Clinical Epigenetics

Papers
(The TQCC of Clinical Epigenetics is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)
ArticleCitations
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis158
DNA methylation patterns associated with konzo in Sub-Saharan Africa101
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells85
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers83
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance73
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients71
Novel epigenetic network biomarkers for early detection of esophageal cancer64
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study62
Whole blood methylome-derived features to discriminate endocrine hypertension53
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer51
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells45
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma41
Aberrant epigenetic and transcriptional events associated with breast cancer risk41
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival40
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer39
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers37
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines37
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain36
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study36
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat35
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy35
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study33
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders33
Epigenome-wide association studies: current knowledge, strategies and recommendations32
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer31
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)31
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study30
Epigenome-wide association study of lung function in Latino children and youth with asthma29
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms28
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study28
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines28
Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach28
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy28
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study27
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance27
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder27
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort25
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer25
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations25
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL24
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics24
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells23
High performance methylated DNA markers for detection of colon adenocarcinoma23
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer23
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder23
The emerging role of epigenetic regulation in the progression of silicosis23
Identification of differentially methylated regions in rare diseases from a single-patient perspective22
Why epigenetics is (not) a biosocial science and why that matters22
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence22
Investigating pathological epigenetic aberrations by epi-proteomics22
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer21
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults21
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature21
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy20
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma20
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis20
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