Theranostics

Article	Citations
Engineering exosomes for targeted drug delivery	547
Turning cold tumors into hot tumors by improving T-cell infiltration	306
Immunopathogenesis and treatment of cytokine storm in COVID-19	301
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	287
The double-edged roles of ROS in cancer prevention and therapy	254
Ferroptosis as a novel therapeutic target for cardiovascular disease	240
Platinum-based drugs for cancer therapy and anti-tumor strategies	201
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer	198
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing	195
Selective autophagy of intracellular organelles: Recent research advances	194
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications	175
Recent progress in nanomedicine for enhanced cancer chemotherapy	173
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment	172
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells	159
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors	147
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy	144
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages	140
m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer	139
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control	129
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury	116
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes	112
Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view	104
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment	104
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia	103
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota	102

Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects	102
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy	100
Recent advances in innovative strategies for enhanced cancer photodynamic therapy	100
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression	97
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions	97
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR	97
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming	96
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28	92
Role of prostaglandin E2 in tissue repair and regeneration	88
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1	88
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I	87
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies	87
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer	87
Pyroptosis in inflammatory diseases and cancer	86
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice	85
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer	84
Glioma stem cells and their roles within the hypoxic tumor microenvironment	83
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections	82
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2	82
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization	82
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models	81
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer	81
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer	81
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle	81
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model	80
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction	80
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17	80
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer	78
Targeting iron metabolism in cancer therapy	78
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B	77
Exosome-inflammasome crosstalk and their roles in inflammatory responses	77
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation	76
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer	76
SERS Tags for Biomedical Detection and Bioimaging	74
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles	74
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images	72
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma	72
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus	71
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria	70
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma	69
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting	68
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages	68
Endothelial cell infection and dysfunction, immune activation in severe COVID-19	67
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment	67
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy	67
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy	67
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets	66
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys	65
Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion	65
The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction	64

CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction	64
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis	63
The 2020 race towards SARS-CoV-2 specific vaccines	63
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma	62
Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity	62
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts	62
Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay	62
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment	61
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats	61
A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity	60
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation	60
High fat diet, gut microbiome and gastrointestinal cancer	60
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review	60
Metal-phenolic networks: facile assembled complexes for cancer theranostics	59
MLKL: Functions beyond serving as the Executioner of Necroptosis	59
Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma	59
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients	59
Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment	59
TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo	59
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics	59
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling	58
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway	58
Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice	58
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy	58
The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies	58
Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives	57
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells	57
MRI-traceable theranostic nanoparticles for targeted cancer treatment	57
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits	56
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges	56
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity	56
Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis	55
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer	55
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling	55
TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG	55
The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling	55
Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellu	55
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma	55
Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin	54
The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy	54
Candida albicans disorder is associated with gastric carcinogenesis	54
3D bioprinting in cardiac tissue engineering	54
Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3	54
Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment	53
Fully end-to-end deep-learning-based diagnosis of pancreatic tumors	53
Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair	53
Recent advances in supramolecular antidotes	53
Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p	52
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel	52
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis	52
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis	51
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells	51
Stimuli-activatable nanomedicine meets cancer theranostics	51
Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry	50
Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem	50
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices	50
Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics	50
Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death	50
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM	49
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications	49
Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2	49
Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications	48
Cancer photo-immunotherapy: from bench to bedside	48
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance	48
Inhibitory effect of PPARγ on NLRP3 inflammasome activation	48
Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability	48
Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice	48
Targeted delivery of extracellular vesicles in heart injury	47
Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies	47
Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis	47
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation	47
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model	47
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3	47
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis	46
Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy	46
Silk fibroin-based biomaterials for cartilage/osteochondral repair	46
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension	46
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis	45
EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells	44
FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts	44

MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer	44
Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway	43
Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics	43
Targeting regulated cell death in tumor nanomedicines	43
Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis	43
Recent progress of carbon dots in targeted bioimaging and cancer therapy	42
Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis	42
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain	42
Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion	42
Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy	42
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1	42
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms	41
Targeting ferroptosis-based cancer therapy using nanomaterials: strategies and applications	41
Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes	41
Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy	41
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin	41
Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy	41
Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis	41
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy	40
Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels	40
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study	40
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients	40
METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication	40
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation	40
Recent advances in nanotechnology for eradicating bacterial biofilm	40
Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer	39
Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles	39
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer	39
The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway	39
Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging	39
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin	39
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein	38
Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis	38
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies	37
Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies	37
Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases	37
M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice	37
Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2	37
Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment	37
Mutational spectrum and precision oncology for biliary tract carcinoma	37
Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer	37
Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment	37
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis	37
EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer	36
Genome-wide study of salivary miRNAs identifies miR-423-5p as promising diagnostic and prognostic biomarker in oral squamous cell carcinoma	36
Ferroptotic stress promotes macrophages against intracellular bacteria	36
LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis	36
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment	36
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness	36
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents	36
Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome	36
Molecular imaging and biochemical response assessment after a single cycle of [225Ac]Ac-PSMA-617/[177Lu]Lu-PSMA-617 tandem therapy in mCRPC patients who have progressed on [	36
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress	36
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation	36
Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome	35
Activatable NIR-II organic fluorescent probes for bioimaging	35
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition	35
Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer	35
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics	35
Distinct placental molecular processes associated with early-onset and late-onset preeclampsia	35
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma	35
An electroporation strategy to synthesize the membrane-coated nanoparticles for enhanced anti-inflammation therapy in bone infection	35
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation	35
Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases	35
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model	35
IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer	34
AIE-active two-photon fluorescent nanoprobe with NIR-II light excitability for highly efficient deep brain vasculature imaging	34
MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease	34
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition	34
miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene	34
Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice	34
CD45RO-CD8+ T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis	34
KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway	34
Smart magnetic resonance imaging-based theranostics for cancer	33
SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways	33
CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors	33
Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardi	33
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model	33
Immunotherapy for targeting cancer stem cells in hepatocellular carcinoma	33
Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling	33
Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly	33
Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation	33
HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment	33
Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression	33
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation	33
Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates	32
A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy	32
The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma	32
Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone re	32
Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy	32
Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium	32
Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments	32
A super-stable homogeneous Lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma	32
Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine	32
GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity	32