OOIR: Observatory of International Research

Papers

(The TQCC of Interdisciplinary Sciences-Computational Life Sciences is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
HRD-Informed Digital Histology Model for Predicting Platinum Chemo-Response and Prognosis in High-Grade Serous Ovarian Cancer	76
Generative Adversarial Networks Based on Fine-Grained Image Recognition for the Progression Prediction of Progressive Mild Cognitive Impairment	53
m6ADP-GCNPUAS: m6A-Disease Prediction via Graph Convolutional Network and Positive-Unlabeled Learning with Self-Adaptive Sampling	48
AttResAMD: An Attention-Driven Deep Learning Framework for Expert-Level Automated Classification of Age-Related Macular Degeneration from Fundus Photography	44
Unraveling Brain Synchronisation Dynamics by Explainable Neural Networks using EEG Signals: Application to Dyslexia Diagnosis	37
Parameter Estimation in Cellular Radiation Effects Using PSO-SQP and GA-SQP Hybrid Methods	36
DP-ID: Interleaving and Denoising to Improve the Quality of DNA Storage Image	36
An Integrated TCN-CrossMHA Model for Predicting circRNA-RBP Binding Sites	30
CA-UNet Segmentation Makes a Good Ischemic Stroke Risk Prediction	27
ResDeepSurv: A Survival Model for Deep Neural Networks Based on Residual Blocks and Self-attention Mechanism	26
Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities	25
IRDRM: Exploring Biological Traits and Clinical Significance in Breast Cancer Through Gene Pairs and Somatic Mutation Profiles	24
GSF-DTA: An Innovative Graph-Sequence Fusion Framework for Drug-Target Affinity Prediction	24
Differential Diagnosis of DCIS and Fibroadenoma Based on Ultrasound Images: a Difference-Based Self-Supervised Approach	24
Cervical Cancer Classification From Pap Smear Images Using Deep Convolutional Neural Network Models	23
PDDGCN: A Parasitic Disease–Drug Association Predictor Based on Multi-view Fusion Graph Convolutional Network	21
Deep Clustering-Based Metabolic Stratification of Non-Small Cell Lung Cancer Patients Through Integration of Somatic Mutation Profile and Network Propagation Algorithm	18
DCPPS: Prediction of Kinase-Specific Phosphorylation Sites Using Dynamic Embedding and Cross-Representation Interaction	18
Automated Brain Tumor Classification and Grading Using Multi-scale Graph Neural Network with Spatio-Temporal Transformer Attention Through MRI Scans	18
Interpretable Multimodal Molecular Language Model for Drug-Target Interaction Prediction	17
AIP-TranLAC: A Transformer-Based Method Integrating LSTM and Attention Mechanism for Predicting Anti-inflammatory Peptides	17
Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks	17
Developing a Novel Methodology by Integrating Deep Learning and HMM for Segmentation of Retinal Blood Vessels in Fundus Images	16
dbMisLoc: A Manually Curated Database of Conditional Protein Mis-localization Events	16
BiGM-lncLoc: Bi-level Multi-Graph Meta-Learning for Predicting Cell-Specific Long Noncoding RNAs Subcellular Localization	16

Identifying Lymph Node Metastasis-Related Factors in Breast Cancer Using Differential Modular and Mutational Structural Analysis	15
AMFCL: Predicting miRNA-Disease Associations Through Adaptive Multi-source Modality Fusion and Contrastive Learning	14
Adaptive Multi-Kernel Graph Neural Network for Drug-Drug Interaction Prediction	14
ViruSeg: Harnessing the Power of Large Language-Image Model for Enhanced Virus Image Segmentation	14
Machine Learning Accelerates De Novo Design of Antimicrobial Peptides	13
A Domain Adaptive Interpretable Substructure-Aware Graph Attention Network for Drug–Drug Interaction Prediction	13
VHGAE: Drug-Target Interaction Prediction Model Based on Heterogeneous Graph Variational Autoencoder	13
Exploring Deep Learning Models for Small Histopathology Datasets: Segmentation and Classification of Glomerular Crescent Lesions with Ablation, Interpretability, and Calibration Analyses	12
Development of an Expert-Level Right Ventricular Abnormality Detection Algorithm Based on Deep Learning	12
ESM-PsyPred: Leveraging Protein Language Models for Accurate Prediction of Psychrophilic Proteins	12
EfficientNet-resDDSC: A Hybrid Deep Learning Model Integrating Residual Blocks and Dilated Convolutions for Inferring Gene Causality in Single-Cell Data	11
A Multi-view Molecular Pre-training with Generative Contrastive Learning	11
Drug Sensitivity Prediction Based on Multi-stage Multi-modal Drug Representation Learning	11
scEM: A New Ensemble Framework for Predicting Cell Type Composition Based on scRNA-Seq Data	10
MKLNID: Identifying Melanoma-related Pathogenic Genes Through Multiple Kernel Learning and Network Impulsive Dynamics	10
OptimDase: An Algorithm for Predicting DNA Binding Sites with Combined Feature Encoding	10
scVAEBGM: Clustering Analysis of Single-Cell ATAC-seq Data Using a Deep Generative Model	10
CR-deal: Explainable Neural Network for circRNA-RBP Binding Site Recognition and Interpretation	10
Protein Multiple Conformation Prediction Using Multi-Objective Evolution Algorithm	10
Exploring Novel Fentanyl Analogues Using a Graph-Based Transformer Model	10
MFFBi-Unet: Merging Dynamic Sparse Attention and Multi-scale Feature Fusion for Medical Image Segmentation	10
Plant lncRNA-miRNA Interaction Prediction Based on Counterfactual Heterogeneous Graph Attention Network	9
Semantic Consistency Network with Edge Learner and Connectivity Enhancer for Cervical Tumor Segmentation from Histopathology Images	9
DCDA: CircRNA–Disease Association Prediction with Feed-Forward Neural Network and Deep Autoencoder	9
Transformative Deep Neural Network Approaches in Kidney Ultrasound Segmentation: Empirical Validation with an Annotated Dataset	9
Construction and Application of Traditional Chinese Medicine Knowledge Graph Based on Large Language Model	9
Review of Progress in Diagnostic Studies of Autism Spectrum Disorder Using Neuroimaging	9
Correction to: Machine Learning Accelerates De Novo Design of Antimicrobial Peptides	9
Multi-Modal Fusion with Supervised Contrastive Learning Model for Early Alzheimer’s Disease Diagnosis and Multi-Modal Biomarker Identification	8
Predicting miRNA-Drug Interactions Based on Multi-source Feature Fusion of Heterogeneous Network	8
Unveiling the Impact of Copper Metabolism on Epithelial-Mesenchymal Transition of Triple-Negative Breast Cancer: Identification of Therapeutic Targets	8
Interpretable Cancer Survival Prediction by Fusing Semantic Labelling of Cell Types and Whole Slide Images	8
GraphTransDTA: Drug-Target Affinity Prediction with Graph Transformer for Multimodal Data Fusion	8
ProtFormer-Site: Ultra-fast and Accurate Prediction of Protein-Protein Interaction Sites with Protein Language Model	8
DOTAD: A Database of Therapeutic Antibody Developability	8
IHDFN-DTI: Interpretable Hybrid Deep Feature Fusion Network for Drug–Target Interaction Prediction	7
A Framework Integrating Spiking Cortical Circuit Modeling and Simulation-Based Inference to Probe Biomarkers of Cortical Dysfunction in Alzheimer’s Disease	7
Identifying Potential Exosome-Derived mRNA Biomarkers for Diagnosis and Prediction of Breast Cancer Using Machine-Learning Approaches	7
Classification of Glomerular Pathology Images in Children Using Convolutional Neural Networks with Improved SE-ResNet Module	7
BEST: Basic Embedding Search Tool Enhancing Discovery of Novel Enzyme	7
CHL-DTI: A Novel High–Low Order Information Convergence Framework for Effective Drug–Target Interaction Prediction	7
DiTSim: A Diffusion-Transformers Based Single-Cell ATAC-seq Data Simulator	7
BMRI-NET: A Deep Stacked Ensemble Model for Multi-class Brain Tumor Classification from MRI Images	7
Identifying Protein Phosphorylation Site-Disease Associations Based on Multi-Similarity Fusion and Negative Sample Selection by Convolutional Neural Network	7
IMF-DDI: Information Mapping and Fusion Framework for Drug-drug Interaction Prediction	6
CRBP-HFEF: Prediction of RBP-Binding Sites on circRNAs Based on Hierarchical Feature Expansion and Fusion	6
Identifying RNA ac4C Modification Sites via Pseudo-Nucleotide Fingerprint Encoding and Multi-Scale Feature Integration	6
Combining Global-Constrained Concept Factorization and a Regularized Gaussian Graphical Model for Clustering Single-Cell RNA-seq Data	6
MTGGF: A Metabolism Type-Aware Graph Generative Model for Molecular Metabolite Prediction	6
iAmyP: A Multi-view Learning for Amyloidogenic Hexapeptides Identification Based on Sequence Least Squares Programming	6

STFusion: A Spatial-Temporal Dual-Pathway Network with Multi-scale Attention Fusion for Early Diagnosis of Parkinson’s Disease	6
stGNN: Spatially Informed Cell-Type Deconvolution Based on Deep Graph Learning and Statistical Modeling	6
Predicting Drug Synergy and Discovering New Drug Combinations Based on a Graph Autoencoder and Convolutional Neural Network	6
NPI-HGNN: A Heterogeneous Graph Neural Network-Based Approach for Predicting ncRNA-Protein Interactions	6
A Novel Deep Learning Model for Medical Image Segmentation with Convolutional Neural Network and Transformer	6
PmliHFM: Predicting Plant miRNA-lncRNA Interactions with Hybrid Feature Mining Network	6
Multi-kernel Learning Fusion Algorithm Based on RNN and GRU for ASD Diagnosis and Pathogenic Brain Region Extraction	6
VFLING: Vertical Federated Learning for Multi-Omics Data Integration with Graphs	6
Diffusion Model-Based Multi-Channel EEG Representation and Forecasting for Early Epileptic Seizure Warning	6