Analytical Methods

Papers
(The median citation count of Analytical Methods is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Contents list85
An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages82
Front cover77
UPLC-QTOF-MS-based metabolomics and chemometrics studies of geographically diverse C. torulosa needles68
Contents list64
An effective method for detecting nitrous oxide using alkaline washing and GC-MS57
Recent progress in gold-derived nanomaterials for tumor theranostics55
Screening and detection of multivalent human papillomavirus antibodies using a high-throughput liquid chip fluoroimmunoassay system49
A high resolution Fourier transform ion trap enabled by image current splicing: a theoretical study41
An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells40
Back cover38
Back cover38
Contents list35
Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors35
Contents list33
Contents list33
Back cover32
Improved estimates of expanded measurement uncertainty32
Amplified electrochemical detection of sulfadiazine based on Cu-BTC-encapsulated FeNi dual-atom catalysts with improved catalytic efficiency32
Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry32
Contents list31
Analysis and electroanalysis of perchlorate in water and food samples: a critical review30
SERS combined with QuEChERS using NBC and Fe3O4 MNPs as cleanup agents to rapidly and reliably detect chlorpyrifos pesticide in citrus30
Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids30
Iodine determination by ICP-MS following platinum-assisted photochemical vapor generation: a strategy to overcome condensed-phase interferences28
Development of a rapid and sensitive single-tube RAA-CRISPR/Cas12a assay for monkeypox virus detection28
A rhodamine coumarin-derived fluorescence probe that selectively detects Fe3+ and measures radiation doses28
Online regeneration of a piezoelectric and impedimetric immunosensor for the detection of C-reactive protein on the oriented antibody gold surface28
Front cover27
Alternative digestion strategy for Ti, Zr and Hf oxides: eliminating hydrofluoric acid27
Electrochemical aptasensor based on DNA-templated copper nanoparticles and RecJf exonuclease-assisted target recycling for lipopolysaccharide detection26
Metal nanoprobe-decorated all-inorganic perovskite nanocrystal-based fluorescence-linked immunosorbent assay for the detection of tumor-derived exosomes26
Retraction: NiFe 2 O 4 nanoparticles decorated with MWCNTs as a selective and sensitive electroche26
Optimization of micro-QuEChERS extraction coupled with gas chromatography-mass spectrometry for the fast determination of phthalic acid esters in mussel samples26
A visual ratiometric fluorescence sensor for glutathione response based on MnO2 nanowires as an oxidant, quencher and recognition unit26
Chemometrics-assisted excitation–emission matrix fluorescence spectroscopy for rapid identification of commercial reconstituted and sweetened grape juices25
Recent advances in the CRISPR/Cas system-based visual detection method25
Optimization of a modified Captiva EMR-lipid method based on micro-matrix solid-phase dispersion coupled with gas chromatography-mass spectrometry for the determination of nine bisphenols in mussel sa25
A nickel porphyrin-based covalent organic framework modified electrode for the electrochemical detection of acetaminophen25
Extraction and determination of aflatoxin B1 in cereal samples using pH-switchable hydrophobic deep eutectic solvents followed by HPLC-FL analysis24
Development of a novel MSRE-dPCR assay for non-invasive prenatal testing of trisomy 2123
A TiO 2 /Ti 3 C 2 MXene photoelectrochemical ch23
Nanoparticle-aptamer based cytosensing for the detection of human non-small cell lung cancer cells23
Development of an iron-metal organic Framework-based dispersive solid phase extraction coupled with flame atomic absorption spectrophotometry for the accurate and sensitive determination of copper in 23
A comparative review on the mitigation of metronidazole residues in aqueous media using various physico-chemical technologies23
Saliva sampling strategies affecting the salivary glucose measurement23
In situ dissolved polypropylene prediction by Raman and ATR-IR spectroscopy for its recycling23
Airborne microplastics: environmental prevalence, human health risks, and mitigation strategies22
A review of organic small-molecule fluorescent probes for the gallium(iii) ion22
Determination of amide herbicides in food by salting-out vortex-assisted dispersive liquid–liquid microextraction coupled with gas chromatography-tandem mass spectrometry22
Recent advances in upconversion nanoparticles for biomolecule detection: a review22
Bulk-lysis protocols as a sensitive method for investigation of circulating CK19 cells in the peripheral blood of patients with breast cancer by flow cytometry22
A nano-imprinted graphene oxide-cellulose composite as a SERS active substrate22
β-Propiolactone, its application and assay methods22
Structural identification ofin vitrometabolites for 23-nordeoxycholic acid by structural analogue matching22
Ultra-high performance liquid chromatography–tandem mass spectrometry for profiling mercapturic acids in human urine after daily exposure to acrylamide, 3-monochloropropane-1,2-diol and glycidol22
Enhanced detection of acetamiprid via a gold nanoparticle-based colorimetric aptasensor integrated with a hybridization chain reaction22
Contents list22
Fast and sustainable active pharmaceutical ingredient (API) screening in over-the-counter and prescription drug products by surface-assisted plasma-based desorption/ionization high-resolution mass spe21
Diagnostic performance of thioflavin T in one-step RT-PCR for detection of a viral RNA21
A polyaniline-enhanced quartz crystal microbalance sensor for room-temperature camphor detection21
Quantification of 37 glucocorticoids in chicken muscle by UHPLC-Q-Orbitrap-MS with parallel reaction monitoring21
Wearable sweat chloride sensors: materials, fabrication and their applications21
High-capacity 4-fluoro-2-formylphenylboronic acid functionalized silica nanoparticles for highly efficient enrichment of cis -diol-containing biomolecule21
Colorimetric immunoassay of carcinoembryonic antigen based on the glucose oxidase/MnO2 nanosheet cascade reaction with self-supplying oxygen21
Dual-mode immunochromatographic test strips based on aggregation-induced luminescence nanoprobes for the detection of ZEN in corn21
DLD-based on-chip sample handling for label-free single-cell MS cytometry20
Single-cell mass cytometry reveals distinct immune signatures in colorectal cancer20
Electrostatic assemblies of molecularly imprinted polymers on the surface of electrospun nanofiber membranes for the point-of-care detection of thiodiglycol, a sulfur mustard poisoning metabolic marke20
Fingerprinting combined with chemometrics: new strategies and advances in quality evaluation of traditional Chinese medicine20
The development and validation of a new method for the fast determination of Al, Ba, Ca, Cu, Fe, K, Mg, Mn, Na, Sr and Zn in rice by inductively coupled plasma optical emission spectrometry20
Multiply charged ion profiles in the UHPLC-HRMS analysis of palytoxin analogues from Ostreopsis cf. ovata blooms19
Rational design to improve the detection sensitivity of sandwich-type lateral flow immunoassays19
Critical analysis of advanced nanosensors for dengue detection19
High-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry19
Membraneless, self-powered immunosensing of a cardiac biomarker by exploiting a PEC platform based on CaBi2Ta2O9 combined with bismuth oxyiodides19
Effects of targeted lung cancer drugs on cardiomyocytes studied by atomic force microscopy19
A pyrolysis gas chromatography high resolution mass spectrometry (Py-GC-MS) method for analysis of phthalic acid esters and its application for screening e-waste materials19
A highly sensitive competitive aptasensor for AFB1 detection based on an exonuclease-assisted target recycling amplification strategy19
A fluorescence sensor array for biothiol detection and disease identification based on a CoOOH nanoflake triggered dual-color fluorescence system19
Removal and detection of phenols through an SPE-HPLC method using microporous organic networks as adsorbent19
Direct detection of acetonitrile at the pptv level with photoinduced associative ionization time-of-flight mass spectrometry19
Effect of hydrotreating on the pyrolysis oil composition: GC-MS studies18
Optimizing the extraction of ursolic acid from loquat leaf using 1 H-qNMR18
Acrylamide in food products and the role of electrochemical biosensors in its detection: a comprehensive review18
Back cover18
Triazine-structured covalent organic framework nanosheets with inherent hydrophilicity for the highly efficient and selective enrichment of glycosylated peptides18
Nanosilver-mediated enzyme-free electrochemical immunosensor with enhanced stability for aflatoxin B1 detection in food safety18
Dual-emission copper nanoclusters for hydrogen sulfide detection: a novel approach18
Front cover18
Near-infrared carbon dots enable ultra-sensitive fluorometric detection of belzutifan: a novel approach for real-time therapeutic drug monitoring in cancer treatment18
Contents list18
Front cover18
Rapid and accurate detection of huanglongbing in citrus by elasticity testing using a piezoelectric finger18
Peptide–DNA conjugate-assisted DNA cyclization for highly efficient and sensitive detection of furin18
A novel 3D-CB/HEC–CH@Cu hybrid electrode for sensitive and rapid ammonia nitrogen detection in environmental water18
Comprehensive HPLC fingerprint analysis based on a two-step extraction method for quality evaluation of Perilla frutescens (L.) Britt18
Back cover18
Contents list18
Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry18
Back cover18
Front cover17
A phenothiazine-based ratiometric fluorescence probe for the detection of hydroxylamine in real water and living cells17
A synergistic polyimide-silver nanowire interface enables simultaneous electrochemical detection of nitrophenol isomers17
Preparation of a national reference material organochlorine pesticide mixture for residue analysis17
Quantification and isotope abundance determination of 13C labeled intracellular sugar metabolites with hydrophilic interaction liquid chromatography17
Accurate automatic analysis of individual uranium particles to improve the timeliness of safeguards environmental sample analysis using an LG-SIMS instrument and SEM-micromanipulation17
Design of a novel rhodamine B based pH-responsive magnetic adsorbent and its application in phosphopeptidomics17
3D printed microfluidic devices with electrodes for electrochemical analysis17
Front cover17
Polluted soil–plant interaction analysis and soil classification based on laser-induced breakdown spectroscopy and machine learning17
Discretized butterfly optimization algorithm for variable selection in the rapid determination of cholesterol by near-infrared spectroscopy17
Validated green ultra-fast UPLC-MS/MS method for the quantification of fedratinib in an HLM matrix: application to in vitro and in17
Low-cost electronic-nose (LC-e-nose) systems for the evaluation of plantation and fruit crops: recent advances and future trends16
l-Tryptophan-based pyrene conjugate for intracellular zinc-guided excimer emission and controlled nano-assembly16
Synthesis and evaluation of a chitosan nanomaterial as efficient sorbent for determination of fungicide residues in waters and wine by liquid chromatography high resolution mass spectrometry16
Facile detection of illicit wastewater discharge into a water source using a kinetic-based optical fingerprinting strategy16
Ultrasensitive detection of crystal violet using a molybdenum sulfide–silver nanostructure-based sensing platform: roles of the adsorbing semiconductor in SERS signal enhancement16
Development of a hybrid integrated moisture content measurement method based on near-infrared (NIR) spectroscopy16
A core–shell structured AuNPs@ZnCo-MOF SERS substrate for sensitive and selective detection of thiram16
A modified QuEChERS method for simultaneous determination of 73 pesticides, 23 PCBs and 16 PAHs in wheat by GC-MS/MS16
Contents list16
Co–Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein16
Contents list16
Modular development of organelle-targeting fluorescent probes for imaging formaldehyde in live cells16
Dual-mode electrochemical–colorimetric immunosensor based on an integrated FeOOH–Au–MB probe for sensitive procalcitonin detection16
A portable optical device for quantitative detection of lithium in blood plasma16
Back cover16
Recent developments of e-sensing devices coupled to data processing techniques in food quality evaluation: a critical review16
Ionophore-modified polyaniline-based optode for the determination of hydrogen sulfite levels in beverages, wastewater, and soil15
Front cover15
Dimethyl sulfoxide as a gas phase charge-reducing agent for the determination of PEGylated proteins' intact mass15
Holey MoS2-based electrochemical sensors for simultaneous dopamine and uric acid detection15
N-doped molybdenum oxide quantum dots as fluorescent probes for the quantitative detection of copper ions in environmental samples15
Non-enzymatic electrochemical detection of creatinine based on a glassy carbon electrode modified with a Pd/Cu2O decorated polypyrrole (PPy) nanocomposite: an analytical approach15
Branched polyethylenimine-assisted boronic acid functionalized magnetic nanoparticles for highly efficient capture of lincomycin and clindamycin15
Arrayed labeling-free cultivation and growth evaluation from a single microorganism15
Conditional regulation of HCR for rapid visualization of endogenous miR-21 in cancer cells15
A simple, green and low-cost agarose-based binding layer for simultaneous determination of cations and anions in aquatic systems using DGT15
Front cover15
Graphene quantum dot/Ag-based metal–organic framework nanocomposite-modified carbon paste electrode for simultaneous determination of diazepam, dopamine, clonazepam and adrenaline in real samples15
Rapid determination of plasma vigabatrin by LC-ESI-MS/MS supporting therapeutic drug monitoring in children with infantile spasms15
Energy value measurement of milk powder using laser-induced breakdown spectroscopy (LIBS) combined with long short-term memory (LSTM)15
Understanding metabolic characteristics and molecular mechanisms of large to giant congenital melanocytic nevi: implications for melanoma risk and therapeutic targets15
Optimized separation of astaxanthin stereoisomers from microbial sources using chiral HPLC15
Rapid diagnosis of acute myocardial infarction based on reverse transcription-accelerated strand exchange amplification of miR-208a15
Fluorescence intensity coded DNA frameworks based on the FRET effect enable multiplexed miRNA imaging in living cells15
One-step synthesis of a pH switched pyrene-based fluorescent probe for ratiometric detection of HS in real water samples15
Determination of promethazine in forensic samples using multi-walled carbon nanotube-gold nanoparticle electrochemical sensor14
Real-time optical detection of mercury contamination in drinking water using an amphiphilic recognition probe at liquid crystal/aqueous interfaces14
Factorial design applied to LC-ESI-QTOF mass spectrometer parameters for untargeted metabolomics14
Identification of dyes on fabric exposed to lake and ocean water using near-infrared excitation Raman spectroscopy14
Scientific investigation of Asian lacquerware14
A machine learning-based electronic nose system using numerous low-cost gas sensors for real-time alcoholic beverage classification14
Raman spectroscopy of brain and skin tissue in a minipig model of Huntington's disease14
A fluorescence and colorimetric dual-mode LAMP method for detection of Vibrio parahaemolyticus14
Advanced detection of bisphenol A in plastic water bottles using liquid–liquid phase extraction and LC-MS14
Sodium hexametaphosphate-treated halloysite based solid-phase extraction of biguanides from dietary supplements14
A novel electrochemical aptasensor based on β-cyclodextrinylated graphene and double-stranded DNA for ultrasensitive detection of ochratoxin A14
Realizing the label-free sensitive detection of carcinoembryogenic antigen (CEA) in blood serum via a MNC-decorated flexible immunosensor14
Study of multifunctional controlled separation performance of PVDF/EAA/MXene nanofiltration membranes for the treatment of dyeing wastewater14
Application of EDXRF and thermal expansion analysis for the study of the origin of celadon from the Song and Jin Dynasties (960–1279CE) at the Shuyuan Street site, China14
Detection & identification of hazardous narcotics and new psychoactive substances using Fourier transform infrared spectroscopy (FTIR)14
Sodium alginate hydrogelation mediated paper-based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of l-lactate14
Retraction: Novel 8,9-dihydroxy-7-methyl-12 H -benzothiazolo[2,3- b ]quinazolin-12-one multiwalled carbon 14
Sensitivity improvement by Langmuir film formation on a spectroelectrochemical fiber-optic sensor surface14
An intelligent diagnostic algorithm for Raman spectroscopy of gastrointestinal cancer based on component modeling14
Self-assembled ZnO microspheres coated with carbon dot-doped CoNi LDH wrinkled films as electrochemical sensors for highly sensitive detection of hydrazine14
IGZO thin-film transistor biosensor array for highly sensitive detection of β2-microglobulin14
Aptasensor based on entropy-driven catalytic amplification system for the sensitive detection of acetamiprid in Chinese herbal medicine13
Back cover13
A novel ATBH-modified gold nanoparticle for colorimetric detection and release monitoring of insulin across a wide concentration range13
Impact of mechanical calibration variations on USP prednisone PVT with standard and apex vessels13
Adaptive spectral band optimization for low-cost multispectral estimation of maize leaf chlorophyll using a LASSO–IARO strategy13
Front cover13
Enzyme-linked immunoassay for simultaneous detection of methyl parathion and sibutramine in apple cider vinegar13
Back cover13
CRISPR/Cas-based detection strategies for tumor biomarker detection13
A Portable Near-Infrared Aptasensor Platform for Derivatization-Assisted On-Site Analysis of Acrylamide in Food Samples13
A portable fluorescence detection device based on a smartphone employing carbon nanodots for Mn2+ sensing13
Magnetite azolla impedimetric nanobiosensor for phthalic acid esters quantification13
Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe13
A five-electrode capacitively coupled contactless conductivity detector with a low limit of detection13
Contents list13
A versatile sensor capable of ratiometric fluorescence detection of trace water and turn-on detection of Cu2+ modulating the binding interaction of a Cu(ii) complex with BSA and 13
Sensitive detection of H2O2 based on a MWCNTs/Ti3C2 nanocomposite-modified electrode13
Determination of paclobutrazol using square wave voltammetry based on a molecularly imprinted polymer and boron-doped copper oxide/graphene nanocomposite13
An environmentally relevant solid-state sensor for the trace detection of triclopyr herbicide13
The development and validation of a liquid chromatography tandem mass spectrometry method for the quantification of selinexor and its application in Chinese multiple myeloma patients13
Contents list13
Expanding luminol activity: UV-enhanced peroxidase-like activity for dual-mode wide-pH biosensing13
Back cover13
Detection of proteins with ascorbic acid-capped gold nanoparticles: a simple and highly sensitive colorimetric assay13
Preparation of matrix-matched standards for the analysis of teeth via laser ablation-inductively coupled plasma-mass spectrometry13
Combining method validation data with additional information for measurement uncertainty evaluation – determination of melatonin content in tea12
Back cover12
Study of anti-tumorigenic actions of essential fatty acids in a murine mammary gland adenocarcinoma by micro-XRF12
Back cover12
A multi-kernel channel attention combined with convolutional neural network to identify spectral information for tracing the origins of rice samples12
Cu-MOFs@AuPtNPs nanozyme-based immunosorbent assay for colorimetric detection of alpha-fetoprotein12
Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+12
Capillary action-driven surface-enhanced Raman spectroscopy (SERS) for the identification of phthalocyanine blue in modern paintings based on the BPG spot test12
Sustainable headspace-in-needle microextraction analysis of phthalates using biomass-derived carbon-coated needles12
NIR-induced label-free subcutaneous PEC biosensor UC@Cu2O@TiO2 for detection of l-cysteine12
mRNA-activated DNAzyme nanoprobe for tumor cell precise imaging and gene therapy12
Back cover12
Visualization of the distribution of carbendazim on the arabidopsis leaf surface by VUV-postionization mass spectrometry12
An optimized rapid assay for dual detection of peanut and soybean allergens in food12
Contents list12
A novel highly sensitive electrochemical immunosensor for the sensitive detection of testosterone based on AgNPs–GO–Nf12
Constructing a 3D interconnected network of Ag nanostructures for high-performance SERS detection of food coloring agents12
A polar viscosity-sensitive fluorescent probe with large Stokes shifts for simultaneous imaging of lipid droplets and lysosomes in tobacco leaf vein cells and biological systems12
An electrochemical sensor based on a triblock polyadenine-based probe and copper nanoclusters for the robust detection of the HPV16 gene12
The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine12
Quantification of four arsenic species in dried seafood via pressure tank-assisted extraction with HPLC-AFS12
Tyrosinase detection via enzyme-triggered structural transformation of a ratiometric fluorescent probe12
A CRISPR/Cas12a-based competitive aptasensor for ochratoxin A detection12
Ambient mass spectrometry and near-infrared spectroscopy – a direct comparison of methods for the quantification of sucralose in e-liquids12
Recent advances in the application of ion resonance methods in ion trap mass spectrometers12
Simultaneous detection of dopamine and ascorbic acid by using a thread-based microfluidic device and multiple pulse amperometry11
Bioactivity-guided isolation of anti-proliferative compounds from Curcuma zedoaria against triple negative breast cancer cells11
A highly selective coumarin-based chemosensor for dual sensing of Cu2+ and Zn2+ ions with logic gate integration and live cell imaging11
Validation of the multivariate models for correlation between texture profile analysis, digital images, and NIR spectroscopy11
A chemodosimetric chemosensor for the ratiometric detection of nerve agent-mimic DCP in solution and vapor phases11
Raman spectroscopy as a promising diagnostic method for rheumatoid arthritis11
Rapid miniaturized electrochemical biosensor based on screen-printed technology for early-stage taurine detection through manganese molybdate nanosheets and bionicimprinted nanofilms11
Construction and application of a coumarin-based fluorescent probe for hypochlorous acid11
An environmentally friendly approach for the characterization of construction materials: determination of trace, minor, and major elements by slurry sampling high-resolution continuum source graphite 11
Rapid identification of chemical constituents of Liaogu Formula based on UHPLC-Q-TOF-MSE combined with UNIFI platform11
An impedimetric immunosensor for diagnosis of Brazilian spotted fever in blood plasma11
A low-cost voltammetric sensor based on multi-walled carbon nanotubes for highly sensitive and accurate determination of nanomolar levels of the anticancer drug Ribociclib in bulk and biological fluid11
Back cover11
Rapid microwave fabrication of red-carbon quantum dots as fluorescent on–off–on probes for the sequential determination of Fe(iii) ion and ascorbic acid in authentic samples11
Integrated microfluidic platforms for heavy metal sensing: a comprehensive review11
Detection of bitter limonin in citrus samples using plasmonic gold nanobipyramid-based dual-mode lateral flow immunoassay11
Innovative method orange gradient index (IMOGI): a new tool for assessing analytical methods in terms of innovation and modernization11
Advancements in electrochemical immunosensors towards point-of-care detection of cardiac biomarkers11
Direct-detection of glyphosate in drinking water via a scalable and low-cost laser-induced graphene sensor11
Folic acid-conjugated long circulating co-encapsulated atorvastatin and quercetin solid lipid nanoparticles: pharmacokinetics and biodistribution in rats11
Zirconium-based metal–organic framework loaded agarose hydrogels for fluorescence turn-on detection of nerve agent simulant vapor11
Colorimetric and ratiometric fluorescent probes for sensitive visualization of hydrazine in water and in living cells11
Biomarkers and optical based biosensors in cardiac disease detection: early and accurate diagnosis11
A rapid, simple, high-performance liquid chromatography method for the clinical measurement of beta-lactam antibiotics in serum and interstitial fluid11
ZIF-67-modified magnetic nanoparticles for extraction of phenoxy carboxylic acid herbicides11
Isothermal amplification-based microfluidic devices for detecting foodborne pathogens: a review11
Environmentally friendly screen-printed electrodes for the selective detection of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in forensic analysis11
Biopolymer supported electroanalytical methods for the determination of biomolecules and food additives – a comprehensive perspective11
Enzyme-free and product-accelerated DNA walker cascade for ultrasensitive detection of tic disorder-associated microRNA11
A method for the quantitative analysis of polar anionic pesticides in milk/infant formula, cereals and fruit and vegetables using ion chromatography coupled to tandem mass spectrometry11
Research and application discussion on new technology for detecting cadmium ions based on a near-red light carbon dot fluorescence quenching method11
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