Current Molecular Pharmacology

Article	Citations
Minocycline and Doxycycline: More Than Antibiotics	41
Impact of Sitagliptin on Non-diabetic Covid-19 Patients	30
Melatonin Receptor as a Drug Target for Neuroprotection	30
Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice	23
Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression	20
Bacterial Siderophores and Their Potential Applications: A Review	19
AdipoRon: A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review	18
Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole	18
Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism	18
Connection between JAK/STAT and PPARγ Signaling During the Progression of Multiple Sclerosis: Insights into the Modulation of T-Cells and Immune Responses in the Brain	18
Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway	16
Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration	16
Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials	16
FAT10: Function and Relationship with Cancer	15
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems	15
CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297	14
Salvia miltiorrhiza in Anti-diabetic Angiopathy	14
Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage	14
Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury	14
Curcumin Efficacy in a Serum/Glucose Deprivation-Induced Neuronal PC12 Injury Model	13
Apelin/Apelin Receptor System: Molecular Characteristics, Physiological Roles, and Prospects as a Target for Disease Prevention and Pharmacotherapy	13
Ginger and Heart Health: From Mechanisms to Therapeutics	13
Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma	13
Interleukin-19 as an Immunoregulatory Cytokine	12
Obesity and Inflammation: Colorectal Cancer Engines	12

Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway	12
Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review	12
miR-4319 Suppresses the Growth of Esophageal Squamous Cell Carcinoma Via Targeting NLRC5	12
Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs	12
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury	11
Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling	11
miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway	11
Ticagrelor Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by the Inhibition of TGF-β1/Smad3 and PI3K/AKT/mTOR Pathways	11
Caveolin-1: A Promising Therapeutic Target for Diverse Diseases	11
Recent Advances in Herbal Nanomedicines for Cancer Treatment	11
Drug Repurposing for Cancer Therapy in the Era of Precision Medicine	10
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways	10
Quinoa (Chenopodium quinoa Willd.): Exploring a Superfood from Andean Indigenous Cultures with Potential to Reduce Cardiovascular Disease (CVD) Risk Markers	10
A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies	10
Epigenetic Regulation and Promising Therapies in Colorectal Cancer	10
Daclatasvir and Sofosbuvir Mitigate Hepatic Fibrosis Through Downregulation of TNF-α / NF-κB Signaling Pathway	9
Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway	9
Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma	9
Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy	9
Alcoholic Neuropathy: Involvement of Multifaceted Signalling Mechanisms	9
Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells	9
Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis	9
Novel Strategy in Breast Cancer Therapy: Revealing The Bright Side of Ginsenosides	9
The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats	8
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases	8
Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines	8
Possibility that the Onset of Autism Spectrum Disorder is Induced by Failure of the Glutamine-Glutamate Cycle	8
Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-Clinical Findings	8
Acetate Suppresses Lipopolysaccharide-stimulated Nitric Oxide Production in Primary Rat Microglia but not in BV-2 Microglia Cells	8
Actions of Alcohol in Brain: Genetics, Metabolomics, GABA Receptors, Proteomics and Glutamate Transporter GLAST/EAAT1	8
Coenzyme Q10 Supplement Rescues Postovulatory Oocyte Aging by Regulating SIRT4 Expression	7
Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme	7
The Impact of Spironolactone on Markers of Myocardial Oxidative Status, Inflammation and Remodeling in Hyperthyroid Rats	7
DNA Methylation in Epithelial Ovarian Cancer: Current Data and Future Perspectives	7
Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats	7
Retinoprotective Effects Of Crocin And Crocetin via Anti-Angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells	7
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion via Targeting DNMT3B	7
Disruption of Wnt/β-catenin Pathway Elevates the Sensitivity of Gastric Cancer Cells to PD-1 Antibody	7
Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy	7
Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity	7
Pain Perception and Management: Where do We Stand?	7
Nf-κb: A Target for Synchronizing the Functioning Nervous Tissue Progenitors of Different Types in Alzheimer's Disease	7
Bovine lactoferrin as a Modulator of Neuroendocrine Components of Stress	7
The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms	7
Dihydrotestosterone Induces Chemo-Resistance of Triple-Negative Breast MDA-MB-231 Cancer Cells Towards Doxorubicin Independent of ABCG2 and miR-328-3p	7
TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy	7
Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention	7
DoE Based Optimization and Development of Spray-Dried Chitosan-Coated Alginate Microparticles Loaded with Cisplatin for the Treatment of Cervical Cancer	6
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats	6
Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development	6

Targeting Signaling Pathway by Curcumin in Osteosarcoma	6
Azacitidine, as a DNMT Inhibitor Decreases hTERT Gene Expression and Telomerase Activity More Effective Compared with HDAC Inhibitor in Human Head and Neck Squamous Cell Carcinoma Cell Lines	6
Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine: Involvement of Autophagy and Sirtuin 1	6
Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells	6
Protective Potential of Ginkgo biloba Against an ADHD-like Condition	6
Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines	6
Dynamics and Interplay between Autophagy and Ubiquitin-proteasome system Coordination in Skeletal Muscle Atrophy	6
Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-Tumor Activity	6
Nutraceuticals and their Derived Nano-Formulations for the Prevention and Treatment of Alzheimer's Disease	6
Quercetin and Glioma: Which Signaling Pathways are Involved?	6
Therapeutic Targets for the Treatment of Comorbidities Associated with Epilepsy	5
Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules	5
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways	5
Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium	5
Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss	5
MicroRNA Regulation of Androgen Receptor in Castration-Resistant Prostate Cancer: Premises, Promises, and Potentials	5
Impact of Buprenorphine on Learning and Memory Ability, Oxidative Status and Inflammation in the Hippocampus of Rats	5
Hypoxia Boosts Aerobic Glycolysis in Carcinoma: A Complex Process for Tumour Development	5
PiWi RNA in Neurodevelopment and Neurodegenerative Disorders	5
Agomelatine: An Astounding Sui-generis Antidepressant?	5
Suppression of Molecular Targets and Antiproliferative Effect of Citronellal on Triple-Negative Breast Cancer Cells	5
Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases	5
The Role of miR-129-5p in Cancer: A Novel Therapeutic Target	5
Comprehensive Analysis of SARS-COV-2 Drug Targets and Pharmacological Aspects in Treating the COVID-19	5
Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease	5
Evaluation of the Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma	4
Sports-Related Brain Injury and Neurodegeneration in Athletes	4
Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis	4
The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies	4
Hesperidin Exerts Anxiolytic-like Effects in Rats with Streptozotocin‐ Induced Diabetes via PKA/CREB Signaling	4
Pretreatment with Gallic Acid Mitigates Cyclophosphamide Induced Inflammation and Oxidative Stress in Mice	4
Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular Targets, Primarily for Synthetic and Natural Drugs Targeting Oncology Therapeutics	4
Determining the Relative Gene Expression Level of Hypoxia Related Genes in Different Cancer Cell Lines	4
Cytochrome bc1-aa3 Oxidase Supercomplex As Emerging and Potential Drug Target Against Tuberculosis	4
Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca+2/PI3K Signaling Pathway	4
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling	4
Small Interfering RNAs and their Delivery Systems: A Novel Powerful Tool for the Potential Treatment of HIV Infections	4
The Therapeutic Effect and Mechanism of Qishen Yiqi Dripping Pills on Cardiovascular and Cerebrovascular Diseases and Diabetic Complications	4
Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics	4
Effect of Curcumin on the Head and Neck Squamous Cell Carcinoma Cell Line HN5	4
Nanoencapsulation of Polyphenols as Drugs and Supplements for Enhancing Therapeutic Profile - A Review	4
Promising Anticancer Activity of Multitarget Cyclin Dependent Kinase Inhibitors against Human Colorectal Carcinoma Cells	4
MiR-143 Inhibits Osteoclastogenesis by Targeting RANK and NF-κB and MAPK Signaling Pathways	4
Crocin Protects Against Beta-Amyloid Peptide-Induced Apoptosis in PC12 Cells Via the PI3 K Pathway	4
Antinociceptive and Anti-Inflammatory Like Effects of Berberis baluchistanica	4
Water Pipe Tobacco Smoking and Risk of Coronary Artery Disease: A Systematic Review and Meta-Analysis	4
Nano-Nutraceuticals Dietary Supplements for Athletes: An Eminent Approach for Managing Traumatic Brain Injuries	4
TRIM65 in White Matter Lesions, Innate Immunity, and Tumor	4
Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver	4
SK1 Inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway	4
Exercise and Nutraceuticals: Eminent Approach for Diabetic Neuropathy	4
Dual Targeting of Autophagy and NF-κB Pathway by PPARγ Contributes to the Inhibitory Effect of Demethoxycurcumin on NLRP3 Inflammasome Priming	4
The Effects of Acute and Chronic Sleep Deprivation on the Immune Profile in the Rat	4
Propitious Profile of Peppery Piperine	4
Sodium Valproate Modulates the Methylation Status of Lysine Residues 4, 9 and 27 in Histone H3 of HeLa Cells	4
Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents	4
Clozapine-induced Myocarditis: Pathophysiologic Mechanisms and Implications for Therapeutic Approaches	3
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma	3
Tumor Organoid Model and Its Pharmacological Applications in Tumorigenesis Prevention	3
Chlorpyrifos with Age-Dependent Effects in Cardiac Tissue of Male Rats	3
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review	3
Studying the Anti-Tumor Effects of siRNA Gene Silencing of Some Metabolic Genes in Pancreatic Ductal Adenocarcinoma	3
Di'ao Xinxuekang: Therapeutic Potential in Cardiovascular Diseases	3
Epigenetic Evaluation of N-(2-hydroxyphenyl)-2-Propylpentanamide, a Valproic Acid Aryl Derivative with Activity Against HeLa Cells	3
Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity	3
Recent Development and Future Prospects of Molecular Targeted Therapy in Prostate Cancer	3
Modulation of Bleomycin-induced Oxidative Stress and Pulmonary Fibrosis by Ginkgetin in Mice via AMPK	3
Anticancer Effects of Ginsenoside Rh2: A Systematic Review	3
Development and Characterization of a Clobetasol Propionate Nanostructured Lipid Carrier-Based Gel for the Treatment of Plaque Psoriasis	3
The Role of microRNAs in Gliomas – Therapeutic Implications	3
Thioacetamide-Induced Norepinephrine Production by Hepatocytes is Associated with Hepatic Stellate Cell Activation and Liver Fibrosis	3
Recent Advances in Vaginal Delivery for the Treatment of Vulvovaginal Candidiasis	3
Interplay between Heat Shock Proteins, Inflammation and Pain: A Promising Therapeutic Approach	3
The Protective Effect of Cilostazol in Genotoxicity Induced by Methotrexate in Human Cultured Lymphocytes	3
A Realistic Approach for Anti-Inflammatory, Antinociceptive and Antimutagenic Activities, and Risk Assessment of the Aqueous Extract of Platanus orientalis L. Leaves	3
SGLT-2 Inhibitors: Ideal Remedy for Cardioprotection in Diabetes Mellitus	3
Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules	3
Overview of Protein Kinase B Enzyme: A Potential Target for Breast and Prostate Cancer	3
siRNAs and Viruses: The good, the Bad and the Way Forward	3
Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer	3

Detailed Molecular Biochemistry for Novel Therapeutic Design Against Nipah and Hendra Virus: A Systematic Review	3
Fangchinoline Inhibited Proliferation of Neoplastic B-lymphoid Cells and Alleviated Sjögren’s Syndrome-like Responses in NOD/Ltj Mice via the Akt/mTOR Pathway	3
Molecular Insights into Agonist/Antagonist Effects on Macromolecules Involved in Human Disease Mechanisms	2
Covid-19: Pathophysiology; Mechanism of Transmission and Possible Molecular Drug Target for Management	2
Bedaquiline in Drug-Resistant Tuberculosis: A Mini-Review	2
Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres	2
Influence of SGLT2 Inhibitors in Remodeling, Substrate and Ion Metabolism of Myocardium to Prevent Cardiovascular Risks: Recent Work and Advancement	2
Neuroprotective Role of Nutritional Supplementation in Athletes	2
D-allose: Molecular Pathways and Therapeutic Capacity in Cancer	2
Ferulic Acid Attenuates Kainate-induced Neurodegeneration in a Rat Poststatus Epilepticus Model	2
Neuroprotective Effects of Shogaol in Metals (Al, As and Pb) and High-fat diet-induced Neuroinflammation and Behavior in Mice	2
Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ ERK Signaling Pathway	2
Nanostructured Lipid Carriers for Intranasal Administration of Olanzapine in the Management of Schizophrenia	2
A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I	2
Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin	2
Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study	2
Resveratrol Augments Doxorubicin and Cisplatin Chemotherapy: A Novel Therapeutic Strategy	2
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats	2
Phytotherapeutic and Natural Compound Applications for Age-Related, Inflammatory and Serious Eye Ailments	2
Berberine: Is it a Promising Agent for Mental Disorders Treatment?	2
Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis	2
COVID-19 and Diabetes: will Novel Drugs for Diabetes Help in COVID-19?	2
Upregulation of Beta 1 and Arachidonic Acid Metabolizing Enzymes in the Mouse Hearts and Kidneys after Sub Chronic Administration of Rofecoxib	2
Cryptotanshinone Induces Necroptosis Through Ca2+ Release and ROS Production in vitro and in vivo	2
Cytotoxic and Antitumoral Activity of N-(9H-purin-6-yl) Benzamide Derivatives and Related Water-soluble Prodrugs	2
Endoplasmic Reticulum Stress and Renin-Angiotensin System Crosstalk in Endothelial Dysfunction	2
Effects of Quercetin and Coenzyme Q10 on Biochemical, Molecular, and Morphological Parameters of Skeletal Muscle in Trained Diabetic Rats	2
A Review of the Potential Receptors of Migraine with a Special Emphasis on CGRP to Develop an Ideal Antimigraine Drug	2
Inactivation of Parathyroid Hormone: Perspectives of Drug Discovery to Combating Hyperparathyroidism	2
Mycotoxin Exposure and Autism: A Systematic Review of the Molecular Mechanism	2
Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in Isolated Rat Aorta: Involvement of cGMP Mediated sGC and Potassium Channel Activation	2
Prevalence of Hepatocellular Carcinoma in Men and the Contribution of Androgen and its Receptor in Pathogenesis and Therapy	2
Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model	2
The Therapeutic Activities of Metformin: Focus on the Nrf2 Signaling Pathway and Oxidative Stress Amelioration	2
An Overview and Therapeutic Promise of Nutraceuticals Against Sports-Related Brain Injury	2