OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Novel epigenetic network biomarkers for early detection of esophageal cancer	150
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	100
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	78
DNA methylation patterns associated with konzo in Sub-Saharan Africa	76
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	72
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	69
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	61
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	59
Whole blood methylome-derived features to discriminate endocrine hypertension	52
Aberrant epigenetic and transcriptional events associated with breast cancer risk	50
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	42
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	42
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	40
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	39
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	38
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation	38
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	37
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	36
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	36
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	35
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)	35
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	35
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	34
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	33
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat	32

Epigenome-wide association studies: current knowledge, strategies and recommendations	31
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	31
Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach	30
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study	29
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	28
Epigenome-wide association study of lung function in Latino children and youth with asthma	28
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	28
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy	28
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance	27
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms	27
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study	27
Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients	27
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder	26
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer	25
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort	25
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations	25
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	24
High performance methylated DNA markers for detection of colon adenocarcinoma	24
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	24
Identification of differentially methylated regions in rare diseases from a single-patient perspective	23
Why epigenetics is (not) a biosocial science and why that matters	23
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	23
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	23
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	22
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	22
The emerging role of epigenetic regulation in the progression of silicosis	21
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	21
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	21
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	20
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	20
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	20
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	20
Investigating pathological epigenetic aberrations by epi-proteomics	20
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	20