Translational Research

Article	Citations
Information for Readers	146
Contents	126
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	79
Author Guidelines	75
Contents	63
Information for Readers	62
Information for Readers	61
Editorial Advisory Board	59
Clonal hematopoiesis and bone marrow inflammation	53
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	51
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	45
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	45
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	44
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	42
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	40
Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury: An integrative RNA-Seq and network analysis	38
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	38
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	37
Masthead	36
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	35
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	35
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	34
Masthead	34
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	34
Contents	33

Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	32
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	32
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	31
Understanding the adipose tissue acetylome in obesity and insulin resistance	30
Kidney organoids: a pioneering model for kidney diseases	30
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	30
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	30
Editorial Advisory Board	29
Masthead	29
Information for Readers	29
Editorial Advisory Board	28
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	28
Information for Readers	27
Contents	27
Contents	27
Editorial Advisory Board	27
Editorial Advisory Board	26
Masthead	26
Editorial Advisory Board	25
Contents	25
Angiogenic and reparative potency of a human cardiac CD90− mesenchymal subpopulation in heart ischemic model	25
Contents	24
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	24
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	23
STIM1 deletion in regulatory T cells restores redox balance and protects against hypertension-induced cardiovascular complications	23
Author Guidelines	23
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	23
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	23
Editorial Advisory Board	23
FAK-TRIM25 promotes HSC activation and glycolysis by inhibiting c-Myc ubiquitination via FBXW7	23
Information for Readers	22
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	22
Masthead	22
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	22
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	22
Contents	22
Information for Readers	22
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	21
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	21
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	21
Masthead	20
Author Guidelines	20
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	20
Author Guidelines	20
Contents	20
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	20
Contents	20
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	19
Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin	19
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	19

Effectiveness of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid for predicting metachronous peritoneal metastasis of gastric cancer	19
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	19
Contents	19
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	19
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	19
Masthead	18
Inhibiting CCR3 expands cancer stem cells via c-Myc–NTSR1 axis and associates with tumor innervation features	18
Contents	18
Author Guidelines	18
Contents	17
Information for Readers	17
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	17
Information for Readers	17
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	17
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	17
Editorial Advisory Board	16
Intranasal application of adeno-associated viruses: a systematic review	16
TSG-6 Exacerbates Myocardial Ischemia-Reperfusion Injury by Activating NLRP3 Inflammasome and Regulating Macrophage Polarization	16
Contents	16
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	16
Contents	16
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	16
Author Guidelines	16
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	16
Contents	16
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	16
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	16
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	16
Contents	15
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	15
Contents	15
Contents	15
Information for Readers	15
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	15
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	15
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	14
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	14
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	14
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	14
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	13
Author Guidelines	13
Trimethylamine N-oxide exacerbates myocardial ischemia-reperfusion injury by sustaining PERK/eIF2α activation and impairing ferredoxin reductase-dependent mitochondrial function	13
Information for Readers	13
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	13
Masthead	13
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	13
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	13
Bronchoscopy-guided synergistic pulsed irreversible electroporation ablation as a novel intervention therapy for lung lesions: A pilot study in a preclinical model	13
Contents	13
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	13
Trehalose-driven TFEB Activation Reprograms Immunosuppressive Macrophages in Glioblastoma	13
Masthead	12
Topical captopril: a promising treatment for secondary lymphedema	12
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	12
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	12
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	12
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	12
Masthead	12
Information for Readers	12
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	12
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	12
Contents	12
Masthead	12
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	12
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	12
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	12
Masthead	11
Editorial Advisory Board	11
Contents	11
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	11
Masthead	11
Editorial Advisory Board	11
Contents	11
Contents	11
Masthead	11
IgG from anti-MDA5⁺ CADM patients impairs NK cell function via CD16 in RP-ILD	11
Unraveling PANoptosis a key player in acute kidney injury and its clinical implications	10
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	10
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	10
The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway	10

The key role of cellular plasticity in the development of colorectal cancer	10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10
Contents	10
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	10
Gender-sex differences in autoimmune atrophic gastritis	10
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	10
Masthead	10
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease	9
Editorial Advisory Board	9
J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway	9
Author Guidelines	9
Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypes	9
Clonal hematopoiesis of indeterminate potential and cardiovascular disease	9
Contents	9
Editorial Advisory Board	9
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	9
Caspase-12 exhibits non-redundant functions in response to endoplasmic reticulum stress to promote GSDMD-mediated NETosis, leading to thoracic aortic dissection	9
Immune cell distribution and DNA methylation signatures differ between tumor and stroma enriched compartment in pancreatic ductal adenocarcinoma	9
Information for Readers	9
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	9
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta	9
Infectious agents in the pathogenesis of autoimmune rheumatic diseases	9
Information for Readers	8
Lympho-myeloid aggregate-infiltrating CD20+ B cells display a double-negative phenotype and correlate with poor prognosis in esophageal squamous cell carcinoma	8
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models	8
Mechanism of adipose-derived stem cell-derived extracellular vesicles affecting macrophage efferocytosis by mediating ADAM17/MerTK in the apoptosis of tubular epithelial cells after sepsis-associated	8
Importin-7 Facilitates Cervical Cancer Progression Through MSI2 Nuclear Import and Is Associated With MSI2–MYC–Linked Glycolytic Reprogramming	8
Editorial Advisory Board	8
Contents	8
Information for Readers	8
Author Guidelines	8
Contents	7
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	7
Author Guidelines	7
Contents	7
Masthead	7
The eicosanoid-cell death axis: A mechanistic review of crosstalk in health and disease	7
Information for Readers	7
PCSK9 inhibition protects mice from food allergy	6
Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma	6
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	6
Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation	6
Targeting lipid metabolism in CAFs: A therapeutic opportunity in solid tumors	6
Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury	6
Inflammasome signaling in colorectal cancer	6
Editorial Advisory Board	6
Masthead	6
Editorial Advisory Board	6
Masthead	6
Corrigendum to Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer [Translational Research 231C (202	6
Contents	6
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis	6
Masthead	6
Epigenetically-regulated miR-30a/c-5p directly target TWF1 and hamper ccRCC cell aggressiveness	6
Editorial Advisory Board	6
Author Guidelines	6
Editorial Advisory Board	6
Metabolic signatures in pericardial fluid and serum are associated with new-onset atrial fibrillation after isolated coronary artery bypass grafting	6
Harnessing innate lymphoid cells (ILCs) for cancer immunotherapy: A new frontier in precision immuno-oncology	6
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	6
Serum neurofilament light as a biomarker of vulnerability to a second mild traumatic brain injury	6
Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice	6
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	6
Editorial Advisory Board	6
Author Guidelines	6
Information for Readers	6
Contents	5
Contents	5
Author Guidelines	5
Information for Readers	5
CTLA-4 blockade improves antifungal treatment outcomes in a murine model of pulmonary paracoccidioidomycosis	5
Editorial Advisory Board	5
Contents	5
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice	5
The rare circulating tumor microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment	5
Masthead	5
Contents	5
Information for Readers	5
Adult hypertensive rats are more prone to gut microflora perturbation and fibrosis in response to moderate restraint stress	5
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy	5
Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function	4
Cardioprotective effects of PARP Inhibitors: A meta-analysis of animal studies	4
Masthead	4
Contents	4
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-1	4
Pharmacologic blockade of the natriuretic peptide clearance receptor promotes weight loss and enhances insulin sensitivity in type 2 diabetes	4
Editorial Advisory Board	4
Contents	4
Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review	4
Microsatellite instability in non-endometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes	4
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway	4
Information for Readers	4
Editorial Advisory Board	4
Masthead	4
Integrating plasma proteomics and cytokine profiles identifies immunopathogenic biomarkers for early acute-stage ANE in children	4