OOIR: Observatory of International Research

Papers

(The H4-Index of Clinical Epigenetics is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification	111
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden	100
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	84
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	84
The epigenetic implication in coronavirus infection and therapy	71
Blood DNA methylation and COVID-19 outcomes	66
Epigenome-wide association studies: current knowledge, strategies and recommendations	64
Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals	63
Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes	61
The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus	57
Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease	54
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects	54
Cellular reprogramming and epigenetic rejuvenation	53
Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer	52
Advances in epigenetic therapeutics with focus on solid tumors	51
Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility	50
Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential	49
Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy	48
Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation	47
Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective	44
Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study	44
Management of epigenomic networks entailed in coronavirus infections and COVID-19	43
Epigenetic modification mechanisms involved in keloid: current status and prospect	42
DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes	41
DNA methylation biomarkers of myocardial infarction and cardiovascular disease	41

Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance	41
Loss-of-function maternal-effect mutations of PADI6 are associated with familial and sporadic Beckwith-Wiedemann syndrome with multi-locus imprinting disturbance	40
Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression	40
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors	40
Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions	40
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts	38
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets	38
Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans	38
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma	38
Current status of development of methylation biomarkers for in vitro diagnostic IVD applications	38
Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner	38
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy	37
Characterisation of an inflammation-related epigenetic score and its association with cognitive ability	37
Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study	37