OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Signaling network regulating osteogenesis in mesenchymal stem cells	54
Matrigel: history/background, uses, and future applications	49
Targeting of the tumor immune microenvironment by metformin	38
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	34
Periostin: an emerging activator of multiple signaling pathways	29
Targeting PI3K/Akt signaling in prostate cancer therapy	28
Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts	27
BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling	27
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway	26
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes	24
tRNA-derived fragments (tRFs) in cancer	23
The CCN2/CTGF interactome: an approach to understanding the versatility of CCN2/CTGF molecular activities	22
Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs	22
Endocannabinoid signaling pathways: beyond CB1R and CB2R	21
A modular map of Bradykinin-mediated inflammatory signaling network	21
SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19	18
The complexity of TGFβ/activin signaling in regeneration	17
The CCN axis in cancer development and progression	16
The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?	16
CD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles	16
Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans	16
The impact of cellular senescence in human adipose tissue	16
The modulation of neuroinflammation by inducible nitric oxide synthase	15
An assembly of galanin–galanin receptor signaling network	15
Opioid receptors signaling network	14

CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis	14
Chemokine signaling in cancer-stroma communications	14
Identification of key regulators associated with colon cancer prognosis and pathogenesis	14
Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle	14
CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling	13
A comprehensive network map of IL-17A signaling pathway	13
The role of extracellular vesicles in podocyte autophagy in kidney disease	13
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?	13
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1	13
YY1 regulated transcription‐based stratification of gastric tumors and identification of potential therapeutic candidates	12
CTHRC1 promotes growth, migration and invasion of trophoblasts via reciprocal Wnt/β-catenin regulation	12
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling	11
Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging	11
Extracellular vesicles from MDA-MB-231 breast cancer cells stimulated with insulin-like growth factor 1 mediate an epithelial–mesenchymal transition process in MCF10A mammary epithelial cells	11
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A	10
Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease	10
CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology	10
Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys	10
Why do humans need thrombospondin-1?	10
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	10
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	9
The network map of Elabela signaling pathway in physiological and pathological conditions	9
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation	9
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action	9
Naringenin alleviates hyperglycemia-induced renal toxicity by regulating activating transcription factor 4–C/EBP homologous protein mediated apoptosis	9
A network map of apelin-mediated signaling	9
A review on Tsukushi: mammalian development, disorders, and therapy	9
Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue	9
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	8
A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions	8
Comparative stemness and differentiation of luminal and basal breast cancer stem cell type under glutamine‐deprivation	8
Cellular communication network factor 3 in cartilage development and maintenance	8
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice	8
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes	8
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer	7
The role of CCNs in controlling cellular communication in the tumor microenvironment	7
Aneurysm severity is suppressed by deletion of CCN4	7
Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway	7
CCN proteins: opportunities for clinical studies—a personal perspective	7
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	7
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling	7
The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression	7
Tools used to assay genomic instability in cancers and cancer meiomitosis	7
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	7
Novel role of long non-coding RNAs in autoimmune cutaneous disease	7
Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer	6
Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice	6
The role of vascular endothelial protein tyrosine phosphatase on nitric oxide synthase function in diabetes: from molecular biology to the clinic	6
Significance of CCNs in liver regeneration	6
Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis	6

Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines	5
Novel peptide—based inhibitor for targeted inhibition of T cell function	5
Renal tumouroids: challenges of manufacturing 3D cultures from patient derived primary cells	5
A pathway map of signaling events triggered upon SARS-CoV infection	5
Structural insights into regulation of CCN protein activities and functions	5
Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF-α/STAT3/autophagy axis	5
A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells	5
Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway	5
The role of nuclear factor kappa B (NF-κB) in filarial pathology	4
A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions	4
Analysis of multiple basal cell carcinomas (BCCs) arising in one individual highlights genetic tumor heterogeneity and identifies novel driver mutations	4
Chondroitin polymerizing factor predicts a poor prognosis and promotes breast cancer progression via the upstream TGF-β1/SMAD3 and JNK axis activation	4
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells	4
The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions	4
Dual RNase activity of IRE1 as a target for anticancer therapies	4
High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing	4
Adipocytes reprogram prostate cancer stem cell machinery	4
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	4
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction	4
Connexin 32 overexpression increases proliferation, reduces gap junctional intercellular communication, motility and epithelial-to-mesenchymal transition in Hs578T breast cancer cells	4
Glucose-limiting conditions induce an invasive population of MDA-MB-231 breast cancer cells with increased connexin 43 expression and membrane localization	4
UTP increases wound healing in the self assembled skin substitute (SASS)	4
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	4
Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling	4
Expression and associated epigenetic mechanisms of the Ca2+-signaling genes in breast cancer subtypes and epithelial-to-mesenchymal transition	4
miR-137/ERRα axis mediates chemoresistance of nasopharyngeal carcinoma cells	4
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes	4
Role of EGFR and FASN in breast cancer progression	4
Transcriptional and epigenetic landscape of Ca2+-signaling genes in hepatocellular carcinoma	4
ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation	4
BLM promotes malignancy in PCa by inducing KRAS expression and RhoA suppression via its interaction with HDGF and activation of MAPK/ERK pathway	4
Use and application of organ-on-a-chip platforms in cancer research	3
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals	3
CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway	3
Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction	3
miR-135 protects against atrial fibrillation by suppressing intracellular calcium-mediated NLRP3 inflammasome activation	3
Do not overwork: cellular communication network factor 3 for life in cartilage	3
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	3
Metastases from metastases: comparative metastatic potential of human cancer cell lines originated from primary tumors or metastases in various tissues	3
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis	3
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1	3
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro	3
The antitumor effects of WNT5A against hematological malignancies	3
A molecular network map of orexin-orexin receptor signaling system	3
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway	3
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma	3
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner	3
A network map of GDNF/RET signaling pathway in physiological and pathological conditions	3
Platelet-lymphocyte co-culture serves as an ex vivo platform of dynamic heterotypic cross-talk	3
Atypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia	3
Bioinformatics analysis reveals molecular connections between non-alcoholic fatty liver disease (NAFLD) and COVID-19	3
Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1	3
A network map of macrophage-stimulating protein (MSP) signaling	3
Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight	3