OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Inhibition of HDAC4 by GSK3β leads to downregulation of KLF5 and ASK1 and prevents the progression of intravertebral disc degeneration	123
A critical appraisal of clinical epigenetics	102
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunothe	83
Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer	80
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes	66
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	64
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma	62
Blood DNA methylation and COVID-19 outcomes	59
High performance methylated DNA markers for detection of colon adenocarcinoma	52
Discovery and validation of methylation signatures in blood-based circulating tumor cell-free DNA in early detection of colorectal carcinoma: a case–control study	52
DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer	50
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy	49
Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination	49
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	46
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer	45
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas	45
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation	44
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	43
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	42
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	42
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	42
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	41
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis	41
Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy	40
Identification of differentially methylated regions in rare diseases from a single-patient perspective	39

Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records	39
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	38
Why epigenetics is (not) a biosocial science and why that matters	37
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	36
HDAC2 enhances esophageal squamous cell carcinoma development through down-regulating microRNA-503-5p and promoting CXCL10	36
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers	35
The dark side of histones: genomic organization and role of oncohistones in cancer	33
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes	32
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation	32
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	32
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	31
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	31
Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside	30
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures	30
DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity	29
Novel epigenetic network biomarkers for early detection of esophageal cancer	29
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	28
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	28
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC	28
DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test	28
Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians	28
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation	27
DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs	27
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study	27
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	26
Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells	26
The role of epigenetic modifications for the pathogenesis of Crohn's disease	26
The emerging role of epigenetic regulation in the progression of silicosis	26
Investigating pathological epigenetic aberrations by epi-proteomics	26
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	25
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	25
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	24
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	24
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study	24
DNA methylation patterns associated with konzo in Sub-Saharan Africa	24
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	23
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women	23
H3K36 trimethylation-mediated biological functions in cancer	23
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA	23
Correction to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology	22
Correction to: Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs	22
The role of DNA methylation in syndromic and non-syndromic congenital heart disease	22
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	22
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	22
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker	22
Correction to: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer	22
Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients	22
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer	21
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line	20
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer	20

Genome-wide methylation patterns in Marfan syndrome	20
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	20
Leveraging epigenetics to enhance the efficacy of immunotherapy	20
Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance	19
Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention	19
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	19
Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines	19
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia	19
Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood	19
Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer	19
Germline variants in genes of the subcortical maternal complex and Multilocus Imprinting Disturbance are associated with miscarriage/infertility or Beckwith–Wiedemann progeny	19
Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes	19
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	18
Whole blood methylome-derived features to discriminate endocrine hypertension	18
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	18
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	18
Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells	18
Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors	18
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs	17
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	17
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	17
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity	17
Differentially hypomethylated cell-free DNA and coronary collateral circulation	17
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study	17
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies	16
Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12	16
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	16
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	16
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life	16
Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics	16
SMYD3: a regulator of epigenetic and signaling pathways in cancer	16
ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance	16
Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines	16
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity	16