Altex-Alternatives to Animal Experimentation

Article	Citations
Probabilistic risk assessment – the keystone for the future of toxicology	25
NAM-supported read-across: From case studies to regulatory guidance in safety assessment	17
Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood monocyte activation test	12
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)	12
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)	10
How a GIVIMP certification program can increase confidence in in vitro methods	10
Reply to comment “Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum”	9
Characteristics to consider when selecting a positive control material for an in vitro assay	8
A strategy towards the generation of testable adverse outcome pathways for nanomaterials	8
Ready for regulatory use: NAMs and NGRA for chemical safety assurance	7
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective	7
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness	7
The state of the scientific revolution in toxicology	7
Continuing animal tests on cosmetic ingredients for REACH in the EU	7
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies	6
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans	6
Academic application of Good Cell Culture Practice for induced pluripotent stem cells	6
Retrospective analysis of dermal absorption triple pack data	6
Educational use of animals in Europe indicates a reluctance to implement alternatives	5
Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics	5
Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?	5
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop	5
Replacing fetal bovine serum (FBS) in research and testing	5
A triangular approach for the validation of new approach methods for skin sensitization	5
On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains	5

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform	5
Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences	4
Using the monocyte activation test as a stand-alone release test for medical devices	4
Consensus statement from the European Network of 3R Centres (EU3Rnet)	4
Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality	4
A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins	4
A high-throughput and highly automated genotoxicity screening assay	4
U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials	4
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories	4
A call for a Human Exposome Project	4
Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system	4
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays	3
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible	3
Proceedings of a workshop to address animal methods bias in scientific publishing	3
ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science	3
Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do	3
Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum	3
COVID-19 – prime time for microphysiological systems, as illustrated for the brain	3
Understanding COVID-19 through adverse outcome pathways – 2nd CIAO AOP Design Workshop	3
Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment	3
SpheraCosmolife: a new tool for the risk assessment of cosmetic products	3
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation	2
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides	2
REACH out-numbered! The future of REACH and animal numbers	2
Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations	2
Engagement of scientists with the public and policymakers to promote alternative methods	2
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms	2
Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges	2
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data	2
Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information	2
A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level	2
An alternative in vivo model to evaluate pluripotency of patient-specific iPSCs	2
Animal metrics: Tracking contributions of new approach methods to reduced animal use	2
A microfluidic thyroid-liver platform to assess chemical safety in humans	2
Applying evidence-based methods to the development and use of adverse outcome pathways	2
Dog as the experimental model: Laboratory uses of dogs in the United States	2
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment	2
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks	2
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells	2
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach	2
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl4	1
Predictive alternative methods for assessing biocompatibility of dental materials: A NIST-NIDCR workshop report	1
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations	1
The nearest neighbor nuclei method to objectify analysis of pertussis toxin-induced clustering	1
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data	1
Systematic review in evidence-based risk assessment	1
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid	1
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion	1
Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference	1
The Monographs Programme of the International Agency for Research on Cancer	1

In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges	1
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment	1
A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells	1
4.2 million and counting… The animal toll for REACH systemic toxicity studies	1
Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs	1
Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens	1
Development of an Evidence-Based Risk Assessment Framework	1
Practical workshop on replacing fetal bovine serum (FBS) in life science research: From theory into practice	1
In vitro-based prediction of human plasma concentrations of food-related compounds	1
Identifying, naming and documenting of test and tool compound stocks	1
Second Virtual Summer School: Alternative methods in science: Towards model complexity	1
Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data	1
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization	1
Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing	1
A survey to assess animal methods bias in scientific publishing	1
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells	1
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	1
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity	1
Potential of concentration-response data to broaden regulatory application of in vitro test guidelines	1
Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity	1
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays	1
Sensitization potential of medical devices detected by in vitro and in vivo methods	1
Development of physiologically based gut absorption model for probabilistic prediction of environmental chemical bioavailability	1
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl2	1
The use of categorical regression in evidence integration	1
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl4	1
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo	1
Exploratory analysis of the application of animal reduction approaches in proteomics: How much is enough?	1
Open-source human skin model with an in vivo-like barrier for drug testing	1
Open letter: Selection of a new Executive Director of the European Chemicals Agency (ECHA) provides an opportunity for the EU to lead in the field of chemicals management and implementation of innovat	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl5	0
Russell and Burch’s 3Rs then and now: The case of Switzerland	0
Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery	0
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories_suppl2	0
Dog as the experimental model: Laboratory uses of dogs in the United States_suppl	0
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells_suppl1	0
Alternative Methods in Science: Towards Fluidic Systems	0
Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl2	0
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations_suppl1	0
Transition to animal-free science: Phasing out animal experiments, phasing in innovation	0
A survey to assess animal methods bias in scientific publishing_suppl2	0
Proceedings of a workshop to address animal methods bias in scientific publishing_suppl	0
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans_suppl	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl	0
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl2	0
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl2	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl1	0
A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening_suppl	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl2	0
How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl2	0
Validation of the monocyte activation test with three therapeutic monoclonal antibodies_suppl	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl1	0
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays_suppl	0
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl1	0
A survey to assess animal methods bias in scientific publishing_suppl5	0
A survey to assess animal methods bias in scientific publishing_suppl1	0
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl1	0
Corrigendum to TBBPA Targets Converging Key Events of Human Oligodendrocyte Development Resulting in Two Novel AOPs	0
An in vitro air-liquid interface inhalation platform for petroleum substances and constituents_suppl	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl5	0
SpheraCosmolife: a new tool for the risk assessment of cosmetic products_suppl	0
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl2	0
A high-throughput and highly automated genotoxicity screening assay_suppl	0
EFSA’s framework for evidence-based scientific assessments: A case study on uncertainty analysis	0
A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells_suppl	0
Challenges integrating skin sensitization data for assessment of difficult to test substances_suppl	0
Cross-industrial applications of organotypic models	0
Enabling a shift towards a human-relevant and predictive paradigm for biomedical research and drug discovery in India	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl5	0
Systematic review in evidence-based risk assessment_suppl	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl3	0
An alternative in vivo model to evaluate pluripotency of patient-specific iPSCs_suppl	0
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl2	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl7	0
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl2	0
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations_suppl2	0
A new gold standard: Paradigm shift in research on human diseases and therapy developments	0
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation_suppl2	0

Open-source human skin model with an in vivo-like barrier for drug testing_suppl	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl8	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl2	0
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl1	0
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays_suppl	0
The GARD™skin assay: Investigation of the applicability domain for metals_suppl	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review_Supplement	0
A survey to assess animal methods bias in scientific publishing_suppl4	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl3	0
Development of an Evidence-Based Risk Assessment Framework_suppl	0
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl1	0
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl1	0
Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)	0
Application of computational methods in replacement – an IPAM webinar	0
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl1	0
CellTox Days 2022 – Inside the barriers: In vitro models and their applications	0
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl1	0
Replacement, reduction, refinement: 3 days for 3Rs	0
Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do_suppl	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl1	0
A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening	0
Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity_suppl2	0
Virtual class on alternative methods: Ethics and science	0
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data_suppl1	0
Microphysiological endothelial models to characterize subcutaneous drug absorption	0
The Humane Research and Testing Act: Advancing science by creating a new Center for Alternatives at the US National Institutes of Health	0
No more secrets: Enhancing transparency in animal research	0
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I	0
The use of categorical regression in evidence integration_suppl	0
The GARD™skin assay: Investigation of the applicability domain for metals	0
An in vitro air-liquid interface inhalation platform for petroleum substances and constituents	0
Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes_suppl1	0
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment_suppl	0
U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials_suppl	0
Enabling a shift towards a human-relevant and predictive paradigm for biomedical research and drug discovery in India_suppl	0
	0
Alternative methods and citizen science	0
The 3Rs in animal welfare bodies at Swedish universities – knowledge, attitudes, implementation	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl1	0
Summer school on innovative approaches in science	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review	0
Validation of the monocyte activation test with three therapeutic monoclonal antibodies	0
Development of physiologically-based gut absorption model for probabilistic prediction of environmental chemical bioavailability_suppl	0
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion_suppl	0
Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network	0
Phase-out planning for animal experimentation: A definition, an argument, and seven action points	0
A survey to assess animal methods bias in scientific publishing_suppl3	0
Development of an Evidence-Based Risk Assessment Framework	0
A strategy towards the generation of testable adverse outcome pathways for nanomaterials_suppl	0
The nearest neighbor nuclei method to objectify analysis of pertussis toxin-induced clustering_suppl	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl4	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl3	0
Exploratory analysis of the application of animal reduction approaches in proteomics: How much is enough?_suppl	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl6	0
Alternative methods go green! Green toxicology as a sustainable approach for assessing chemical safety and designing safer chemicals	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl1	0
Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law	0
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration_suppl	0
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells_suppl2	0
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories_suppl1	0
Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery_suppl	0
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays	0
	0
Protectiveness of NAM-based hazard assessment – which testing scope is required?	0
Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs	0
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl2	0
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo_suppl	0
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop_suppl	0
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation_suppl1	0
Potential of concentration-response data to broaden regulatory application of in vitro test guidelines_suppl	0
The 3Rs in animal welfare bodies at Swedish universities – knowledge, attitudes, implementation_suppl	0
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl3	0
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration	0
The probable future of toxicology - probabilistic risk assessment	0
Understanding COVID-19 through adverse outcome pathways – 2nd CIAO AOP Design Workshop_suppl	0
TEDD Annual Meeting 2020: 10th anniversary – 10 years of innovation in tissue engineering	0
VitroScreen Seminar - Substance-based medical device qualification and classification: Pre-clinical approaches to mechanism of action	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl4	0
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays_suppl	0
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl3	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl3	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl1	0
Toward implementing virtual control groups in nonclinical safety studies	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl3	0
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)_suppl	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl4	0
Academic application of Good Cell Culture Practice for induced pluripotent stem cells_suppl	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl6	0
Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research	0
In vitro-based prediction of human plasma concentrations of food-related compounds_suppl1	0
4.2 million and counting… The animal toll for REACH systemic toxicity studies_suppl	0
Microphysiological endothelial models to characterize subcutaneous drug absorption_suppl	0
Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl2	0
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform_suppl	0