OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmaceutical Innovation is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Editorial: Biopharmaceutical Innovation	52
Development and Characterization of Copper Cross-Linked Freeze-Dried Bioscaffolds for Potential Wound Healing Activity	24
Fabrication of Zein-Chitosan-Zein Sandwich-Like Nanofibers Containing Teicoplanin as a Local Antibacterial Drug Delivery System	22
Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin Calcium by Solid Dispersion Technique Using a Modified Natural Polymer as a Hydrophilic Carrier	17
A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)	16
Accelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval	16
Gastroprotective Efficacy of Prebiotic-based Oral Formulation of Amoxicillin	16
A Gel-Free Reservoir System for Once-a-Day Ophthalmic Delivery of Timolol Maleate	15
Novel Ketoconazole-Loaded Niosomal Gel with Carbamide for Enhanced Topical Delivery and Skin Hydration in Fungal Infections	14
Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders	13
Surface Functionalization of Piperine-Loaded Liposomes with Sophorolipids Improves Drug Loading and Stability	12
Hemoglobin-Polyvinyl Alcohol (Hb-PVA) Macroporous Cryogels As Swelling-Controlled Drug Delivery System Optimization and Release Kinetics of Vancomycin	11
Passive Targeted Drug Delivery of Venlafaxine HCl to the Brain by Modified Chitosan Nanoparticles: Characterization, Cellular Safety Assessment, and In Vivo Evaluation	11
Baicalein-Loaded Aspasomal Formulations: Development, Characterization and Evaluation of Antioxidant and Anti-Inflammatory Effects	11
Impact of Process Parameters and Formulation Properties on Dissolution Performance of an Extended Release Tablet: a Multivariate Analysis	11
A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies	10
Lutein and β-Carotene Characterization in Free and Nanodispersion Forms in Terms of Antioxidant Activity and Cytotoxicity	10
Enhancing the Entrapment Efficiency of Alginate Floating Beads Using Double Emulsion Technique	9
Evaluation and Monitoring of the API Content of a Portable Near Infrared Instrument Combined with Chemometrics Based on Fluidized Bed Mixing Process	9
Synthesis, Structural Characterization, and Antimicrobial Evaluation of Silver Nanoparticle-embedded Layered Double Hydroxides for Delivery in Polymeric Hydrogel Matrices	9
Ciprofloxacin HCl-loaded Albumin Nanoparticles for the Treatment of Recurrent Urinary Tract Infections: Preparation, Optimization, and Evaluation of Antibacterial Activity	9
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan	9
Colloidal Copper Nanoparticles Loaded with Vanillic Acid as Liquid Dressings: Development, Characterisation and Evaluation	9
Box–Behnken Design-Based Optimized Kinetic Approach to Develop an Eco-friendly Analytical Method for the Quantitation of Glimepiride Using Spectrophotometry	8
DoE-Based Solid Self-microemulsifying Drug Delivery System (S-SMEDDS) Approach for Improving the Dissolution Properties of Raltegravir Potassium	8

Assessment of Imaging Flow Cytometry for the Simultaneous Discrimination of Protein Particles and Silicone Oil Droplets in Biologicals	8
Investigation of In Vivo Bioavailability Enhancement of Iloperidone-Loaded Solid Self-Nanoemulsifying Drug Delivery Systems: Formulation and Optimization Using Box-Behnken Design and Desirability Func	8
Preparation and Characterization of Gatifloxacin-Loaded Polyacrylonitrile Nanofiber for the Management of Dry Eye Infection	8
Preparation and Evaluation of N-Acetyl D-Glucosamine Ethosomal Gel for the Treatment of Hyperpigmentation	8
Determination of Mixing Efficiency in Various Laboratory-Scale Semi-Solid Formulation Techniques Through Computational Fluid Dynamics and Finite Volume Simulations	8
Influence of Nanocarrier Type on the Drug Delivery Aspects of Docetaxel: Empirical Evidences	8
Application of Artificial Intelligence in Identifying Human Immunoglobulin and Albumin in Commercial Intravenous Drugs	8
Systematic Optimization of Solid Lipid Nanoparticles of Silybin for Improved Oral Drug Delivery by Box-Behnken Design: In Vitro and In Vivo Evaluations	8
Design and Development of Fluconazole-Loaded Nanocellulose-Eudragit Vaginal Drug Delivery System	7
A Simple Approach to Preparation of Surfactant Nano-Micelles Loaded Drugs	7
Development and Characterization of Viburnum opulus L. Extract-Loaded Orodispersible Films: Potential Route of Administration for Phytochemicals	7
Assessment of the HaLCon® Protein Analyzer for At-Line Titer Measurements in Biomanufacturing Applications	7
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances	7
Editorial: September 2022, What’s Next?	7
Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100	7
Editorial: Biologics and Parenterals: Major Newsmakers	7
Defining the Range of Calibration Burden: From Full Calibration to Calibration-Free	6
Editorial: Big Changes for the Journal of Pharmaceutical Innovation… and It is All Good!	6
Formulation and Development of Posaconazole Loaded Controlled Release Nanosponge Topical Gel for the Treatment of Fungal Infection	6
Fusidic Acid Microemulsion Based on a Pseudoternary Phase Diagram: Development, Characterization, and Evaluation	6
Process Monitoring and Characterization for Extraction of Herbal Medicines Based on Proton (1H) Nuclear Magnetic Resonance Spectroscopy and Multivariate Batch Modeling: a Case Study	6
Mucoadhesive (Type-I) and Floating (Type-II) Chitosan Beads for Improved Gastric Retention of Clarithromycin	6
A Dynamic Model for GMP Compliance and Regulatory Science	6
Bioinspired Chitosan-Based Patches Enriched With Lipid-Casein Nanocarriers: An Innovative Approach for Wound Management and Evaluation in a Rat Model	6
Spray Angle Measurement in Pharmaceutical Sprays: Correct Methodology and Common Pitfalls	6
A Novel Azathioprine Polysaccharide Nanoparticle Enhances the Efficacy of Systemic Lupus Erythematosus Therapy	6
A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management	5
Fluconazole-Niosome-Laden Contact Lens: A Promising Therapeutic Approach for Prolonged Ocular Delivery and Enhanced Antifungal Activity	5
Optimization, Formulation, and Stability of Topical Rapamycin Used for Rare Tuberous Sclerosis Disease: from Ointment to Liposomes	5
“Implementation of Quality by Design of Sublingual Antihypertensive Drugs"	5
Prospects and Analysis of Traditional Chinese Medicine Standards Through the Transition of Chinese Pharmacopeia	5
Using of Oxygen Species in the Sterilization of Medical Equipment and Assessment of the Test Results	5
Correction to: The Reform of the Orphan Drug Assessment System in China	5
Optimizing Continuous Feeding of Poorly Flowing Excipients: Impact of Batch-To-Batch Variability and Process Design	5
A Review on Solid Microneedles for Biomedical Applications	5
Preparation of Chitosan-Tripolyphosphate Formulated Insulin Microparticles, Their Characterization, ANN Prediction, and Release Kinetics	5
Editorial: Innovation Accelerates into the Future	5
Novel Chitosan Beeswax Matrix for Gastro-Retentive Delivery of Curcumin: A Promising Adjuvant Therapy for Helicobacter Infection	5
Development and Optimization of Curcumin-Loaded Citric Acid Functionalized Multi-Walled Carbon Nanotubes for Enhanced Breast Cancer Treatment Using Design of Experiment	5
Continuous and Size-Controlled Preparation of Ibuprofen Nanosuspension by Antisolvent Crystallization Method Using Hollow Fiber Membrane	5
Good Laboratory Practice in Preclinical Research: Lessons Learned from Warning Letters Issued Between 2019 and 2024 Addressing Violations to the 21 Code of Federal Regulation Part 58	5
Green Synthesis of Silver Nanoparticles by Using Anthemis Tricolor Boiss., Factorial Design for Parameter Optimization, Characterization and In-Vitro Biological Activities	4
Effect of Manufacturing Conditions on Particle Characteristics in the Drug-Layering Process of a Novel Melt Granulation Technology, MALCORE®, Using a Design of Experiments	4
Polymethylmethacrylate Copolymer-Based Microcarriers for Culturing Mammalian Cells	4
Development of Paediatric Formulation of Baclofen for Improved Safety and Palatability	4
Formulation, Characterization, Optimization, and Pharmacokinetic Evaluation of Cilnidipine-Loaded Liquisolid Compacts with Improved Dissolution and Bioavailability	4
3D Drug Printing by Semi-Solid Extrusion Through Reusable Cartridges: Usability Evaluation	4
Formulate Lornoxicam Bio Adhesive Microspheres Using Different Polymers by Ionotropic Gelation Method and Emulsion Cross Linking Method: An Integrated Molecular Dynamics Approach	4
23 Factorial Design and Optimization of Effervescent Floating Matrix Tablet of Neratinib	4
Screening of Polysaccharide Films Consisting of pH-Dependent Systems in Combination with Microbial Decomposition-Dependent Systems to Determine the Appropriate Coating for Colonic Drug Delivery	4

Biosynthesis and Characterization of Silver Nanoparticle by Using Artocarpus altilis Fruit Extract for Its Biological Activity	4
Rapid Determination in the Quality Control of Chinese Patent Medicine	4
Physicochemical Characterization of Three Active Pharmaceutical Ingredients for Compound Glycyrrhizin Solid Formulation and Compatibility Analysis via Thermal and Non-thermal Techniques	4
Design of a Pharmaceutical 3D Printer Using Quality-by-Design Approach	4
Improving the Intestinal Permeability of Aprepitant via Self-Microemulsifying Delivery System: In Vitro Development and in Situ Permeation Assessment	4
Blockchain for Data Originality in Pharma Manufacturing	4
Preparation and Transformation of Solid Glass Solutions of Clotrimazole to Nanosuspensions with Improved Physicochemical and Antifungal Properties	4
Quality by Design (QbD) Enabled and Central-Composite Design Assisted Approach for Formulation of Oral Herbal Gastro-retentive In-situ Gel	4
Comparative Study of Methods for the Pharmaceutical Preparation and Effectiveness of Darunavir Ethanolate Compositions with Mesoporous Carriers and Polymer Solid Dispersions	4
Ocular Delivery of Itraconazole Loaded Leciplex to Treat Fungal Infection	4
Nanosized Intranasal Delivery of Novel Self-Assembled Cubic Liquid Crystals: Formulation and Evaluation	4
FDA Warning Letters: A Retrospective Analysis of Letters Issued to Pharmaceutical Companies from 2010–2020	4
Development, Optimization and In Vitro Characterization of Eudragit-Ganciclovir Nanosuspension or Treating Herpes Simplex Keratitis	4
The Assessment of Vaginal permeability – in silico Approach	4
Identification and Predictive Analysis of Revenue Determinants in the Pharma Industry: A Longitudinal Analysis of Financial, Regulatory and Pipeline Data	3
QbD Enabled Formulation Development of Nanoemulsion of Nimodipine for Improved Biopharmaceutical Performance	3
New Insight into Acidifier-Induced Enhancement of Dissolution of Weakly Basic Drug, Dipyridamole	3
Editorial: The World Coming Out of Its Shell	3
Studies in Development and Statistical Optimization of Levofloxacin Solid Lipid Nanoparticles for the Treatment of Tuberculosis	3
Cardiovascular Drugs: an Insight of In Silico Drug Design Tools	3
A Communication Effectiveness Study of the FDA GMP Warning Letters	3
Novel Glyceryl Monostearate- and Polyethylene Glycol 6000-Based Ibuprofen Pellets Prepared by Hot-Melt Extrusion: Evaluation and Stability Assessment	3
Has the Establishment of a FTZ Promoted the High-quality Development of the Pharmaceutical Manufacturing Industry?——Quasi Natural Experiments Based on the Establishment of the First Three Batches of P	3
Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells	3
Development of Chitosan-Based Microencapsulation System for Mitragyna speciosa Alkaloids: A Novel Approach for Alzheimer’s Disease Treatment	3
Design, Optimization, and Characterization of Lysozyme-Loaded Poly(ɛ-Caprolactone) Microparticles for Pulmonary Delivery	3
Ensuring Product Safety: A Comprehensive Retrospective Study of USFDA Drug Recalls (2019–2023)	3
Design and Critical Characterization the Pharmaceutical Cocrystal of Azelnidipine With Coformers for Boosting Physicochemical Properties	3
Melt Granulation Techniques as an Alternative Manufacturing Technology for the Generic Development of Apixaban 5 mg Immediate-Release Tablets: A Case Study	3
Design of a Production Planning System in a Pharmaceutical Factory: Spreadsheet Model and Case Study	3
Producing High-Dose Liqui-Tablet (Ketoprofen 100 mg) for Enhanced Drug Release Using Novel Liqui-Mass Technology	3
Investigating the Effect of Particle Size on Cellular Uptake by Aggregation-Caused Quenching Probe–Encapsulating Solid Lipid Nanoparticles, Inhaled	3
Development and Optimization of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Delivery of Dolutegravir	3
Gossypol-Embedded Casein Nanoparticles for Potential Targeting of Ovarian Cancer: Formulation, Characterization, and Anticancer Activity	3
Innovative Polymeric Micelles with In-Situ Gelation for Enhanced Ocular Delivery of Ketoconazole	3
Development and In-Vitro Characterization of Capsaicin Microsponges Loaded Topical Gels for Management of Arthritis	3
Quality-by-Design Approach for Optimization and Processing of PLGA Polymer Film by Hot Melt Extrusion	3
Enhancement of Valsartan Dissolution Rate by the Increased Porosity of Pellets Using Supercritical CO2: Optimization via Central Composite Design	3
Bioactive Extract Production from Citrullus Clocynthis Fruit via Microwave-Assisted Extraction: Experimental Optimization, Process Design and Economics with Uncertainty Quantification	3
Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS)	3
Preparation of Stable Clindamycin Phosphate Niosomes by Combination of Sorbitan Esters and their Ethoxylaed Derivatives	3
Fabrication and Characterisation of Taste-Masked Orally Dissolving Films Containing Ondansetron Hydrochloride Using Novel Poly(Amide-Thioester) Nanocapsules Based on L-Cysteine Amino-Acid	3
Unveiling the Pharmacological Mechanism of Cosmos Caudatus Compounds as Lung Cancer Drug Candidates: Pharmacology Networking, Molecular Docking, and Experimental Validation	3