OOIR: Observatory of International Research

Papers

(The H4-Index of Theranostics is 87. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Engineering exosomes for targeted drug delivery	783
Turning cold tumors into hot tumors by improving T-cell infiltration	436
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	398
Platinum-based drugs for cancer therapy and anti-tumor strategies	383
Ferroptosis as a novel therapeutic target for cardiovascular disease	347
The double-edged roles of ROS in cancer prevention and therapy	342
Immunopathogenesis and treatment of cytokine storm in COVID-19	340
Selective autophagy of intracellular organelles: Recent research advances	269
Recent progress in nanomedicine for enhanced cancer chemotherapy	267
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing	259
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy	246
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment	241
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer	229
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications	224
Pyroptosis in inflammatory diseases and cancer	207
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages	203
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells	195
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors	184
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury	161
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation	156
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming	154
m⁶A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer	152
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment	151
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control	150
SERS Tags for Biomedical Detection and Bioimaging	148

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view	147
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia	147
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer	142
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes	138
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota	137
Role of prostaglandin E2 in tissue repair and regeneration	136
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions	134
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy	133
Glioma stem cells and their roles within the hypoxic tumor microenvironment	129
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects	128
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages	125
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies	123
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression	123
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28	122
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer	122
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models	120
Recent advances in innovative strategies for enhanced cancer photodynamic therapy	119
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle	116
Stimuli-activatable nanomedicine meets cancer theranostics	116
Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications	115
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR	115
Targeting iron metabolism in cancer therapy	114
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2	112
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I	112
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model	110
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1	109
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma	108
Exosome-inflammasome crosstalk and their roles in inflammatory responses	108
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17	107
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment	107
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer	106
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization	105
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation	105
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice	104
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer	103
Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay	103
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections	101
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer	101
High fat diet, gut microbiome and gastrointestinal cancer	100
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy	100
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria	98
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction	97
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review	97
Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment	95
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets	95
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer	94
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy	94
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma	93
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment	93
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells	93

Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion	92
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles	91
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images	91
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus	91
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation	90
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy	89
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys	89
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction	88
Silk fibroin-based biomaterials for cartilage/osteochondral repair	88
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B	88
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts	87
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices	87