OOIR: Observatory of International Research

Papers

(The TQCC of Theranostics is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)

Article	Citations
Engineering exosomes for targeted drug delivery	408
Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics	386
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy	382
Silver nanoparticles: Synthesis, medical applications and biosafety	381
Circular RNA-protein interactions: functions, mechanisms, and identification	337
Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics	276
Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy	275
Immunopathogenesis and treatment of cytokine storm in COVID-19	262
Turning cold tumors into hot tumors by improving T-cell infiltration	221
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	216
Carbon Dots as Potent Antimicrobial Agents	209
The double-edged roles of ROS in cancer prevention and therapy	186
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs	186
Type H blood vessels in bone modeling and remodeling	174
Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics	170
Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation	168
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer	163
Ferroptosis as a novel therapeutic target for cardiovascular disease	162
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target	162
Nanocarrier-based drug combination therapy for glioblastoma	161
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing	151
CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients	148
ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury	142
Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis	140
SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy	140

Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications	139
Stem cell programs in cancer initiation, progression, and therapy resistance	136
Selective autophagy of intracellular organelles: Recent research advances	133
Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications	132
Ultrasmall gold nanoparticles in cancer diagnosis and therapy	128
Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives	127
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells	127
m⁶A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer	121
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis	114
Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair	114
Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner	114
Recent progress in nanomedicine for enhanced cancer chemotherapy	113
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors	113
Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis	111
Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment	111
Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities	111
Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy	110
A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy	109
Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis	108
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications	107
¹⁸F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging	106
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control	105
Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications	105
Autophagy Modulated by Inorganic Nanomaterials	104
COVID-19: Progress in diagnostics, therapy and vaccination	102
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment	100
Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway	99
Platinum-based drugs for cancer therapy and anti-tumor strategies	98
Red blood cell membrane-enveloped O₂ self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy	98
Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rat	97
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway	97
Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy	96
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients	95
Mesenchymal stem cell-loaded thermosensitive hydroxypropyl chitin hydrogel combined with a three-dimensional-printed poly(ε-caprolactone) /nano-hydroxyapatite scaffold to repair bone defects via osteo	94
Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study	93
Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium	91
Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications	89
Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway	89
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages	89
Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2	89
Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria	88
The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer	87
Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts	87
Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration	86
Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy	86
TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity	85
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation	85
Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer	85
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury	85
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression	85

Recent advances in innovative strategies for enhanced cancer photodynamic therapy	84
Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer	84
Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma	83
Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus	83
Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-2	83
RNA Nanotechnology-Mediated Cancer Immunotherapy	83
A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing	80
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy	79
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment	79
Radiomics Analysis of Computed Tomography helps predict poor prognostic outcome in COVID-19	78
Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion	78
Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy	78
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects	78
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression	77
Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors	77
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR	76
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells	76
Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1	76
EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: From animal to human with theranostic AGuIX nanoparticles	75
Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells	75
A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance	74
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia	74
Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics	74
USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer	73
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia	73
Monoclonal antibody-based molecular imaging strategies and theranostic opportunities	73
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes	72
Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis	72
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming	71
IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE₂-mediated M2 macrophage polarization	70
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota	70
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy	70
Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications	70
Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis	69
Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice	69
RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA	69
Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury	68
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization	68
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models	68
An immune cell infiltration-based immune score model predicts prognosis and chemotherapy effects in breast cancer	68
An ultrasensitive hybridization chain reaction-amplified CRISPR-Cas12a aptasensor for extracellular vesicle surface protein quantification	68
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions	67
Ferritins as natural and artificial nanozymes for theranostics	67
In vivo photoacoustic imaging dynamically monitors the structural and functional changes of ischemic stroke at a very early stage	67
HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling	67
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2	67
Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view	66
Efficacy and safety of ²²⁵Ac-PSMA-617 targeted alpha therapy in metastatic castration-resistant Prostate Cancer patients	66
Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy	66
3D approaches to model the tumor microenvironment of pancreatic cancer	66
Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis	66
FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism	65
Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice	65
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1	65
Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients	65
Ellagic acid-Fe@BSA nanoparticles for endogenous H₂S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy	64
Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine	64
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer	64
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice	64
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I	64
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17	63
Towards extracellular matrix normalization for improved treatment of solid tumors	62
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28	62
Glioma stem cells and their roles within the hypoxic tumor microenvironment	62
Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis	62
Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity	61
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer	61
The 2020 race towards SARS-CoV-2 specific vaccines	61
Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation	61
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo phot	61
Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease	61
NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates	61
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma	61
Analysis of PSMA expression and outcome in patients with advanced Prostate Cancer receiving ¹⁷⁷Lu-PSMA-617 Radioligand Therapy	61
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B	61
LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network	61
Deep tissue photoacoustic imaging of nickel(II) dithiolene-containing polymeric nanoparticles in the second near-infrared window	60
Targeting REV-ERBα for therapeutic purposes: promises and challenges	60
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway	60
Tumor microenvironment-responsive multifunctional peptide coated ultrasmall gold nanoparticles and their application in cancer radiotherapy	60

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer	59
Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion	59
Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases	59
On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer	59
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma	58
Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation	58
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies	58
Ceria-based nanotheranostic agent for rheumatoid arthritis	58
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation	58
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections	58
Liquid biopsy for infectious diseases: a focus on microbial cell-free DNA sequencing	57
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction	57
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle	57
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation	57
Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease	57
Role of prostaglandin E2 in tissue repair and regeneration	57
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma	57
Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism	57
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer	56
Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy	56
circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma	56
Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications	56
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model	56
Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis	56
ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma	56
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles	55
Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis	55
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus	55
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer	55
Ultrasmall CuS@BSA nanoparticles with mild photothermal conversion synergistically induce MSCs-differentiated fibroblast and improve skin regeneration	55
Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy	55
Nanoparticle-based Cell Trackers for Biomedical Applications	54
Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer	54
Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer	54
Biomechanically, structurally and functionally meticulously tailored polycaprolactone/silk fibroin scaffold for meniscus regeneration	53
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells	53
Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect	53
Molecular imaging biomarkers for immune checkpoint inhibitor therapy	53
Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells	53
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies	53
The biological implications of Yin Yang 1 in the hallmarks of cancer	53
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma	52
Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy	52
Tumor Microenvironment-triggered Nanosystems as dual-relief Tumor Hypoxia Immunomodulators for enhanced Phototherapy	52
Light-activated gold nanorod vesicles with NIR-II fluorescence and photoacoustic imaging performances for cancer theranostics	52
CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2	52
A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects	52
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma	52
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria	52
Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation	52
Endothelial cell infection and dysfunction, immune activation in severe COVID-19	51
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images	51
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting	51
Association of clinical and radiographic findings with the outcomes of 93 patients with COVID-19 in Wuhan, China	51
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy	51
A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity	51
Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials	51
Exosome-inflammasome crosstalk and their roles in inflammatory responses	51
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride	51
Magnetic targeted near-infrared II PA/MR imaging guided photothermal therapy to trigger cancer immunotherapy	51
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer	51
Targeting phosphatidylserine for Cancer therapy: prospects and challenges	51
Mussel-inspired conductive Ti₂C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction	50
Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology	50
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress	50
Exquisite design of injectable Hydrogels in Cartilage Repair	50
Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis	50
A sericin/ graphene oxide composite scaffold as a biomimetic extracellular matrix for structural and functional repair of calvarial bone	50
Phototherapy-based combination strategies for bacterial infection treatment	50
The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction	50
Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment	50
SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway	50
Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy	49
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway	49
Targeting iron metabolism in cancer therapy	49
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis	49
Dissolving Microneedles with Spatiotemporally controlled pulsatile release Nanosystem for Synergistic Chemo-photothermal Therapy of Melanoma	49
Versatile Nanoplatforms with enhanced Photodynamic Therapy: Designs and Applications	49
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts	49
The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination	48
Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer	48
Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis	48
Palladium-based nanomaterials for cancer imaging and therapy	48
Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells/tissues	48
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription	48
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma	48
Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration	48
Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications	47
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy	47
Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing	47
Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis	47
LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1	47
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity	47
NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review	47
TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury	47
Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens	47
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys	47
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges	47
The crosstalk between m⁶A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling	46
Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion	46
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer	46
The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies	46
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics	46
ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy	45
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction	45
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits	45
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner	45
Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma	45
P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer	45
Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format	45
Recent advances in supramolecular antidotes	45
M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation	45
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients	45
Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of Human Colorectal Cancer	44
Fully end-to-end deep-learning-based diagnosis of pancreatic tumors	44
Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin	44
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer	44
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications	44
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats	44
Re-recognition of pseudogenes: From molecular to clinical applications	44
m⁶A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer	44
Candida albicans disorder is associated with gastric carcinogenesis	44
Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer	43
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m⁶A signaling	43
Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE^-/- mice	43
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment	43
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation	43
Metal-phenolic networks: facile assembled complexes for cancer theranostics	43
Bacterial extracellular vesicle-coated multi-antigenic nanovaccines protect against drug-resistant Staphylococcus aureus infection by modulating antigen processing and presentation pathways	43
Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3	43
Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity	43
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel	43
Novel insights into ferroptosis: Implications for age-related diseases	43
3D bioprinting in cardiac tissue engineering	43
TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo	43
Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells	43
Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis	43
Virus-induced p38 MAPK activation facilitates viral infection	42
Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs	42
The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy	42
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model	42
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system	42
MRI-traceable theranostic nanoparticles for targeted cancer treatment	42
pH-responsive perylenediimide nanoparticles for cancer trimodality imaging and photothermal therapy	42
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells	42

Inhibitory effect of PPARγ on NLRP3 inflammasome activation	42
Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair	42
Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy	42
⁶⁸Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study	41
BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway	41
Probing and Enhancing Ligand-Mediated Active Targeting of Tumors Using Sub-5 nm Ultrafine Iron Oxide Nanoparticles	41
Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with ⁶⁸Ga-PSMA-11-PET	41
Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2	41
Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2	41
NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer	41
Catalytic patch with redox Cr/CeO₂ nanozyme of noninvasive intervention for brain trauma	41
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets	41
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis	41
Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p	41
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel	41
Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice	41
Cancer photo-immunotherapy: from bench to bedside	41
Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions	41
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis	41
circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis	41
Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability	40
Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity	40
Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression	40
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation	40
Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy	40
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives	40
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death	40
Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy	40
Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10	40
SERS Tags for Biomedical Detection and Bioimaging	40
DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis	39
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression	39
The emerging role of super enhancer-derived noncoding RNAs in human cancer	39
Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment	39
Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay	39
Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study	39
Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease	39
Size profile of cell-free DNA: A beacon guiding the practice and innovation of clinical testing	39
YTHDF1-enhanced iron metabolism depends on TFRC m⁶A methylation	39
Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth	39
Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo ¹⁸F-FDG-PET	39
Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives	39
Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors	39
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis	39
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy	38
Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes	38
Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis	38
Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis	38
Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellu	38
Aptamer-guided extracellular vesicle theranostics in oncology	38
SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression	38
Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy	38
Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer	38
MLKL: Functions beyond serving as the Executioner of Necroptosis	38
Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity	38
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling	38
PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation	38
ASIC1a induces synovial inflammation via the Ca²⁺/NFATc3/ RANTES pathway	37
Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway	37
Exosome-like vesicles derived from Hertwig's epithelial root sheath cells promote the regeneration of dentin-pulp tissue	37
Mcl-1 inhibition overcomes intrinsic and acquired Regorafenib resistance in Colorectal Cancer	37
Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy	37
Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer	37
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM	37
Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy	37
The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies”	36
Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis	36
Single-cell analysis reveals immune landscape in kidneys of patients with chronic transplant rejection	36
Targeted delivery of extracellular vesicles in heart injury	36
Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension	36
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review	36
Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer	36
Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis	36
A pH-responsive Pickering Nanoemulsion for specified spatial delivery of Immune Checkpoint Inhibitor and Chemotherapy agent to Tumors	36
Urine biopsy technologies: Cancer and beyond	36
NLRP3 inflammasome via IL-1β regulates PCSK9 secretion	36
Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy	36
Nanocarrier-mediated antioxidant delivery for liver diseases	36
Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling	36
pH responsive superporogen combined with PDT based on poly Ce6 ionic liquid grafted on SiO₂ for combating MRSA biofilm infection	36
miR-17-5p and miR-20a-5p suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-κB positive feedback loop	36
BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFR^T790M mutation	36
A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse	36
LDH-stabilized ultrasmall iron oxide nanoparticles as a platform for hyaluronidase-promoted MR imaging and chemotherapy of tumors	36
LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription	36
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension	36
CDK12 and PAK2 as novel therapeutic targets for human gastric cancer	36
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects	36
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity	35
3D printed in vitro tumor tissue model of colorectal cancer	35
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress	35
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization	35
Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21	35
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein	35
Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy	35
Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer	35
Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis	35
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development	35
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma	35
Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms	35
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3	35
Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response	35
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment	35
S-nitrosothiols loaded mini-sized Au@silica nanorod elicits collagen depletion and mitochondrial damage in solid tumor treatment	35
TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG	35
Bacteria responsive polyoxometalates nanocluster strategy to regulate biofilm microenvironments for enhanced synergetic antibiofilm activity and wound healing	35
NAD⁺-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin	35
In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging	35
Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death	34
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages	34
MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma	34
Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis	34
Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry	34
Improving nanotherapy delivery and action through image-guided systems pharmacology	34
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis	34
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study	34
Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles	34
Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues	34
Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia	34
Muscone/RI7217 co-modified upward messenger DTX liposomes enhanced permeability of blood-brain barrier and targeting glioma	34
Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies	34
A biocompatible vascularized graphene oxide (GO)-collagen chamber with osteoinductive and anti-fibrosis effects promotes bone regeneration in vivo	33
Self-eating: friend or foe? The emerging role of autophagy in fibrotic diseases	33
Specific ablation of CD4⁺ T-cells promotes heart regeneration in juvenile mice	33
Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy	33
Myocardial injury and COVID-19: Serum hs-cTnI level in risk stratification and the prediction of 30-day fatality in COVID-19 patients with no prior cardiovascular disease	33
An intestinal model with a finger-like villus structure fabricated using a bioprinting process and collagen/SIS-based cell-laden bioink	33
Theta-burst transcranial magnetic stimulation promotes stroke recovery by vascular protection and neovascularization	33
Extrahepatic cholangiography in near-infrared II window with the clinically approved fluorescence agent indocyanine green: a promising imaging technology for intraoperative diagnosis	33
Near-IR emissive rare-earth nanoparticles for guided surgery	33
Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles	33
Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice	33
Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition	33
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing	33
Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation	33
Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway	33
CXCR4 mediates matrix stiffness-induced downregulation of UBTD1 driving hepatocellular carcinoma progression via YAP signaling pathway	32
Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy	32
Quantitative chemical imaging of breast calcifications in association with neoplastic processes	32
Imaging of tumor colonization by Escherichia coli using ¹⁸F-FDS PET	32
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain	32
A S100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis	32
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy	32
Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis	32
High fat diet, gut microbiome and gastrointestinal cancer	32
Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies	32
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance	32
Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis	32
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis	32
Pyroptosis in inflammatory diseases and cancer	32
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices	32
IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer	32
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer	32
MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer	32
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells	31
Coordination-induced exfoliation to monolayer Bi-anchored MnB₂ nanosheets for multimodal imaging-guided photothermal therapy of cancer	31
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition	31
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin	31
Imaging-assisted anticancer nanotherapy	31
Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration	31
Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer	31
Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis	31
Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer	31
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss	31
PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood	31
Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics	31
Hemoglobin-mediated biomimetic synthesis of paramagnetic O₂-evolving theranostic nanoprobes for MR imaging-guided enhanced photodynamic therapy of tumor	31
Refining Cancer Management Using Integrated Liquid Biopsy	31
Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer	31
EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells	30
miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism	30
Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies	30
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus	30
Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses	30
Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics	30
Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures	30
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1	30
STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma	30
A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer	30
Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging	30
Circulating tumor cells in hepatocellular carcinoma: single-cell based analysis, preclinical models, and clinical applications	30
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer	30
Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells	30
N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming	30
Nanomedicine therapies modulating Macrophage Dysfunction: a potential strategy to attenuate Cytokine Storms in severe infections	30
Dysregulations of Functional RNA Modifications in Cancer, Cancer Stemness and Cancer Therapeutics	30
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma	30
Tumor-neuroglia interaction promotes pancreatic cancer metastasis	30
SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer	30
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients	30
Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p	30
KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling	30
Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2	29
Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria	29
Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus	29
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress	29
Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways	29
Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression	29
Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications	29
NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression	29