OOIR: Observatory of International Research

Papers

(The TQCC of Translational Stroke Research is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Crosstalk Between Signaling Stroke Cascade and Therapeutic Receptors PPAR-γ, ROCK, CB1R, and CB2R: From Mechanism to Therapies	60
Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review	60
Unpacking the Role of Extracellular Vesicles in Ischemic and Hemorrhagic Stroke: Pathophysiology and Therapeutic Implications	52
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke	46
Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting	45
Blood Oxygenation Level–Dependent Cerebrovascular Reactivity–Derived Steal Phenomenon May Indicate Tissue Reperfusion Failure After Successful Endovascular Thrombectomy	40
Reporting Compliance and Factors Influencing Timeliness of Stroke-Related Trial Results on ClinicalTrials.gov	37
Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke	36
Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease	35
Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease	33
Anti-Apoptotic Effects of AMPA Receptor Antagonist Perampanel in Early Brain Injury After Subarachnoid Hemorrhage in Mice	32
Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage	30
Comparison of Long-Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management	29
Remote Ischemic Post-conditioning Reduces Cognitive Impairment in Rats Following Subarachnoid Hemorrhage: Possible Involvement in STAT3/STAT5 Phosphorylation and Th17/Treg Cell Homeostasis	28
Decompressive Craniectomy Decreases Neuroinflammation after Ischemic Stroke in Mice	27
Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms	27
Prevalence and Predictors of Hemorrhagic Foci on Long-term Follow-up MRI of Recent Single Subcortical Infarcts	25
All Three Supersystems—Nervous, Vascular, and Immune—Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage	25
Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH	25
Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8	25
Associations Between Early Functional Brain Network Topology and 6-Month Upper Limb Motor Outcomes in Stroke Patients	24
Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors	24
Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model	24
Distinct Cytokine Responses in Central and Systemic Compartments after Subarachnoid Haemorrhage	23
Collateral-Core Ratio as a Novel Predictor of Clinical Outcomes in Acute Ischemic Stroke	23

A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings	22
Nomogram for Predicting Long-term Outcomes of Encephaloduroarteriosynangiosis in Toddlers with Moyamoya Disease: a Longitudinal and Cross-sectional Study	21
RNF213 p.Arg4810Lys Wild Type is Associated with De Novo Hemorrhage in Asymptomatic Hemispheres with Moyamoya Disease	20
Correction to: The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism	20
Internal Capsule Involvement Explains the Prognostic Impact of ASPECTS after Endovascular Thrombectomy for Large-Core Infarction	20
Quantitative Evaluation of Incomplete Stent Apposition in Intracranial Aneurysms Using Optical Coherence Tomography: a Porcine Model Study	20
Stroke Mechanisms in Intracranial Atherosclerotic Disease: A Modified Classification System and Clinical Implications	20
Intracerebral Administration of a Novel Self-Assembling Peptide Hydrogel Is Safe and Supports Cell Proliferation in Experimental Intracerebral Haemorrhage	20
Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study	20
Switching Off Vascular MAPK Signaling: A Novel Strategy to Prevent Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage	19
Opportunities for Neuroprotective Drugs in the Era of Vascular Recanalization	19
Methylated MFGE8 Promotes Early Brain Injury After Subarachnoid Hemorrhage and Inhibiting Autophagy of Nerve Cell	19
Comparative Outcomes of Combined Balloon Angioplasty and Intra-arterial Calcium Channel Blockers Versus Monotherapy for Cerebral Vasospasm Management: A Systematic Review and Meta-analysis	19
Correction to: The Mfn1‑βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage	18
Correction to: An Alternative Photothrombotic Model of Transient Ischemic Attack	18
Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke	17
Cost-Effectiveness of Carotid Endarterectomy vs. Carotid Stenting: a Systematic Review and Meta-Analysis	17
Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage	17
Vascular Endothelial Growth Factor-A and Collateral Circulation in Patients with Acute Ischemic Stroke due to Intracranial Large Vessel Occlusion	16
Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways	16
Prevention of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage—Summary of Existing Clinical Evidence	16
Use of Tirofiban to Prevent Ischemic Events in Patients with CYP2C19 Loss-of-Function Alleles during Flow Diversion of Intracranial Aneurysm: A Multicenter Cohort Study	16
A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score	16
Correction to: Iron‑Induced Hydrocephalus: The Role of Choroid Plexus Stromal Macrophages	15
Jugular Vein Evans Blue Injection for Blood–Brain Barrier Assessment Following Hemorrhagic Stroke in a Mouse Model	15
Minimally Invasive Intracerebral Hemorrhage Evacuation Improves Pericavity Cerebral Blood Volume	15
Revisiting Transcranial Light Stimulation as a Stroke Therapeutic—Hurdles and Opportunities	15
What to Measure in Aneurysmal Subarachnoid Haemorrhage Research—An International Delphi Survey	15
Integrating Bulk RNA and Single-Cell Sequencing Data Unveils Efferocytosis Patterns and ceRNA Network in Ischemic Stroke	15
Association of Genetic Variants with Postoperative Donor Artery Development in Moyamoya Disease: RNF213 and Other Moyamoya Angiopathy-Related Gene Analysis	15
Motor Rehabilitation Provides Modest Functional Benefits After Intracerebral Hemorrhage: a Systematic Review and Meta-Analysis of Translational Rehabilitation Studies	15
Correction to: Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage	14
Integrated Strategies for Targeting Arteriogenesis and Angiogenesis After Stroke	14
Promising Cerebral Blood Flow Enhancers in Acute Ischemic Stroke	14
Modulation of the Immunological Milieu in Acute Aneurysmal Subarachnoid Hemorrhage: The Potential Role of Monocytes Through CXCL10 Secretion	14
The Hyperacute Phase of Cerebral Infarction in a Swine Model Investigated with Cone-Beam CT Perfusion Imaging	14
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis	13
Collaterals and Elusive Ischemic Penumbra	13
SLC45A3 Serves as a Potential Therapeutic Biomarker to Attenuate White Matter Injury After Intracerebral Hemorrhage	13
Advances in the Genetics and Molecular Biology of Brain Arteriovenous Malformations	13
Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic	13
Comprehensive Profiling of Secreted Factors in the Cerebrospinal Fluid of Moyamoya Disease Patients	13
Collateral Status and Outcomes after Thrombectomy	13
Cilostazol Alleviates Delayed Cerebral Ischemia After Subarachnoid Hemorrhage by Attenuating Microcirculatory Dysfunction	13
Aspirin and Subarachnoid Haemorrhage in the UK Biobank	13
Collateral Blood Flow and Ischemic Core Growth	12
Spatial and Temporal Assessment of Cerebral Blood Flow in a Novel Piglet Model of Neonatal Arterial Ischemic Stroke	12
Transcutaneous Auricular Vagus Nerve Stimulation Reduces Inflammatory Biomarkers after Large Vessel Occlusion Stroke: Results of a Prospective Randomized Open-Label Blinded Endpoint Trial	12
Dysregulated Genes and Signaling Pathways in the Formation and Rupture of Intracranial Aneurysm	12
Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke	12

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke	12
Cerebral Small Vessel Disease and Infarct Growth in Acute Ischemic Stroke Treated with Intravenous Thrombolysis	12
Dynamic Measurements of Cerebral Blood Flow Responses to Cortical Spreading Depolarization in the Murine Endovascular Perforation Subarachnoid Hemorrhage Model	11
Plasma Metabolites of Kynurenine Pathway and Risk of Stroke in the General Population: A Nested Case–control Study	11
Cerebral Small Vessel Disease and Blood-Brain Barrier Disruption: Mechanisms and Therapeutic Strategies in Cognitive Impairment	11
Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke	11
Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage	11
Neural Stem Cell Extracellular Vesicles Carrying YBX1 Inhibited Neuronal Pyroptosis Through Increasing m6A-modified GPR30 Stability and Expression in Ischemic Stroke	11
Non-Linear Temporal Dynamics of Endothelial Progenitor Cells After Stroke: Associations with Perfusion Imaging, ASPECTs and Functional Outcome	11
Accounting for Truncation Artifacts in Angiographic Perfusion	11
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke	11
TdCCA with Dual-Modal Signal Fusion: Degenerated Occipital and Frontal Connectivity of Adult Moyamoya Disease for Early Identification	10
Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke	10
Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke	10
Correction to: Endogenous Neural Stem Cell–induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives	10
Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke	10
Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization	10
Hyperthermia and Early Growth of Cerebral Infarct: The Potential Role of Blood–Brain Barrier Permeability	10
Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques	10
Predictive Utility of Cerebral Blood Flow Transients in Experimental Stroke	10
Reinventing the Penumbra — the Emerging Clockwork of a Multi-modal Mechanistic Paradigm	9
Catecholamine-Induced Inflammasome Activation in the Heart Following Photothrombotic Stroke	9
The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium	9
Simultaneous Four Supratentorial Lesions Predict Tube Dependency Due to an Impaired Anticipatory Phase of Ingestion	9
Long-Term Outcomes of Stereotactic Radiosurgery Focused Treatment of Brain Arteriovenous Malformations Based on Rupture Status: A Systematic Review and Meta-Analysis	9
Inverse Association between the Body Mass Index and the Incidence of Unruptured Intracranial Aneurysms—Insights from the Hamburg City Health Population Study	9
Correction to: Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondri	9
Blockade of the Platelet-Driven CXCL7-CXCR1/2 Inflammatory Axis Prevents Murine Cerebral Aneurysm Formation and Rupture	9
New Wine in an Old Bottle: tPA for Ischemic Stroke Management	9
Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations	9
Letter to the Editor	9
Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage	9
New Drug Developments for Stroke: from Basics to Clinics	9
Effect of INR on Outcomes of Endovascular Treatment for Acute Vertebrobasilar Artery Occlusion	9