Theranostics

Article	Citations
Engineering exosomes for targeted drug delivery	783
Turning cold tumors into hot tumors by improving T-cell infiltration	436
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	398
Platinum-based drugs for cancer therapy and anti-tumor strategies	383
Ferroptosis as a novel therapeutic target for cardiovascular disease	347
The double-edged roles of ROS in cancer prevention and therapy	342
Immunopathogenesis and treatment of cytokine storm in COVID-19	340
Selective autophagy of intracellular organelles: Recent research advances	269
Recent progress in nanomedicine for enhanced cancer chemotherapy	267
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing	259
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy	246
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment	241
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer	229
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications	224
Pyroptosis in inflammatory diseases and cancer	207
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages	203
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells	195
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors	184
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury	161
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation	156
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming	154
m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer	152
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment	151
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control	150
SERS Tags for Biomedical Detection and Bioimaging	148

Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia	147
Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view	147
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer	142
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes	138
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota	137
Role of prostaglandin E2 in tissue repair and regeneration	136
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions	134
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy	133
Glioma stem cells and their roles within the hypoxic tumor microenvironment	129
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects	128
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages	125
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies	123
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression	123
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer	122
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28	122
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models	120
Recent advances in innovative strategies for enhanced cancer photodynamic therapy	119
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle	116
Stimuli-activatable nanomedicine meets cancer theranostics	116
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR	115
Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications	115
Targeting iron metabolism in cancer therapy	114
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I	112
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2	112
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model	110
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1	109
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma	108
Exosome-inflammasome crosstalk and their roles in inflammatory responses	108
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment	107
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17	107
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer	106
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation	105
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization	105
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice	104
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer	103
Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay	103
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer	101
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections	101
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy	100
High fat diet, gut microbiome and gastrointestinal cancer	100
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria	98
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review	97
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction	97
Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment	95
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets	95
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy	94
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer	94
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment	93
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells	93
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma	93

Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion	92
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images	91
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus	91
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles	91
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation	90
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy	89
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys	89
Silk fibroin-based biomaterials for cartilage/osteochondral repair	88
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B	88
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction	88
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices	87
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts	87
Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice	86
The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies	86
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies	85
TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo	85
Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives	84
MRI-traceable theranostic nanoparticles for targeted cancer treatment	83
Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy	83
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting	82
Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging	82
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics	82
Endothelial cell infection and dysfunction, immune activation in severe COVID-19	81
Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis	81
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis	81
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents	80
Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis	79
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer	79
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling	79
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel	78
The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction	77
Metal-phenolic networks: facile assembled complexes for cancer theranostics	77
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats	77
Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity	76
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells	75
3D bioprinting in cardiac tissue engineering	75
MLKL: Functions beyond serving as the Executioner of Necroptosis	75
Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma	74
Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem	74
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma	74
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity	74
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges	73
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms	73
Recent advances in nanotechnology for eradicating bacterial biofilm	73
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma	72
Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis	71
A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity	71
TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG	71
Recent advances in the medical applications of hemostatic materials	70
Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellu	70
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling	70
Candida albicans disorder is associated with gastric carcinogenesis	69
Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3	69
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM	69
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits	69
Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin	68
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients	68
Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics	68
Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment	67
The 2020 race towards SARS-CoV-2 specific vaccines	67
Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2	67
Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry	67
Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p	67
Fully end-to-end deep-learning-based diagnosis of pancreatic tumors	67
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway	67
Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death	66
Recent advances in supramolecular antidotes	66
The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy	65
Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics	64
The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling	64
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation	64
Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer	64
Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway	63
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model	63
Ferroptotic stress promotes macrophages against intracellular bacteria	63
Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy	63
Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels	63
Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies	61
Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis	61
FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts	61

Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation	60
Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair	60
CD45RO-CD8+ T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis	60
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance	59
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis	59
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis	59
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3	59
Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy	59
Targeting regulated cell death in tumor nanomedicines	59
M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice	58
HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment	58
Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis	58
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis	58
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications	57
Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice	57
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy	57
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis	57
Cancer photo-immunotherapy: from bench to bedside	57
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin	56
Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases	56
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation	56
Inhibitory effect of PPARγ on NLRP3 inflammasome activation	56
Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway	56
SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways	55
Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability	55
EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells	55
MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer	55
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension	55
Activatable NIR-II organic fluorescent probes for bioimaging	54
Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion	54
Targeted delivery of extracellular vesicles in heart injury	53
Recent progress of carbon dots in targeted bioimaging and cancer therapy	53
GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity	53
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function	53
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain	52
The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway	52
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics	52
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage	52
METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication	51
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model	51
Targeting ferroptosis-based cancer therapy using nanomaterials: strategies and applications	50
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients	50
Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment	50
Nanomaterial-based CT contrast agents and their applications in image-guided therapy	50
Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy	50
MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease	50
Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment	50
Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies	49
miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene	49
Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke	49
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin	49
Molecular imaging and biochemical response assessment after a single cycle of [225Ac]Ac-PSMA-617/[177Lu]Lu-PSMA-617 tandem therapy in mCRPC patients who have progressed on [	48
Distinct placental molecular processes associated with early-onset and late-onset preeclampsia	48
Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine	48
Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis	48
Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy	48
EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer	48
Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer	48
Strategies targeting PD-L1 expression and associated opportunities for cancer combination therapy	48
TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling	48
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing	48
Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling	48
Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles	48
N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming	47
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis	47
Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes	47
An electroporation strategy to synthesize the membrane-coated nanoparticles for enhanced anti-inflammation therapy in bone infection	47
Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy	47
Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins	47
KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway	47
Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer	47
Mutational spectrum and precision oncology for biliary tract carcinoma	46
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment	46
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1	46
Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1	46
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1	46
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition	46
Smart magnetic resonance imaging-based theranostics for cancer	46
Artificial intelligence in pancreatic cancer	46
Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine	46
Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment	45
Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases	45
Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2	45
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein	45
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study	45
Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression	45
Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIδ pathway in vitro and in vivo	45
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation	44
Antibacterial PDT nanoplatform capable of releasing therapeutic gas for synergistic and enhanced treatment against deep infections	44
Role of p53 in breast cancer progression: An insight into p53 targeted therapy	44
Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium	44
Emerging early diagnostic methods for acute kidney injury	44
Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis	44
How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?	44
Tumor microenvironment-activated single-atom platinum nanozyme with H2O2 self-supplement and O2-evolving for tumor-specific cascade catalysis chemodynamic and chemorad	44