OOIR: Observatory of International Research

Papers

(The H4-Index of Theranostics is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Engineering exosomes for targeted drug delivery	547
Turning cold tumors into hot tumors by improving T-cell infiltration	306
Immunopathogenesis and treatment of cytokine storm in COVID-19	301
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	287
The double-edged roles of ROS in cancer prevention and therapy	254
Ferroptosis as a novel therapeutic target for cardiovascular disease	240
Platinum-based drugs for cancer therapy and anti-tumor strategies	201
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer	198
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing	195
Selective autophagy of intracellular organelles: Recent research advances	194
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications	175
Recent progress in nanomedicine for enhanced cancer chemotherapy	173
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment	172
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells	159
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors	147
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy	144
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages	140
m⁶A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer	139
Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control	129
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury	116
Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes	112
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment	104
Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view	104
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia	103
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects	102

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota	102
Recent advances in innovative strategies for enhanced cancer photodynamic therapy	100
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy	100
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR	97
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression	97
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions	97
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming	96
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28	92
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1	88
Role of prostaglandin E2 in tissue repair and regeneration	88
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer	87
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I	87
Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies	87
Pyroptosis in inflammatory diseases and cancer	86
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice	85
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer	84
Glioma stem cells and their roles within the hypoxic tumor microenvironment	83
Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2	82
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization	82
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections	82
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer	81
Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer	81
Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle	81
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models	81
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17	80
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model	80
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction	80
Targeting iron metabolism in cancer therapy	78
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer	78
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B	77
Exosome-inflammasome crosstalk and their roles in inflammatory responses	77
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer	76
Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation	76
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles	74
SERS Tags for Biomedical Detection and Bioimaging	74
Assessing PD-L1 expression in non-small cell lung cancer and predicting responses to immune checkpoint inhibitors using deep learning on computed tomography images	72
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma	72
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus	71
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria	70
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma	69
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages	68
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting	68
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy	67
Endothelial cell infection and dysfunction, immune activation in severe COVID-19	67
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment	67
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy	67