OOIR: Observatory of International Research

Papers

(The TQCC of CNS & Neurological Disorders-Drug Targets is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model	54
Scopolamine, a Toxin-Induced Experimental Model, Used for Research in Alzheimer’s Disease	48
The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory	44
Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder	35
When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient	34
Benzodiazepines and Sleep Architecture: A Systematic Review	30
Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol	26
Role of Calcium Homeostasis in Ischemic Stroke: A Review	26
MAPK: A Key Player in the Development and Progression of Stroke	25
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases	23
Autoimmune Encephalitis: Current Knowledge on Subtypes, Disease Mechanisms and Treatment	23
Arachidonic Acid Derivatives and Neuroinflammation	20
Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic Disease-induced Rats	19
Detection, Treatment Planning, and Genetic Predisposition of Bruxism: A Systematic Mapping Process and Network Visualization Technique	19
Role of Vitamins in Neurodegenerative Diseases: A Review	18
Current Strategies and Novel Drug Approaches for Alzheimer Disease	17
Persons with Co-Existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic	17
Levodopa Therapy for Parkinson's Disease: History, Current Status and Perspectives	17
ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel Drug Targets in Neurodegenerative Disorders	17
Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues	17
Speech as a Biomarker for Depression	17
Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immun	17
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure	16
Oxidative Stress in the Pathogenesis of Alzheimer’s Disease and Cerebrovascular Disease with Therapeutic Implications	16
Modeling Parkinson’s Disease in Zebrafish	16

The Effects and Regulatory Mechanism of Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi in Promoting Neurogenesis and Improving Memory Impairment Mediated by the BDNF-ERK-CREB Signa	15
BDNF-TrkB and proBDNF-p75NTR/Sortilin Signaling Pathways are Involved in Mitochondria-Mediated Neuronal Apoptosis in Dorsal Root Ganglia after Sciatic Nerve Transection	15
Melatonin and Sleep Disturbances in Alzheimer’s Disease	14
Novel Targets Explored in the Treatment of Alcohol Withdrawal Syndrome	14
The MMP-2/TIMP-2 System in Alzheimer Disease	14
Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders	14
Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article	13
Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis	13
Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update	13
Neurological Associations of SARS-CoV-2 Infection: A Systematic Review	13
Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases	12
An Insight into Molecular Mechanisms and Novel Therapeutic Approaches in Epileptogenesis	12
Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s Disease	12
Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease	12
Arachidonic Acid Metabolites in Neurologic Disorders	12
The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms	11
Smartphone Addiction among Students and its Harmful Effects on Mental Health, Oxidative Stress, and Neurodegeneration towards Future Modulation of Anti-Addiction Therapies: A Comprehensive Survey base	11
Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death	11
Tumor Treating Fields – Behind and Beyond Inhibiting the Cancer Cell Cycle	11
Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi Regulate the Brain Tau Hyperphosphorylation at Multiple Sites Induced by Composited Aβ in Rats	10
Dietary Nutrients and Prevention of Alzheimer’s Disease	10
Understanding Abnormal c-JNK/p38MAPK Signaling in Amyotrophic Lateral Sclerosis: Potential Drug Targets and Influences on Neurological Disorders	10
Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies	10
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease	10
Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches	10
Role of Natural Plant Products Against Alzheimer’s Disease	10
Improvement of a Novel Proposal for Antioxidant Treatment Against Brain Damage Occurring in Ischemic Stroke Patients	10
Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?	10
MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice	10
Neuroprotective and Anti-Inflammatory Effects of Pioglitazone on Parkinson's Disease: A Comprehensive Narrative Review of Clinical and Experimental Findings	9
Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease	9
Rethinking Catatonia: New Insights from the Autism Spectrum	9
The Development of a PBPK Model for Atomoxetine Using Levels in Plasma, Saliva and Brain Extracellular Fluid in Patients with Normal and Deteriorated Kidney Function	9
Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology and Cognitive Impairments	9
Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications	9
Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review	9
Drosophila melanogaster a Versatile Model of Parkinson’s Disease	9
The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease	8
Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration	8
A Pivotal Role of the Nrf2 Signaling Pathway in Spinal Cord Injury: A Prospective Therapeutics Study	8
Overview of Therapeutic Drugs and Methods for the Treatment of Parkinson’s Disease	8
Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke	8
Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease	8
Nanoparticles as Powerful Tools for Crossing the Blood-brain Barrier	8
Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update	8
Dopamine as a Potential Target for Learning and Memory: Contributing to Related Neurological Disorders	8
Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review	8
Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition	8
Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders	7
Neuroprotective Role of the B Vitamins in the Modulation of the Central Glutamatergic Neurotransmission	7

Nanotechnology: Its Application in Treating Neurodegenerative Diseases	7
GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies	7
Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a	7
Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy	7
Exploring the Various Aspects of Brain-Derived Neurotropic Factor (BDNF) in Diabetes Mellitus	7
Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease	7
Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management	7
Tremor and Rigidity in Patients with Parkinson’s Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors	7
Oxytocin Effect in Adult Patients with Autism: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials	7
Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation	7
Elucidations of Molecular Mechanism and Mechanistic Effects of Environmental Toxicants in Neurological Disorders	7
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO	6
Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to the Essential Oil Components	6
The Role of Statins in the Management of Delirium: Recent Advances	6
CGRP and CGRP-Receptor as Targets of Migraine Therapy: Brain Prize-2021	6
APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease	6
Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s Disease	6
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction	6
Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases	6
A Concise Review of Common Plant-derived Compounds as a Potential Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into Structure-Activity-Relationship	6
Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders	6
Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia	6
Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment	6
Transdermal Nutraceuticals Delivery System for CNS Disease	6
Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS) Opinion Paper	6
The AMPAR Antagonist Perampanel Regulates Neuronal Necroptosis via Akt/GSK3β Signaling After Acute Traumatic Injury in Cortical Neurons	6
Targeting Microglial Polarization to Improve TBI Outcomes	6
In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity	6
Mechanistic Insight and Possible Mechanism of Seizure in Covid-19: The Nuances and Focal Points	6
Nanomedicinal Strategies as Emerging Therapeutic Avenues to Treat and Manage Cerebral Ischemia	6
Integrated System Pharmacology and In Silico Analysis Elucidating Neuropharmacological Actions of Withania somnifera in the Treatment of Alzheimer’s Disease	6
Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia	5
Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease	5
The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease	5
Myasthenia Gravis and Vitamin D Serum Levels: A Systematic Review and Meta-analysis	5
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease	5
Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis	5
Madecassic Acid Reduces Fast Transient Potassium Channels and Promotes Neurite Elongation in Hippocampal CA1 Neurons	5
The Endocannabinoid System and Alcohol Dependence: Will Cannabinoid Receptor 2 Agonism be More Fruitful than Cannabinoid Receptor 1 Antagonism?	5
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health	5
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets	5
Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells	5
In Vitro and In Vivo Neuroprotective Effects of Etifoxine in β-Amyloidinduced Toxicity Models	5
Cardiac Biomarkers in Stroke, Alzheimer’s Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations	5
Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches	5
Radiotherapy and Its Impact on the Nervous System of Cancer Survivors	5
Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition	5
Non-hepatic Hyperammonemia: A Potential Therapeutic Target for Sepsis-associated Encephalopathy	5
Melatonin Alleviates Pyroptosis of Retinal Neurons Following Acute Intraocular Hypertension	5
Immunotherapies for Parkinson’s Disease: Progression of Clinical Development	5
Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways	5
Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders	5
Fibrosis and Regulation of Nerve Regeneration in the Peripheral and Central Nervous Systems	5
Neuronal Excitability in Epileptogenic Zones Regulated by the Wnt/ Β-Catenin Pathway	5
Neurorestoratology: New Advances in Clinical Therapy	5
Natural Products as Bioactive Agents in the Prevention of Dementia	5
Histone Deacetylase Inhibitors Prevented the Development of Morphine Tolerance by Decreasing IL6 Production and Upregulating μ-Opioid Receptors	5
Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development	5