(The TQCC of Theranostics is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
Engineering exosomes for targeted drug delivery408
Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics386
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy382
Silver nanoparticles: Synthesis, medical applications and biosafety381
Circular RNA-protein interactions: functions, mechanisms, and identification337
Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics276
Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy275
Immunopathogenesis and treatment of cytokine storm in COVID-19262
Turning cold tumors into hot tumors by improving T-cell infiltration221
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance216
Carbon Dots as Potent Antimicrobial Agents209
The double-edged roles of ROS in cancer prevention and therapy186
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs186
Type H blood vessels in bone modeling and remodeling174
Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics170
Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation168
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer163
Ferroptosis as a novel therapeutic target for cardiovascular disease162
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target162
Nanocarrier-based drug combination therapy for glioblastoma161
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing151
CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients148
ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury142
Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis140
SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy140
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications139
Stem cell programs in cancer initiation, progression, and therapy resistance136
Selective autophagy of intracellular organelles: Recent research advances133
Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications132
Ultrasmall gold nanoparticles in cancer diagnosis and therapy128
Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives127
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells127
m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer121
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis114
Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair114
Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner114
Recent progress in nanomedicine for enhanced cancer chemotherapy113
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors113
Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis111
Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment111
Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities111
Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy110
A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy109
Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis108
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications107
18F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging106
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control105
Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications105
Autophagy Modulated by Inorganic Nanomaterials104
COVID-19: Progress in diagnostics, therapy and vaccination102
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment100
Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway99
Platinum-based drugs for cancer therapy and anti-tumor strategies98
Red blood cell membrane-enveloped O2 self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy98
Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rat97
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway97
Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy96
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients95
Mesenchymal stem cell-loaded thermosensitive hydroxypropyl chitin hydrogel combined with a three-dimensional-printed poly(ε-caprolactone) /nano-hydroxyapatite scaffold to repair bone defects via osteo94
Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study93
Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium91
Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications89
Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway89
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages89
Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB289
Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria88
The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer87
Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts87
Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration86
Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy86
TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity85
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation85
Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer85
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury85
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression85
Recent advances in innovative strategies for enhanced cancer photodynamic therapy84
Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer84
Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma83
Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus83
Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-283
RNA Nanotechnology-Mediated Cancer Immunotherapy83
A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing80
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy79
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment79
Radiomics Analysis of Computed Tomography helps predict poor prognostic outcome in COVID-1978
Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion78
Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy78
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects78
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression77
Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors77
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR76
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells76
Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK176
EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: From animal to human with theranostic AGuIX nanoparticles75
Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells75
A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance74
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia74
Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics74
USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer73
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia73
Monoclonal antibody-based molecular imaging strategies and theranostic opportunities73
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes72
Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis72
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming71
IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization70
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota70
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy70
Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications70
Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis69
Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice69
RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA69
Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury68
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization68
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models68
An immune cell infiltration-based immune score model predicts prognosis and chemotherapy effects in breast cancer68
An ultrasensitive hybridization chain reaction-amplified CRISPR-Cas12a aptasensor for extracellular vesicle surface protein quantification68
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions67
Ferritins as natural and artificial nanozymes for theranostics67
In vivo photoacoustic imaging dynamically monitors the structural and functional changes of ischemic stroke at a very early stage67
HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling67
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM267
Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view66
Efficacy and safety of 225Ac-PSMA-617 targeted alpha therapy in metastatic castration-resistant Prostate Cancer patients66
Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy66
3D approaches to model the tumor microenvironment of pancreatic cancer66
Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis66
FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism65
Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice65
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF165
Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients65
Ellagic acid-Fe@BSA nanoparticles for endogenous H2S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy64
Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine64
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer64
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice64
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I64
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL1763
Towards extracellular matrix normalization for improved treatment of solid tumors62
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP2862
Glioma stem cells and their roles within the hypoxic tumor microenvironment62
Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis62
Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity61
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer61
The 2020 race towards SARS-CoV-2 specific vaccines61
Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation61
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo phot61
Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease61
NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates61
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma61
Analysis of PSMA expression and outcome in patients with advanced Prostate Cancer receiving 177Lu-PSMA-617 Radioligand Therapy61
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B61
LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network61
Deep tissue photoacoustic imaging of nickel(II) dithiolene-containing polymeric nanoparticles in the second near-infrared window60
Targeting REV-ERBα for therapeutic purposes: promises and challenges60
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway60
Tumor microenvironment-responsive multifunctional peptide coated ultrasmall gold nanoparticles and their application in cancer radiotherapy60
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer59
Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion59
Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases59
On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer59
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma58
Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation58
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies58
Ceria-based nanotheranostic agent for rheumatoid arthritis58
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation58
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections58
Liquid biopsy for infectious diseases: a focus on microbial cell-free DNA sequencing57
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction57
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle57
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation57
Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease57
Role of prostaglandin E2 in tissue repair and regeneration57
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma57
Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism57
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer56
Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy56
circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma56
Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications56
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model56
Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis56
ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma56
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles55
Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis55
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus55
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer55
Ultrasmall CuS@BSA nanoparticles with mild photothermal conversion synergistically induce MSCs-differentiated fibroblast and improve skin regeneration55
Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy55
Nanoparticle-based Cell Trackers for Biomedical Applications54
Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer54
Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer54
Biomechanically, structurally and functionally meticulously tailored polycaprolactone/silk fibroin scaffold for meniscus regeneration53
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells53
Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect53
Molecular imaging biomarkers for immune checkpoint inhibitor therapy53
Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells53
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies53
The biological implications of Yin Yang 1 in the hallmarks of cancer53
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma52
Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy52
Tumor Microenvironment-triggered Nanosystems as dual-relief Tumor Hypoxia Immunomodulators for enhanced Phototherapy52
Light-activated gold nanorod vesicles with NIR-II fluorescence and photoacoustic imaging performances for cancer theranostics52
CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad252
A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects52
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma52
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria52
Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation52
Endothelial cell infection and dysfunction, immune activation in severe COVID-1951
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images51
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting51
Association of clinical and radiographic findings with the outcomes of 93 patients with COVID-19 in Wuhan, China51
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy51
A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity51
Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials51
Exosome-inflammasome crosstalk and their roles in inflammatory responses51
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride51
Magnetic targeted near-infrared II PA/MR imaging guided photothermal therapy to trigger cancer immunotherapy51
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer51
Targeting phosphatidylserine for Cancer therapy: prospects and challenges51
Mussel-inspired conductive Ti2C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction50
Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology50
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress50
Exquisite design of injectable Hydrogels in Cartilage Repair50
Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis50
A sericin/ graphene oxide composite scaffold as a biomimetic extracellular matrix for structural and functional repair of calvarial bone50
Phototherapy-based combination strategies for bacterial infection treatment50
The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction50
Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment50
SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway50
Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy49
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway49
Targeting iron metabolism in cancer therapy49
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis49
Dissolving Microneedles with Spatiotemporally controlled pulsatile release Nanosystem for Synergistic Chemo-photothermal Therapy of Melanoma49
Versatile Nanoplatforms with enhanced Photodynamic Therapy: Designs and Applications49
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts49
The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination48
Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer48
Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis48
Palladium-based nanomaterials for cancer imaging and therapy48
Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells/tissues48
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription48
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma48
Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration48
Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications47
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy47
Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing47
Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis47
LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F147
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity47
NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review47
TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury47
Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens47
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys47
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges47
The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling46
Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion46
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer46
The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies46
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics46
ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy45
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction45
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits45
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner45
Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma45
P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer45
Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format45
Recent advances in supramolecular antidotes45
M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation45
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients45
Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of Human Colorectal Cancer44
Fully end-to-end deep-learning-based diagnosis of pancreatic tumors44
Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin44
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer44
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications44
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats44
Re-recognition of pseudogenes: From molecular to clinical applications44
m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer44
Candida albicans disorder is associated with gastric carcinogenesis44
Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer43
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling43
Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice43
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment43
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation43
Metal-phenolic networks: facile assembled complexes for cancer theranostics43
Bacterial extracellular vesicle-coated multi-antigenic nanovaccines protect against drug-resistant Staphylococcus aureus infection by modulating antigen processing and presentation pathways43
Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A343
Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity43
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel43
Novel insights into ferroptosis: Implications for age-related diseases43
3D bioprinting in cardiac tissue engineering43
TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo43
Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells43
Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis43
Virus-induced p38 MAPK activation facilitates viral infection42
Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs42
The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy42
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model42
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system42
MRI-traceable theranostic nanoparticles for targeted cancer treatment42
pH-responsive perylenediimide nanoparticles for cancer trimodality imaging and photothermal therapy42
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells42
Inhibitory effect of PPARγ on NLRP3 inflammasome activation42
Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair42
Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy42
68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study41
BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway41
Probing and Enhancing Ligand-Mediated Active Targeting of Tumors Using Sub-5 nm Ultrafine Iron Oxide Nanoparticles41
Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with 68Ga-PSMA-11-PET41
Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK241
Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB241
NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer41
Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma41
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets41
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis41
Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p41
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel41
Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice41
Cancer photo-immunotherapy: from bench to bedside41
Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions41
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis41
circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis41
Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability40
Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity40
Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression40
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation40
Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy40
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives40
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death40
Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy40
Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD1040
SERS Tags for Biomedical Detection and Bioimaging40
DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis39
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression39
The emerging role of super enhancer-derived noncoding RNAs in human cancer39
Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment39
Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay39
Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study39
Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease39
Size profile of cell-free DNA: A beacon guiding the practice and innovation of clinical testing39
YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation39
Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth39
Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo 18F-FDG-PET39
Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives39
Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors39
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis39
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy38
Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes38
Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis38
Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis38
Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellu38
Aptamer-guided extracellular vesicle theranostics in oncology38
SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression38
Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy38
Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer38
MLKL: Functions beyond serving as the Executioner of Necroptosis38
Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity38
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling38
PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation38
ASIC1a induces synovial inflammation via the Ca2+/NFATc3/ RANTES pathway37
Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway37
Exosome-like vesicles derived from Hertwig's epithelial root sheath cells promote the regeneration of dentin-pulp tissue37
Mcl-1 inhibition overcomes intrinsic and acquired Regorafenib resistance in Colorectal Cancer37
Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy37
Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer37
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM37
Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy37
The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies”36
Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis36
Single-cell analysis reveals immune landscape in kidneys of patients with chronic transplant rejection36
Targeted delivery of extracellular vesicles in heart injury36
Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension36
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review36
Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer36
Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis36
A pH-responsive Pickering Nanoemulsion for specified spatial delivery of Immune Checkpoint Inhibitor and Chemotherapy agent to Tumors36
Urine biopsy technologies: Cancer and beyond36
NLRP3 inflammasome via IL-1β regulates PCSK9 secretion36
Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy36
Nanocarrier-mediated antioxidant delivery for liver diseases36
Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling36
pH responsive superporogen combined with PDT based on poly Ce6 ionic liquid grafted on SiO2 for combating MRSA biofilm infection36
miR-17-5p and miR-20a-5p suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-κB positive feedback loop36
BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFRT790M mutation36
A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse36
LDH-stabilized ultrasmall iron oxide nanoparticles as a platform for hyaluronidase-promoted MR imaging and chemotherapy of tumors36
LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription36
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension36
CDK12 and PAK2 as novel therapeutic targets for human gastric cancer36
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects36
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity35
3D printed in vitro tumor tissue model of colorectal cancer35
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress35
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization35
Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 2135
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein35
Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy35
Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer35
Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis35
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development35
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma35
Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms35
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN335
Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response35
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment35
S-nitrosothiols loaded mini-sized Au@silica nanorod elicits collagen depletion and mitochondrial damage in solid tumor treatment35
TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG35
Bacteria responsive polyoxometalates nanocluster strategy to regulate biofilm microenvironments for enhanced synergetic antibiofilm activity and wound healing35
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin35
In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging35
Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death34
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages34
MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma34
Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis34
Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry34
Improving nanotherapy delivery and action through image-guided systems pharmacology34
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis34
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study34
Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles34
Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues34
Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia34
Muscone/RI7217 co-modified upward messenger DTX liposomes enhanced permeability of blood-brain barrier and targeting glioma34
Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies34
A biocompatible vascularized graphene oxide (GO)-collagen chamber with osteoinductive and anti-fibrosis effects promotes bone regeneration in vivo33
Self-eating: friend or foe? The emerging role of autophagy in fibrotic diseases33
Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice33
Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy33
Myocardial injury and COVID-19: Serum hs-cTnI level in risk stratification and the prediction of 30-day fatality in COVID-19 patients with no prior cardiovascular disease33
An intestinal model with a finger-like villus structure fabricated using a bioprinting process and collagen/SIS-based cell-laden bioink33
Theta-burst transcranial magnetic stimulation promotes stroke recovery by vascular protection and neovascularization33
Extrahepatic cholangiography in near-infrared II window with the clinically approved fluorescence agent indocyanine green: a promising imaging technology for intraoperative diagnosis33
Near-IR emissive rare-earth nanoparticles for guided surgery33
Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles33
Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice33
Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition33
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing33
Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation33
Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway33
CXCR4 mediates matrix stiffness-induced downregulation of UBTD1 driving hepatocellular carcinoma progression via YAP signaling pathway32
Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy32
Quantitative chemical imaging of breast calcifications in association with neoplastic processes32
Imaging of tumor colonization by Escherichia coli using 18F-FDS PET32
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain32
A S100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis32
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy32
Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis32
High fat diet, gut microbiome and gastrointestinal cancer32
Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies32
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance32
Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis32
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis32
Pyroptosis in inflammatory diseases and cancer32
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices32
IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer32
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer32
MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer32
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells31
Coordination-induced exfoliation to monolayer Bi-anchored MnB2 nanosheets for multimodal imaging-guided photothermal therapy of cancer31
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition31
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin31
Imaging-assisted anticancer nanotherapy31
Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration31
Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer31
Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis31
Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer31
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss31
PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood31
Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics31
Hemoglobin-mediated biomimetic synthesis of paramagnetic O2-evolving theranostic nanoprobes for MR imaging-guided enhanced photodynamic therapy of tumor31
Refining Cancer Management Using Integrated Liquid Biopsy31
Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer31
EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells30
miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism30
Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies30
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus30
Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses30
Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics30
Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures30
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail130
STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma30
A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer30
Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging30
Circulating tumor cells in hepatocellular carcinoma: single-cell based analysis, preclinical models, and clinical applications30
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer30
Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells30
N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming30
Nanomedicine therapies modulating Macrophage Dysfunction: a potential strategy to attenuate Cytokine Storms in severe infections30
Dysregulations of Functional RNA Modifications in Cancer, Cancer Stemness and Cancer Therapeutics30
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma30
Tumor-neuroglia interaction promotes pancreatic cancer metastasis30
SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer30
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients30
Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p30
KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling30
Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG229
Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria29
Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus29
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress29
Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways29
Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression29
Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications29
NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression29