Translational Research

(The median citation count of Translational Research is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases1688
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome247
Macrophage polarization and diabetic wound healing238
TMAO: how gut microbiota contributes to heart failure126
New tuberculosis drug targets, their inhibitors, and potential therapeutic impact101
miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer94
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients89
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort77
Immune responses to injury and their links to eye disease76
New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter76
Oral wound healing models and emerging regenerative therapies73
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?70
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies66
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease66
Pathogenesis of heparin-induced thrombocytopenia63
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet61
Microvascular thrombosis: experimental and clinical implications60
Frailty and cognitive decline60
Frailty and aging in cancer survivors55
Mechanisms and biomarkers of cancer-associated thrombosis52
Topical application of bacteriophages for treatment of wound infections51
Cutaneous innervation in impaired diabetic wound healing49
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials49
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?47
Antiphospholipid syndrome47
Targeting T-type/CaV3.2 channels for chronic pain46
Diabetic wound healing in soft and hard oral tissues43
Next-generation direct-acting influenza therapeutics42
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study41
Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF37
Cellular senescence in age-related disorders37
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease36
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities36
Long and short non-coding RNA and radiation response: a review36
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host35
Sex related differences in the pathogenesis of organ fibrosis34
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy33
Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers33
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions32
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms32
Development of oncolytic viruses for cancer therapy32
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future31
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling31
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora30
Vascular contributions to Alzheimer's disease30
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage29
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises29
RETRACTED: Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation28
Inflammasome signaling in colorectal cancer28
Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury28
The use of fecal microbiota transplant in sepsis27
NLRP3 inflammasome in neurodegenerative disease27
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury27
Evaluating for-profit public benefit corporations as an additional structure for antibiotic development and commercialization27
Form follows function: The endothelial glycocalyx26
Gene therapy for bone healing: lessons learned and new approaches26
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer25
Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients25
COVID-19 Survival and its impact on chronic kidney disease24
Biphasic effect of metformin on human cardiac energetics24
Brain mechanisms of chronic pain: critical role of translational approach24
Role of senescence in the chronic health consequences of COVID-1923
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation23
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis23
Transcription factor HIF1α promotes proliferation, migration, and invasion of cholangiocarcinoma via long noncoding RNA H19/microRNA-612/Bcl-2 axis23
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer23
Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition22
Inflammasome activation in traumatic brain injury and Alzheimer's disease22
Vaccines to prevent genital herpes22
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury22
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy22
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities22
The gut microbiome and frailty22
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets22
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae21
Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease21
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier21
Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases21
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis21
Antisense antibacterial compounds20
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats20
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics20
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection20
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients20
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients20
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization20
Central nervous system outcomes of COVID-1919
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway19
The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility18
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis18
Inflammatory arthritis in patients with COVID-1918
IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung18
Influence of immunomodulatory drugs on the gut microbiota17
Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases17
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data17
Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome17
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells17
A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer16
Therapeutic Vaccines for the Treatment of HIV16
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis16
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study16
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats16
Advances in mRNA and other vaccines against MERS-CoV16
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene15
Pathobiology of frailty in lung disease15
An mRNA vaccine to prevent genital herpes15
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation15
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions15
Back and neck pain: in support of routine delivery of non-pharmacologic treatments as a way to improve individual and population health15
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional15
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors15
Genetics of frailty: A longevity perspective15
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study15
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge15
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer15
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients15
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research14
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice14
Trehalose as quantitative biomarker for in vivo diagnosis and treatment follow-up in cryptococcomas14
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies14
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner14
Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea13
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo13
Post-COVID-19 patients show an increased endothelial progenitor cell production13
Pain in sickle cell disease: current and potential translational therapies13
Engineering approaches for cardiac organoid formation and their characterization13
Serum levels of the soluble urokinase plasminogen activator receptor (suPAR) correlates with disease activity in early rheumatoid arthritis and reflects joint damage over time13
Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study13
Formulation of host-targeted therapeutics against bacterial infections13
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels13
Methodological approaches for the prediction of opioid use-related epidemics in the United States: a narrative review and cross-disciplinary call to action13
New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae13
Kidney organoids: a pioneering model for kidney diseases13
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside13
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease12
MicroRNA expression profiling in acute kidney injury12
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway12
Venous thrombosis of the liver: current and emerging concepts in management12
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease12
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling12
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection12
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis12
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis12
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota12
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls12
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis12
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type12
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen12
Current opinion and emerging trends on the treatment, diagnosis, and prevention of pregnancy-associated venous thromboembolic disease: a review11
MicroRNA Expression Profiling in Diabetic Kidney Disease11
Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: A five-year follow-up of the AChPOL registry, with special focus on patients 11
Venous thromboembolism in people living with HIV infection (PWH)11
Innovative highlights of clinical drug trial design11
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?11
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease11
Immunity, immunotherapy, and rectal cancer: A clinical and translational science review11
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma11
Inflammasomes as mediators of inflammation in HIV-1 infection11
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial11
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment11
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities11
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies11
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets11
Fibrinolytics for the treatment of pulmonary embolism11
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge10
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation10
Emerging molecular mediators and targets for age-related skeletal muscle atrophy10
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-1910
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia10
Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia10
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway10
Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors10
Skeletal muscle MiR-210 expression is associated with mitochondrial function in peripheral artery disease patients10
Intertwined pathways of complement activation command the pathogenesis of lupus nephritis10
PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity10
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful10
Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and α7 nicotinic receptor expression9
Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study)9
Protein glycosylation in urine as a biomarker of diseases9
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors9
The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology9
New mechanistic insights to PLOD1-mediated human vascular disease9
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature9
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage9
Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors9
CD11b agonists offer a novel approach for treating lupus nephritis9
Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease9
Retinal organoid light responsivity: current status and future opportunities9
Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pi8
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models8
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease8
Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori8
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy8
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders8
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure8
Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes8
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B8
Novel treatments for chronic pain: moving beyond opioids8
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts8
Metformin and myocardial ischemia and reperfusion injury: Moving toward “prime time” human use?8
Cytokine signature of inflammation mediated by autoreactive Th-cells, in calf muscle of claudicating patients with Fontaine stage II peripheral artery disease8
Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function8
Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells8
PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK48
Gender-sex differences in autoimmune atrophic gastritis8
Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities8
Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease8
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations7
Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis7
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells7
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions7
Hormones and thrombosis: risk across the reproductive years and beyond7
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes7
Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis7
CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling7
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine7
Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation7
Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer7
Aldosterone suppresses cardiac mitochondria7
Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems7
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer7
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity7
Effects of estrogen receptor signaling on prostate cancer carcinogenesis7
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis7
The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats7
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway7
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)7
Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold7
CD71 mesangial IgA1 receptor and the progression of IgA nephropathy7
The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome7
Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy7
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human7
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 26
Targeting DAMPs with nucleic acid scavengers to treat lupus6
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling6
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-16
Understanding the adipose tissue acetylome in obesity and insulin resistance6
Topical captopril: a promising treatment for secondary lymphedema6
Next generation patient derived tumor organoids6
Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma6
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction6
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles6
Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like phenotype6
Insights from experimental post-thrombotic syndrome and potential for novel therapies6
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex6
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets6
MicroRNA and protein-coding gene expression analysis in idiopathic pulmonary fibrosis yields novel biomarker signatures associated to survival6
Systems approaches for the clinical diagnosis of Clostridioides difficile infection6
Spectrins and human diseases6
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects6