Translational Research

Article	Citations
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	336
Serum neurofilament light as a biomarker of vulnerability to a second mild traumatic brain injury	159
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolem	105
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex	103
Retinal organoid light responsivity: current status and future opportunities	99
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	93
Next generation patient derived tumor organoids	87
Information for Readers	77
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis	70
New Association Announcement - High-Impact Elsevier Journal and Leading Chinese Institute Join Forces	69
Masthead	64
Editorial Advisory Board	60
Information for Readers	59
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	59
Editorial Advisory Board	55
Contents	55
Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation	46
Clonal hematopoiesis and bone marrow inflammation	44
Contents	42
Masthead	39
Author Guidelines	37
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	36
Information for Readers	35
Contents	35
Editorial Advisory Board	34

Contents	34
Information for Readers	33
Contents	33
Editorial Advisory Board	32
Information for Readers	32
Author Guidelines	32
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer	31
Information for Readers	30
Contents	30
Contents	30
Editorial Advisory Board	29
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	29
Masthead	29
Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice	28
Editorial Advisory Board	28
Contents	27
Author Guidelines	27
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	26
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	26
Masthead	26
Masthead	25
Author Guidelines	25
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI	24
Contents	24
Circulating chaperones in patients with aortic valve stenosis undergoing TAVR: impact of concomitant chronic kidney disease	24
Editorial Advisory Board	24
Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice	24
Contents	24
Contents	23
Glyburide confers neuroprotection against age-related macular degeneration (AMD)	22
TIR8 protects against nonalcoholic steatohepatitis by antagonizing lipotoxicity-induced PPARα downregulation and reducing the sensitivity of hepatocytes to LPS	22
Contents	22
Immune checkpoint activity exacerbate renal interstitial fibrosis progression by enhancing PD-L1 expression in renal tubular epithelial cells	22
Topical delivery of mitogen-activated protein kinase inhibitor binimetinib prevents the development of cutaneous neurofibromas in neurofibromatosis type 1 mutant mice	22
PCSK9 inhibition protects mice from food allergy	22
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	21
CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway	21
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	21
Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression	20
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage	20
The effect of macrophage-targeted interventions on blood pressure – a systematic review and meta-analysis of preclinical studies	19
The unveiled mosaic of intra-tumor heterogeneity in ovarian cancer through spatial transcriptomic technologies: A systematic review	19
Information for Readers	18
Contents	18
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	18
Editorial Advisory Board	18
Chronic kidney disease and pulmonary hypertension: Progress in diagnosis and treatment	18
Contents	17
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	17
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	17

Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities	17
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	17
Contents	17
Editorial Advisory Board	17
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway	17
Diabetic wound healing in soft and hard oral tissues	16
Author Guidelines	16
Contents	16
Author Guidelines	16
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	16
Editorial Advisory Board	16
Masthead	16
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	16
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	16
Contents	16
Diagnostic molecular markers predicting aggressive potential in low-grade prostate cancer	16
Contents	15
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	15
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	15
Substance P blocks β-aminopropionitrile-induced aortic injury through modulation of M2 monocyte-skewed monocytopoiesis	15
Hypophosphatemia in acute liver failure of a broad range of etiologies is associated with phosphaturia without kidney damage or phosphatonin elevation	15
Fu's subcutaneous needling promotes axonal regeneration and remyelination by inhibiting inflammation and endoplasmic reticulum stress	14
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	14
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	14
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2	14
Author Guidelines	14
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	14
Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy	14
TMAO: how gut microbiota contributes to heart failure	13
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	13
Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: Implications for improving treatment modalities	13
Vascular contributions to Alzheimer's disease	13
Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators	13
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	13
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	13
Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation	13
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors	13
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	13
Arginine methylation and respiratory disease	12
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	12
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	12
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	12
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	12
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	12
Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma	12
Corrigendum to Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer [Translational Research 231C (202	12
Spectrins and human diseases	12
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	12
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell	12
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	12
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	12
Contents	12
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	12
Engineering approaches for cardiac organoid formation and their characterization	12
Lactate promotes bone healing by regulating the osteogenesis of bone marrow mesenchymal stem cells through activating Olfr1440	11
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	11
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	11
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	11
Inflammasomes as mediators of inflammation in HIV-1 infection	11
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy	11
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	11
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort	11
Masthead	10
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	10
Pin1 and Alzheimer's disease	10
Contents	10
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	10
Recent advances in the development of transplanted colorectal cancer mouse models	10
Understanding the adipose tissue acetylome in obesity and insulin resistance	10
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	10
Editorial Advisory Board	10
Author Guidelines	10
Role of senescence in the chronic health consequences of COVID-19	10
Information for Readers	10
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	10
A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism	10
COVID-19 Survival and its impact on chronic kidney disease	10
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	10
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles	10
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice	9

Editorial Advisory Board	9
Topical captopril: a promising treatment for secondary lymphedema	9
Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease	9
Masthead	9
Contents	9
NLRP3 inflammasome in neurodegenerative disease	9
Author Guidelines	9
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy	9
Contents	9
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	9
Contents	9
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	9
Information for Readers	9
Masthead	9
Author Guidelines	9
Contents	8
Information for Readers	8
Information for Readers	8
Contents	8
A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma	8
Masthead	8
Masthead	8
Masthead	8
Author Guidelines	8
Contents	8
Biotherapy of experimental acute kidney injury: emerging novel therapeutic strategies	8
Editorial Advisory Board	8
Author Guidelines	8
Contents	8
Masthead	8
Contents	8
Contents	8
Development of strategies for community engaged research dissemination by basic scientists: a case study	7
Information for Readers	7
Author Guidelines	7
Editorial Advisory Board	7
Information for Readers	7
Author Guidelines	7
Contents	7
Contents	7
Contents	7
Contents	7
Information for Readers	7
Contents	7
Contents	7
Editorial Advisory Board	7
Adult hypertensive rats are more prone to gut microflora perturbation and fibrosis in response to moderate restraint stress	7
Contents	7
Contents	7
Author Guidelines	7
Editorial Advisory Board	7
Author Guidelines	7
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	6
Information for Readers	6
Information for Readers	6
Contents	6
Masthead	6
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	6
Spleen derived monocytes regulate pulmonary vascular permeability in Hepatopulmonary syndrome through the OSM-FGF/FGFR1 signaling	6
Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy	6
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	6
Author Guidelines	6
Author Guidelines	6
Information for Readers	6
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	6
Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like phenotype	6
The rare circulating tumor microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment	6
Author Guidelines	6
Editorial Advisory Board	6
Inflammatory arthritis in patients with COVID-19	6
Masthead	6
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study	6
Effect of sildenafil on right ventricular performance in an experimental large-animal model of postcapillary pulmonary hypertension	6
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	5
Information for Readers	5
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors	5
CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling	5
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	5
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	5
Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis	5
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	5
Pain in sickle cell disease: current and potential translational therapies	5
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	5
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis	5
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	5
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	5
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	5
AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG)	5
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	5
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy	5
Pathophysiological characterization of the Townes mouse model for sickle cell disease	4
Editorial Advisory Board	4
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis	4
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity	4
Contents	4