OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
	146
JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development	95
Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice	79
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling	49
Role of the calcium‐sensing receptor in regulating vascular function	45
Next‐generation signaling: Powering the future of publications in the Journal of Cell Communication and Signaling	34
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	33
Human brain pericytes protect the blood–brain barrier from triple‐negative breast cancer cells while promoting tumor aggressiveness	29
A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system	28
Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies	27
	25
Trans‐Coumaryl acetate mediates GRK5/NF‐κB/Nrf2 signaling axis to ameliorate septic acute kidney injury	25
Mendelian randomization analysis identifies HLA‐A and AP2M1 as genetic biomarkers linked to immune–endocytic crosstalk in intervertebral disc degeneration	23
The antitumor effects of WNT5A against hematological malignancies	22
CD99 contributes to the EWS::FLI1 transcriptome by specifically affecting FOXM1‐targets involved in the G2/M cell cycle phase, thus influencing the Ewing sarcoma genetic landscape	22
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells	21
Adipocyte enhancer binding protein 1 knockdown alleviates osteoarthritis through inhibiting NF‐κB signaling pathway‐mediated inflammation and extracellular matrix degradation	21
Correction to an immunometabolism‐related signature for renal clear cell carcinoma diagnosis and therapeutic target	20
Urinary exosomes aggravate diabetic kidney disease by inducing podocyte ferroptosis via the miR‐217/SIRT1/Nrf2 pathway	19
Correction to Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR 1) in lupus nephritis: A novel therapeutic target	19
Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway	19
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	19
The regulation and functions of the matricellular CCN proteins induced by shear stress	18
Dual RNase activity of IRE1 as a target for anticancer therapies	17
ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia‐derived mesenchymal stem cells	17

Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation	17
Modulation of podocyte extracellular matrix remodeling in membranous nephropathy by the NFATc3/LRRC55/BK channel pathway	17
Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer	16
The 12th international workshop on the CCN family of genes in pictures	16
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation	16
Role of EGFR and FASN in breast cancer progression	16
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer	16
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine	15
Ceramide‐mediated mitochondrial dysfunction in nonobese nonalcoholic fatty liver disease: A regulatory role for serine palmitoyltransferase subunit 2	15
Gemcitabine activates the Hippo signaling pathway and suppresses tumor growth by stabilizing large tumor suppressor kinase 2 through the hypoxia‐inducible factor 1‐alpha/ubiquitin protein ligase E3 co	14
Fat mass and obesity‐associated protein downregulation enhances N6‐methyladenosine methylation and drives ovarian cancer progression	14
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1	14
Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy	13
Farewell Springer… Hello Wiley	13
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix	13
	12
Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo	12
Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential	12
ATOX1 alleviates radiation‐induced cardiac injury by modulating AMPK/NRF2 to inhibit myocardial oxidative stress and mitochondrial dysfunction	11
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis	11
The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling	11
Structural insights into regulation of CCN protein activities and functions	11
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	11
Notch NICD domains form biomolecular condensates	11
Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation	11
The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease	11
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	10
SIRT1: Protean roles at the nexus of health, disease, and therapeutics	10
miRNAs as short non-coding RNAs in regulating doxorubicin resistance	10
The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease	10
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A	9
The power of combined spatial transcriptomics and genome wide association studies (GWAS) approaches to heritable prostate cancer	9
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells	9
P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species‐mediated mitogen‐activated protein kinase signaling activation	9
POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration	9
Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis	9
Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population	8
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues	8
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells	8
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals	8
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	8
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1	8
Evaluation of altered cell–cell communication between glia and neurons in the hippocampus of 3xTg‐AD mice at two time points	8
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression	7
The small molecule peptide ANXA114‐26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor	7
The signaling pathways in obesity‐related complications	7
Report on the 12th international workshop on the CCN family of genes, Oslo, June 20–23, 2024	7
Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes	7
Identification of diagnostic biomarkers for neonatal necrotizing enterocolitis via machine learning screening and single‐cell virtual gene knockout validation	7
Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles	7

Role for the PIP₂‐binding protein myristoylated alanine‐rich C‐kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease	6
Matricellular proteins: Potential biomarkers in head and neck cancer	6
The advance of CCN3 in fibrosis	6
tRNA-derived fragments (tRFs) in cancer	6
CD2–CD58 axis orchestrates cytotoxic T lymphocyte function and metabolic crosstalk in breast cancer brain metastasis	6
Biological functions of CRTC2 and its role in metabolism-related diseases	6
Correction to: Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	6
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies	6
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway	6
Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery	6
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells	6
Therapeutic targeting of MALT1 in oncology: Mechanism, inhibitor development, and clinical prospects	5
A network map of macrophage-stimulating protein (MSP) signaling	5
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets	5
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	5
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma	5
Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats	5
CCNs and other extracellular matrix proteins: an introduction to the special issue	5
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	5
The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications	5
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	5
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells	5
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	5
Pan‐cancer analysis and oncogenic implications of MGAM and MGAM2 : Toward precision oncology and drug repu	4
	4
Hsa_circ_0000515 sequesters microRNA‐296‐5p and elevates RNF44 expression to encourage the NSCLC progression	4
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells	4
A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments	4
Naa10p impairs PGC‐1α/Pparγ2 interaction to inhibit mitochondrial protection in pancreatitis	4
Retraction: A network map of cytoskeleton‐associated protein 4 (CKAP4) mediated signaling pathway in cancer	4
Tert‐butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death	4
Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway	4
Hypoxic adipose‐derived stem cell exosomes as carriers of miR‐100‐5p to enhance angiogenesis and suppress inflammation in diabetic foot ulcers	4
A molecular network map of orexin-orexin receptor signaling system	4
The case of Connective Tissue Growth Factor (CTGF) and the pit of misleading and improper nomenclatures	4
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2‐mediated pathway	3
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes	3
Use and application of organ-on-a-chip platforms in cancer research	3
Stent treatment improves cerebral microcirculatory disorder and blood–brain barrier function in internal carotid artery stenosis via intercellular adhesion molecule 1 modulation	3
The opposite effect of ELP4 and ZEB2 on TCF7L2‐mediated microglia polarization in ischemic stroke	3
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer	3
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells	3
Gut microbiota‐derived trimethylamine‐N‐oxide inhibits SIRT1 to regulate SM22α‐mediated smooth muscle cell inflammation and promote atherosclerosis progression	3
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	3
Structural maintenance of chromosome protein 1A exacerbates liver fibrosis by enhancing hepatic stellate cell activation and extracellular matrix synthesis via laminin subunit gamma 2 activation	3
Enoyl coenzyme a hydratase 1 attenuates aortic valve calcification by suppressing Runx2 via Wnt5a/Ca²⁺ pathway	3
Targeting the PI3K/Akt/NF‐κB axis: Cluster of differentiation 5‐like‐mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm	3
The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia–reperfusion injury	3
Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related facto	3
Significance of CCNs in liver regeneration	3
	2
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway	2
Celebrating milestones in cell communication and signaling: Forthcoming joint ICCNS–ARBIOCOM anniversary meeting	2
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes	2
	2
CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies	2
Correction to “Extracellular vesicle‐LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR‐375/CDH2 pathway”	2
IL‐22Rα1 restrains pancreatic injury independently of its C‐terminal STAT3‐amplifying domain	2
Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway	2
Emerging role of IRE1α in vascular diseases	2
Nuclear binding SET domain 1 alleviates cartilage ferroptosis in knee osteoarthritis by upregulating the krüppel‐like factor 9/autophagy‐related 14 pathway via H3K36me2 modification	2
Correction to “LncRNA HOTTIP promotes LPS‐induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP‐C”	2
M2‐polarized tumor‐associated macrophage‐secreted exosomal lncRNA NEAT1 upregulates galectin‐3 by recruiting KLF5 and promotes HCC immune escape	2
The 11th international workshop on the CCN family of genes in pictures	2
Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity	2
Tri‐domain proteins 27 alleviates ischemia‐reperfusion injury‐induced acute kidney injury by promoting Gli‐like transcription factor 1 expression via the inhibition of polycomb repressive complex 2 ac	2