(The TQCC of ChemMedChem is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics221
METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes91
Antitumour Anthracyclines: Progress and Perspectives89
Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections88
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**87
Porphyrin‐Based Metal−Organic Framework Compounds as Promising Nanomedicines in Photodynamic Therapy64
Cyclobutanes in Small‐Molecule Drug Candidates61
Recent Development of Pyrimidine‐Containing Antimicrobial Agents56
Pectin: A Long‐Neglected Broad‐Spectrum Antibacterial54
Strategies To Design Selective Histone Deacetylase Inhibitors53
The Critical Role of Passive Permeability in Designing Successful Drugs52
Recent Advances in the Prediction of Pharmacokinetics Properties in Drug Design Studies: A Review46
Recent Advances in Radiometals for Combined Imaging and Therapy in Cancer44
2‐Isoxazolines: A Synthetic and Medicinal Overview43
Benzimidazoles in Drug Discovery: A Patent Review42
Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications40
Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature40
Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics39
Cyclic Dipeptide: A Privileged Molecular Scaffold to Derive Structural Diversity and Functional Utility37
A Patent Review on the Current Developments of Benzoxazoles in Drug Discovery37
When Virtual Screening Yields Inactive Drugs: Dealing with False Theoretical Friends35
E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity35
Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite34
Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure‐Activity Relationships33
MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**33
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐1933
1,2,4‐Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase32
Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐232
Do Drug‐likeness Rules Apply to Oral Prodrugs?31
O‐GlcNAcase: Emerging Mechanism, Substrate Recognition and Small‐Molecule Inhibitors30
Functional Nanomaterials in Biomedicine: Current Uses and Potential Applications30
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy30
New Antivirals and Antibacterials Based on Silver Nanoparticles30
Carbon Dots as Drug Delivery Vehicles for Antimicrobial Applications: A Minireview29
Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P‐Glycoprotein ABCB529
A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads29
Gold(I) and Gold(III) N‐Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase29
ACE2, the Receptor that Enables Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators28
Structure‐Based Macrocyclization of Substrate Analogue NS2B‐NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses28
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders28
Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents27
A CaO2@Tannic Acid‐FeIII Nanoconjugate for Enhanced Chemodynamic Tumor Therapy26
Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy26
Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro25
Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease25
An Organogold Compound as Potential Antimicrobial Agent against Drug‐Resistant Bacteria: Initial Mechanistic Insights25
Alternating Cationic‐Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity25
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs25
The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products25
Synthesis of Tamoxifen‐Artemisinin and Estrogen‐Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer25
Scanning Protein Surfaces with DNA‐Encoded Libraries25
Advances in Nucleoside and Nucleotide Analogues in Tackling Human Immunodeficiency Virus and Hepatitis Virus Infections25
Fluorinated Cycloalkyl Building Blocks for Drug Discovery24
Explicit Treatment of Non‐Michaelis‐Menten and Atypical Kinetics in Early Drug Discovery**24
Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View24
Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat Tuberculosis24
BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect24
Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy23
Recent Advances in the Discovery of Multitargeted Tyrosine Kinase Inhibitors as Anticancer Agents23
Platinum Cyclooctadiene Complexes with Activity against Gram‐positive Bacteria23
Prioritizing Small Sets of Molecules for Synthesis throughin‐silicoTools: A Comparison of Common Ranking Methods23
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14‐Residue‐Long de novo AMPs23
Peptide‐Mimicking Poly(2‐oxazoline)s Displaying Potent Antimicrobial Properties22
Acidity and Glutathione Dual‐Responsive Polydopamine‐Coated Organic‐Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery22
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors22
Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes22
Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy22
The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)22
A Patent Review on SARS Coronavirus Main Protease (3CLpro) Inhibitors21
Advancements in the Development of Non‐Nitrogen‐Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance21
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat21
Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives21
Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer21
Pt(IV) Anticancer Prodrugs – A Tale of Mice and Men20
Synthesis of Dihydrobenzofuro[3,2‐b]chromenes as Potential 3CLpro Inhibitors of SARS‐CoV‐2: A Molecular Docking and Molecular Dynamics Study20
Preparing (Metalla)carboranes for Nanomedicine20
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine‐2,5‐dione Hybrids as Potential Antitumor Agents20
Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids20
Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy20
Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models20
Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T1 MRI Contrast Agents19
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C19
Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells19
First‐Generation Bispidine Chelators for 213BiIII Radiopharmaceutical Applications19
LYTACs: An Emerging Tool for the Degradation of Non‐Cytosolic Proteins19
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity19
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design19
Recent Advances on Carbon Monoxide Releasing Molecules for Antibacterial Applications19
Evaluation of Water‐Soluble Mannich Base Prodrugs of 2,3,4,5‐Tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as Multitarget‐Directed Agents for Alzheimer's Disease19
Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface‐Active Ionic Liquids in Drug Development and Delivery19
Benzimidazole Derivatives as Novel Zika Virus Inhibitors19
A Library of Thiazolidin‐4‐one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt To Discover Novel Antidiabetic Agents18
Amino Acid Based Antimicrobial Agents – Synthesis and Properties18
Theranostics Through the Synergistic Cooperation of Heterometallic Complexes18
Spermine Derivatives of Indole‐3‐carboxylic Acid, Indole‐3‐acetic Acid and Indole‐3‐acrylic Acid as Gram‐Negative Antibiotic Adjuvants18
Synthesis and Biological Evaluation of CF3Se‐Substituted α‐Amino Acid Derivatives17
Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design17
Design, Synthesis, Structure‐Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl‐1,2,4‐Trioxanes as Potent Antiplasmodial as well as Anticancer Agents17
Stimuli‐Responsive DNA Origami Nanodevices and Their Biological Applications17
Iminodiacetic Acid as a Novel Metal‐Binding Pharmacophore for New Delhi Metallo‐β‐lactamase Inhibitor Development17
Towards the Prediction of Antimicrobial Efficacy for Hydrogen Bonded, Self‐Associating Amphiphiles17
Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment17
Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy17
Application of Deep Neural Network Models in Drug Discovery Programs16
Amino Acid and Peptide‐Based Antiviral Agents16
Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and Future Prospects16
Gold Drugs with {Au(PPh3)}+ Moiety: Advantages and Medicinal Applications16
A “Golden Age” for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system16
Bioengineering of Anti‐Inflammatory Natural Products16
Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans16
Movement of Mitochondria with Mutant DNA through Extracellular Vesicles Helps Cancer Cells Acquire Chemoresistance16
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer16
Desorption Electrospray Ionization Mass Spectrometry Assay for Label‐Free Characterization of SULT2B1b Enzyme Kinetics16
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism16
Identification of the FDA‐Approved Drug Pyrvinium as a Small‐Molecule Inhibitor of the PD‐1/PD‐L1 Interaction16
Aggregation‐Induced Emission Luminogens for Mitochondria‐Targeted Cancer Therapy16
Water‐Soluble Gold(III)–Metformin Complex Alters Mitochondrial Bioenergetics in Breast Cancer Cells15
Poly‐l‐lysine Glycoconjugates Inhibit DC‐SIGN‐mediated Attachment of Pandemic Viruses15
Metal‐Based Catalytic Drug Development for Next‐Generation Cancer Therapy15
Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self‐assembly Chemical Library15
Coumarin‐Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action15
The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition15
Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development15
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity15
Recent Development of Copper (II) Complexes of Polypyridyl Ligands in Chemotherapy and Photodynamic Therapy15
Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐b][1,3,4]thiadiazole Analogues15
4‐Fluorobenzylpiperazine‐Containing Derivatives as Efficient Inhibitors of Mushroom Tyrosinase15
New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐215
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent15
Mechanism toward Turn‐on of Polysaccharide‐Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells15
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders14
Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**14
Structure‐Activity Relationships of Butyrophilin 3 Ligands14
Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases14
Short Photoswitchable Antibacterial Peptides14
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes14
Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus14
The Quest for Orally Available Selective Estrogen Receptor Degraders (SERDs)14
γ‐Non‐Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV14
Stimulation of Ca2+‐ATPase Transport Activity by a Small‐Molecule Drug14
Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors13
Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses13
New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells13
Prediction of Chameleonic Efficiency13
Controlling PROTACs with Light13
Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents13
Aliphatic 18F‐Radiofluorination: Recent Advances in the Labeling of Base‐Sensitive Substrates**13
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease13
Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)13
Contribution of Knoevenagel Condensation Products toward the Development of Anticancer Agents: An Updated Review13
Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses13
Supramolecular Nanodrugs Based on Covalent Assembly of Therapeutic Peptides toward In Vitro Synergistic Anticancer Therapy12
Effective Oral Administration of an Antitumorigenic Nanoformulated Titanium Complex12
Carborane‐Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron‐Capture Therapy (BNCT)12
Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer12
Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods12
Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives12
Next‐Generation Kinase Inhibitors Targeting Specific Biomarkers in Non‐Small Cell Lung Cancer (NSCLC): A Recent Overview12
Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities12
Styryl Group, a Friend or Foe in Medicinal Chemistry12
Fragment‐Based Drug Discovery for RNA Targets12
Anticancer Activity of Mannich Bases: A Review of Recent Literature12
Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)12
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease12
Ligand Accessibility Insights to the Dengue Virus NS3‐NS2B Protease Assessed by Long‐Timescale Molecular Dynamics Simulations12
Anti‐Lung Cancer Activities of 1,2,3‐Triazole Curcumin Derivatives via Regulation of the MAPK/NF‐κB/STAT3 Signaling Pathways12
Metal‐Based Aggregation‐Induced Emission Theranostic Systems12
Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro12
A New Potent and Selective Monoamine Oxidase‐B Inhibitor with Extended Conjugation in a Chalcone Framework: 1‐[4‐(Morpholin‐4‐yl)phenyl]‐5‐phenylpenta‐2,4‐dien‐1‐one11
Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells11
Discovery and Characterization of Multiple Classes of Human CatSper Blockers11
Synthesis and Antimicrobial Evaluation of Bis‐morpholine Triazine Quaternary Ammonium Salts11
Expanding the Spectrum of Antibiotics Capable of Killing Multidrug‐Resistant Staphylococcus aureus and Pseudomonas aeruginosa11
Chemical and Structural Strategies to Selectively Target mTOR Kinase11
Dual Parasiticidal Activities of Phthalimides: Synthesis and Biological Profile against Trypanosoma cruzi and Plasmodium falciparum11
Experimental Methods for Evaluating the Bacterial Uptake of Trojan Horse Antibacterials11
Science's Response to CoVID‐1911
Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents11
A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia11
Turning Donepezil into a Multi‐Target‐Directed Ligand through a Merging Strategy11
Modelling and Phenotypic Screening of NAP‐6 and 10‐Cl‐BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro11
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes11
7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation11
New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures11
Inspecting the Mechanism of Fragment Hits Binding on SARS‐CoV‐2 Mpro by Using Supervised Molecular Dynamics (SuMD) Simulations11
Allosteric Molecular Switches in Metabotropic Glutamate Receptors11
Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin11
Hybrid Quinazoline 1,3,5‐Triazines as Epidermal Growth Factor Receptor (EGFR) Inhibitors with Anticancer Activity: Design, Synthesis, and Computational Study11
Design of Trehalose‐Based Amide/Sulfonamide C‐type Lectin Receptor Signaling Compounds11
Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase11
The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues11
The Structures of Gd(III) Chelates Conjugated at the Periphery of 3‐(1’‐Hexyloxy)ethyl‐3‐devinylpyropheophorbide‐a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer11
Clickable Selenylation – a Paradigm for Seleno‐Medicinal Chemistry11
Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors11
PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue10
Natural and Semisynthetic Pentacyclic Triterpenes for Chronic Myeloid Leukemia Therapy: Reality, Challenges and Perspectives10
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L110
A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potentin vitroandex vivoAnticancer Activity10
Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor10
Organofluorine Hydrazone Derivatives as Multifunctional Anti‐Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features10
β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD310
Small‐Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview10
Anticancer Activity and Mechanism of Action Evaluation of an Acylhydrazone Cu(II) Complex toward Breast Cancer Cells, Spheroids, and Mammospheres10
A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer10
A Computer‐Driven Scaffold‐Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2‐a]quinoxaline Core10
Targeting the Water Network in Cyclin G‐Associated Kinase (GAK) with 4‐Anilino‐quin(az)oline Inhibitors10
Bicyclic Imidazolium Inhibitors of Gli Transcription Factor Activity10
Synthesis and Biological Evaluation of 10‐Substituted Camptothecin Derivatives with Improved Water Solubility and Activity10
Enhancement of CD8+ T‐Cell‐Mediated Tumor Immunotherapy via Magnetic Hyperthermia10
Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease10
Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid10
Stability and Cell Permeability of Sulfonyl Fluorides in the Design of Lys‐Covalent Antagonists of Protein‐Protein Interactions10
6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy10
Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines10
Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis10
Development of Novel Benzodiazepine‐Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense10
Virus‐Based Nanoreactors with GALT Activity for Classic Galactosemia Therapy10
Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors10
Strategies towards Targeting Gαi/s Proteins: Scanning of Protein‐Protein Interaction Sites To Overcome Inaccessibility10
A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx10
Aromatic Linkers Unleash the Antiproliferative Potential of 3‐Chloropiperidines Against Pancreatic Cancer Cells10
Physicochemical Properties of Zwitterionic Drugs in Therapy10
Pentafluoro‐3‐hydroxy‐pent‐2‐en‐1‐ones Potently Inhibit FNT‐Type Lactate Transporters from all Five Human‐Pathogenic Plasmodium Species10
Into the Fray! A Beginner's Guide to Medicinal Chemistry10
Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids10
Preclinical Anticancer Activity of an Electron‐Deficient Organoruthenium(II) Complex10
Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light‐Mediated Antibacterial Activity10
Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides10
Design, Synthesis, and Structure‐Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase10
Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex10
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects10
Increased in vitro Anti‐HIV Activity of Caffeinium‐Functionalized Polyoxometalates9
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema9
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes9
Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility9
Tricepyridinium‐inspired QACs yield potent antimicrobials and provide insight into QAC resistance9
1,2,4‐Triazole‐3‐Thione Analogues with a 2‐Ethylbenzoic Acid at Position 4 as VIM‐type Metallo‐β‐Lactamase Inhibitors9
Computing Metal‐Binding Proteins for Therapeutic Benefit9
Sulfonylguanidine Derivatives as Potential Antimelanoma Agents9
A Series of 2‐((1‐Phenyl‐1H‐imidazol‐5‐yl)methyl)‐1H‐indoles as Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitors9
The Stone Guest: How Does pH Affect Binding Properties of PD‐1/PD‐L1 Inhibitors?9
Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo‐β‐Lactamase NDM‐19
Cell‐Penetrating Peptide‐Conjugated BF2‐Oxasmaragdyrins as NIRF Imaging and Photothermal Agents9
Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding9
A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF48779
Using NMR Spectroscopy in the Fragment‐Based Drug Discovery of Small‐Molecule Anticancer Targeted Therapies9
Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors9
Recent Developments on the Synthesis and Biological Activities of Fused Pyrimidinone Derivatives9
Discovery of Isatin‐Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase9
Activating Effect of 3‐Benzylidene Oxindoles on AMPK: From Computer Simulation to High‐Content Screening9