OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Pharmacology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease	81
RNA Interference-based Therapies for the Reduction of Cardiovascular Risk	57
Targeting of Lysosomes as a Therapeutic Target in Cancer	47
Deregulated MicroRNAs involved in P53 Signaling Pathway in Breast Cancer with Focus on Triple-negative Breast Cancer	34
Pain Perception and Management: Where do We Stand?	32
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats	28
Obesity and Inflammation: Colorectal Cancer Engines	28
Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration	27
Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity	26
Mutations in Rv0678, Rv2535c, and Rv1979c Confer Resistance to Bedaquiline in Clinical Isolates of Mycobacterium Tuberculosis	25
Chimeric Antigen Receptor T-cells (CARs) in Cancer Treatment	25
Adipose Tissue Dysfunction Following Trauma and Hypoxia Increases the Risk of Post-Surgical Adhesion: Potential for Therapeutic Interventions	24
Large language models in drug development: Current progress and future directions	23
Grp94 Inhibitor HCP1 Suppressed the Replication of SVA in BHK-21 Cells and PK-15 Cells	23
Recombinant Human Regenerating Gene 4 Attenuates the Severity of Osteoarthritis by Promoting the Proliferation of Articular Chondrocyte in an Animal Model	22
Cytotoxic and Antitumoral Activity of N-(9H-purin-6-yl) Benzamide Derivatives and Related Water-soluble Prodrugs	21
Mechanism, Potential, and Concerns of Immunotherapy for Hepatocellular Carcinoma and Liver Transplantation	21
Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects	21
Promising Anticancer Activity of Multitarget Cyclin Dependent Kinase Inhibitors against Human Colorectal Carcinoma Cells	21
Anticancer Properties of Baicalin against Breast Cancer and other Gynecological Cancers: Therapeutic Opportunities based on Underlying Mechanisms	20
A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I	19
Cryptotanshinone Induces Necroptosis Through Ca2+ Release and ROS Production in vitro and in vivo	17
Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer	17
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways	17
Exploring the Immune-Related Molecular Mechanisms Underlying the Comorbidity of Temporal Lobe Epilepsy and Major Depressive Disorder through Integrated Data Set Analysis	16

Targeting FGFR3 is a Useful Therapeutic Strategy for Rheumatoid Arthritis Treatment	16
Ginger and Heart Health: From Mechanisms to Therapeutics	16
The Involvement of the NEAT1-1/miR-873-5p/GalNAcT-I Axis in the Development of Neuroblastoma	15
BAPST. A Combo of Common Use Drugs as Metabolic Therapy for Cancer: A Theoretical Proposal	15
SK1 Inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway	15
PIASA, A Novel Peptide, Prevents SH-SY5Y Neuroblastoma Cells against Rotenone-induced Toxicity	15
Prevalence of Hepatocellular Carcinoma in Men and the Contribution of Androgen and its Receptor in Pathogenesis and Therapy	14
A Review of the Dual Role of MicroRNA-21 in Cardiovascular Diseases: Risk Factor or a Potential Therapeutic Target	14
Protective Effect of Chrysin against Chlorpyrifos-Induced Metabolic Impairment and Pancreatitis in Male Rats	13
The Therapeutic Effect and Mechanism of Qishen Yiqi Dripping Pills on Cardiovascular and Cerebrovascular Diseases and Diabetic Complications	13
The Treatment of Parkinson’s Disease with Sodium Oxybate	13
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion via Targeting DNMT3B	13
Anti-Cancer Role of Dendrosomal Nano Solanine in Chronic Myelogenous Leukemia Cell Line through Attenuation of PI3K/AKT/mTOR Signaling Pathway and Inhibition of hTERT Expression	13
BBOX1-AS1 Activates Hedgehog Signaling Pathway to Facilitate the Proliferation and Stemness of Esophageal Squamous Cell Carcinoma Cells via miR-506-5p/EIF5A/PTCH1 Axis	13
Dual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease	12
Sericic Acid Ameliorates DSS-induced Ulcerative Colitis in Mice by Modulating the NF-κB and Nrf2 Pathways	12
Molecular Insight into the Apoptotic Mechanism of Cancer Cells: An Explicative Review	12
Water Pipe Tobacco Smoking and Risk of Coronary Artery Disease: A Systematic Review and Meta-Analysis	12
Tumor Organoid Model and Its Pharmacological Applications in Tumorigenesis Prevention	12
Novel Chalcone BDD-39 Mitigated Diabetic Nephropathy through the Activation of Nrf2/ARE Signaling	12
Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1 : miR-3130-5p Enhances HCC Growth via Inhibiting FDX1	11
An Essential Role of c-Fos in Notch1-mediated Promotion of Proliferation of KSHV-Infected SH-SY5Y Cells	11
Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention	11
Gentiopicroside Ameliorated Ductular Reaction and Inflammatory Response in DDC-induced Murine Cholangiopathies Model	11
Natural Products and Cardiovascular Diseases	11
D-allose: Molecular Pathways and Therapeutic Capacity in Cancer	11
Thyroidectomy and PTU-Induced Hypothyroidism: Effect of L-Thyroxine on Suppression of Spatial and Non-Spatial Memory Related Signaling Molecules	10
Aloperine Alleviates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation in Macrophages and ApoE-/- Mice	10
Antinociceptive and Anti-Inflammatory Like Effects of Berberis baluchistanica	10
Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells	10
Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study	10
Fenbufen Alleviates Severe Acute Pancreatitis by Suppressing Caspase-1/Caspase-11-mediated Pyroptosis in Mice	10
Reduction of Genotoxicity of Carbamazepine to Human Lymphocytes by Pre-treatment with Vitamin B12	10
Ergothioneine Suppresses Amyloid β-Induced Tau Phosphorylation and Cytotoxicity by Inactivating Glycogen Synthase Kinase-3β in Cultured Neurons	9
Molecular Insights into Agonist/Antagonist Effects on Macromolecules Involved in Human Disease Mechanisms	9
PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK/p65 Pathway	9
PCSK9 Biomarker and Key Modulator for Cardiovascular Disorders: Heralding a New Therapeutic Era and Their Future Perspectives	9
Gut Microbiota Modulation for Therapeutic Management of Various Diseases: A New Perspective Using Stem Cell Therapy	9
Ketamine Metabolites-waiting in the Wings as Therapeutic Candidate for Depression?	9
Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells	8
Acknowledgements to Reviewers	8
Research Progress and Future Development Potential of Oridonin in Pharmacological Activities	8
Nrf2 Mediates Effect of Resveratrol in Ischemia-reperfusion Injury	8
Review of the Role of Metabolic Factors in Determining the Post-surgical Adhesion and its Therapeutic Implications, with a Focus on Extracellular Matrix and Oxidative Stress	8
Preface	8
RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling	8
A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies	8
Extracts from Artemisia annua Alleviates Myocardial Remodeling through TGF-β1/Smad2/3 Pathway and NLRP3 Inflammasome	8
Effects of Mycotoxins on Child Development	8
A Comprehensive Review of Essential Aspects of Molecular Pathophysiological Mechanisms with Emerging Interventions for Sarcopenia in Older People	8

Sanguinarine Attenuates Lung Cancer Progression via Oxidative Stress-induced Cell Apoptosis	8
Upregulation of LncRNA WT1-AS Inhibits Tumor Growth and Promotes Autophagy in Gastric Cancer via Suppression of PI3K/Akt/mTOR Pathway	8