OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Endocrinology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Immune cell population prevents weight regain	640
Non-nutritive sweeteners — too sweet to be wholesome?	584
Timed high-fat diet feeding restores small bowel circadian rhythms	572
Memory of obesity stored in adipocytes	364
Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations	287
Author Correction: Adrenocortical stem cells in health and disease	273
The role of DNA damage in diabetic complications	264
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead	261
Limiting the use and misuse of liothyronine in hypothyroidism	244
The gut microbiota in obesity and weight management: microbes as friends or foe?	221
Thyroid function and iodine intake: global recommendations and relevant dietary trends	216
Effects of diet on atherosclerotic plaque development	203
The challenges of assessing adiposity in a clinical setting	200
Patients’ insights into diabetes insipidus	174
Neurons in the diagonal band of Broca moderate food intake	171
Reply to ‘Ensuring diverse representation and minimizing conflicts of interest in clinical practice guidelines’	162
Ensuring diverse representation and minimizing conflicts of interest in clinical practice guidelines	161
Obesity phenotypes: explaining the unexplained	157
Midlife and the menopause transition in type 2 diabetes mellitus prevention	150
Reply to ‘Why the science on T3 and genomics is not settled’	148
Fusion with blood vessel organoids supports pancreatic islet function	142
mTORC1 is the central regulator in pancreatic β-cells	142
A pivotal year for NAFLD and NASH therapeutics	134
Intestinal mitochondrial complex I inhibition essential for clinical benefits of metformin	130
Steroid hormones as modulators of anti-tumoural immunity	120

Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus	117
The interactions between energy homeostasis and neurovascular plasticity	112
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity	105
Genetic risk scores improve prediction of obesity in survivors of childhood cancer	102
Primary aldosteronism — a multidimensional syndrome	102
New role for bone marrow adipocytes in obesity	102
A role for the kidney in metformin action	99
Endosomal trafficking in metabolic homeostasis and diseases	98
Advances in incretin-based therapeutics for obesity	95
New maps and new challenges in the post-genomic era	91
RalA links obesity and mitochondrial dysfunction	91
The metabolic mythos of ketones	90
Advances in basic biology and translation in islet research	89
Inflammation-induced adrenal dysfunction	88
Epigenetic effects of maternal type 1 diabetes mellitus	84
Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption	83
Language evolves — so can you	81
Endocrinologists gather at ECE 2026	80
Dysfunctional adipose tissue–lymphatic crosstalk in obesity	79
Targeting the incretin system in obesity and type 2 diabetes mellitus	79
Luteal phase support in assisted reproductive technology	76
Bone and muscle crosstalk in ageing and disease	76
Untangling the pathways of SDHx loss of function	76
Author Correction: Drug Insight: selective agonists and antagonists of the glucocorticoid receptor	71
Islet hormones at the intersection of glucose and amino acid metabolism	70
Tracing the biological roots of obesity resistance in humans	70
Leptin–thyroid hormone axis affects energy use in muscle	70
The metabolic benefits of exercise-induced hepatic autophagy	68
Hepatic neurons and metabolically induced liver dysfunction	66
Potential downsides of calorie restriction	65
REG3G — a potential link between the intestinal microbiome and host physiology	61
The role of ultra-processed food in obesity	60
Iatrogenic adrenal insufficiency in adults	57
Length of light exposure alters energy metabolism in mice	55
A global view of hypertensive disorders and diabetes mellitus during pregnancy	55
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger	54
Vitamin D supplementation and fracture risk	54
GPR110 as a regulator of MASH	54
Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?	53
Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response	53
Investigating the effects of artificial sweeteners	53
The complexity of the relationship between thyroid disease and body weight	53
The autonomic nervous system in the regulation of glucose and lipid metabolism	51
Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice	51
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus	50
Metabolic control of feto–placental development and pregnancy outcomes	49
Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?	48
Lipid droplet biogenesis and functions in health and disease	47
Engineered Tregs prevent diabetes mellitus in mice	45
Sarcopenic obesity in older adults: a clinical overview	45

Large study on hormone therapy for transgender youth provides reassurance amid treatment politicization	44
Metformin and GDF15: where are we now?	44
Targeting senescent cells in ageing-related endocrine diseases	43
Mitigating the environmental effects of healthcare: the role of the endocrinologist	42
Energy intake at the intersection of the clock and ageing	42
OBEClust: joining forces to prevent obesity	42
ZMIZ1 supports endometrial oestrogen and progesterone signalling	42
Highlights from SfE BES 2026	41
Growth hormone-releasing hormone and its analogues in health and disease	41
Variation in serotonin 2C receptor linked with obesity and behaviour	40
The glymphatic system as a nexus between obesity and neurological diseases	40
Myostatin-targeting antibody protects lean mass during incretin-induced weight loss	40
Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency	39
Sertoli cell lysosomal dysfunction drives age-related testicular degeneration	39
New genes associated with adult-onset obesity	38
Exercise in adults with type 1 diabetes mellitus	38
Can obesity pharmacotherapy be used to manage male infertility?	37
Brown adipose tissue fights the battle against leukaemia	36
Greater recognition required for thyroid disorders	36
A mitochondrial trigger for beige adipocyte development	35
Interventions in people newly diagnosed with type 1 diabetes mellitus	35
GWAS gives insights into glucose regulation	35
Individualized and innovative gender healthcare for transgender and nonbinary youth	35
Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss	34
Elucidating the structure of TRH: a defining moment for modern neuroendocrinology	34
Diabetes mellitus and work participation	34
The regulation of endocrine-disrupting chemicals to minimize their impact on health	33
Models of hyperglycaemia in diabetes mellitus and its complications	32
Medically not yet explained symptoms in hypothyroidism	32
International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia	32
Paracrine signalling in thermogenesis	32
Metabolic effects of gender-affirming hormone therapy	31
Blood-based obesity biomarkers and their relevance for disease risk	31
Advancing precision nutrition: bridging mechanistic insight and clinical implementation	31
Knowledge in youth is wisdom in age: involving young people in research	30
Highlights from ADA 85th Scientific Sessions	30
Combination therapy increases human β-cell mass in vivo	30
Negative effects of ultra-processed foods beyond increasing calories	28
Variation in metformin pharmacokinetics	28
Sex differences in diabetic kidney disease explained	27
Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents	27
Exposure to fat odour during development predisposes offspring to obesity	27
The public health burden of diabetes mellitus and thyroid disease: twin epidemics	24
Peritumoural adipose tissue protects colorectal cancer from immune attack	24
Monogenic diabetes mellitus hidden in autoantibody-negative diabetes mellitus	24
Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia	24
Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation	23
From ENDO 2026	22
Unravelling the rise in thyroid cancer incidence and addressing overdiagnosis	22
Cancer prevention through metabolic remission	22
The complex effects of dietary restriction on longevity and health	21
The study that pioneered islet isolation techniques	20
AcroBATics: how dying brown adipocytes trigger browning	20
Antioxidant liver myeloid cell population identified	20
Advances in incretin-based drug discovery in 2025	19
Author Correction: Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits	19
Dysfunctional lipid metabolism in ageing muscle: effects on glucose tolerance	19
Obesity induces epigenetic memory in innate immune cells	19
Menopause in the spotlight: important research and clinical advances	18
Skeletal stem and progenitor cells in bone physiology, ageing and disease	18
New variant for monogenic obesity	17
CAMK1D required for ghrelin-mediated food intake	17
Consensus on acromegaly therapeutic outcomes: an update	17
Genomics suggest role for IGF1 resistance in T2DM	17
Endoscopic sleeve gastroplasty: safe and effective	16
Antigen-specific Treg cells induce infectious tolerance	16
The progesterone receptor’s journey through mouse models	16
Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences	16
IL-17 has a role in whole-body homeostasis	16
Macronutrient mixtures and interactions in health and disease	16