OOIR: Observatory of International Research

Papers

(The median citation count of Bioscience Trends is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Formulation and interpretation of the Chinese Guidelines for Surgical Treatment of Obesity and Type 2 Diabetes Mellitus	223
Using a multidisciplinary team for the staged management and optimally minimally invasive treatment of severe acute pancreatitis	136
New progress in elucidating the relationship between cancer therapy and cardiovascular toxicity	113
Feasibility of novel intraoperative navigation for anatomical liver resection using real-time virtual sonography combined with indocyanine green fluorescent imaging technology	110
Corrigendum to "Shufengjiedu capsules protect against neuronal loss in olfactory epithelium and lung injury by enhancing autophagy in rats with allergic rhinitis", BioScience Trends. 2019; 13(6):530-5	89
Multimodal optimal matching and augmentation method for small sample gesture recognition	69
Neoadjuvant therapy <i>vs</i>. upfront surgery for resectable pancreatic cancer: An update on a systematic review and meta-analysis	67
Trends in the treatment of advanced pancreatic cancer	51
Deep cervical lymphaticovenous anastomosis in Alzheimer's disease: A promising frontier or premature enthusiasm?	49
Advances in research on receptor heterogeneity in breast cancer liver metastasis	33
Exploring the multiple therapeutic mechanisms and challenges of mesenchymal stem cell-derived exosomes in Alzheimer's disease	32
Integration of wearable devices and deep learning: New possibilities for health management and disease prevention	28
The management of dementia worldwide: A review on policy practices, clinical guidelines, end-of-life care, and challenge along with aging population	27
Strengthening medical facility responses to respiratory infectious diseases: Global trends, challenges, and innovations post-COVID-19	25
Liver transplantation for patients with hepatocellular carcinoma: Its current status and advances	24
Advances in systemic therapy leading to conversion surgery for advanced hepatocellular carcinoma	21
Donor-recipient matching in adult liver transplantation: Current status and advances	21
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner	19
Establishment of nomogram prediction model of contrast-enhanced ultrasound and Gd-EOB-DTPA-enhanced MRI for vessels encapsulating tumor clusters pattern of hepatocellular carcinoma	18
Elevated serum CA19-9 indicates severe liver inflammation and worse survival after curative resection in hepatitis B-related hepatocellular carcinoma	17
Genetic features of TP53 mutation and its downstream FOXA1 in prostate cancer	15
Opportunities and challenges to the use of neutralizing monoclonal antibody therapies for COVID-19	15
Unveiling the unexplored secret: Aggressive behavior and poor survival in intrahepatic mucinous adenocarcinoma compared to conventional adenocarcinoma	15
Sequelae of long COVID, known and unknown: A review of updated information	14
From SARS to the Omicron variant of COVID-19: China's policy adjustments and changes to prevent and control infectious diseases	14

Combating syphilis resurgence: China's multifaceted approach	13
Increasing demand for point-of-care testing and the potential to incorporate the Internet of medical things in an integrated health management system	13
China should emphasize key issues inherent in rational medication management for the elderly	12
Verification of the efficiency of saline gargle sampling for detection of the Omicron variant of SARS-CoV-2, a pilot study	12
Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study	12
Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma	11
The profile and clinical predicting effect of non-rash dermatologic toxicity related to targeted therapy in stage-IV non-small cell lung cancer patients	11
Liver transplantation in China: Achievements over the past 30 years and prospects for the future	10
Development and validation of a nomogram model for predicting immune-mediated hepatitis in cancer patients treated with immune checkpoint inhibitors	10
SNRPA promotes hepatocellular carcinoma proliferation and lenvatinib resistance <i>via</i> B7-H6-STAT3/AKT axis by facilitating B7-H6 pre-mRNA maturation	10
Promoting active health with AI technologies: Current status and prospects of high-altitude therapy, simulated hypoxia, and LLM-driven lifestyle rehabilitation approaches	10
C-C chemokine receptor type 6 modulates the biological function of osteoblastogenesis by altering the expression levels of Osterix and OPG/RANKL	10
Exosomes derived from olfactory mucosa mesenchymal stem cells attenuate cognitive impairment in a mouse model of Alzheimer's disease	10
Longitudinal impact of compliance with routine CD4 monitoring on all cause deaths among treated people with HIV in China	10
Financial inclusion and financial gerontology in Japan's aging society	10
Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Stratified analysis based on tumor burden score	10
Infectious disease activity during the COVID-19 epidemic in Japan: Lessons learned from prevention and control measures	9
Association of the national level of human development with the incidence and mortality of congenital birth defects in 2019: A cross-sectional study from 189 countries	9
Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease	9
Neurosurgical perioperative management of frail elderly patients	8
Can nasal irrigation with chlorine dioxide be considered as a potential alternative therapy for respiratory infectious diseases? The example of COVID-19	8
Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions	8
The multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus	8
Update on hormone therapy for the management of postmenopausal women	8
The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy	8
A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan	8
How spousal cognitive functioning affects the level of depression in middle-aged and older adults: An instrumental variable study based on CHARLS in China	8
Association of angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists use with risk of atrial fibrillation after pacemaker implantation among very old patients	7
Role of a multidisciplinary team (MDT) in the diagnosis, treatment, and outcomes of inflammatory bowel disease: a single Chinese center's experience	7
Breast cancer and pregnancy: Why special considerations prior to treatment are needed in multidisciplinary care	7
Clinical characteristics of solitary intrahepatic biliary cyst	7
Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects	7
Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia	7
Trends in managing COVID-19 from an emerging infectious disease to a common respiratory infectious disease: What are the subsequent impacts on and new challenges for healthcare systems?	7
Contemporary oral anticoagulant therapy of patients with atrial fibrillation in China: Status, obstacles, and strategies for improvement	7
Automated machine learning-based model for the prediction of pedicle screw loosening after degenerative lumbar fusion surgery	7
An update on diagnosis and treatment of hepatoblastoma	6
Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora	6
Current status of gastroesophageal reflux disease after sleeve gastrectomy: Still a long way to go	6
A predictive radiotranscriptomics model based on DCE-MRI for tumor immune landscape and immunotherapy in cholangiocarcinoma	6
Poor emotional status increases the risk of attempted suicide for the elderly age 55 and older in Shanghai, China: A longitudinal follow-up study	6
Liquid-liquid phase separation: A new perspective to understanding aging and pathogenesis	6
Elderly patients with comorbid hypertension who prefer primary care have a lower rate of polypharmacy: A cross-sectional study in Shanghai, China	6
The APP Score: A simple serum biomarker model to enhance prognostic prediction in hepatocellular carcinoma	6
Investigating perioperative pressure injuries and factors influencing them with imbalanced samples using a Synthetic Minority Over-sampling Technique	6
Monkeypox – A danger approaching Asia	6
The framework for modern community medicine in Japan	6
Development and validation of a machine-learning model to predict lymph node metastasis of intrahepatic cholangiocarcinoma: A retrospective cohort study	6
Rapid evolution of the COVID-19 pandemic calls for a unified public health response	6
Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children	6

First-line systemic therapy and sequencing options in advanced biliary tract cancer: A systematic review and network meta-analysis	6
Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma	6
The potential of 'Segment Anything' (SAM) for universal intelligent ultrasound image guidance	6
The initiation, exploration, and development of hospital-based health technology assessment in China: 2005 ‒ 2022	6
Effects and mechanisms of microenvironmental acidosis on osteoclast biology	6
Dysfunction of peripheral regulatory T cells predicts lung injury after cardiopulmonary bypass	6
FOXA2 plays a critical role in hepatocellular carcinoma progression and lenvatinib-associated drug resistance	6
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance	5
Characteristics, scope of activity, and negative emotions in elderly women with urinary incontinence: Based on a longitudinal follow-up in Shanghai, China	5
Impact of China's COVID-19 prevention and control efforts on outbreaks of influenza	5
Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma <i>via</i> the miRNA-4474-3P-ALOX-15 and EMT axes	5
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information	5
Machine learning-based prognostic prediction and surgical guidance for intrahepatic cholangiocarcinoma	5
New possibilities for medical support systems utilizing artificial intelligence (AI) and data platforms	5
Optimized concurrent hearing and genetic screening in Beijing, China: A cross-sectional study	5
How do RNA binding proteins trigger liquid-liquid phase separation in human health and diseases?	5
Detecting latent tuberculosis infection with a breath test using mass spectrometer: A pilot cross-sectional study	5
Expert consensus on sequential surgery after immune-targeted conversion therapy for advanced hepatocellular carcinoma in China	5
mFOLFOX-HAIC+lenvatinib+PD-1 inhibitors versus GC/GS/GEMOX chemotherapy as a first line therapy for advanced biliary tract cancer: A single-center retrospective cohort study	4
Current status and perspectives of non-coding RNA and phase separation interactions	4
The impact of COVID-19 pandemic on the utilization of ambulatory care for patients with chronic neurological diseases in Japan: Evaluation of an administrative claims database	4
Genome-wide identification of mammalian cell-cycle invariant and mitotic-specific macroH2A1 domains	4
Traditional Chinese medicine for treatment of novel infectious diseases: Current status and dilemma	4
Evaluation of the value of <i>Synechococcus</i> 7942 as a sensitizer for photo-sonodynamic therapy against breast cancer	4
Surgical treatment of hepatocellular carcinoma	4
Risk stratification model for predicting distant metastasis after hepatectomy for hepatocellular carcinoma: A multi-institutional analysis	4
The strategy behind Japan's response to COVID-19 from 2020-2021 and future challenges posed by the uncertainty of the Omicron variant in 2022	4
From light to insight: Functional near-infrared spectroscopy for unravelling cognitive impairment during task performance	4
An overview: Management of patients with advanced hepatocellular carcinoma	4
Epigenetic modification of <i>Kiss1</i> gene expression in the AVPV is essential for female reproductive aging	4
Real-time intraoperative near-infrared autofluorescence imaging to locate the parathyroid glands: A preliminary report	4
Treating patients infected with the SARS-CoV-2 Omicron variant with a traditional Chinese medicine, Shufeng Jiedu capsule	3
SEC24C suppresses the propagation and chemoresistance of hepatocellular carcinoma by promoting unfolded protein response-related apoptosis	3
EMG-FRNet: A feature reconstruction network for EMG irrelevant gesture recognition	3
Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of <i>Mycobacterium tuberculosis </i>	3
Alzheimer's disease with frailty: Prevalence, screening, assessment, intervention strategies and challenges	3
An innovative two-wing model for balancing the demands of inpatients with COVID-19 and general medical service in a designated hospital for COVID-19 in Shenzhen, China	3
Changes in and challenges regarding the surgical treatment of hepatocellular carcinoma in China	3
Growth and differentiation factor 15: An emerging therapeutic target for brain diseases	3
Management of non-alcoholic fatty liver disease-associated hepatocellular carcinoma	3
New mechanisms: From lactate to lactylation to rescue heart failure	3
Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti–PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics	3
Integrative neurorehabilitation using brain-computer interface: From motor function to mental health after stroke	3
More effective vaccines and oral antivirals: Keys for the battle against Omicron	3
Recent trends and new developments in liver transplantation	3
Predictive deep learning models for cognitive risk using accessible data	3
Use of chemotherapy to treat hepatocellular carcinoma	3
Metformin acts on the gut-brain axis to ameliorate antipsychotic-induced metabolic dysfunction	3
Immunity debt: Hospitals need to be prepared in advance for multiple respiratory diseases that tend to co-occur	2
Cytomegalovirus viremia is associated with poor outcomes in AIDS patients with disseminated nontuberculous mycobacterial disease	2
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma	2
Revealing the magic of acupuncture based on biological mechanisms: A literature review	2
Thrombin cleaves recombinant soluble thrombomodulin into a lectin-like domain fragment and a fragment with protein C-activating cofactor activity	2
Genetic screening of newborns for deafness over 11 years in Beijing, China: More infants could benefit from an expanded program	2
HIV/AIDS strategies should focus on outcomes and the psychological status of older patients diagnosed with HIV	2
High social capital facilitates the alleviation of psychological distress in breast cancer patients: Insights from a cross-sectional study in Anhui Province, China	2
Intestinal microbiota distribution and changes in different stages of Parkinson's disease: A meta-analysis, bioinformatics analysis and <i>in vivo</i> simulation	2
Delayed gastric emptying after aggressive surgery for retroperitoneal sarcoma – Incidence, characteristics, and risk factors	2
The effect of the female genital tract and gut microbiome on reproductive dysfunction	2
What does oral care mean to society?	2
Trends in the treatment of pancreatic cancer in Japan	2
Reflections on abortion rights: From policy to medicine	2
Autism spectrum disorder: Status of primary care in China	2
Different clinical guidelines, common goal: To reduce COVID-19 mortality	2
Emerging infectious diseases never end: The fight continues	2
Timing of parathyroidectomy for kidney transplant patients with secondary hyperparathyroidism: A practical overview	2
Marburg virus disease: A deadly rare virus is coming	2
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects	2
Improving the accessibility of health care for internal migrants in China: Achieving the aim of equalization	2
Imaging of pulmonary cryptococcosis with consolidations or diffuse infiltrates suggests longer clinical treatment in non-HIV patients	2
The positive role of traditional Chinese medicine as an adjunctive therapy for cancer	2