CNS & Neurological Disorders-Drug Targets

Papers
(The TQCC of CNS & Neurological Disorders-Drug Targets is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model58
Role of Calcium Homeostasis in Ischemic Stroke: A Review46
Benzodiazepines and Sleep Architecture: A Systematic Review44
Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder43
Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol35
Autoimmune Encephalitis: Current Knowledge on Subtypes, Disease Mechanisms and Treatment31
Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues27
Role of Vitamins in Neurodegenerative Diseases: A Review26
Speech as a Biomarker for Depression24
Levodopa Therapy for Parkinson's Disease: History, Current Status and Perspectives23
Arachidonic Acid Derivatives and Neuroinflammation23
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure19
The MMP-2/TIMP-2 System in Alzheimer Disease19
Current Strategies and Novel Drug Approaches for Alzheimer Disease18
Modeling Parkinson’s Disease in Zebrafish18
ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel Drug Targets in Neurodegenerative Disorders18
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases18
Persons with Co-Existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic17
Melatonin and Sleep Disturbances in Alzheimer’s Disease17
Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update17
The Effects and Regulatory Mechanism of Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi in Promoting Neurogenesis and Improving Memory Impairment Mediated by the BDNF-ERK-CREB Signa17
Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease16
Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s Disease16
Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches16
Smartphone Addiction among Students and its Harmful Effects on Mental Health, Oxidative Stress, and Neurodegeneration towards Future Modulation of Anti-Addiction Therapies: A Comprehensive Survey base16
Arachidonic Acid Metabolites in Neurologic Disorders16
Detection, Treatment Planning, and Genetic Predisposition of Bruxism: A Systematic Mapping Process and Network Visualization Technique15
Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis15
An Insight into Molecular Mechanisms and Novel Therapeutic Approaches in Epileptogenesis15
Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article15
Neurological Associations of SARS-CoV-2 Infection: A Systematic Review14
Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology and Cognitive Impairments14
Novel Targets Explored in the Treatment of Alcohol Withdrawal Syndrome14
Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders14
Role of Natural Plant Products Against Alzheimer’s Disease14
Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases13
Nanoparticles as Powerful Tools for Crossing the Blood-brain Barrier13
Tremor and Rigidity in Patients with Parkinson’s Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors13
Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?12
GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies12
Neuroprotective and Anti-Inflammatory Effects of Pioglitazone on Parkinson's Disease: A Comprehensive Narrative Review of Clinical and Experimental Findings12
Tumor Treating Fields – Behind and Beyond Inhibiting the Cancer Cell Cycle12
Understanding Abnormal c-JNK/p38MAPK Signaling in Amyotrophic Lateral Sclerosis: Potential Drug Targets and Influences on Neurological Disorders12
Dopamine as a Potential Target for Learning and Memory: Contributing to Related Neurological Disorders11
The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms11
Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies11
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO11
Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi Regulate the Brain Tau Hyperphosphorylation at Multiple Sites Induced by Composited Aβ in Rats11
The Development of a PBPK Model for Atomoxetine Using Levels in Plasma, Saliva and Brain Extracellular Fluid in Patients with Normal and Deteriorated Kidney Function11
MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice11
Rethinking Catatonia: New Insights from the Autism Spectrum11
Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review11
Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review11
Improvement of a Novel Proposal for Antioxidant Treatment Against Brain Damage Occurring in Ischemic Stroke Patients10
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction10
Drosophila melanogaster a Versatile Model of Parkinson’s Disease10
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease10
Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update10
Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke10
Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease10
Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management10
Dietary Nutrients and Prevention of Alzheimer’s Disease9
Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition9
Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation9
Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration9
In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity9
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health9
The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease9
Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications9
Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease9
Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death9
Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy9
Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders8
Nanotechnology: Its Application in Treating Neurodegenerative Diseases8
A Critical Analysis of Quercetin as the Attractive Target for the Treatment of Parkinson's Disease8
Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a 8
Neurorestoratology: New Advances in Clinical Therapy8
Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition8
Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease8
Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells8
The Protective Effect of Vitexin Compound B-1 on Rat Cerebral I/R Injury through a Mechanism Involving Modulation of miR-92b/NOX4 Pathway8
Oxytocin Effect in Adult Patients with Autism: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials8
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets8
Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases7
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease7
Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial7
Nanotechnological Advances in the Treatment of Epilepsy7
Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders7
Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s Disease7
Integrated System Pharmacology and In Silico Analysis Elucidating Neuropharmacological Actions of Withania somnifera in the Treatment of Alzheimer’s Disease7
Minocycline Inhibits mTOR Signaling Activation and Alleviates Behavioral Deficits in the Wistar Rats with Acute Ischemia stroke7
Targeting Microglial Polarization to Improve TBI Outcomes7
The Role of Statins in the Management of Delirium: Recent Advances7
Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease7
Exploring the Various Aspects of Brain-Derived Neurotropic Factor (BDNF) in Diabetes Mellitus7
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions7
Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches7
Non-hepatic Hyperammonemia: A Potential Therapeutic Target for Sepsis-associated Encephalopathy7
Elucidations of Molecular Mechanism and Mechanistic Effects of Environmental Toxicants in Neurological Disorders7
The AMPAR Antagonist Perampanel Regulates Neuronal Necroptosis via Akt/GSK3β Signaling After Acute Traumatic Injury in Cortical Neurons7
Drosophila: A Model to Study the Pathogenesis of Parkinson’s Disease7
Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis7
Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways7
Neuroprotective Role of the B Vitamins in the Modulation of the Central Glutamatergic Neurotransmission7
Targeted Delivery of Montelukast for the Treatment of Alzheimer’s Disease7
Mechanistic Insight and Possible Mechanism of Seizure in Covid-19: The Nuances and Focal Points7
Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration7
Transdermal Nutraceuticals Delivery System for CNS Disease7
Immunotherapies for Parkinson’s Disease: Progression of Clinical Development6
Herbal Approaches in the Management of Mental Depression6
Role of Potassium Ion Channels in Epilepsy: Focus on Current Therapeutic Strategies6
A Concise Review of Common Plant-derived Compounds as a Potential Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into Structure-Activity-Relationship6
Natural Products as Bioactive Agents in the Prevention of Dementia6
Nanomedicinal Strategies as Emerging Therapeutic Avenues to Treat and Manage Cerebral Ischemia6
Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease6
Modulation of Huntington’s Disease in Drosophila6
Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to the Essential Oil Components6
Impact of Cannabis-Based Medicine on Alzheimer’s Disease by Focusing on the Amyloid β-Modifications: A Systematic Study6
Ethanolamine: A Potential Promoiety with Additional Effects on the Brain6
Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development6
Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment6
Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS) Opinion Paper6
Mechanistic and Etiological Similarities in Diabetes Mellitus and Alzheimer’s Disease: Antidiabetic Drugs as Optimistic Therapeutics in Alzheimer’s Disease6
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond O-6-Methylguanine-DNA Methyltransferase6
Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia6
APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease6
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