meta-analysis of preclinical studies	15
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	15
Fu's subcutaneous needling promotes axonal regeneration and remyelination by inhibiting inflammation and endoplasmic reticulum stress	15
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	15
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	14
Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice	14
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	14
Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities	14
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI	14
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	14
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	14
Diabetic wound healing in soft and hard oral tissues	13
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	13
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis	13
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	13
Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation	13
Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation	13
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	13
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	13
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	13
Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: Implications for improving treatment modalities	13
CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway	13
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage	13
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolem	12
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	12
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	12
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	12
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	12
Immune checkpoint activity exacerbate renal interstitial fibrosis progression by enhancing PD-L1 expression in renal tubular epithelial cells	12
Spectrins and human diseases	12
Information for Readers	12
Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma	12
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	12
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway	12
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy	12
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression	12
Masthead	11
A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism	11
Editorial Advisory Board	11
Recent advances in the development of transplanted colorectal cancer mouse models	11
Information for Readers	11
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	11
Editorial Advisory Board	11
Contents	11
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	11
The rare circulating tumor microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment	11
Masthead	11
Author Guidelines	11
Editorial Advisory Board	11
Author Guidelines	10
Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease	10
Contents	10
Contents	10
Contents	10
Information for Readers	10
Masthead	10
Information for Readers	10
Biotherapy of experimental acute kidney injury: emerging novel therapeutic strategies	10
Contents	10

Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy	10
Contents	10
Masthead	10
Masthead	10
Author Guidelines	10
A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma	9
Contents	9
Masthead	9
Editorial Advisory Board	9
Information for Readers	9
Contents	9
Contents	9
Contents	9
Information for Readers	9
Masthead	9
Masthead	9
Information for Readers	9
Author Guidelines	9
Author Guidelines	9
Contents	9
Contents	9
Contents	9
Author Guidelines	8
Contents	8
Author Guidelines	8
Editorial Advisory Board	8
Author Guidelines	8
Contents	8
Editorial Advisory Board	8
Contents	8
Information for Readers	8
Editorial Advisory Board	8
Editorial Advisory Board	8
Information for Readers	8
Contents	8
Author Guidelines	8
Author Guidelines	7
Author Guidelines	7
Information for Readers	7
AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG)	7
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen	7
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients	7
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	7
Masthead	7
Contents	7
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy	7
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	7
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	7
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type	7
Inflammatory arthritis in patients with COVID-19	7
Information for Readers	7
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	7
Author Guidelines	7
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	7
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	7
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	7
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	6
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	6
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	6
NLRP3 inflammasome in neurodegenerative disease	6
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	6
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	6
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis	6
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	6
Pain in sickle cell disease: current and potential translational therapies	6
Inflammasomes as mediators of inflammation in HIV-1 infection	6
Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis	6
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	6
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	6
Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy	6
COVID-19 Survival and its impact on chronic kidney disease	6
Aging increases circulating BH2 without modifying BH4 levels and impairs peripheral vascular function in healthy adults	6
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles	6
CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling	6
Pin1 and Alzheimer's disease	6
Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like phenotype	6
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	5
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice	5
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	5
Role of senescence in the chronic health consequences of COVID-19	5
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	5
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis	5
Understanding the adipose tissue acetylome in obesity and insulin resistance	5
Spleen derived monocytes regulate pulmonary vascular permeability in Hepatopulmonary syndrome through the OSM-FGF/FGFR1 signaling	5
Development of strategies for community engaged research dissemination by basic scientists: a case study	5
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	5
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	5
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	5
Lactate promotes bone healing by regulating the osteogenesis of bone marrow mesenchymal stem cells through activating Olfr1440	5
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	5
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects	5
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	5
Topical captopril: a promising treatment for secondary lymphedema	5
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	4
Editorial Advisory Board	4