OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	113
Natural-derived drug carriers (NDDCs) for precision therapy	69
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	23
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	17
Multidrug resistance reversal effect of tenacissoside I through impeding EGFR methylation mediated by PRMT1 inhibition	17
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	16
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	16
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	14
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	14
Progress in approved drugs from natural product resources	13
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	13
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	13
Taohe Chengqi decoction inhibits PAD4-mediated neutrophil extracellular traps and mitigates acute lung injury induced by sepsis	12
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	10
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	10
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	10
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	9
Pure drug nanomedicines - where we are?	9
Identification of Andrographis Herba and its common products using mini-barcode	9
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	9
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	9
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	9
Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine	9
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	9
TSZAF monomer combination downregulates the Wnt/β-catenin signaling pathway and inhibits neutrophil recruitment to prevent lung cancer metastasis	9

Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	9
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	9
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	9
De novo production of 24-epi-ergosterol in bioengineered yeast	9
Transdermal delivery of natural products against atopic dermatitis	9
Identification of natural product-based drug combination (NPDC) using artificial intelligence	8
Natural products targeting NLRP3 inflammasome for metabolic dysfunction-associated fatty liver disease: the known unknowns	8
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice	8
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	8
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	8
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	8
Atractylodimers A−D, unprecedented sesquiterpenoid dimers with cage-like skeletons from Atractylodes macrocephala and their neuroprotective activities	8
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	8
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	8
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	7
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	7
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	7
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	7
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	7
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	7
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	7
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	7
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	7
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	7
Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes	6
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	6
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	6
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	6
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	6
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	6
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	6
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	6
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	6
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	6
Intervention of natural products targeting novel mechanisms after myocardial infarction	6
KG-CNNDTI: a knowledge graph-enhanced prediction model for drug-target interactions and application in virtual screening of natural products against Alzheimer’s disease	6
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	6
A comprehensive review of natural products with anti-hypoxic activity	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	5
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	5
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	5
Abietane diterpenoids and iridoids from Caryopteris mongolica	5
NO inhibitory constituents from Glycosmis craibii var. glabra	5
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	5
Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects	5
Protective mechanisms of Qingda granule in hypertensive kidney injury: Focus on ERK/RSK1-mediated mitochondrial protection	5
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	5

Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	5
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	5
TCM network pharmacology: new perspective integrating network target with artificial intelligence and multi-modal multi-omics technologies	5
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	5
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	5
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	4
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity	4
Geranylated or prenylated flavonoids from Cajanus volubilis	4
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	4
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	4
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	4
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	4
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	4
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	4
Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity	4
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8	4
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans	4