OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Minocycline and Doxycycline: More Than Antibiotics	41
Impact of Sitagliptin on Non-diabetic Covid-19 Patients	30
Melatonin Receptor as a Drug Target for Neuroprotection	30
Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice	23
Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression	20
Bacterial Siderophores and Their Potential Applications: A Review	19
Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism	18
Connection between JAK/STAT and PPARγ Signaling During the Progression of Multiple Sclerosis: Insights into the Modulation of T-Cells and Immune Responses in the Brain	18
AdipoRon: A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review	18
Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole	18
Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials	16
Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway	16
Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration	16
FAT10: Function and Relationship with Cancer	15
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems	15
Salvia miltiorrhiza in Anti-diabetic Angiopathy	14
Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage	14
Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury	14
CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297	14
Ginger and Heart Health: From Mechanisms to Therapeutics	13
Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma	13
Curcumin Efficacy in a Serum/Glucose Deprivation-Induced Neuronal PC12 Injury Model	13
Apelin/Apelin Receptor System: Molecular Characteristics, Physiological Roles, and Prospects as a Target for Disease Prevention and Pharmacotherapy	13
Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review	12
miR-4319 Suppresses the Growth of Esophageal Squamous Cell Carcinoma Via Targeting NLRC5	12

Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs	12
Interleukin-19 as an Immunoregulatory Cytokine	12
Obesity and Inflammation: Colorectal Cancer Engines	12
Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway	12
Caveolin-1: A Promising Therapeutic Target for Diverse Diseases	11
Recent Advances in Herbal Nanomedicines for Cancer Treatment	11
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury	11
Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling	11
miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway	11
Ticagrelor Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by the Inhibition of TGF-β1/Smad3 and PI3K/AKT/mTOR Pathways	11
A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies	10
Epigenetic Regulation and Promising Therapies in Colorectal Cancer	10
Drug Repurposing for Cancer Therapy in the Era of Precision Medicine	10
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways	10
Quinoa (Chenopodium quinoa Willd.): Exploring a Superfood from Andean Indigenous Cultures with Potential to Reduce Cardiovascular Disease (CVD) Risk Markers	10
Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells	9
Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis	9
Novel Strategy in Breast Cancer Therapy: Revealing The Bright Side of Ginsenosides	9
Daclatasvir and Sofosbuvir Mitigate Hepatic Fibrosis Through Downregulation of TNF-α / NF-κB Signaling Pathway	9
Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway	9
Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma	9
Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy	9
Alcoholic Neuropathy: Involvement of Multifaceted Signalling Mechanisms	9
Possibility that the Onset of Autism Spectrum Disorder is Induced by Failure of the Glutamine-Glutamate Cycle	8
Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-Clinical Findings	8
Acetate Suppresses Lipopolysaccharide-stimulated Nitric Oxide Production in Primary Rat Microglia but not in BV-2 Microglia Cells	8
Actions of Alcohol in Brain: Genetics, Metabolomics, GABA Receptors, Proteomics and Glutamate Transporter GLAST/EAAT1	8
The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats	8
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases	8
Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines	8
Pain Perception and Management: Where do We Stand?	7
Nf-κb: A Target for Synchronizing the Functioning Nervous Tissue Progenitors of Different Types in Alzheimer's Disease	7
Bovine lactoferrin as a Modulator of Neuroendocrine Components of Stress	7
The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms	7
Dihydrotestosterone Induces Chemo-Resistance of Triple-Negative Breast MDA-MB-231 Cancer Cells Towards Doxorubicin Independent of ABCG2 and miR-328-3p	7
TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy	7
Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention	7
Coenzyme Q10 Supplement Rescues Postovulatory Oocyte Aging by Regulating SIRT4 Expression	7
Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme	7
The Impact of Spironolactone on Markers of Myocardial Oxidative Status, Inflammation and Remodeling in Hyperthyroid Rats	7
DNA Methylation in Epithelial Ovarian Cancer: Current Data and Future Perspectives	7
Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats	7
Retinoprotective Effects Of Crocin And Crocetin via Anti-Angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells	7
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion via Targeting DNMT3B	7
Disruption of Wnt/β-catenin Pathway Elevates the Sensitivity of Gastric Cancer Cells to PD-1 Antibody	7
Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy	7
Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity	7
Protective Potential of Ginkgo biloba Against an ADHD-like Condition	6
Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines	6
Dynamics and Interplay between Autophagy and Ubiquitin-proteasome system Coordination in Skeletal Muscle Atrophy	6

Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-Tumor Activity	6
Nutraceuticals and their Derived Nano-Formulations for the Prevention and Treatment of Alzheimer's Disease	6
Quercetin and Glioma: Which Signaling Pathways are Involved?	6
DoE Based Optimization and Development of Spray-Dried Chitosan-Coated Alginate Microparticles Loaded with Cisplatin for the Treatment of Cervical Cancer	6
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats	6
Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development	6
Targeting Signaling Pathway by Curcumin in Osteosarcoma	6
Azacitidine, as a DNMT Inhibitor Decreases hTERT Gene Expression and Telomerase Activity More Effective Compared with HDAC Inhibitor in Human Head and Neck Squamous Cell Carcinoma Cell Lines	6
Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine: Involvement of Autophagy and Sirtuin 1	6
Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells	6
Agomelatine: An Astounding Sui-generis Antidepressant?	5
MicroRNA Regulation of Androgen Receptor in Castration-Resistant Prostate Cancer: Premises, Promises, and Potentials	5
Impact of Buprenorphine on Learning and Memory Ability, Oxidative Status and Inflammation in the Hippocampus of Rats	5
Hypoxia Boosts Aerobic Glycolysis in Carcinoma: A Complex Process for Tumour Development	5
PiWi RNA in Neurodevelopment and Neurodegenerative Disorders	5
Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease	5
Suppression of Molecular Targets and Antiproliferative Effect of Citronellal on Triple-Negative Breast Cancer Cells	5
Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases	5
The Role of miR-129-5p in Cancer: A Novel Therapeutic Target	5
Comprehensive Analysis of SARS-COV-2 Drug Targets and Pharmacological Aspects in Treating the COVID-19	5
Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss	5
Therapeutic Targets for the Treatment of Comorbidities Associated with Epilepsy	5
Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules	5
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways	5
Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium	5