OOIR: Observatory of International Research

Papers

(The TQCC of Translational Stroke Research is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review	100
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke	53
Blood Oxygenation Level–Dependent Cerebrovascular Reactivity–Derived Steal Phenomenon May Indicate Tissue Reperfusion Failure After Successful Endovascular Thrombectomy	49
Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting	41
Crosstalk Between Signaling Stroke Cascade and Therapeutic Receptors PPAR-γ, ROCK, CB1R, and CB2R: From Mechanism to Therapies	36
Unpacking the Role of Extracellular Vesicles in Ischemic and Hemorrhagic Stroke: Pathophysiology and Therapeutic Implications	35
Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8	32
Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice	31
Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH	31
Reporting Compliance and Factors Influencing Timeliness of Stroke-Related Trial Results on ClinicalTrials.gov	30
Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease	30
Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage	28
Comparison of Long-Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management	27
The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage	27
Anti-Apoptotic Effects of AMPA Receptor Antagonist Perampanel in Early Brain Injury After Subarachnoid Hemorrhage in Mice	26
Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke	25
Remote Ischemic Post-conditioning Reduces Cognitive Impairment in Rats Following Subarachnoid Hemorrhage: Possible Involvement in STAT3/STAT5 Phosphorylation and Th17/Treg Cell Homeostasis	25
Prevalence and Predictors of Hemorrhagic Foci on Long-term Follow-up MRI of Recent Single Subcortical Infarcts	25
Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms	24
All Three Supersystems—Nervous, Vascular, and Immune—Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage	22
Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease	22
Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model	21
Nomogram for Predicting Long-term Outcomes of Encephaloduroarteriosynangiosis in Toddlers with Moyamoya Disease: a Longitudinal and Cross-sectional Study	21
Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study	21
RNF213 p.Arg4810Lys Wild Type is Associated with De Novo Hemorrhage in Asymptomatic Hemispheres with Moyamoya Disease	21

Quantitative Evaluation of Incomplete Stent Apposition in Intracranial Aneurysms Using Optical Coherence Tomography: a Porcine Model Study	21
Stroke Mechanisms in Intracranial Atherosclerotic Disease: A Modified Classification System and Clinical Implications	20
Distinct Cytokine Responses in Central and Systemic Compartments after Subarachnoid Haemorrhage	20
Collateral-Core Ratio as a Novel Predictor of Clinical Outcomes in Acute Ischemic Stroke	20
Intracerebral Administration of a Novel Self-Assembling Peptide Hydrogel Is Safe and Supports Cell Proliferation in Experimental Intracerebral Haemorrhage	19
A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings	19
Comparative Outcomes of Combined Balloon Angioplasty and Intra-arterial Calcium Channel Blockers Versus Monotherapy for Cerebral Vasospasm Management: A Systematic Review and Meta-analysis	19
Correction to: An Alternative Photothrombotic Model of Transient Ischemic Attack	18
Correction to: The Mfn1‑βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage	18
Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke	18
Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage	18
Opportunities for Neuroprotective Drugs in the Era of Vascular Recanalization	18
Response to Letter to Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy	17
High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes	17
Recycled Translation: Repurposing Drugs for Stroke	17
Methylated MFGE8 Promotes Early Brain Injury After Subarachnoid Hemorrhage and Inhibiting Autophagy of Nerve Cell	17
Use of Tirofiban to Prevent Ischemic Events in Patients with CYP2C19 Loss-of-Function Alleles during Flow Diversion of Intracranial Aneurysm: A Multicenter Cohort Study	17
A Novel Plant-Produced Asialo-rhuEPO Protects Brain from Ischemic Damage Without Erythropoietic Action	17
A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score	17
Cost-Effectiveness of Carotid Endarterectomy vs. Carotid Stenting: a Systematic Review and Meta-Analysis	17
Switching Off Vascular MAPK Signaling: A Novel Strategy to Prevent Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage	17
Correction to: Iron‑Induced Hydrocephalus: The Role of Choroid Plexus Stromal Macrophages	16
Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways	16
Association of Genetic Variants with Postoperative Donor Artery Development in Moyamoya Disease: RNF213 and Other Moyamoya Angiopathy-Related Gene Analysis	16
Minimally Invasive Intracerebral Hemorrhage Evacuation Improves Pericavity Cerebral Blood Volume	15
Prevention of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage—Summary of Existing Clinical Evidence	15
Integrating Bulk RNA and Single-Cell Sequencing Data Unveils Efferocytosis Patterns and ceRNA Network in Ischemic Stroke	15
Revisiting Transcranial Light Stimulation as a Stroke Therapeutic—Hurdles and Opportunities	14
Modulation of the Immunological Milieu in Acute Aneurysmal Subarachnoid Hemorrhage: The Potential Role of Monocytes Through CXCL10 Secretion	14
Ultrasound-Induced Release of Nimodipine from Drug-Loaded Block Copolymer Micelles: In Vivo Analysis	14
Cilostazol Alleviates Delayed Cerebral Ischemia After Subarachnoid Hemorrhage by Attenuating Microcirculatory Dysfunction	14
Cerebral Microvascular Injury in Patients with Left Ventricular Assist Device: a Neuropathological Study	14
Collaterals and Elusive Ischemic Penumbra	14
Correction to: Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage	14
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis	14
What to Measure in Aneurysmal Subarachnoid Haemorrhage Research—An International Delphi Survey	14
Motor Rehabilitation Provides Modest Functional Benefits After Intracerebral Hemorrhage: a Systematic Review and Meta-Analysis of Translational Rehabilitation Studies	14
Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke	13
Integrated Strategies for Targeting Arteriogenesis and Angiogenesis After Stroke	13
Jugular Vein Evans Blue Injection for Blood–Brain Barrier Assessment Following Hemorrhagic Stroke in a Mouse Model	13
Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke	13
SLC45A3 Serves as a Potential Therapeutic Biomarker to Attenuate White Matter Injury After Intracerebral Hemorrhage	13
Promising Cerebral Blood Flow Enhancers in Acute Ischemic Stroke	13
Collateral Status and Outcomes after Thrombectomy	13
Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage	13
Aspirin and Subarachnoid Haemorrhage in the UK Biobank	13
Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic	13
Comprehensive Profiling of Secreted Factors in the Cerebrospinal Fluid of Moyamoya Disease Patients	13
Dynamic Measurements of Cerebral Blood Flow Responses to Cortical Spreading Depolarization in the Murine Endovascular Perforation Subarachnoid Hemorrhage Model	12
Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease	12

Dysregulated Genes and Signaling Pathways in the Formation and Rupture of Intracranial Aneurysm	12
Cerebral Small Vessel Disease and Infarct Growth in Acute Ischemic Stroke Treated with Intravenous Thrombolysis	12
Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke	12
Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching	12
Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke	12
Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke	12
Reinventing the Penumbra — the Emerging Clockwork of a Multi-modal Mechanistic Paradigm	11
Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke	11
Collateral Blood Flow and Ischemic Core Growth	11
Hyperthermia and Early Growth of Cerebral Infarct: The Potential Role of Blood–Brain Barrier Permeability	11
Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke	11
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke	11
Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke	11
Endovascular Thrombectomy for Acute Basilar Artery Occlusion: Latest Findings and Critical Thinking on Future Study Design	11
The Fate of Erythrocytes after Cerebral Hemorrhage	11
TdCCA with Dual-Modal Signal Fusion: Degenerated Occipital and Frontal Connectivity of Adult Moyamoya Disease for Early Identification	11
Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization	11
Correction to: Endogenous Neural Stem Cell–induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives	11
Neural Stem Cell Extracellular Vesicles Carrying YBX1 Inhibited Neuronal Pyroptosis Through Increasing m6A-modified GPR30 Stability and Expression in Ischemic Stroke	11
Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques	11
Catecholamine-Induced Inflammasome Activation in the Heart Following Photothrombotic Stroke	10
Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage	10
New Drug Developments for Stroke: from Basics to Clinics	10
Blockade of the Platelet-Driven CXCL7-CXCR1/2 Inflammatory Axis Prevents Murine Cerebral Aneurysm Formation and Rupture	10
Microstructural Gray Matter Integrity Deteriorates After an Ischemic Stroke and Is Associated with Processing Speed	10
High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents	10
An Ambiguous Role for Fever in Worsening Outcome After Intracerebral Hemorrhage	10
Correction to: The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium	10
Inverse Association between the Body Mass Index and the Incidence of Unruptured Intracranial Aneurysms—Insights from the Hamburg City Health Population Study	10
Correction to: Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondri	10
The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium	10
Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations	10
Relation of Carotid Plaque Features Detected with Ultrasonography-Based Radiomics to Clinical Symptoms	9
Prognostic Value of Venous Outflow Profiles on Multiphase CT Angiography for the Patients with Acute Ischemic Stroke After Endovascular Thrombectomy	9
New Wine in an Old Bottle: tPA for Ischemic Stroke Management	9
Tissue Outcome Prediction in Patients with Proximal Vessel Occlusion and Mechanical Thrombectomy Using Logistic Models	9
U-net Models Based on Computed Tomography Perfusion Predict Tissue Outcome in Patients with Different Reperfusion Patterns	9
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep	9
Simultaneous Four Supratentorial Lesions Predict Tube Dependency Due to an Impaired Anticipatory Phase of Ingestion	9