Altex-Alternatives to Animal Experimentation

Article	Citations
Alternative Methods in Science: Towards Fluidic Systems	51
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl1	28
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl5	18
Sensitivity analysis and quality indicators for an in vitro oral irritation assay	16
Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism_suppl	15
Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law	13
The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose rate dependent_suppl	10
REACH out-numbered! The future of REACH and animal numbers	9
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl1	9
Predicting Acute Oral Toxicity Using AcutoX: An Animal Product-Free and Metabolically Relevant Human Cell-Based Test	9
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization	9
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency	9
A sensitive cell-based assay for testing potency of Botulinum neurotoxin type A	8
Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing	7
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl4	7
Chemical selection for the Thyroid Validation Study coordinated by EURL ECVAM and involving EU-NETVAL laboratories_suppl1	7
E-validation – Unleashing AI for validation	7
Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study	7
The long way from raw data to NAM-based information: Overview on data layers and processing steps	6
Developing a global education hub for animal-free innovation_suppl	6
Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA)_suppl2	6
Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing	6
Validation study for the evaluation of MCTT HCE™ test method for eye safety assessment of medical devices	6
Chemical selection for the Thyroid Validation Study coordinated by EURL ECVAM and involving EU-NETVAL laboratories_suppl3	5
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl1	5

Non-animal approaches – Concept, validation, and regulatory acceptance: The fourth Asian Congress of Alternatives to Animal Experiments (4ACAAE) and the seventh Annual Meeting of the Society for Alter	4
Lost in NAMs-lation: A review of animal-free science definitions	4
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl6	4
3Rs: Progress or a fig leaf?	4
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations	4
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology	4
Investigation of the publication rate of recent research projects using non-human primates in France	4
Exploring the synergy of CRISPR and microphysiological systems	4
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays_suppl3	4
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl2	4
AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting_suppl1	4
In vitro-based prediction of human plasma concentrations of food-related compounds_suppl1	3
Women in Alternatives	3
The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States	3
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays_suppl2	3
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay	3
Low rejection rate for animal experiments in Germany despite legal reform	3
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl3	3
The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data	3
From cellular perturbation to probabilistic risk assessments	2
ALTEX Proceedings TIERethik Corrigendum to Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	2
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl1	2
The SCAHT Adverse Outcome Pathway (AOP)_HUB: A hands-on platform for information exchange, sharing, and developing AOPs	2
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl7	2
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare	2
Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications	2
Transition to animal-free science: Phasing out animal experiments, phasing in innovation	2
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	2
Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans_suppl	2
Material-mediated pyrogens in medical devices: Myth or reality?_suppl2	2
Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity_suppl1	2
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl6	2
Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment	2
Human relevant frontiers in drug safety and efficacy	2
Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways	2
A path forward advancing microphysiological systems	2
Role of standards and funding in accelerating the development and use of microphysiological systems	2
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis_suppl1	2
Building confidence in PBK model predictions in the absence of human kinetic data: Benzophenone-4 case study_suppl1	2
Second scientific sessions and international conference of the Society for Alternatives to Animal Testing in Sri Lanka (SAAT-SL)	2
Micro-replace systems	2
Towards NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos	1
International conference and workshop on “New Approach Methodologies (NAMs) in Pharmacology and Toxicology”	1
Phase-out planning for animal experimentation: A definition, an argument, and seven action points	1
Phasing in human-relevant science: Why the UK’s roadmap matters – and how to make it work	1
Advancing humane and human-relevant science: The 8th Annual Conference of the Society for Alternatives to Animal Experiments – India (SAAE-I 2025)	1
Material-mediated pyrogens in medical devices: Myth or reality?_suppl1	1
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment	1
Guidance for Good In Vitro Reporting Standards (GIVReSt) – A draft for stakeholder discussion and background documentation	1
Fish Count, Too – The Animal Toll of REACH Aquatic Toxicity Tests_suppl2	1

AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting	1
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl2	1
Virtual control groups in non-clinical toxicology – A replicability challenge	1
The benefits of validation of methods for toxicity testing outweigh its costs	1
Advancing skin sensitization potency categorization using U-SENS™ in OECD TG 497	1
3 Days for 3Rs 2023: Refinement, reduction, replacement	1
Ways to broaden the awareness, consideration and adoption of new approach methodologies (NAMs)	1
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis	1
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl2	1
A sensitive cell-based assay for testing potency of Botulinum neurotoxin type A_suppl	1
The need for epigenotoxicity testing	1
A call for a Human Exposome Project	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl1	0
Report on the 5th and 6th Mystery of Reactive Oxygen Species Conferences	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_suppl2	0
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare_suppl	0
The probable future of toxicology - probabilistic risk assessment	0
Serum-free in vitro assessment of receptor-mediated endocrine activity including Phase-1 metabolism_suppl	0
Developing a global education hub for animal-free innovation	0
Application of microphysiological systems for nonclinical evaluation of cell therapies	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl3	0
An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process_suppl	0
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl2	0
Organizing shipping studies to evaluate the transferability of cell- and tissue-based test systems and reagents: An end user perspective	0
Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development	0
Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling	0
Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems	0
Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context_suppl1	0
A survey to assess animal methods bias in scientific publishing_suppl3	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl1	0
Possible applications of new approach methodologies (NAMs) in ecotoxicology	0
Material-mediated pyrogens in medical devices: Myth or reality?	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl1	0
Erratum to National Workshop on Alternatives to Higher Animals in Toxicology and Biomedical Science	0
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity_suppl	0
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology_suppl	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl4	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl3	0
Have the non-technical summaries of animal experiments in Europe improved? An update	0
Low rejection rate for animal experiments in Germany despite legal reform_suppl	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl3	0
Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes	0
Serum-free in vitro assessment of receptor-mediated endocrine activity including Phase-1 metabolism	0
In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation	0
Review on organ-on-chips for medicines safety assessment: A European regulatory perspective	0
The turning point: April 2025 marks historic shift in US animal testing policy	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl2	0
Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals_suppl2	0
In vitro-based prediction of human plasma concentrations of food-related compounds	0
Challenges and opportunities for validation of AI-based new approach methods	0
Building confidence in PBK model predictions in the absence of human kinetic data: Benzophenone-4 case study	0
Development of physiologically based gut absorption model for probabilistic prediction of environmental chemical bioavailability	0
Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)	0
Investigation of the potential of bisphenol A substitutes to induce allergic contact sensitization using OECD defined approaches	0
Custom GPTs to aid in compliance checking for reporting standards in academic publishing	0
Argentina's progress towards adopting new alternative methods in safety testing: The role of the Laboratorio de Métodos Alternativos	0
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl1	0
Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs	0
Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context_suppl2	0
Software tools for systematic review literature screening and data extraction: Qualitative user experiences from succinct formal tests	0
Review on organ-on-chips for medicines safety assessment: A European regulatory perspective_suppl1	0
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis_suppl2	0
National workshop on alternatives to higher animals in toxicology and biomedical science	0
3D bioprinting of human skin and squamous cell tumors (SCCs) as advanced models for precision medicine (BIOSQIN)	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl8	0
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl2	0
Advancing skin sensitization potency categorization using U-SENS™ in OECD TG 497_suppl	0
Implementation of reduction and refinement-related parameters in repeated dose toxicity studies	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl1	0
Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications_suppl1	0
National workshop on non-mammalian models in research with emphasis on the 3Rs principle	0
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data	0
The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose rate dependent	0
Multiparametric evaluation of different FBS-free replacement media for widely used human cancer cell lines_Suppl5	0
In vitro evaluation of the carcinogenic potential of perfluorinated chemicals	0
A survey to assess animal methods bias in scientific publishing_suppl2	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl2	0
The validation of regulatory test methods – Conceptual, ethical, and philosophical foundations	0
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays	0
Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA)	0

Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl3	0
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration	0
Opportunities and challenges for human microphysiological systems in drug development	0
Indian Society for Alternatives to Animal Experiments: Sixth annual meeting and international conference	0
Multiparametric evaluation of different FBS-free replacement media for widely used human cancer cell lines_Suppl3	0
Fish Count, Too – The Animal Toll of REACH Aquatic Toxicity Tests_suppl1	0
Development of a Monoclonal Antibody Sandwich ELISA for the Determination of Antigen Content and Quality in Human and Animal Tetanus Vaccines	0
Non-animal models: Complexity for interactions…Connecting science	0
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups	0
Statistical derivation of cut-off values for in vitro assays	0
Characterization and optimization of variability in a human colonic epithelium culture model	0
The road to virtual control groups and the importance of proper body-weight selection	0
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment_suppl2	0
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl2	0
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups_suppl	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl2	0
Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications_suppl2	0
Tracing progress: The evolution of a protocol for relative metal release in surrogate gastric fluid_suppl	0
ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science	0
State of the science on assessing developmental neurotoxicity using new approach methods	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl1	0
Pyrogen testing at a turning point – On occasion of the 30th anniversary of the whole blood monocyte activation test	0
Elements and development processes for test methods in toxicology and human health-relevant life science research	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl5	0
Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants	0
EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable	0
Validation study for the evaluation of MCTT HCE™ test method for eye safety assessment of medical devices_Suppl1	0
Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use	0
Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review_Supplement	0
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays _suppl1	0
A survey to assess animal methods bias in scientific publishing_suppl5	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl7	0
Trends in the use of animals and non-animal methods over the last 20 years	0
Towards NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos_suppl1	0
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl3	0
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity	0
Perception and power: Barriers to animal-free research - Animalfree Research Forum 2025	0
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I	0
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl2	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl5	0
Review on organ-on-chips for medicines safety assessment: A European regulatory perspective_suppl2	0
The Implementation Moonshot Project for Alternative Chemical Testing (IMPACT) toward a Human Exposome Project	0
Investigation of the publication rate of recent research projects using non-human primates in France_suppl1	0
Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study_suppl2	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl6	0
Sensitivity analysis and quality indicators for an in vitro oral irritation assay_suppl	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl4	0
Improved identification of human hepatotoxic potential by summary variables of gene expression_suppl	0
Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system	0
Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study_suppl1	0
Potential value of animal microphysiological systems	0
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl1	0
Fish count, too – The animal toll of REACH aquatic toxicity tests	0
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment_suppl	0
InViTe2 Retreat: Advancing new approach methodologies in chemical safety testing and drug discovery	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl2	0
Statistical derivation of cut-off values for in vitro assays_suppl	0
KoCVAM-led validation of KeraSkin™ Phototoxicity Assay for inclusion in OECD TG 498	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_suppl3	0
Russell and Burch’s 3Rs then and now: The case of Switzerland	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review	0
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays_suppl	0
Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals	0
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment_suppl1	0
Tracing progress: The evolution of a protocol for relative metal release in surrogate gastric fluid	0
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl8	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment	0
Toward implementing virtual control groups in nonclinical safety studies	0
Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants_suppl	0
Challenges integrating skin sensitization data for assessment of difficult to test substances_suppl	0
Multiparametric evaluation of different FBS-free replacement media for widely used human cancer cell lines	0
Animal pilot studies should not be used to estimate sample size if effect size and population variance are unknown	0
Development of a defined approach for eye hazard identification of solid chemicals according to the three UN GHS categories	0
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays_suppl5	0
60 Years of the 3Rs symposium: Lessons learned and the road ahead	0
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays	0
An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process	0
AOPs to connect food additives’ effects on gut microbiota to health outcomes	0
Validation study for the evaluation of MCTT HCE™ test method for eye safety assessment of medical devices_Suppl2	0
Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans	0
What does “success” look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations_suppl5	0
Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing	0
Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling_suppl	0
Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context	0
Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges	0
Chemical fate in vitro: A physiological biokinetic (PBK) model for cell-based assays_suppl4	0
Chemical selection for the Thyroid Validation Study coordinated by EURL ECVAM and involving EU-NETVAL laboratories_suppl2	0
Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity	0
Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals_suppl1	0
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data_suppl1	0
Multiparametric evaluation of different FBS-free replacement media for widely used human cancer cell lines_Suppl2	0
New approach methodologies (NAMs): The strategic vision in science	0
4.2 million and counting… The animal toll for REACH systemic toxicity studies_suppl	0