Chinese Journal of Natural Medicines

Article	Citations
TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches	138
The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin	36
Research progress on the source, production, and anti-cancer mechanisms of paclitaxel	33
Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19	28
A review of the phytochemistry and pharmacological activities of Ephedra herb	18
HIF-1: structure, biology and natural modulators	15
Andrographolide as a potent and promising antiviral agent	14
Advances in biosynthesis of triterpenoid saponins in medicinal plants	14
Identification of medicinal plants within the Apocynaceae family using ITS2 and psbA-trnH barcodes	14
Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation	14
Nitric oxide donating anti-glaucoma drugs: advances and prospects	14
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019	14
A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids	13
Complete chloroplast genome of Salvia plebeia: organization, specific barcode and phylogenetic analysis	13
Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota	12
Advances on hormone-like activity of Panax ginseng and ginsenosides	12
Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology	12
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway	12
Network pharmacology approaches for research of Traditional Chinese Medicines	12
Comparative metabolism study on chlorogenic acid, cryptochlorogenic acid and neochlorogenic acid using UHPLC-Q-TOF MS coupled with network pharmacology	12
A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan	11
Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology	11
Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitra	11
Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway	11
CO as a therapeutic agent: discovery and delivery forms	10

Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway	10
Chemical profiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MS	9
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	9
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes	9
Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK	9
Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments	9
Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells	8
Prodrugs of hydrogen sulfide and related sulfur species: recent development	8
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling	8
Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway	8
Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3	8
The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway	8
Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy	8
Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review	8
Pancreatic lipase inhibitory constituents from Fructus Psoraleae	8
Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides	7
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α	7
Protective effect of paeoniflorin on H2O2 induced Schwann cells injury based on network pharmacology and experimental validation	7
Modern research thoughts and methods on bio-active components of TCM formulae	7
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	7
Drimane-type sesquiterpenoids from fungi	7
Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation	7
Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy	7
Bufalin-induced cardiotoxicity: new findings into mechanisms	7
Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology	7
Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling	6
Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms	6
Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability	6
Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae	6
In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism	6
New meroterpenoid compounds from the culture of mushroom Panus lecomtei	6
Honokiol: A naturally occurring lignan with pleiotropic bioactivities	6
Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer	6
Engineering CrtW and CrtZ for improving biosynthesis of astaxanthin in Escherichia coli	6
Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles	6
New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242	6
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	6
Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201	5
Candidate genes involved in the biosynthesis of lignan in Schisandra chinensis fruit based on transcriptome and metabolomes analysis	5
Biosynthesis and regulation of diterpenoids in medicinal plants	5
A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells	5
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products	5
New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity	5
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	5
Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS	5
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	5
Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities	5
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside	5
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	5
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway	5

Recent progress on anti-Candida natural products	5
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.	5
Genome-wide identification and analysis of AP2/ERF transcription factors related to camptothecin biosynthesis in Camptotheca acuminata	5
Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling	5
Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits	5
Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation	5
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	5
Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants	5
Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus	5
New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens	5
Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling	4
Pathogenesis of NASH and Promising Natural Products	4
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	4
The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats	4
Sangguayin preparation prevents palmitate-induced apoptosis by suppressing endoplasmic reticulum stress and autophagy in db/db mice and MIN6 pancreatic β-cells	4
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway	4
Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation	4
Identification of anti-cancer compounds from natural products	4
Dysideanones F—G and dysiherbols D—E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara	4
Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials	4
A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059	4
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents	4
Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy	4
Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora	4
A review: biosynthesis of plant-derived labdane-related diterpenoids	4
Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer	4
Strictosidine synthase, an indispensable enzyme involved in the biosynthesis of terpenoid indole and β-carboline alkaloids	4
Polysaccharide from Astragalus membranaceus promotes the activation of human peripheral blood and mouse spleen dendritic cells	4
Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis	4
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	4
Physiological and transcriptional responses to heat stress in a typical phenotype of Pinellia ternata	4
Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity	4
Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis	4
Novel SNP markers on ginsenosides biosynthesis functional gene for authentication of ginseng herbs and commercial products	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	4
Chemical ecology-driven discovery of bioactive marine natural products as potential drug leads	4
Molecular cloning and functional characterization of multiple ApOSCs from Andrographis paniculata	4
Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing	4
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop	3
Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic	3
Total synthesis of D-glycero-D-mannno-heptose 1β, 7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative	3
Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three original species of Pyrrosiae Folium	3
The cardiovascular protective effect and mechanism of calycosin and its derivatives	3
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	3
Potential quality evaluation approach for the absolute growth years’ wild and transplanted Astragali Radix based on anti-heart failure efficacy	3
Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice	3
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	3
20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway	3
Ligustroflavone ameliorates CCl4-induced liver fibrosis through down-regulating the TGF-β/Smad signaling pathway	3
GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy	3
Alkaloid constituents from the fruits of Flueggea virosa	3
Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro	3
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts	3
Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs	3
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	3
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	3
Overexpression of ribonucleotide reductase small subunit, RNRM, increases cordycepin biosynthesis in transformed Cordyceps militaris	3
Recent developments in natural products for white adipose tissue browning	3
Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway	3
Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.	3
Tetracycline natural products: discovery, biosynthesis and engineering	3
Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibition of acylcarnitine in rats	3
Combining microbial and chemical syntheses for the production of complex natural products	3
Probiotics with anti-type 2 diabetes mellitus properties: targets of polysaccharides from traditional Chinese medicine	3
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	3
Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang	3
Effect of Sargassum fusiforme polysaccharide on apoptosis and its possible mechanism in human erythroleukemia cells	3
Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish	3
Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods	3
A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces	3
New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla	2
Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes	2
A systematic review on the safety of Psoraleae Fructus: potential risks, toxic characteristics, underlying mechanisms and detoxification methods	2
Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress	2
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	2
Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis	2
Genome-wide identification of abscisic acid (ABA) receptor pyrabactin resistance 1-like protein (PYL) family members and expression analysis of PYL genes in response to different concentrations of ABA	2
Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation	2
Penicacids E–G, three new mycophenolic acid derivatives from the marine-derived fungus Penicillium parvum HDN17-478	2

Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells	2
Three new polyketides from vasR2 gene over-expressed mutant strain of Verrucosispora sp. NS0172	2
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	2
Old fusidane-type antibiotics for new challenges: Chemistry and biology	2
Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.	2
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis	2
Research progress on the pharmacological effects and chemical constituents of Pien Tze Huang and its potential Q-markers	2
Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway	2
New tirucallane-type triterpenoids from the resin of Boswellia carteriiand their NO inhibitory activities	2
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease	2
New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba	2
Comprehensive chemical profiling and quantitative analysis of ethnicYi medicine Miao-Fu-Zhi-Tong granules using UHPLC-MS/MS	2
Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo	2
New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex	2
Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism	2
Research progress on naturally-occurring and semi-synthetic ocotillol-type ginsenosides in the genus Panax L. (Araliaceae)	2
Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway	2
Potential of ginsenoside Rh2and its derivatives as anti-cancer agents	2
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875	2
Natural products: potential therapeutic agents for atherosclerosis	2
Probing the new strategy for the oral formulations of taxanes: changing the method with the situation	2
The Chinese patent medicine, Jin-tang-ning, ameliorates hyperglycemia through improving β cell function in pre-diabetic KKAy mice	2
Determination of ribose and phosphorus contents in Haemophilus influenzae type b capsular polysaccharide by a quantitative NMR method using a single internal standard	2
Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells	2
Systematic chemical characterization of Xiexin decoctions using high performance liquid chromatography coupled with electrospray ionization mass spectrometry	2
Molecular cloning and characterization of three phenylalanine ammonia-lyase genes from Schisandra chinensis	2
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	2
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum	2
Lignans with NO inhibitory activity from Tinospora sinensis	2
Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents	2
Scutellaria baicalensis: a promising natural source of antiviral compounds for the treatment of viral diseases	2
Sesquiterpenoids from the leaves of Sarcandra glabra	2
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	2
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	2
Bioactive sesquineolignans from the twigs of Litsea cubeba	2
3, 4-seco-Isopimarane and 3, 4-seco-pimarane diterpenoids from Callicarpa nudiflora	2
Synthesis, and anti-inflammatory activities of gentiopicroside derivatives	2
Identification of Andrographis Herba and its common products using mini-barcode	2
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	2
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	2
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	2
Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation	2
New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1	2
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa	2
Anomeric configuration-dependence of the Lattrell-Dax epimerization from D-glucose to synthetically useful D-allose derivatives	2