OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	63
The opposite effect of ELP4 and ZEB2 on TCF7L2‐mediated microglia polarization in ischemic stroke	63
Farewell Springer… Hello Wiley	45
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling	36
Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight	36
LncRNA HOTTIP promotes LPS‐induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP‐C	34
Role for the PIP₂‐binding protein myristoylated alanine‐rich C‐kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease	28
	28
M2‐polarized tumor‐associated macrophage‐secreted exosomal lncRNA NEAT1 upregulates galectin‐3 by recruiting KLF5 and promotes HCC immune escape	27
Matricellular proteins: Potential biomarkers in head and neck cancer	25
Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice	23
Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo	22
Hypoxia drives CBR4 down‐regulation promotes gastroenteropancreatic neuroendocrine tumors via activation mammalian target of rapamycin mediated by fatty acid synthase	21
JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development	20
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway	19
The network map of Elabela signaling pathway in physiological and pathological conditions	18
CTHRC1 promotes growth, migration and invasion of trophoblasts via reciprocal Wnt/β-catenin regulation	18
The advance of CCN3 in fibrosis	17
Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity	17
Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway	17
Novel role of long non-coding RNAs in autoimmune cutaneous disease	16
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?	16
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes	15
Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis	15
A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions	14

ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma	14
Aneurysm severity is suppressed by deletion of CCN4	14
tRNA-derived fragments (tRFs) in cancer	14
Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease	14
The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions	13
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction	12
From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction	12
Metastases from metastases: comparative metastatic potential of human cancer cell lines originated from primary tumors or metastases in various tissues	12
Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions	12
Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans	11
Biological functions of CRTC2 and its role in metabolism-related diseases	11
Severe heat stress modulated nuclear factor erythroid 2-related factor 2 and macrophage migration inhibitory factor pathway in rat liver	11
BLM promotes malignancy in PCa by inducing KRAS expression and RhoA suppression via its interaction with HDGF and activation of MAPK/ERK pathway	11
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies	11
Significance of CCNs in liver regeneration	11
Primary cilia: turning points in establishing their ubiquity, sensory role and the pathological consequences of dysfunction	10
2022, a year of the water tiger	10
Exosomal miR-129 and miR-342 derived from intermittent hypoxia-stimulated vascular smooth muscle cells inhibit the eIF2α/ATF4 axis from preventing calcified aortic valvular disease	10
Yay team!: 5.782	10
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma	10
Association for research on biosignaling and communication first world conference on cellular communication and signaling	10
The 11th international workshop on the CCN family of genes in pictures	10
Cytokine expression and cytokine‐mediated cell–cell communication during skeletal muscle regeneration revealed by integrative analysis of single‐cell RNA sequencing data	9
Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway	9
Emerging role of IRE1α in vascular diseases	9
Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats	9
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	9
Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies	9
BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling	8
Friend and foe: the regulation network of ascites components in ovarian cancer progression	8
Structural insights into regulation of CCN protein activities and functions	8
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling	8
Potential of extracellular vesicles for early prediction of severity and potential risk stratification in critical inflammatory diseases	8
Role of the calcium‐sensing receptor in regulating vascular function	8
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	7
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	7
The CCN2/CTGF interactome: an approach to understanding the versatility of CCN2/CTGF molecular activities	7
Advances in research of biological functions of Isthmin-1	7
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes	7
Chondroitin polymerizing factor predicts a poor prognosis and promotes breast cancer progression via the upstream TGF-β1/SMAD3 and JNK axis activation	7
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	7
A comprehensive network map of IL-17A signaling pathway	7
Correction to: Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	7
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis	6
Expression and function of CCN2-derived circRNAs in chondrocytes	6
A review on Tsukushi: mammalian development, disorders, and therapy	6
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells	6
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway	6
A network map of macrophage-stimulating protein (MSP) signaling	6
The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?	6

miRNAs as short non-coding RNAs in regulating doxorubicin resistance	5
Modeling the microenvironment special issue	5
Matrigel: history/background, uses, and future applications	5
Lactate drives CD38 signaling to promote Epithelial‐Mesenchymal Transition through Snail induction in non‐small cell lung cancer cells	5
Endocannabinoid signaling pathways: beyond CB1R and CB2R	5
Targeting PI3K/Akt signaling in prostate cancer therapy	5
IncRNA AC004943.2 regulates miR‐135a‐5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression	5
Sustained AWT1 expression by Dupuytren’s disease myofibroblasts promotes a proinflammatory milieu	5
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling	5
Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice	5
	5
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	5
Moscatilin alleviates oxidative stress and inflammatory response of Müller cells in diabetic retinopathy through suppressing the p38 mitogen‐activated protein kinase/c‐Jun N‐terminal kinase and nuclea	4
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	4
Do not overwork: cellular communication network factor 3 for life in cartilage	4
miR-135 protects against atrial fibrillation by suppressing intracellular calcium-mediated NLRP3 inflammasome activation	4
Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?	4
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1	4
Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis	4
Signaling network regulating osteogenesis in mesenchymal stem cells	4
The antitumor effects of WNT5A against hematological malignancies	4
A molecular network map of orexin-orexin receptor signaling system	4
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets	4
CCNs and other extracellular matrix proteins: an introduction to the special issue	4
Chemokine signaling in cancer-stroma communications	4
The role of CCNs in controlling cellular communication in the tumor microenvironment	4
Periostin: an emerging activator of multiple signaling pathways	4
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	4
The impact of cellular senescence in human adipose tissue	3
Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis	3
AMPK targets a proto-oncogene TPD52 (isoform 3) expression and its interaction with LKB1 suppress AMPK-GSK3β signaling axis in prostate cancer	3
Cellular communication network factor 3 in cartilage development and maintenance	3
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	3
Adipocytes reprogram prostate cancer stem cell machinery	3
A network map of cytoskeleton-associated protein 4 (CKAP4) mediated signaling pathway in cancer	3
	3
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells	3
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action	3
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro	3
Expression and associated epigenetic mechanisms of the Ca2+-signaling genes in breast cancer subtypes and epithelial-to-mesenchymal transition	3
A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells	3
A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions	3
Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys	3
Bioinformatics analysis reveals molecular connections between non-alcoholic fatty liver disease (NAFLD) and COVID-19	3
Novel peptide—based inhibitor for targeted inhibition of T cell function	3
BMP-1-induced GBA1 nuclear accumulation provokes CCN2 mRNA expression via importin-β-mediated nucleocytoplasmic pathway	3
Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance	3
Retraction Note: Long non-coding RNA TP73-AS1 promotes TFAP2B-mediated proliferation, metastasis and invasion in retinoblastoma via decoying of miRNA-874-3p	3
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells	3
High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing	3
How does the same ligand activate signaling of different receptors in TNFR superfamily: a computational study	3
Correction to “LncRNA HOTTIP promotes LPS‐induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP‐C”	3