Altex-Alternatives to Animal Experimentation

Article	Citations
Alternative Methods in Science: Towards Fluidic Systems	48
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl1	28
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl1	26
Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law	21
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency	14
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl5	11
Sensitivity analysis and quality indicators for an in vitro oral irritation assay	9
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl1	9
The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose rate dependent_suppl	8
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment	8
Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)	7
Validation of the monocyte activation test with three therapeutic monoclonal antibodies	7
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization	7
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl4	7
Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing	6
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl4	6
REACH out-numbered! The future of REACH and animal numbers	6
Predicting Acute Oral Toxicity Using AcutoX: An Animal Product-Free and Metabolically Relevant Human Cell-Based Test	6
The long way from raw data to NAM-based information: Overview on data layers and processing steps	5
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop	5
Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing	5
Microphysiological endothelial models to characterize subcutaneous drug absorption_suppl	5
E-validation – Unleashing AI for validation	5
A sensitive cell-based assay for testing potency of Botulinum neurotoxin type A	5
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl6	4

The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data	4
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl1	4
The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States	4
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl2	4
A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening_suppl	4
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology	4
Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity	4
3Rs: Progress or a fig leaf?	4
Developing a global education hub for animal-free innovation_suppl	4
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl4	3
Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways	3
Designing a national strategy to enable human-relevant research in India: A multistakeholder roundtable meeting report	3
Women in Alternatives	3
In vitro-based prediction of human plasma concentrations of food-related compounds_suppl1	3
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay	3
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms	2
Proceedings of a workshop to address animal methods bias in scientific publishing_suppl	2
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis_suppl1	2
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl1	2
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl3	2
A path forward advancing microphysiological systems	2
Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment	2
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl	2
Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity_suppl1	2
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl2	2
Transition to animal-free science: Phasing out animal experiments, phasing in innovation	2
Role of standards and funding in accelerating the development and use of microphysiological systems	2
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays_suppl	2
Human relevant frontiers in drug safety and efficacy	2
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare	2
The SCAHT Adverse Outcome Pathway (AOP)_HUB: A hands-on platform for information exchange, sharing, and developing AOPs	2
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells_suppl2	2
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop_suppl	2
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	2
ALTEX Proceedings TIERethik Corrigendum to Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment	2
Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans_suppl	2
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl2	2
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective	1
Open-source human skin model with an in vivo-like barrier for drug testing_suppl	1
On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains	1
3 Days for 3Rs 2023: Refinement, reduction, replacement	1
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays	1
Predictive alternative methods for assessing biocompatibility of dental materials: A NIST-NIDCR workshop report	1
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl2	1
Micro-replace systems	1
Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment	1
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis	1
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment	1
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation_suppl1	1
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)	1

Ready for regulatory use: NAMs and NGRA for chemical safety assurance	1
Virtual control groups in non-clinical toxicology – A replicability challenge	1
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells_suppl1	1
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl2	1
The benefits of validation of methods for toxicity testing outweigh its costs	1
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl2	1
Phase-out planning for animal experimentation: A definition, an argument, and seven action points	1
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl3	1
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl3	1
A sensitive cell-based assay for testing potency of Botulinum neurotoxin type A_suppl	1
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations_suppl1	1
A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening	0
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis_suppl2	0
The validation of regulatory test methods – Conceptual, ethical, and philosophical foundations	0
Application of microphysiological systems for nonclinical evaluation of cell therapies	0
Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity	0
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology_suppl	0
Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl1	0
Organizing shipping studies to evaluate the transferability of cell- and tissue-based test systems and reagents: An end user perspective	0
A survey to assess animal methods bias in scientific publishing_suppl5	0
Argentina's progress towards adopting new alternative methods in safety testing: The role of the Laboratorio de Métodos Alternativos	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl1	0
How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment	0
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl1	0
Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl4	0
Russell and Burch’s 3Rs then and now: The case of Switzerland	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl6	0
Erratum to National Workshop on Alternatives to Higher Animals in Toxicology and Biomedical Science	0
A microfluidic thyroid-liver platform to assess chemical safety in humans	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_suppl3	0
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion_suppl	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl1	0
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl5	0
Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes_suppl2	0
A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level_suppl	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl1	0
The road to virtual control groups and the importance of proper body-weight selection	0
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl3	0
CellTox Days 2022 – Inside the barriers: In vitro models and their applications	0
Dog as the experimental model: Laboratory uses of dogs in the United States_suppl	0
Toward implementing virtual control groups in nonclinical safety studies	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment	0
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl2	0
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups	0
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl1	0
International STakeholder NETwork (ISTNET) Workshop for creating a developmental and reproductive toxicity (DART) testing roadmap for regulatory purposes	0
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms_suppl	0
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl3	0
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation	0
Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use	0
In vitro evaluation of the carcinogenic potential of perfluorinated chemicals	0
Development of physiologically based gut absorption model for probabilistic prediction of environmental chemical bioavailability	0
A call for a Human Exposome Project	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl1	0
Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration	0
Development of a Monoclonal Antibody Sandwich ELISA for the Determination of Antigen Content and Quality in Human and Animal Tetanus Vaccines	0
Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl3	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl4	0
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl1	0
Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing	0
Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences	0
Development of a defined approach for eye hazard identification of solid chemicals according to the three UN GHS categories	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review	0
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations	0
Potential value of animal microphysiological systems	0
A survey to assess animal methods bias in scientific publishing_suppl2	0
Development of an Evidence-Based Risk Assessment Framework	0
Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems	0
The use of categorical regression in evidence integration_suppl	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl5	0
Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system	0
In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges	0
60 Years of the 3Rs symposium: Lessons learned and the road ahead	0
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Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl4	0

No more secrets: Enhancing transparency in animal research	0
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups_suppl	0
Challenges and opportunities for validation of AI-based new approach methods	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl3	0
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl2	0
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment_suppl1	0
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl2	0
Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs	0
Trends in the use of animals and non-animal methods over the last 20 years	0
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity	0
Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens	0
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data	0
State of the science on assessing developmental neurotoxicity using new approach methods	0
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl6	0
Opportunities and challenges for human microphysiological systems in drug development	0
The GARD™skin assay: Investigation of the applicability domain for metals_suppl	0
Corrigendum to TBBPA Targets Converging Key Events of Human Oligodendrocyte Development Resulting in Two Novel AOPs	0
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment_suppl2	0
Software tools for systematic review literature screening and data extraction: Qualitative user experiences from succinct formal tests	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity	0
EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable	0
A survey to assess animal methods bias in scientific publishing_suppl4	0
In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation	0
Improved identification of human hepatotoxic potential by summary variables of gene expression	0
Cross-industrial applications of organotypic models	0
The probable future of toxicology - probabilistic risk assessment	0
Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences_suppl	0
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid	0
Improved identification of human hepatotoxic potential by summary variables of gene expression_suppl	0
A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells_suppl	0
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl2	0
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays_suppl	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl5	0
The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose rate dependent	0
Alternative methods and citizen science	0
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare_suppl	0
Possible applications of new approach methodologies (NAMs) in ecotoxicology	0
Challenges integrating skin sensitization data for assessment of difficult to test substances_suppl	0
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells	0
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible	0
Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing	0
Statistical derivation of cut-off values for in vitro assays_suppl	0
The Implementation Moonshot Project for Alternative Chemical Testing (IMPACT) toward a Human Exposome Project	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl2	0
Non-animal models: Complexity for interactions…Connecting science	0
National workshop on alternatives to higher animals in toxicology and biomedical science	0
Dog as the experimental model: Laboratory uses of dogs in the United States	0
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl1	0
Characterization and optimization of variability in a human colonic epithelium culture model	0
The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays_suppl	0
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl2	0
Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants_suppl	0
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity_suppl	0
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness	0
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells	0
Animal pilot studies should not be used to estimate sample size if effect size and population variance are unknown	0
Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants	0
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl2	0
	0
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review_Supplement	0
3D bioprinting of human skin and squamous cell tumors (SCCs) as advanced models for precision medicine (BIOSQIN)	0
Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference	0
Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges	0
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays	0
Practical workshop on replacing fetal bovine serum (FBS) in life science research: From theory into practice	0
Have the non-technical summaries of animal experiments in Europe improved? An update	0
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl1	0
The GARD™skin assay: Investigation of the applicability domain for metals	0
Third Virtual Summer School 3Rs for ONE Science: Alternative methods: From complexity to predictivity	0
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform_suppl	0
Statistical derivation of cut-off values for in vitro assays	0
4.2 million and counting… The animal toll for REACH systemic toxicity studies	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl1	0
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl3	0
Replacement, reduction, refinement: 3 days for 3Rs	0
Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations	0
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_suppl2	0
In vitro-based prediction of human plasma concentrations of food-related compounds	0
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration_suppl	0
ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science	0
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl3	0
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks	0
Protectiveness of NAM-based hazard assessment – which testing scope is required?_suppl2	0
Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development	0
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl2	0
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl2	0
4.2 million and counting… The animal toll for REACH systemic toxicity studies_suppl	0
Indian Society for Alternatives to Animal Experiments: Sixth annual meeting and international conference	0
Development of an Evidence-Based Risk Assessment Framework	0
Validation of the monocyte activation test with three therapeutic monoclonal antibodies_suppl	0
Sensitivity analysis and quality indicators for an in vitro oral irritation assay_suppl	0
The use of categorical regression in evidence integration	0
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data	0