Clinical Epigenetics

Papers
(The TQCC of Clinical Epigenetics is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)
ArticleCitations
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas135
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer123
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments101
Gender-affirming hormone therapy induces specific DNA methylation changes in blood86
Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records79
Novel epigenetic network biomarkers for early detection of esophageal cancer69
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunothe64
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells62
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance57
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women57
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder55
A critical appraisal of clinical epigenetics52
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature51
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics50
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy50
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers50
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults50
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis47
Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy46
DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs46
Inhibition of HDAC4 by GSK3β leads to downregulation of KLF5 and ASK1 and prevents the progression of intravertebral disc degeneration45
HDAC2 enhances esophageal squamous cell carcinoma development through down-regulating microRNA-503-5p and promoting CXCL1044
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA44
The dark side of histones: genomic organization and role of oncohistones in cancer44
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis41
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC41
Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer40
Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients40
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy38
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study38
Correction to: Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs37
The role of epigenetic modifications for the pathogenesis of Crohn's disease35
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes35
Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells35
Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside34
Blood DNA methylation and COVID-19 outcomes33
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation33
DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity33
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain33
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma32
Correction to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology31
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals31
H3K36 trimethylation-mediated biological functions in cancer30
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes29
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance29
Associations between indicators of socioeconomic position and DNA methylation: a scoping review29
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers29
Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians29
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes28
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL27
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients27
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer27
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation27
High performance methylated DNA markers for detection of colon adenocarcinoma27
The emerging role of epigenetic regulation in the progression of silicosis26
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells26
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence26
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study26
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures26
Why epigenetics is (not) a biosocial science and why that matters25
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation25
Identification of differentially methylated regions in rare diseases from a single-patient perspective25
DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test25
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer25
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker25
Investigating pathological epigenetic aberrations by epi-proteomics25
DNA methylation patterns associated with konzo in Sub-Saharan Africa25
Correction to: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer24
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity24
Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells24
Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling23
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity23
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer23
Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability23
BDNF exon IV promoter methylation and antidepressant action: a complex interplay23
Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling22
Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines22
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung di22
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies22
ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance21
The role of DNA methylation in syndromic and non-syndromic congenital heart disease21
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs21
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia21
Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer20
Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance20
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker20
Epigenetic mechanisms underlying prostate cancer radioresistance20
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application19
DNA methylation of the KLK8 gene in depression symptomatology19
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood19
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes19
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation19
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA19
Aberrant epigenetic and transcriptional events associated with breast cancer risk18
Germline variants in genes of the subcortical maternal complex and Multilocus Imprinting Disturbance are associated with miscarriage/infertility or Beckwith–Wiedemann progeny18
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma18
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival18
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer18
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer18
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study18
Correction to: Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer18
Correction to: Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS‑CoV‑2 infectivity18
Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B1218
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles18
Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, hu18
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer18
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