OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Epigenetics is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Novel epigenetic network biomarkers for early detection of esophageal cancer	150
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	100
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	78
DNA methylation patterns associated with konzo in Sub-Saharan Africa	76
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	72
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	69
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	61
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	59
Whole blood methylome-derived features to discriminate endocrine hypertension	52
Aberrant epigenetic and transcriptional events associated with breast cancer risk	50
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	42
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	42
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	40
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	39
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation	38
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	38
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	37
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	36
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	36
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	35
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	35
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)	35
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	34
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	33
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat	32

Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	31
Epigenome-wide association studies: current knowledge, strategies and recommendations	31
Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach	30
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study	29
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	28
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy	28
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	28
Epigenome-wide association study of lung function in Latino children and youth with asthma	28
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms	27
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study	27
Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients	27
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance	27
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder	26
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort	25
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations	25
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer	25
High performance methylated DNA markers for detection of colon adenocarcinoma	24
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	24
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	24
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	23
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	23
Identification of differentially methylated regions in rare diseases from a single-patient perspective	23
Why epigenetics is (not) a biosocial science and why that matters	23
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	22
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	22
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	21
The emerging role of epigenetic regulation in the progression of silicosis	21
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	21
Investigating pathological epigenetic aberrations by epi-proteomics	20
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	20
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	20
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	20
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	20
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	20
SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples	19
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	19
Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression	18
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing	18
NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family	18
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population	18
Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence	18
Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer	17
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies	17
Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array	17
Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion	17
5-Hydroxymethylation alterations in cell-free DNA reflect molecular distinctions of diffuse large B cell lymphoma at different primary sites	16
Chromatin accessibility analysis identifies GSTM1 as a prognostic marker in human glioblastoma patients	16
The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer	16
DNA methylation and aeroallergen sensitization: The chicken or the egg?	16
The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells	16

Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	16
Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells	16
Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker	16
A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources	16
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women	15
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures	15
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	15
LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer	15
DNA methylation mediates the association between breastfeeding and early-life growth trajectories	15
Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway	15
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals	15
Differentially hypomethylated cell-free DNA and coronary collateral circulation	15
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	15
Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis	15
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes	15
Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer	14
Detection of ovarian cancer using plasma cell-free DNA methylomes	14
Identification of DNA methylation-regulated genes as potential biomarkers for coronary heart disease via machine learning in the Framingham Heart Study	14
Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure	14
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans	14
Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma	14
A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features	14
Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages	14
Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease	14
Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression	13
Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis	13
Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency	13
Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study	13
The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study	13
Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study	13
Distinguishing transgender DNA methylation	13
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes	13
Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes	13
An examination of mediation by DNA methylation on birthweight differences induced by assisted reproductive technologies	13
Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways	12
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	12
Methylation-derived inflammatory measures and lung cancer risk and survival	12
Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis	12
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	12
Gene body methylation in cancer: molecular mechanisms and clinical applications	12
Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals	12
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	12
Cardiovascular health and four epigenetic clocks	12
Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett’s esophagus	12