OOIR: Observatory of International Research

Papers

(The TQCC of CNS & Neurological Disorders-Drug Targets is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Meet the Editorial Board Member	89
Meet the Regional Editor	78
Neurobiology of Amphetamine use in Stroke Recovery Combined with Rehabilitative Training and Brain Stimulation	55
Na+/HCO3− Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil’s Hippocampus	55
Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (HABC) Due to UFM1 Mutation in Roma Patients - Severe Early Encephalopathy with Stridor and Severe Hearing and Visual Impairment. A Single	51
CRISPR/Cas9 Gene Editing: A Novel Approach Towards Alzheimer's Disease Treatment	48
The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine- Induced Parkinson’s Disease in Zebrafish: The Current Applications and Perspectives	46
The Potential Effect of Blueberry on Cognitive Health and Mood State based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis	42
Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation	35
Memory Reflections of the Microbiota-Gut and Oligodendrocyte Axis	33
Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation	33
Emerging Nanotechnology for the Treatment of Alzheimer’s Disease	29
Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a	28
Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders	26
Targeting JNK3: An In-silico Approach to Uncover Potential Therapeutics for Alzheimer's Disease	26
Cholinesterase Inhibitory and In Silico Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound	25
Unravelling the Role of Tyrosine and Tyrosine Hydroxylase in Parkinson’s Disease: Exploring Nanoparticle-based Gene Therapies	25
The Emerging Role of Marine Natural Products for the Treatment of Parkinson’s Disease	24
Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia	23
Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review	23
GFAP and UCHL1 in Non-traumatic SAH: The Story thus Far. A Systematic Review of the Literature	22
Pathological Insights into Neurodegenerative and Neurodevelopmental Disorders: Perspectives for the Development of Novel Treatment Approaches	21
Danshensu Enhances Cerebral Angiogenesis in Mice by Regulating the PI3K/Akt/Mtor/VEGF Signaling Axis	21
Insights into the Diagnosis, Treatment, and Management of Prion Diseases	21
Unraveling the Triad: A Bioinformatics Analysis of the Interplay between Prenatal Depression, Inflammation, and the Gut Microbiota	21

Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology and Cognitive Impairments	20
Clozapine in a Young Female with Drug-Resistant Schizophrenia: A Case Report of Development of Serositis	20
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health	20
Are Lysosomes Potential Therapeutic Targets for Parkinson’s Disease?	20
Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1- Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated by Serotonergic and GABAergic Pathways	20
A Critical Analysis of Quercetin as the Attractive Target for the Treatment of Parkinson's Disease	19
Vasospasm in Pediatric Subarachnoid Hemorrhage	19
A Systematic Review of Updated Mechanistic Insights Towards Alzheimer’s Disease	19
WITHDRAWN: Nigella Fixed Oil Mitigates Memory Impairment in a Rat-Aged Model of Cognitive Decline; A Pivotal Role of BDNF and CREB Signaling Pathways in the Hippocampus	18
High-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Accelerates onset Time of Beneficial Treating Effects and Improves Clinical Symptoms of Depression	18
An Overview of the Natural Neuroprotective Agents for the Management of Cognitive Impairment Induced by Scopolamine in Zebrafish (Danio rerio)	18
Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment	18
Analysis of Concentrations of Monomethyl Fumarate in Patients with Multiple Sclerosis: Result from Routine Health Care	18
Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol	17
The Landscape of Randomized Clinical Trial Meta-analyses on Statins for Aneurysmal Subarachnoid Hemorrhage: A Scoping Review	16
Induced Depressive Disorder Following the First Dose of COVID-19 Vaccine	16
Hematological Consequences of Valproic Acid in Pediatric Patients: A Systematic Review with a Mechanistic Approach	16
Neuroprotective and Anti-Inflammatory Effects of Pioglitazone on Parkinson's Disease: A Comprehensive Narrative Review of Clinical and Experimental Findings	15
Evolutionary Unmasking Resuscitative Therapeutics Potential of Centhaquin Citrate in Hypovolemic Shock	15
Effects of GABAergic Agents on Multiple Sclerosis. A Narrative Review of In-vivo Models	15
Navigated Transcranial Magnetic Stimulation (nTMS) based Preoperative Planning for Brain Tumor Treatment	14
Decoding the Gut-Brain Axis in Alzheimer's Disease: Emerging Perspectives	14
Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial	14
Genetic Predisposition and Severity of Eating Disorders- A Review	14
An Updated Review of Epigenetic-Related Mechanisms and their Contribution to Multiple Sclerosis Disease	14
Natural Products as Bioactive Agents in the Prevention of Dementia	14
Exploring the Potential of Herbal Compounds as Autophagy Modulators in Alzheimer's Disease: A Comprehensive Review	14
Obesity and Depression: Common Link and Possible Targets	14
Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article	13
The Effects and Regulatory Mechanism of Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi in Promoting Neurogenesis and Improving Memory Impairment Mediated by the BDNF-ERK-CREB Signa	13
Bis-iodine-labeled Curcumin as a Potential CT Imaging Agent for β-amyloid Plaques in the Brain	13
Emerging Treatments for Subarachnoid Hemorrhage	13
Dietary Nutrients and Prevention of Alzheimer’s Disease	13
Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology	13
Acknowledgements to Reviewers	13
COVID-19, the Brain, and the Future: Is Infection by the Novel Coronavirus a Harbinger of Neurodegeneration?	13
Circadian Rhythm and Risk of Hemorrhagic Transformation after Acute Ischemic Stroke Treated with Intravenous Thrombolysis - A Systematic Review	13
Phosphodiesterase 2 and Its Isoform A as Therapeutic Targets in the Central Nervous System Disorders	13
Approaches for Ear-targeted Delivery Systems in Neurosensory Disorders to avoid Chronic Hearing Loss Mediated Neurological Diseases	13
Acknowledgements to Reviewers	12
Effectiveness of Highly Purified Cannabidiol in Refractory and Super-Refractory Status Epilepticus: A Case Series	12
Meet the Editorial Board Member	12
Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain Injury in the Females	12
Lithium Chloride Rescues Dopaminergic Neurons in a Parkinson’s Disease Rat Model Challenged with Rotenone	12
The Potential Role of Dopamine Pathways in the Pathophysiology of Depression: Current Advances and Future Aspects	12
Arachidonic Acid Derivatives and Neuroinflammation	12
Inhibiting Monoamine Oxidase in CNS and CVS would be a Promising Approach to Mitigating Cardiovascular Complications in Neurodegenerative Disorders	12
One-Trial Appetitive Learning Tasks for Drug Targeting	11
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO	11
WITHDRAWN: Neurological Studies Of Herbal Medicinal Plants For The Treatment Of Memory Impairment: A Review	11

Pharmacotherapy in SAH: Clinical Trial Lessons	11
Lorcaserin: Worthy of Further Insights? Results from Recent Research	11
Valproate Exposure as an In vitro Model for Studying Morpho-Molecular Features of ASD: A Systematic Review	11
Prospects for Neurotrophic Factor-Based Early Intervention in Schizophrenia: Lessons Learned from the Effects of Antipsychotic Drugs on Cognition, Neurogenesis, and Neurotrophic Factors	11
Nanoparticle-Based Approaches for Glioblastoma Treatment: Advances and Future Prospects	11
The Peripheral Profile of the Chitinase 3-like-1 in Benign Multiple Sclerosis – A Single Centre’s Experience	10
Rationale and Development of Tavapadon, a D1/D5-Selective Partial Dopamine Agonist for the Treatment of Parkinson’s Disease	10
Arachidonic Acid Metabolites in Neurologic Disorders	10
Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases	10
Modulation of Huntington’s Disease in Drosophila	10
Benzodiazepines and Sleep Architecture: A Systematic Review	10
Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders	10
Endophenotypes and Pathway Phenotypes in Neuro-psychiatry: Crossdisciplinary Implications for Diagnosis	10
Neurological Manifestations Following Traumatic Brain Injury: Role of Behavioral, Neuroinflammation, Excitotoxicity, Nrf-2 and Nitric Oxide	10
Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities	10
Nanotechnological Advances in the Treatment of Epilepsy	10
Rethinking Catatonia: New Insights from the Autism Spectrum	10
Traumatic Brain Injury in COVID-19 Patients with the Manifestation of Paroxysmal Sympathetic Hyperactivity and Cytokine Storm	10
Meet the Editorial Board Member	9
Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia	9
Neurological Complications Caused by Human Immunodeficiency Virus (HIV) and Associated Opportunistic Co-infections: A Review on their Diagnosis and Therapeutic Insights	9
Design and Molecular Docking Studies of N-Mannich Base Derivatives of Primaquine Bearing Isatin on the Targets involved in the Pathophysiology of Cerebral Malaria	9
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets	9
In Vivo Antidepressant Efficacy of 3-Substituted Thietane-1,1-dioxide Derivative - A Preliminary Study for Novel Anti-Depression Therapy in Neurological Disorders	9
The Protective Role of L-carnitine on Psychosocial Stress-induced Changes in Gene Expression and Protein Levels of Matrix Metalloproteinases, Serum Corticosterone in a Rat Model	9
An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease	9
Atorvastatin's Reduction of Alzheimer's Disease and Possible Alteration of Cognitive Function in Midlife as well as its Treatment	9
Peripheral Vascular Disease is Associated with Impaired Activities of Daily Living in the Elderly with Dementia: A Prospective Study	8
Acute Peripheral Facial Nerve Palsy in Children and Adolescents: Clinical Aspects and Treatment Modalities	8
Neurodegenerative Disorders and the Current State, Pathophysiology, and Management of Parkinson’s Disease	8
Preface	8
Direct Modulation of the Gut Microbiota as a Therapeutic Approach for Alzheimer’s Disease	8
Ameliorating Effects of Virgin Coconut Oil (VCO) on Nicotine Dependence and Quality of Life in Smokers	8
Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration	8
Neurotoxicity of Endogenous Neurotoxin Salsolinol in Parkinson's Disease	8
Parkinson’s Disease: A Progressive Neurodegenerative Disorder and Structure-Activity Relationship of MAO Inhibitor Scaffolds as an Important Therapeutic Regimen	8
Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report	8
Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial	8
Valproic Acid and Celecoxib Enhance the Effect of Temozolomide on Glioblastoma Cells	8
Role of Unani Polyherbal Formulations in the Treatment of Diseases with Special Reference to Neurodegenerative Disorders	8
The Role of Ca2+ Permeable AMPA Receptors in Neurodegeneration, Neurotoxicity, and Neuroinflammation	8
Imbalance of Th1 and Th2 Cytokines and Stem Cell Therapy in Pathological Pain	8
The Possible Protective Effect of Taurine on Bisphenol Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study	7
Meet the Editorial Board Member	7
Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis	7
An Overview of Acute Flaccid Myelitis	7
Role of Lipocalin-2 in N1/N2 Neutrophil Polarization After Stroke	7
Brain-Derived Neurotrophic Factor – The Protective Agent Against Neurological Disorders	7
Recent Development of Zolmitriptan Formulation in Migraine Therapy: Production, Metabolism and Pharmaceutical Aspects	7
The Protective Effects of Pioglitazone Against Cognitive Impairment Caused by L-methionine Administration in a Rat Model	7
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease	7
Pre-clinical Aspects and Contemporary Treatments of Parkinson’s Disease	7
Foresee Novel Targets for Alzheimer’s Disease by Investigating Repurposed Drugs	7
In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity	7
Flow Diversion for the Management of Posterior Circulation’s Intracranial Aneurysms	7
Association between Frequency of Seizures and Number of Antiseizure Medications (ASM) in Patients with Epilepsy	7
Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review	7
Preface	7
Metabolic Disorder Therapeutics and their Effects on Memory	7
Role of Imaging Genetics in Alzheimer’s Disease: A Systematic Review and Current Update	7
How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age?	7
An Insight into Medicinal Chemistry and SAR Studies of Cholinesterase and BACE-1 Inhibitors for Alzheimer's Disease	7
The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic Applications in Depression and Anxiety	7
Early Detection of Glioma: Investigating Inflammatory Markers (CRP), Kidney, and Liver Function	7
Abnormality of Voltage-Gated Sodium Channels in Disease Development of the Nervous System. A Review Article	7
WITHDRAWN: Neuroprotective Effect of 3,3′-Diindolylmethane and ɑ-Naphthoflavone, Aryl Hydrocarbon Receptor Modulators, in an Experimental Model of Ischemic Stroke	7
Meet the Editorial Board Member	7
Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease	7