OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches	162
Research progress on the source, production, and anti-cancer mechanisms of paclitaxel	36
Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19	33
Network pharmacology approaches for research of Traditional Chinese Medicines	28
HIF-1: structure, biology and natural modulators	18
A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids	15
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019	15
Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology	13
Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway	13
A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan	12
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway	12
Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy	12
Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments	11
Drimane-type sesquiterpenoids from fungi	11
Comparative metabolism study on chlorogenic acid, cryptochlorogenic acid and neochlorogenic acid using UHPLC-Q-TOF MS coupled with network pharmacology	11
Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitra	11
Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway	10
Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway	10
Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK	9
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	9
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	9
Chemical profiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MS	9
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α	9
The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway	9
Modern research thoughts and methods on bio-active components of TCM formulae	9

Biosynthesis and regulation of diterpenoids in medicinal plants	9
Protective effect of paeoniflorin on H2O2 induced Schwann cells injury based on network pharmacology and experimental validation	8
Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants	8
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes	8
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	8
Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer	7
Honokiol: A naturally occurring lignan with pleiotropic bioactivities	7
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	7
Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability	7
Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation	7
A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells	6
A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces	6
The cardiovascular protective effect and mechanism of calycosin and its derivatives	6
Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology	6
New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242	6
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	6
Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS	6
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	6
Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation	6
Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway	6
Ligustroflavone ameliorates CCl4-induced liver fibrosis through down-regulating the TGF-β/Smad signaling pathway	6
Physiological and transcriptional responses to heat stress in a typical phenotype of Pinellia ternata	6
Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits	6
Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress	5
Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis	5
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	5
Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer	5
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	5
Progress in approved drugs from natural product resources	5
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	5
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products	5
Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling	5
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents	5
A review: biosynthesis of plant-derived labdane-related diterpenoids	5
Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review	5
Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling	5
Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities	5
Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in	5
Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms	5
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.	5
Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity	5
Research progress on naturally-occurring and semi-synthetic ocotillol-type ginsenosides in the genus Panax L. (Araliaceae)	5
Scutellaria baicalensis: a promising natural source of antiviral compounds for the treatment of viral diseases	5
Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice	5
Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling	5
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside	5
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	5
Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus	5
Tetracycline natural products: discovery, biosynthesis and engineering	4
Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation	4

Pathogenesis of NASH and Promising Natural Products	4
Dysideanones F—G and dysiherbols D—E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara	4
Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora	4
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	4
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	4
Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials	4
Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis	4
Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang	4
Synthesis, and anti-inflammatory activities of gentiopicroside derivatives	4
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	4
Natural products: potential therapeutic agents for atherosclerosis	4
Polysaccharide from Astragalus membranaceus promotes the activation of human peripheral blood and mouse spleen dendritic cells	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	4
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa	4
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum	4
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	4
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	4
Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibition of acylcarnitine in rats	4
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	4
The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats	4
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis	4
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway	4
Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.	4
Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis	4
Recent progress on anti-Candida natural products	4