Clinical Epigenetics

Article	Citations
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	110
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	102
Epigenome-wide association studies: current knowledge, strategies and recommendations	83
Blood DNA methylation and COVID-19 outcomes	80
Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes	77
Cellular reprogramming and epigenetic rejuvenation	66
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects	64
Advances in epigenetic therapeutics with focus on solid tumors	62
Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective	59
Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential	56
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma	53
Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility	53
Epigenetic modification mechanisms involved in keloid: current status and prospect	52
Gene body methylation in cancer: molecular mechanisms and clinical applications	52
Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance	52
Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans	49
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors	46
DNA methylation biomarkers of myocardial infarction and cardiovascular disease	45
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy	44
Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression	44
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures	44
Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array	44
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts	42
SMYD3: a regulator of epigenetic and signaling pathways in cancer	42
Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside	42

The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	41
Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner	41
Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice	40
A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer	40
DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs	39
The dark side of histones: genomic organization and role of oncohistones in cancer	39
Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction	39
The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium	38
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	38
DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies	36
Association of peripheral blood DNA methylation level with Alzheimer’s disease progression	36
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study	35
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	34
H3K36 trimethylation-mediated biological functions in cancer	33
Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine	33
A review of epigenetic changes in asthma: methylation and acetylation	32
Characteristics of epigenetic aging across gestational and perinatal tissues	32
DNA methylation and gene expression integration in cardiovascular disease	32
Ethical implications of epigenetics in the era of personalized medicine	31
The role of DNA methylation in syndromic and non-syndromic congenital heart disease	31
Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy	31
Association of cardiovascular health and epigenetic age acceleration	30
DNA methylation epi-signature is associated with two molecularly and phenotypically distinct clinical subtypes of Phelan-McDermid syndrome	30
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies	30
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	30
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions	30
STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease	29
Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD	28
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	28
High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations	28
The role of epigenetic modifications for the pathogenesis of Crohn's disease	28
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells	28
Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging	27
DNA methylation: a potential mediator between air pollution and metabolic syndrome	27
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity	27
Male obesity impacts DNA methylation reprogramming in sperm	27
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	27
DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas	26
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies	26
Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial	26
Sensitive detection of colorectal cancer in peripheral blood by a novel methylation assay	26
Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism	26
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes	25
Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals	25
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations	25
Cardiovascular health and four epigenetic clocks	24
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC	24
NEFM DNA methylation correlates with immune infiltration and survival in breast cancer	24
DNA methylation mediates the association between breastfeeding and early-life growth trajectories	24
Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing	23

Gender-affirming hormone therapy induces specific DNA methylation changes in blood	23
Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers	23
Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression	23
Reproductive technologies, female infertility, and the risk of imprinting-related disorders	23
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	23
Non-invasive detection of endometrial cancer by DNA methylation analysis in urine	22
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes	22
The impact of CBP expression in estrogen receptor-positive breast cancer	22
UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE	22
The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling	22
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	22
Childhood-onset dystonia-causing KMT2B variants result in a distinctive genomic hypermethylation profile	22
Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences	22
Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms	22
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation	22
METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors	21
Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays	21
Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples	21
DNA methylation analysis of tumor suppressor genes in liquid biopsy components of early stage NSCLC: a promising tool for early detection	20
Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs	20
Leveraging epigenetics to enhance the efficacy of immunotherapy	20
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans	20
Discovery and validation of methylation signatures in blood-based circulating tumor cell-free DNA in early detection of colorectal carcinoma: a case–control study	20
Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning	19
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	19
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	19
DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter	19
Epigenetic mechanisms underlying prostate cancer radioresistance	19
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy	19
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function	19
Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival	19
Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer	19
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer	19
LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression	18
Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples	18
Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer	18
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	18
DNA methylation impact on Fabry disease	18
DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque	17
Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndr	17
Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer	17
Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome	17
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer	17
Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia	17
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer	17
Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records	17
Race/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study	16
Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program	16
BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response	16
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA	16
Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient	16
Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer	16
Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction	16
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs	16
DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring	16
A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features	16
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights	16
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	16
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	15
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma	15
Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion	15
Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia	15
5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients	15
Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines	15
Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study	15
Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction	15
Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids	15
Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, hu	15
Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy	15
Detection of ovarian cancer using plasma cell-free DNA methylomes	15
Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study	15
High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats	15
Batch-effect detection, correction and characterisation in Illumina HumanMethylation450 and MethylationEPIC BeadChip array data	14
Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking	14
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	14
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	14
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	14
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells	14
Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ	14
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals	14

Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes	14
Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis	14
Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives	14
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	14
DNA methylation biomarker for cumulative lead exposure is associated with Parkinson’s disease	14
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes	14
Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight	14
DNA methylation in cord blood in association with prenatal depressive symptoms	13
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung di	13
Novel epigenetic network biomarkers for early detection of esophageal cancer	13
Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis	13
DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health	13
Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy	13
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity	13
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	13
Epigenome-wide association study of lung function in Latino children and youth with asthma	13
Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression	13
Epigenetic modelling of former, current and never smokers	13
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint	13
ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance	13
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer	13
Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer	13
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	13
CAMK2N1/RUNX3 methylation is an independent prognostic biomarker for progression-free and overall survival of platinum-sensitive epithelial ovarian cancer patients	12
Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia	12
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunothe	12
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	12
Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients	12
FK228 sensitizes radioresistant small cell lung cancer cells to radiation	12
A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events	12
Development of a prognostic risk model for clear cell renal cell carcinoma by systematic evaluation of DNA methylation markers	12
Aberrant epigenetic and transcriptional events associated with breast cancer risk	12
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation	12
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	12
Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study	12
Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology	12
Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome	12
Identification of DNA methylation biomarkers for risk of liver metastasis in early-stage colorectal cancer	12
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	12
Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors	12
Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells	12
Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis	12
Prenatal risk factors and neonatal DNA methylation in very preterm infants	12
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA	12
Discovery and validation of tissue-specific DNA methylation as noninvasive diagnostic markers for colorectal cancer	11
Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes	11
Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation	11
Clinical validation of a novel quantitative assay for the detection of MGMT methylation in glioblastoma patients	11
Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics	11
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	11
Roles for the methyltransferase SETD8 in DNA damage repair	11
Estimands in epigenome-wide association studies	11
Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations	11
Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence	11
Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus	11
Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention	11
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer	11
Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes	11
A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease	11
DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma	11
Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood	11
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes	11
Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12	10
Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer	10
Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis	10
DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study	10
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing	10
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	10
Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus	10
Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease	10
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood	10
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	10
PRC2: an epigenetic multiprotein complex with a key role in the development of rhabdomyosarcoma carcinogenesis	10
Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes	10
Epigenetic imprinting alterations as effective diagnostic biomarkers for early-stage lung cancer and small pulmonary nodules	10