OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmaceutical Innovation is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Preparation and Physicochemical Characterizations of Niosomal Benzoyl Peroxide and Clindamycin Phosphate Formulation for Acne Vulgaris	30
Improving the Intestinal Permeability of Aprepitant via Self-Microemulsifying Delivery System: In Vitro Development and in Situ Permeation Assessment	26
Revolutionizing Pharma: Prioritizing Industry 4.0 Implementation Challenges in the Indian Pharmaceutical Landscape Through Analytical Hierarchy Process Analysis	17
Statistical Design of Experiments Using R Program for the Optimization of an Extended-Release Neem Oil Matrix Tablet	16
Development and Characterization of Copper Cross-Linked Freeze-Dried Bioscaffolds for Potential Wound Healing Activity	15
Impact of Process Parameters and Formulation Properties on Dissolution Performance of an Extended Release Tablet: a Multivariate Analysis	14
Editorial: Wrapping Up 2021 and Looking Forward to 2022	13
Formulation, Development, and Comparative Study of Azelastine-Loaded Temperature Sensitive In Situ Gelling Micelles for Allergic Conjunctivitis	13
Oral Dissolving Film of Rivastigmine: Optimization Using Factorial Design	11
Passive Targeted Drug Delivery of Venlafaxine HCl to the Brain by Modified Chitosan Nanoparticles: Characterization, Cellular Safety Assessment, and In Vivo Evaluation	11
Liquid Crystal Nanoparticles-based Fluocinolone Acetonide Topical Gel for Atopic Dermatitis: In vitro and in vivo Study	10
An Integrated Real-time Monitoring and Statistical Process Control Approach for Coating Process and Product Quality via In-line Optical Coherence Tomography	10
Lutein and β-Carotene Characterization in Free and Nanodispersion Forms in Terms of Antioxidant Activity and Cytotoxicity	9
A Systems Evaluation Model for the Development of Companion Diagnostics and Associated Molecularly Targeted Therapies	8
Novel Nanoaggregates from Phoenix dactylifera (date palm) for Inhalational Management of Cystic Fibrosis Using Dry Powder Inhalers	8
Design of Dual Principles Floating Osmotic Drug Delivery System of Pioglitazone Hydrochloride for Gastro-retention: In Vitro-In Vivo Evaluation	8
SGLT-2i: Nanoparticular-Based Strategies, Solutions, and Clinical Applications in Opposition to Low Bioavailability	8
Similar but Not Same: Impact of Structurally Similar Coformers on Co-crystallization with Telmisartan	8
Utilizing Quality by Design to Develop and Evaluate Extended-Release Upadacitinib Tablets Incorporating a Biosynthesized Polymer	8
Surface Functionalization of Piperine-Loaded Liposomes with Sophorolipids Improves Drug Loading and Stability	7
Fabrication and Evaluation of Differential Release Bilayer Tablets of Clarithromycin and Levofloxacin by 3D Printing	7
Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine	7
Commercial Low Molecular Weight Heparins — Patent Ecosystem and Technology Paradigm for Quality Characterization	7
Development and Evaluation of Fucoidan-Based Liposomes: Targeting Smooth Muscle Cells for Atherosclerosis Treatment	7
Application of Amorphous Solid Dispersion Technology for Improving the Physicochemical Properties, Saturation Solubility, and In Vitro Dissolution of Withania somnifera Methanolic Root Powder Extract	7

Coloaded Surface–Modified PLGA Nanoparticles for Sustained Ocular Delivery of Levofloxacin and Flurbiprofen	7
Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin Calcium by Solid Dispersion Technique Using a Modified Natural Polymer as a Hydrophilic Carrier	7
QbD Application for a Fixed-Dose Combination with Biowaiver Potential: Evaluations of In Vitro and In Vivo Applications	6
QBD Approach for the Design, Optimization, Development, and Characterization of Naringenin-Loaded Phytosomes to Enhance Solubility and Oral Bioavailability	6
Gastroretentive Floating Microsponges of Mitiglinide: Design, Preparation, and Pharmacokinetic Evaluation	6
Development, Optimization and In Vitro Characterization of Eudragit-Ganciclovir Nanosuspension or Treating Herpes Simplex Keratitis	6
Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders	6
Blockchain for Data Originality in Pharma Manufacturing	6
Gene Expression Effects of the Delivery of SN-38 via Poly(D-L-lactide-co-caprolactone) Nanoparticles Comprising Dense and Collapsed Poloxamer Coronae	6
Ultrasound-Assisted Anti-Solvent Crystallization of Ibuprofen: Effect of Ultrasonic Treatment and Additive	6
Nanostructured Lipid Carriers (NLCs) of Lumefantrine with Enhanced Permeation	6
Analysis of the COVID-19 Vaccine Development Process: an Exploratory Study of Accelerating Factors and Innovative Environments	6
Handsheet Coated by Polyvinyl Acetate as a Drug Release System	6
PEGylated Lipid Nanocontainers Tailored with Sunseed-Oil-Based Solidified Reverse Micellar Solution for Enhanced Pharmacodynamics and Pharmacokinetics of Metformin	6
Enhancement of Solubility and Dissolution Rate Using Tailored Rapidly Dissolving Oral Films Containing Felodipine Solid Dispersion: In Vitro Characterization and Ex Vivo Studies	5
Posaconazole loaded Lipid Polymer Hybrid Nanoparticles: Design and Development for Vaginal Drug Delivery	5
Editorial: Biopharmaceutical Innovation	5
Fabrication of Zein-Chitosan-Zein Sandwich-Like Nanofibers Containing Teicoplanin as a Local Antibacterial Drug Delivery System	5
Self-emulsifying Drug Delivery System for Praziquantel with Enhanced Ex Vivo Permeation	5
Design, Development, and In Vitro Characterization of Pirfenidone-Loaded Biodegradable Nanoparticles for Idiopathic Pulmonary Fibrosis	5
A Gel-Free Reservoir System for Once-a-Day Ophthalmic Delivery of Timolol Maleate	5
An Automated Jet Nebulizer with Dynamic Flow Regulation	5
Dissolving Microneedle Formulation of Ceftriaxone: Effect of Polymer Concentrations on Characterisation and Ex Vivo Permeation Study	4
New Approach to Formulate Methotrexate-Loaded Niosomes: In Vitro Characterization and Cellular Effectiveness	4
Accelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval	4
Development of Liposomal Formulation for Controlled Delivery of Valacyclovir: an In Vitro Study	4
Lutein-Loaded Solid Lipid Nanoparticles for Ocular Delivery: Statistical Optimization and Ex Vivo Evaluation	4
Development and Evaluation of Novel Amoxicillin and Phytic Acid-Loaded Gastro-Retentive Mucoadhesive Pectin Microparticles for the Management of Helicobacter pylori Infections	4
QbD Enabled Formulation Development of Nanoemulsion of Nimodipine for Improved Biopharmaceutical Performance	4
Increasing the Stability of Pellets Containing Lycopene by Using Dual-Coating	4
Formulate Lornoxicam Bio Adhesive Microspheres Using Different Polymers by Ionotropic Gelation Method and Emulsion Cross Linking Method: An Integrated Molecular Dynamics Approach	4
Nanoarchitectonics: a New Horizon for Drug Targeting	4
In Vitro Profiling of Gliclazide-Loaded Aerosil 380 Solid Dispersion–Based Tablets with Co-Processed Excipients	4
FDA Approaches in Monitoring Drug Quality, Forces Impacting the Drug Quality, and Recent Alternative Strategies to Assess Quality in the US Drug Supply	4
Optimizing Nateglinide Liquisolid Compacts: Achieving Formulation Excellence Through the Quality by Design Approach	4
Exploring Potential Coformer Screening Techniques Based on Experimental and Virtual Strategies in the Manufacturing of Pharmaceutical Cocrystal of Efavirenz	4
Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus	4
Quality by Design (QbD) based Formulation Optimization of Isoniazid Loaded Novel Nanostructured Lipid Carriers for Controlled Release Effect	3
Box–Behnken Design-Based Optimized Kinetic Approach to Develop an Eco-friendly Analytical Method for the Quantitation of Glimepiride Using Spectrophotometry	3
Studies in Development and Statistical Optimization of Levofloxacin Solid Lipid Nanoparticles for the Treatment of Tuberculosis	3
Elucidating of Fluconazole Cocrystallization With a Cutting-Edge Nutraceutical Coformer for Enhanced Formulation Strategies	3
Preparation and Characterization of Gatifloxacin-Loaded Polyacrylonitrile Nanofiber for the Management of Dry Eye Infection	3
A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)	3
3D Drug Printing by Semi-Solid Extrusion Through Reusable Cartridges: Usability Evaluation	3
Gastroprotective Efficacy of Prebiotic-based Oral Formulation of Amoxicillin	3
Editorial: The World Coming Out of Its Shell	3
Redesigning the Clinical Trial Development Process as a Global Pharmaceutical Firm: Gaining Velocity via Lean-Sprint	3
Development of a Statistical Approach for Microbial Monitoring in Non-sterile Pharmaceutical Environments	3
Evaluation and Monitoring of the API Content of a Portable Near Infrared Instrument Combined with Chemometrics Based on Fluidized Bed Mixing Process	3
Effect of Curcumin-Hydroxypropyl-$$\beta$$-Cyclodextrin Complex and the Complex Loaded Gelatin Carrageenan Microparticles on the Various Chemical and Biological Properties	3

Improving Ampoule Opening Safety: An Exploratory Comparative Study on an Innovative Ampoule Opener	3
Deciphering the Impact of Hyaluronic Acid Grafting Density and Molecular Weight on Paclitaxel Liposome in CD-44 Receptor Targeting	3
Fabrication of Carboxymethylcellulose-Gelatin Dissolving Microneedle Patch for Pain-Free, Efficient, and Controlled Transdermal Delivery of Insulin	3
23 Factorial Design and Optimization of Effervescent Floating Matrix Tablet of Neratinib	3
Polymeric Film Loaded with Plinia cauliflora Peels Extract has a Differential Curative Effect on Injuries	3
The Reform of the Orphan Drug Assessment System in China	3
Moisture Content Prediction Model for Pharmaceutical Granules Using Machine Learning Techniques	3
Quality-by-Design Approach for Optimization and Processing of PLGA Polymer Film by Hot Melt Extrusion	3
Investigation of In Vivo Bioavailability Enhancement of Iloperidone-Loaded Solid Self-Nanoemulsifying Drug Delivery Systems: Formulation and Optimization Using Box-Behnken Design and Desirability Func	3
Saturation Solubility and Dissolution Property Improvement of Albendazole by Salt Formation Approach	3
Silver Nanoparticle Synthesized with Fenugreek Leaves Is Biologically Potent than Chemically Synthesized Nanoparticle	3
Micelles-Encapsulated with Azithromycin and Ibuprofen for Synergistic Antibacterial at Different pH	3
An Investigation into the Preparation, Characterization, and Therapeutic Applications of Novel Gefitinib/Capric Acid Deep Eutectic Systems	3
Unveiling the Therapeutic Potential: Okra-Derived Flavonoids in Breast Cancer Treatment	3
Extrusion-Based Three-Dimensional Printing of Metronidazole Immediate Release Tablets: Impact of Processing Parameters and in Vitro Evaluation	3
Correction to: A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management	3
Compatibility Study Between Fenbendazole and Poly(Ethylene Oxide) with Application in Solid Dispersion Formulations Using Hot-Melt Extrusion	3
Carvedilol-Loaded Cubosome Gel to Accelerate Wound Healing	2
Bioactive Extract Production from Citrullus Clocynthis Fruit via Microwave-Assisted Extraction: Experimental Optimization, Process Design and Economics with Uncertainty Quantification	2
Design and Critical Characterization the Pharmaceutical Cocrystal of Azelnidipine With Coformers for Boosting Physicochemical Properties	2
Synthesis, Structural Characterization, and Antimicrobial Evaluation of Silver Nanoparticle-embedded Layered Double Hydroxides for Delivery in Polymeric Hydrogel Matrices	2
Quantitative Analysis of the QMS for Pharmaceutical Manufacturing	2
Inulin Stearate Self-assembly Micro-rod Containing Paclitaxel: Synthesis and In Vitro Cytotoxicity MTT Assay in HeLa Cell Line	2
Synergistic Effect of Nitric Oxide for Wound Healing Using Etherification of Cotton	2
Coconut Oil and Shea Butter as Lipids for the Formulation of Ciprofloxacin-Loaded Nanoparticles	2
Backgrounded Membrane Imaging—A Valuable Alternative for Particle Detection of Biotherapeutics?	2
Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative Study of PVP K17 and Eudragit® RS 30D as Coating Polymer	2
Development and Evaluation of Letrozole-Loaded Hyaluronic Acid/Chitosan-Coated Poly(d,l-lactide-co-glycolide) Nanoparticles	2
Topical Delivery of Methoxsalen Co-loaded Curcumin Using Hybrid Nanocarrier-Based Polymeric Hydrogel for Synergistic Therapy in the Treatment of Psoriasis	2
The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol	2
Cross-Linked β-Cyclodextrin Based Nanosponges for Allyl Methyl Sulfide Delivery-Physicochemical Characterization and In Vitro Study	2
A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies	2
Synthesis, Characterization, In Silico Analysis, and Pharmacological Evaluation of Metoprolol-Modified Saccharide Conjugates for Cardiovascular Targeting	2
Electrospun PCL/PVP Nanofibers Meshes, A Novel Bisabolol Delivery System for Antidermatophytic Treatment	2
Appraisal of Surelease Clear E-7–19040, an Ethylcellulose Aqueous Dispersion, as a Release Modifier for the Hydrophilic Core	2
Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier Based Oral Drug Delivery for Enhanced Anticancer Activity	2
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan	2
Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model	2
DoE-Based Solid Self-microemulsifying Drug Delivery System (S-SMEDDS) Approach for Improving the Dissolution Properties of Raltegravir Potassium	2
Improved Anti-inflammatory Activity and Minimum Systemic Absorption from Topical Gels of Ibuprofen Formulated by Micelle or Nanoemulsion	2
New Insight into Acidifier-Induced Enhancement of Dissolution of Weakly Basic Drug, Dipyridamole	2
Development and Evaluation of Stable Long Circulating Decitabine-loaded Copolymeric Nanoparticles: Harnessing QbD Approach and Lyophilization Technique	2
Esomeprazole-Loaded Flash Release Sublingual Wafers: Formulation, Optimization, and Characterization	2
Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin	2
Single-crystal Drying: Development of a Continuous Drying Prototype to Optimize Particle Flow and Residence Time Distribution	2
Design and Development of Dual Release Reconstitutable Oral Suspension of Cefpodoxime Proxetil for Pediatric Patient Using Risk-Based Quality by Design Approach	2
Orally Disintegrating Film of High-Dose BCS II Drug by Hot Melt Extrusion through Design of Experiment	2
Influence of Nanocarrier Type on the Drug Delivery Aspects of Docetaxel: Empirical Evidences	2
Preparation and Evaluation of Dual–release Esomeprazole Magnesium Pulsed Capsules Filled with Two Kinds of Enteric-coated Pellets	2
Synergistic Effect of Synthetic Magnesium Aluminometasilicate and Dual Polymer in Celecoxib Solubilization by Solid Dispersion Method	2
Development and In-Vitro Characterization of Capsaicin Microsponges Loaded Topical Gels for Management of Arthritis	2
A Novel Mesalamine Loaded Hybrid Nanoparticle-in-Microparticle for Colon Targeting: In-vitro and In-vivo Investigations	2
Gossypol-Embedded Casein Nanoparticles for Potential Targeting of Ovarian Cancer: Formulation, Characterization, and Anticancer Activity	2
Computational Identification of Bioactive Molecules from Caralluma stalagmifera L. as Potential VEGFR2 Inhibitors for Endometriosis Treatment	2
Enhancing the Entrapment Efficiency of Alginate Floating Beads Using Double Emulsion Technique	2
Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization	2
Design, Optimization, and Characterization of Lysozyme-Loaded Poly(ɛ-Caprolactone) Microparticles for Pulmonary Delivery	2
The Development of Digital Therapies as a New Therapeutic Option to Treat Diseases: Focus on the International Regulatory Framework	2
Ciprofloxacin HCl-loaded Albumin Nanoparticles for the Treatment of Recurrent Urinary Tract Infections: Preparation, Optimization, and Evaluation of Antibacterial Activity	2
Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells	2
Innovative Polymeric Micelles with In-Situ Gelation for Enhanced Ocular Delivery of Ketoconazole	2