OOIR: Observatory of International Research

Papers

(The TQCC of Altex-Alternatives to Animal Experimentation is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Probabilistic risk assessment – the keystone for the future of toxicology	40
NAM-supported read-across: From case studies to regulatory guidance in safety assessment	22
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)	21
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective	17
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)	16
Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood monocyte activation test	13
Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system	11
How a GIVIMP certification program can increase confidence in in vitro methods	11
ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science	11
The state of the scientific revolution in toxicology	9
Reply to comment “Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum”	9
Ready for regulatory use: NAMs and NGRA for chemical safety assurance	9
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness	9
A call for a Human Exposome Project	8
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform	8
Characteristics to consider when selecting a positive control material for an in vitro assay	8
A strategy towards the generation of testable adverse outcome pathways for nanomaterials	8
On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains	7
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans	7
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data	7
Consensus statement from the European Network of 3R Centres (EU3Rnet)	6
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies	6
Retrospective analysis of dermal absorption triple pack data	6
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories	6
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides	5

Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment	5
U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials	5
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop	5
Replacing fetal bovine serum (FBS) in research and testing	5
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible	5
Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences	5
Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?	5
4.2 million and counting… The animal toll for REACH systemic toxicity studies	4
Continuing animal tests on cosmetic ingredients for REACH in the EU	4
Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment	4
Proceedings of a workshop to address animal methods bias in scientific publishing	4
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach	4
A high-throughput and highly automated genotoxicity screening assay	4
Educational use of animals in Europe indicates a reluctance to implement alternatives	4
Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information	4
Academic application of Good Cell Culture Practice for induced pluripotent stem cells	4
Using the monocyte activation test as a stand-alone release test for medical devices	4
Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics	4
Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality	4
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells	4
Engagement of scientists with the public and policymakers to promote alternative methods	4
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms	4
A microfluidic thyroid-liver platform to assess chemical safety in humans	4
A survey to assess animal methods bias in scientific publishing	3
Applying evidence-based methods to the development and use of adverse outcome pathways	3
COVID-19 – prime time for microphysiological systems, as illustrated for the brain	3
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I	3
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion	3
Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing	3
Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways	3
Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do	3
A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level	3
REACH out-numbered! The future of REACH and animal numbers	3
Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum	3
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays	3
A triangular approach for the validation of new approach methods for skin sensitization	3
Potential of concentration-response data to broaden regulatory application of in vitro test guidelines	3
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks	3
Understanding COVID-19 through adverse outcome pathways – 2nd CIAO AOP Design Workshop	2
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data	2
The probable future of toxicology - probabilistic risk assessment	2
Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations	2
Alternative methods go green! Green toxicology as a sustainable approach for assessing chemical safety and designing safer chemicals	2
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization	2
SpheraCosmolife: a new tool for the risk assessment of cosmetic products	2
Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs	2
Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges	2
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations	2
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid	2
Phase-out planning for animal experimentation: A definition, an argument, and seven action points	2

Development of an Evidence-Based Risk Assessment Framework	2
An alternative in vivo model to evaluate pluripotency of patient-specific iPSCs	2
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment	2
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells	2
Open-source human skin model with an in vivo-like barrier for drug testing	2
Elements and development processes for test methods in toxicology and human health-relevant life science research	2
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	2
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation	2
Development of an Evidence-Based Risk Assessment Framework	2
Dog as the experimental model: Laboratory uses of dogs in the United States	2
The Monographs Programme of the International Agency for Research on Cancer	2
Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)	2
Animal metrics: Tracking contributions of new approach methods to reduced animal use	2
A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells	2
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity	2