Cell Host & Microbe

Article	Citations
Viral mimicry protects from infection when you’re expecting	960
Breathe and bloom: Gut hypoxia limits C. albicans growth	912
Gut commensals expand vitamin A metabolic capacity of the mammalian host	656
Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites	468
Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis	465
Secretory IgA: Linking microbes, maternal health, and infant health through human milk	458
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans	336
Sowing the seeds of infection	306
Virus hunters: Discovering the evolutionary origins of SARS-CoV-2	289
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction	276
The dominoes fall after long-term antibiotic exposure	270
Commensals make the most of their hosts	264
Trick and no treat: Carbohydrate preemption by commensal Enterobacteriaceae	234
Neutrophils flash their GLUTs to beat back detestable fungi	219
Even old foes can learn sweet new tricks	207
Salmonella “RecAmends” self-healing	195
Find a little help from my (microbial) friends	181
Norovirus cell tropism: The road to uncovering its secret hideout	180
Holding back: HLA-associated inhibition of NK cells gives HIV a leg up	174
Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly	167
The devil in the details: Herd immunity and pandemic response	166
From parent to progeny	165
A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development	164
Candidalysin: An unlikely aide for fungal gut commensalism	164
From poo to promise: Fecal microbiota transplants support immunotherapy re-sensitization in solid tumors	157

Microbiome modification for personalized treatment of dysbiotic diseases	154
Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode	150
Candida lipase packs a punch against IL-17	139
Multi-armed antibiotics for Gram-positive bacteria	138
Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia	132
Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes	131
A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation	130
Anatomy promotes neutral coexistence of strains in the human skin microbiome	129
A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior	128
The mouth opens wide onto an additional view of immune development at mucosal borders	125
The quest for control	119
Worming into infancy: Exploring helminth-microbiome interactions in early life	118
Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes	117
Detect and destroy: CRISPR-based technologies for the response against viruses	114
Divide and conquer: Spatiotemporal plant innate immunity at single-cell resolution	114
RNAi, a sword of plant seeds to combat viral infections	114
Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts	111
Growing up: A NOD2 our microbes	108
Stress-induced condensate switch awakens sleeping viruses	107
Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance	106
Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders	106
Microbial genome mining expedition unearths trove of antiviral defenses	105
Improving ICI outcomes with a little help from my microbial friends	104
The gut-brain axis goes viral	104
Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence	102
Engineered bacteria recycle tumor metabolic waste to boost immunotherapy	99
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating	99
Fighting the invisible foe in cancer therapy	98
Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller	97
Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis	97
Mommy’s microbes: Gestational diabetes mellitus shapes the maternal and infant gut microbiome	95
A prophage competition element protects Salmonella from lysis	95
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19	94
Selenium nanoboosting of plant-beneficial microbiome	94
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation	93
A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants	92
Walking down the phosphorylation path to root immunity	88
Fiber-deficient diets reprogram the microbiota	88
The blue-light receptor CRY1 serves as a switch to balance photosynthesis and plant defense	87
Characterization of gut microbial structural variations as determinants of human bile acid metabolism	86
A calmodulin-binding transcription factor links calcium signaling to antiviral RNAi defense in plants	86
Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota	84
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19	84
Early life host-microbe interactions in skin	83
Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway	83
Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics	82
Fecal matters: Microbial signatures distinguish clinically relevant subtypes of precancerous colorectal polyps	81
Mutation, Selection, and Bottlenecks in Polio Vaccine Reversion	81
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants	81
The Early Evolution of Oral Poliovirus Vaccine Is Shaped by Strong Positive Selection and Tight Transmission Bottlenecks	80

Fungi make fun guys	79
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1	79
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor	79
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival	79
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies	79
Bacteroides acidifaciens drives a liver detox program	78
Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response	78
Gut commensal E. coli outer membrane proteins activate the host food digestive system through neural-immune communication	78
Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae	77
mRNA vaccines: A promising platform for safer, more effective next-generation Orthopoxvirus immunization	77
Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution	75
Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence	75
INDELible impact: How structural variants drive virulence and resistance	75
Trained immunity: Target for prophylaxis and therapy	74
Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination	74
Pangenomes of human gut microbiota uncover links between genetic diversity and stress response	73
HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses	72
Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome	72
Combatting superbugs using the evolutionary record of microbial warfare	71
Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine	71
A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion	71
Epithelial hypoxia maintains colonization resistance against Candida albicans	70
Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers	69
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation	68
Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization	68
Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes	68
Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity	67
Signatures of antagonistic pleiotropy in a bacterial flagellin epitope	66
MAMPs: A devil tamed becomes an angel	66
Phages and their satellites encode hotspots of antiviral systems	65
A complex immune response to flagellin epitope variation in commensal communities	65
Prophages encode phage-defense systems with cognate self-immunity	64
Going viral: The role of mobile genetic elements in bacterial immunity	64
Virus vaccines: proteins prefer prolines	64
Longitudinal comparison of the developing gut virome in infants and their mothers	64
Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria	63
Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2	63
An atlas of continuous adaptive evolution in endemic human viruses	63
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology	62
Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease	62
The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages	61
Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities	61
Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models	61
Evolutionarily conserved bacterial effectors hijack abscisic acid signaling to induce an aqueous environment in the apoplast	60
SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies	60
A short prokaryotic Argonaute activates membrane effector to confer antiviral defense	59
A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans	59
Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria	59
High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction	59
Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response	57
Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin	56
Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes	56
Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses	56
Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice	56
Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year	55
A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1	55
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial	55
Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics	55
Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems	55
Rethinking phage-bacteria-eukaryotic relationships and their influence on human health	54
Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin	54
Developmental trajectory of the healthy human gut microbiota during the first 5 years of life	54
Stealth strategies of Candida albicans to evade host immunity	54
Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation	53
An expanded arsenal of immune systems that protect bacteria from phages	53
Robbing the thief	52
Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology	52
Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host	52
Quorum sensing-activated phenylalanine metabolism drives OMV biogenesis to enhance mosquito commensal colonization resistance to Plasmodium	51
Gut microbiome and bladder cancer: A new link through nitrosamine metabolism	51
Plant cellular messengers mobilized to defend	51
A selfish bacteriocin dictates pneumococcal domination	51
Invade to evade: E. coli’s gutsy survival strategies	51
Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants	51
Human influenza virus challenge identifies cellular correlates of protection for oral vaccination	50
Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication	50
SnapShot: The Expobiome Map	50
Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis	49
Help from commensals: β-hex to regulate gut immunity	48
Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics	48

Milk to mucus: How B. fragilis colonizes the gut	48
To err is human, to forgive may require different vaccines	47
Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses	47
Defined mouse microbiota: An “evolving” tool	46
A colon cancer “prequel”	46
Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis	45
Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors	45
Road to the discovery of HO-2’s myristate binding activity	45
Two-for-one: Dual host-microbe functions of S. epidermidis Sph	44
Intestinal mucus and their glycans: A habitat for thriving microbiota	44
Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation	44
H19 influenza A virus exhibits species-specific MHC class II receptor usage	44
Large-scale phage cultivation for commensal human gut bacteria	44
BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism	44
Diarrheal pathogens trigger rapid evolution of the guanylate cyclase-C signaling axis in bats	43
Tryptophan metabolites get the gut moving	42
From top to bottom: Staphylococci in atopic dermatitis	42
Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes	42
Hair of the mouse: A skin bacteria “cocktail” gets follicles back on their feet	42
Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans	41
Beyond neutralization for BNT162b2 mRNA vaccination	40
Helminths are positively AMPing up gut de-bugging	40
The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice	40
Lessons learned by an organic chemist entering the microbiome field	39
License to LAP	38
Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling	38
Streptomyces use umbrella toxins to gently compete with kin	38
Tactical terminase: How a Salmonella prophage navigates oxidative stress	38
Fatty liver? Microbiome sphingolipids to the rescue	37
The vagina question: Can maternal vaginal fluid impact the infant gut microbiome and neurodevelopment?	37
Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection	37
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART	36
A layered effect in bacterial defense	36
Fusobacterium nucleatum subsp. animalis comes to the spotlight in oral diseases	36
E. coli enhance colonization resistance against Salmonella Typhimurium by competing for galactitol, a context-dependent limiting carbon source	35
Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq	35
Can maternal-child microbial seeding interventions improve the health of infants delivered by Cesarean section?	35
An aberrant inflammatory response in severe COVID-19	35
Antibiotic treatment ignites a fire that lasts	34
Conspecific versus heterospecific transmission shapes host specialization of the phyllosphere microbiome	33
Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides	33
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease	33
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques	33
Single-genome sequencing reveals within-host evolution of human malaria parasites	32
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus	32
How do bacteria transform plants into their oasis?	32
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses	32
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization	32
The Arabidopsis TIR-NBS-LRR protein CSA1 guards BAK1-BIR3 homeostasis and mediates convergence of pattern- and effector-induced immune responses	32
A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota	32
The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape	31
Stoking inflammasome fires in the COVID-19 neighborhood	31
Global mapping of Salmonella enterica-host protein-protein interactions during infection	31
A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery	30
Mimicry games: NPC-like MX2 condensates trap viruses	30
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies	30
Intestinal newborn regulatory B cell antibodies modulate microbiota communities	30