OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	65
Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation	37
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	24
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	19
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	18
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	15
Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials	14
Natural-derived drug carriers (NDDCs) for precision therapy	14
Three new coumarins and a new coumarin glycoside from Micromelum integerrimum	13
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	13
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	11
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	11
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	11
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	10
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	10
Pure drug nanomedicines - where we are?	10
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	10
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	9
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	9
Progress in approved drugs from natural product resources	9
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	8
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	8
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	8
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	8
Identification of Andrographis Herba and its common products using mini-barcode	8

Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	7
Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii	7
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	7
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	7
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice	7
Transdermal delivery of natural products against atopic dermatitis	7
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	7
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	7
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	7
De novo production of 24-epi-ergosterol in bioengineered yeast	7
Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling	7
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	7
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	7
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	7
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	6
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	6
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	6
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	6
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	6
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	6
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	6
Bufotenine and its derivatives: synthesis, analgesic effects identification and computational target prediction	6
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	6
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	6
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	6
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	5
Chemical profiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MS	5
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	5
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	5
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	5
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	5
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	5
Abietane diterpenoids and iridoids from Caryopteris mongolica	5
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	5
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	5
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	5
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop	5
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	5
New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba	5
NO inhibitory constituents from Glycosmis craibii var. glabra	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
A comprehensive review of natural products with anti-hypoxic activity	5
Lignans with NO inhibitory activity from Tinospora sinensis	5
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
Sulfite as the substrate of C-sulfonate metabolism of α, β-unsaturated carbonyl containing andrographolide: analysis of sulfite in rats' intestinal tract and the reaction kinetics of andrographolide w	4
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	4

Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity	4
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	4
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	4
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	4
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	4
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	4
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	4
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	4
Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity	4
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	4
Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	4
Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome	4
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	4
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	4
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	4