OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	110
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	102
Epigenome-wide association studies: current knowledge, strategies and recommendations	83
Blood DNA methylation and COVID-19 outcomes	80
Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes	77
Cellular reprogramming and epigenetic rejuvenation	66
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects	64
Advances in epigenetic therapeutics with focus on solid tumors	62
Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective	59
Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential	56
Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility	53
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma	53
Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance	52
Epigenetic modification mechanisms involved in keloid: current status and prospect	52
Gene body methylation in cancer: molecular mechanisms and clinical applications	52
Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans	49
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors	46
DNA methylation biomarkers of myocardial infarction and cardiovascular disease	45
Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array	44
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy	44
Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression	44
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures	44
Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside	42
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts	42
SMYD3: a regulator of epigenetic and signaling pathways in cancer	42

Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner	41
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	41
A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer	40
Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice	40
Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction	39
DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs	39
The dark side of histones: genomic organization and role of oncohistones in cancer	39
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	38
The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium	38
Association of peripheral blood DNA methylation level with Alzheimer’s disease progression	36
DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies	36
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study	35
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	34
Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine	33
H3K36 trimethylation-mediated biological functions in cancer	33
DNA methylation and gene expression integration in cardiovascular disease	32
A review of epigenetic changes in asthma: methylation and acetylation	32
Characteristics of epigenetic aging across gestational and perinatal tissues	32
Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy	31
Ethical implications of epigenetics in the era of personalized medicine	31
The role of DNA methylation in syndromic and non-syndromic congenital heart disease	31
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions	30
Association of cardiovascular health and epigenetic age acceleration	30
DNA methylation epi-signature is associated with two molecularly and phenotypically distinct clinical subtypes of Phelan-McDermid syndrome	30
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies	30
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	30
STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease	29
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells	28
Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD	28
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	28
High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations	28
The role of epigenetic modifications for the pathogenesis of Crohn's disease	28
Male obesity impacts DNA methylation reprogramming in sperm	27
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	27
Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging	27
DNA methylation: a potential mediator between air pollution and metabolic syndrome	27
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity	27
Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial	26
Sensitive detection of colorectal cancer in peripheral blood by a novel methylation assay	26
Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism	26
DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas	26
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies	26
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations	25
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes	25
Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals	25
DNA methylation mediates the association between breastfeeding and early-life growth trajectories	24
Cardiovascular health and four epigenetic clocks	24
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC	24
NEFM DNA methylation correlates with immune infiltration and survival in breast cancer	24
Reproductive technologies, female infertility, and the risk of imprinting-related disorders	23

Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	23
Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing	23
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	23
Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers	23
Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression	23
Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences	22
Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms	22
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation	22
The impact of CBP expression in estrogen receptor-positive breast cancer	22
Non-invasive detection of endometrial cancer by DNA methylation analysis in urine	22
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes	22
Childhood-onset dystonia-causing KMT2B variants result in a distinctive genomic hypermethylation profile	22
UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE	22
The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling	22
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	22
Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples	21
METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors	21
Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays	21
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans	20
Discovery and validation of methylation signatures in blood-based circulating tumor cell-free DNA in early detection of colorectal carcinoma: a case–control study	20
DNA methylation analysis of tumor suppressor genes in liquid biopsy components of early stage NSCLC: a promising tool for early detection	20
Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs	20
Leveraging epigenetics to enhance the efficacy of immunotherapy	20
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer	19
Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning	19
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	19
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	19
DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter	19
Epigenetic mechanisms underlying prostate cancer radioresistance	19
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy	19
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function	19
Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival	19
Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer	19
DNA methylation impact on Fabry disease	18
LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression	18
Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples	18
Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer	18
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	18
Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia	17
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer	17
Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records	17
DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque	17
Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndr	17
Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer	17
Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome	17
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer	17