Translational Research

Article	Citations
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases	1672
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome	240
Macrophage polarization and diabetic wound healing	194
TMAO: how gut microbiota contributes to heart failure	109
New tuberculosis drug targets, their inhibitors, and potential therapeutic impact	95
Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model	86
miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer	84
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients	83
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort	72
New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter	69
Immune responses to injury and their links to eye disease	66
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	64
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease	64
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies	62
Microvascular thrombosis: experimental and clinical implications	59
Oral wound healing models and emerging regenerative therapies	59
Pathogenesis of heparin-induced thrombocytopenia	58
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet	58
Frailty and cognitive decline	53
Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy	49
Mechanisms and biomarkers of cancer-associated thrombosis	48
Frailty and aging in cancer survivors	48
Topical application of bacteriophages for treatment of wound infections	46
Cutaneous innervation in impaired diabetic wound healing	45
Antiphospholipid syndrome	43

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?	43
Targeting T-type/CaV3.2 channels for chronic pain	43
Next-generation direct-acting influenza therapeutics	42
NLRP3 inflammasome activity is required for wound healing after burns	40
Diabetic wound healing in soft and hard oral tissues	40
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	39
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study	39
Long and short non-coding RNA and radiation response: a review	34
Cellular senescence in age-related disorders	34
Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice	33
Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers	32
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome	31
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease	31
Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities	31
Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF	30
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host	30
Sex related differences in the pathogenesis of organ fibrosis	30
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms	30
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future	30
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy	29
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions	29
Development of oncolytic viruses for cancer therapy	29
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	29
Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury	28
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora	27
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	27
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury	26
Vascular contributions to Alzheimer's disease	26
Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation	25
Evaluating for-profit public benefit corporations as an additional structure for antibiotic development and commercialization	25
The use of fecal microbiota transplant in sepsis	24
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	24
NLRP3 inflammasome in neurodegenerative disease	24
Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients	24
Inflammasome signaling in colorectal cancer	24
Biphasic effect of metformin on human cardiac energetics	23
Gene therapy for bone healing: lessons learned and new approaches	22
Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer	22
Transcription factor HIF1α promotes proliferation, migration, and invasion of cholangiocarcinoma via long noncoding RNA H19/microRNA-612/Bcl-2 axis	22
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer	22
The gut microbiome and frailty	21
Role of senescence in the chronic health consequences of COVID-19	21
Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation	21
Form follows function: The endothelial glycocalyx	20
Brain mechanisms of chronic pain: critical role of translational approach	20
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis	20
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	20
Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets	20
COVID-19 Survival and its impact on chronic kidney disease	20
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae	20

Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients	20
Vaccines to prevent genital herpes	20
Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases	19
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients	19
Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition	19
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier	19
Antisense antibacterial compounds	19
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities	19
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection	18
Central nervous system outcomes of COVID-19	18
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats	18
IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung	18
Inflammatory arthritis in patients with COVID-19	18
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis	17
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells	17
Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases	17
The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility	17
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis	17
Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease	17
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	17
Role of placental fibrinogen-like protein 1 in gestational diabetes	17
Inflammasome activation in traumatic brain injury and Alzheimer's disease	16
Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome	16
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization	16
Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1	16
A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer	15
Genetics of frailty: A longevity perspective	15
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats	15
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	15
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions	15
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional	15
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy	14
Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data	14
Back and neck pain: in support of routine delivery of non-pharmacologic treatments as a way to improve individual and population health	14
Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy	14
Influence of immunomodulatory drugs on the gut microbiota	14
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation	14
New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae	13
Therapeutic Vaccines for the Treatment of HIV	13
Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: a case-control study	13
Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study	13
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer	13
Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway	13
Pathobiology of frailty in lung disease	13
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice	13
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	13
Methodological approaches for the prediction of opioid use-related epidemics in the United States: a narrative review and cross-disciplinary call to action	13
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis	12
An mRNA vaccine to prevent genital herpes	12
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen	12
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge	12
Venous thrombosis of the liver: current and emerging concepts in management	12
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	12
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway	12
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies	12
Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea	11
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	11
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene	11
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies	11
Formulation of host-targeted therapeutics against bacterial infections	11
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels	11
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	11
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	11
Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: A five-year follow-up of the AChPOL registry, with special focus on patients	11
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	11
NK cell tumor therapy modulated by UV-inactivated oncolytic herpes simplex virus type 2 and checkpoint inhibitors	11
Innovative highlights of clinical drug trial design	11
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota	11
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo	11
Immunity, immunotherapy, and rectal cancer: A clinical and translational science review	11
Post-COVID-19 patients show an increased endothelial progenitor cell production	11
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type	11
Pathogenic implications of dysregulated miRNAs in propionic acidemia related cardiomyopathy	11
Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside	10
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease	10
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls	10
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis	10
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	10
Pain in sickle cell disease: current and potential translational therapies	10
Engineering approaches for cardiac organoid formation and their characterization	10

Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors	10
Advances in mRNA and other vaccines against MERS-CoV	10
Venous thromboembolism in people living with HIV infection (PWH)	10
Salt-sensitive blood pressure rise in type 1 diabetes patients is accompanied by disturbed skin macrophage influx and lymphatic dilation—a proof-of-concept study	10
Kidney organoids: a pioneering model for kidney diseases	10
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis	10
CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?	10
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	10
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling	10
Serum levels of the soluble urokinase plasminogen activator receptor (suPAR) correlates with disease activity in early rheumatoid arthritis and reflects joint damage over time	10
Emerging molecular mediators and targets for age-related skeletal muscle atrophy	10
The embedded researcher model in Australian healthcare settings: comparison by degree of “embeddedness”	10
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	10
Current opinion and emerging trends on the treatment, diagnosis, and prevention of pregnancy-associated venous thromboembolic disease: a review	10
MicroRNA Expression Profiling in Diabetic Kidney Disease	9
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	9
CD11b agonists offer a novel approach for treating lupus nephritis	9
PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity	9
Retinal organoid light responsivity: current status and future opportunities	9
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia	9
Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia	9
Trehalose as quantitative biomarker for in vivo diagnosis and treatment follow-up in cryptococcomas	9
Inflammasomes as mediators of inflammation in HIV-1 infection	9
Fibrinolytics for the treatment of pulmonary embolism	9
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge	9
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	9
MicroRNA expression profiling in acute kidney injury	9
Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis	9
Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes	8
Novel treatments for chronic pain: moving beyond opioids	8
Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors	8
Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells	8
New mechanistic insights to PLOD1-mediated human vascular disease	8
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage	8
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models	8
Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study)	8
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	8
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	8
Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors	8
Intertwined pathways of complement activation command the pathogenesis of lupus nephritis	8
Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pi	8
Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and α7 nicotinic receptor expression	7
Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold	7
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	7
Proteomic analysis of malignant and benign endometrium according to obesity and insulin-resistance status using Reverse Phase Protein Array	7
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	7
Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease	7
Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems	7
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)	7
Protein glycosylation in urine as a biomarker of diseases	7
Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori	7
Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities	7
Metformin and myocardial ischemia and reperfusion injury: Moving toward “prime time” human use?	7
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	7
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	7
Gender-sex differences in autoimmune atrophic gastritis	7
Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy	7
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	7
Systems approaches for the clinical diagnosis of Clostridioides difficile infection	6
Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis	6
Effects of estrogen receptor signaling on prostate cancer carcinogenesis	6
The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats	6
The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology	6
Nf1 heterozygous mice recapitulate the anthropometric and metabolic features of human neurofibromatosis type 1	6
Aldosterone suppresses cardiac mitochondria	6
Hormones and thrombosis: risk across the reproductive years and beyond	6
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease	6
PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4	6
Identifying endotypes of individuals after an attack of pancreatitis based on unsupervised machine learning of multiplex cytokine profiles	6
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	6
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex	6
Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly	6
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway	6
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells	6
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	6
MicroRNA and protein-coding gene expression analysis in idiopathic pulmonary fibrosis yields novel biomarker signatures associated to survival	6
A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states	6
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	6
A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects	6
CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling	6
Skeletal muscle MiR-210 expression is associated with mitochondrial function in peripheral artery disease patients	6
Differential expression of members of SOX family of transcription factors in failing human hearts	6
Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function	6
Targeting DAMPs with nucleic acid scavengers to treat lupus	6
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	6
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway	6
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	5
Insights from experimental post-thrombotic syndrome and potential for novel therapies	5
Downregulating the P2X3 receptor in the carotid body to reduce blood pressure via acoustic gene delivery in canines	5
Recent advances in the development of transplanted colorectal cancer mouse models	5
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	5
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	5
Spectrins and human diseases	5
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI	5
Next generation patient derived tumor organoids	5