OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Natural-derived drug carriers (NDDCs) for precision therapy	138
Multidrug resistance reversal effect of tenacissoside I through impeding EGFR methylation mediated by PRMT1 inhibition	80
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	31
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	21
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	21
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	18
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	18
Therapeutic potential of Ziziphora clinopodioides in cardiovascular diseases: a review	17
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	15
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	14
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	14
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	12
Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine	11
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	11
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	11
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	11
Taohe Chengqi decoction inhibits PAD4-mediated neutrophil extracellular traps and mitigates acute lung injury induced by sepsis	11
Pure drug nanomedicines - where we are?	11
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	10
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	10
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	10
Progress in approved drugs from natural product resources	10
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	10
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	10
Identification of Andrographis Herba and its common products using mini-barcode	9

Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	9
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	9
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	9
Transdermal delivery of natural products against atopic dermatitis	9
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	9
Identification of natural product-based drug combination (NPDC) using artificial intelligence	9
TSZAF monomer combination downregulates the Wnt/β-catenin signaling pathway and inhibits neutrophil recruitment to prevent lung cancer metastasis	9
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	9
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	9
De novo production of 24-epi-ergosterol in bioengineered yeast	9
The ethyl acetate extract of Schefflera kwangsiensis ameliorates oxaliplatin-induced peripheral neuropathic pain via SERCA2b	9
Atractylodimers A−D, unprecedented sesquiterpenoid dimers with cage-like skeletons from Atractylodes macrocephala and their neuroprotective activities	9
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	8
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	8
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	8
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	8
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	8
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	8
Natural products targeting NLRP3 inflammasome for metabolic dysfunction-associated fatty liver disease: the known unknowns	8
An overview of the advantageous effects and underlying mechanisms of natural polysaccharides in inflammatory bowel disease	8
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	8
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	8
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	8
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	7
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	7
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	7
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	7
Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes	7
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	7
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	7
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	7
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	7
Intervention of natural products targeting novel mechanisms after myocardial infarction	7
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	7
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	7
The extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro	6
KG-CNNDTI: a knowledge graph-enhanced prediction model for drug-target interactions and application in virtual screening of natural products against Alzheimer’s disease	6
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	6
Protective mechanisms of Qingda granule in hypertensive kidney injury: Focus on ERK/RSK1-mediated mitochondrial protection	6
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	6
Identification and screening of bioactive peptides against nephropathy derived from Mantidis Oötheca based on complement C3 inhibition	6
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	6
NO inhibitory constituents from Glycosmis craibii var. glabra	6
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
A polysaccharide from Arthrospira platensis alleviates pancreatic cancerassociated with negatively regulating galectin-3 and glypican-6 expression	6
Pulchinenoside B4 attenuates gouty arthritis by regulating NLRP3 inflammasome and macrophage polarization: a transcriptomics-based analysis	6
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	6
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	6
Abietane diterpenoids and iridoids from Caryopteris mongolica	6

NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	5
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	5
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
A comprehensive review of natural products with anti-hypoxic activity	5
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	5
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	5
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	5
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	5
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	5
Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	5
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	5
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	5
TCM network pharmacology: new perspective integrating network target with artificial intelligence and multi-modal multi-omics technologies	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	5
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	5
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	5
Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma herbal pair restores intestinal mucosal barrier function in ulcerative colitis via activating Epac1/Rap1 pathway and inhibiting PI3K/AKT pathway	5
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Isodons A−H, seco-abietane and abietane-type diterpenoids from Isodon lophanthoides: isolation, structural elucidation, and anti-cholestatic activity	4
Asponchimides A−E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis	4
Geranylated or prenylated flavonoids from Cajanus volubilis	4
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity	4
Exploring artificial intelligence approaches for predicting synergistic effects of active compounds in traditional Chinese medicine based on molecular compatibility theory	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Research progress of 3-n-butylphthalide and its derivatives in combating cerebral ischemia	4
Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza	4
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Structurally diverse rhamnofolane, tigliane, and daphnane diterpenoids from Euphorbia wallichii as anti-liver fibrosis agents	4
Unveiling the therapeutic mechanism of Epimedium Herba on prostate cancer through network pharmacology and experimental validation	4
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection	4
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans	4
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8	4
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	4
Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors	4
Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Effect and mechanism of Chinese medicine on inhibiting the senescence of mesenchymal stem cells	4
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	4
MolP-PC: a multi-view fusion and multi-task learning framework for drug ADMET property prediction	4