OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
	73
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes	70
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma	70
JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development	48
Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice	42
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling	41
Role of the calcium‐sensing receptor in regulating vascular function	38
Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies	33
A comprehensive network map of IL-17A signaling pathway	32
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	27
BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling	26
Chemokine signaling in cancer-stroma communications	25
	25
Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis	24
The antitumor effects of WNT5A against hematological malignancies	20
Novel peptide—based inhibitor for targeted inhibition of T cell function	20
Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance	19
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells	18
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	16
Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling	16
Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys	16
CD99 contributes to the EWS::FLI1 transcriptome by specifically affecting FOXM1‐targets involved in the G2/M cell cycle phase, thus influencing the Ewing sarcoma genetic landscape	16
The regulation and functions of the matricellular CCN proteins induced by shear stress	15
Adipocyte enhancer binding protein 1 knockdown alleviates osteoarthritis through inhibiting NF‐κB signaling pathway‐mediated inflammation and extracellular matrix degradation	15
Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway	15

Tools used to assay genomic instability in cancers and cancer meiomitosis	14
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation	14
Role of EGFR and FASN in breast cancer progression	14
Dual RNase activity of IRE1 as a target for anticancer therapies	14
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation	13
The 12th international workshop on the CCN family of genes in pictures	13
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine	13
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1	13
Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging	12
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix	12
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer	12
A review on Tsukushi: mammalian development, disorders, and therapy	11
Farewell Springer… Hello Wiley	11
Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease	11
The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions	11
Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo	11
Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer	11
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	10
Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice	10
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis	10
miRNAs as short non-coding RNAs in regulating doxorubicin resistance	10
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	10
Structural insights into regulation of CCN protein activities and functions	10
Modeling the microenvironment special issue	10
Sustained AWT1 expression by Dupuytren’s disease myofibroblasts promotes a proinflammatory milieu	10
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A	9
Blisters on your fingers	9
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action	9
POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration	9
Cellular communication network factor 3 in cartilage development and maintenance	9
The power of combined spatial transcriptomics and genome wide association studies (GWAS) approaches to heritable prostate cancer	9
Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis	9
Opioid receptors signaling network	9
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1	9
Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population	8
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues	8
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells	8
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells	8
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals	8
Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines	7
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1	7
Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles	7
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	7
Evaluation of altered cell–cell communication between glia and neurons in the hippocampus of 3xTg‐AD mice at two time points	7
ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation	7
The small molecule peptide ANXA114‐26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor	6
The signaling pathways in obesity‐related complications	6
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression	6
The miR-302c/transforming growth factor-β receptor type-2 axis modulates interleukin-1β-induced degenerative changes in osteoarthritic chondrocytes	6
Report on the 12th international workshop on the CCN family of genes, Oslo, June 20–23, 2024	6

Role for the PIP₂‐binding protein myristoylated alanine‐rich C‐kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease	6
The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression	6
A modular map of Bradykinin-mediated inflammatory signaling network	6
tRNA-derived fragments (tRFs) in cancer	6
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway	5
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	5
The advance of CCN3 in fibrosis	5
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies	5
A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions	5
The network map of Elabela signaling pathway in physiological and pathological conditions	5
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells	5
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma	5
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?	5
Biological functions of CRTC2 and its role in metabolism-related diseases	5
Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats	5
Correction to: Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	5
Matricellular proteins: Potential biomarkers in head and neck cancer	5
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	4
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells	4
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells	4
The case of Connective Tissue Growth Factor (CTGF) and the pit of misleading and improper nomenclatures	4
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer	4
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	4
CCNs and other extracellular matrix proteins: an introduction to the special issue	4
The CCN2/CTGF interactome: an approach to understanding the versatility of CCN2/CTGF molecular activities	4
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	4
Retraction: A network map of cytoskeleton‐associated protein 4 (CKAP4) mediated signaling pathway in cancer	4
Hsa_circ_0000515 sequesters microRNA‐296‐5p and elevates RNF44 expression to encourage the NSCLC progression	4
CD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles	4
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets	4
A network map of macrophage-stimulating protein (MSP) signaling	4
A molecular network map of orexin-orexin receptor signaling system	4
Enoyl coenzyme a hydratase 1 attenuates aortic valve calcification by suppressing Runx2 via Wnt5a/Ca²⁺ pathway	4
Tert‐butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death	4
	4
Atypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia	4
Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?	4
Aneurysm severity is suppressed by deletion of CCN4	3
SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19	3
Use and application of organ-on-a-chip platforms in cancer research	3
M2‐polarized tumor‐associated macrophage‐secreted exosomal lncRNA NEAT1 upregulates galectin‐3 by recruiting KLF5 and promotes HCC immune escape	3
Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway	3
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway	3
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction	3
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner	3
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes	3
The opposite effect of ELP4 and ZEB2 on TCF7L2‐mediated microglia polarization in ischemic stroke	3
Significance of CCNs in liver regeneration	3
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	3
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes	3
Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis	3
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells	3
Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity	3
The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia–reperfusion injury	3
Novel role of long non-coding RNAs in autoimmune cutaneous disease	3
Emerging role of IRE1α in vascular diseases	3
The 11th international workshop on the CCN family of genes in pictures	3