Nature Reviews Endocrinology

Article	Citations
COVID-19 and diabetes mellitus: from pathophysiology to clinical management	677
Exerkines in health, resilience and disease	395
Mitochondrial and metabolic dysfunction in ageing and age-related diseases	394
The burden and risks of emerging complications of diabetes mellitus	392
The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases	377
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19	346
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)	335
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics	293
Current understanding of the molecular and cellular pathology of diabetic retinopathy	275
Type 2 diabetes mellitus in older adults: clinical considerations and management	268
The health effects of vitamin D supplementation: evidence from human studies	267
Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus	259
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease	235
Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy	233
Autophagy in metabolic disease and ageing	213
Endocrine toxicities of immune checkpoint inhibitors	198
Metformin: update on mechanisms of action and repurposing potential	193
Current practice in patients with differentiated thyroid cancer	192
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver	191
The role of insufficient sleep and circadian misalignment in obesity	178
Environmental factors in declining human fertility	173
Lipid droplet biogenesis and functions in health and disease	153
Clinical application of intermittent fasting for weight loss: progress and future directions	142
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus	130
Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus	118

Metabolic pathways in obesity-related breast cancer	111
Paracetamol use during pregnancy — a call for precautionary action	109
Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement	109
Macrophage functional diversity in NAFLD — more than inflammation	108
Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations	105
Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD	102
Epigenetic inheritance of polycystic ovary syndrome — challenges and opportunities for treatment	101
The evolving view of thermogenic adipocytes — ontogeny, niche and function	99
The gut microbiota in obesity and weight management: microbes as friends or foe?	95
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions	92
International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers	91
The importance of the RET gene in thyroid cancer and therapeutic implications	91
Novel therapies with precision mechanisms for type 2 diabetes mellitus	89
Brain insulin signalling in metabolic homeostasis and disease	87
Aggressive pituitary tumours and pituitary carcinomas	80
Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1	80
Clinical aspects of multiple endocrine neoplasia type 1	77
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period	77
Metabolic implications of pancreatic fat accumulation	76
Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis	76
Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour	76
Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus	75
The physiological role of β-cell heterogeneity in pancreatic islet function	75
A global view of hypertensive disorders and diabetes mellitus during pregnancy	74
International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia	69
One hundred years of insulin therapy	69
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities	68
The multiple roles of life stress in metabolic disorders	67
Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges	66
Primary hypothyroidism and quality of life	66
Hormonal regulation of mammary gland development and lactation	66
Cellular and molecular features of EDC exposure: consequences for the GnRH network	65
The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism	63
Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease	61
Uterine bleeding: how understanding endometrial physiology underpins menstrual health	61
The G protein-coupled oestrogen receptor GPER in health and disease: an update	61
Hormonal regulation of biomineralization	61
Long-term and sequential treatment for osteoporosis	60
Interdisciplinary management of FGF23-related phosphate wasting syndromes: a Consensus Statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia	60
Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases	59
Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis	58
Management challenges and therapeutic advances in congenital adrenal hyperplasia	57
Global accessibility of therapeutics for diabetes mellitus	55
Treating menopause — MHT and beyond	55
Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis	54
The role of biomineralization in disorders of skeletal development and tooth formation	54
Metabolic disorders, COVID-19 and vaccine-breakthrough infections	52
Optoacoustic imaging in endocrinology and metabolism	50
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits	50
Primary aldosteronism — a multidimensional syndrome	48

Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?	47
Multikinase inhibitors in thyroid cancer: timing of targeted therapy	45
Advances in differential diagnosis and management of growth hormone deficiency in children	42
The role of regulated necrosis in endocrine diseases	42
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus	40
Modelling metabolic diseases and drug response using stem cells and organoids	40
Intermuscular adipose tissue in metabolic disease	40
Adrenal cortex renewal in health and disease	37
Long COVID — metabolic risk factors and novel therapeutic management	37
Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia	36
Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice	35
Heterogeneity and endotypes in type 1 diabetes mellitus	35
Skeletal and extraskeletal disorders of biomineralization	34
The interplay between diabetes mellitus and menopause: clinical implications	34
Exercise in adults with type 1 diabetes mellitus	33
Challenges in the care of transgender and gender-diverse youth: an endocrinologist’s view	31
Consensus Statement on the definition and classification of metabolic hyperferritinaemia	31
Insights into non-classic and emerging causes of hypopituitarism	30
The regulation of endocrine-disrupting chemicals to minimize their impact on health	30
Potential gut–brain mechanisms behind adverse mental health outcomes of bariatric surgery	30
Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities	30
How can social jetlag affect health?	30
Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation	30
Machine intelligence in non-invasive endocrine cancer diagnostics	29
X chromosome agents of sexual differentiation	29
The emerging osteo-metabolic phenotype of COVID-19: clinical and pathophysiological aspects	28
Strategies for modelling endometrial diseases	27
The role of ChREBP in carbohydrate sensing and NAFLD development	27
SGLT2 inhibitors in people with and without T2DM	27
The importance of metabolic dysfunction in polycystic ovary syndrome	26
Primary bilateral macronodular adrenal hyperplasia: definitely a genetic disease	26
Is there a role for the adrenal glands in long COVID?	25
Metabolic determinants of tumour initiation	25
Sarcopenic obesity in older adults: a clinical overview	24
Immune dysfunction in developmental programming of type 2 diabetes mellitus	23
Lactate as a major myokine and exerkine	22
Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?	22
Towards a better understanding of diabetes mellitus using organoid models	22
Insulin detection in diabetes mellitus: challenges and new prospects	21
Exosomes as novel biomarkers in metabolic disease and obesity-related cancers	21
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity	20
COVID-19 alters thinking and management in metabolic diseases	20
Adipose tissue in communication: within and without	20
Pituitary crosstalk with bone, adipose tissue and brain	19
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus	19
Progress in islet transplantation is more important than ever	19
Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity	19
High resolution 3D structures of mineralized tissues in health and disease	18
A spectacular year for islet and stem cell transplantation	18
Metabolism and exercise: the skeletal muscle clock takes centre stage	18
Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?	18
Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer	18
Diagnostic and therapeutic advances in neuroendocrine tumours	17
Severe COVID-19 outcomes — the role of physical activity	17
An integrated model of obesity pathogenesis that revisits causal direction	17
Improving clinical outcomes through attention to sex and hormones in research	16
Obesity-induced and weight-loss-induced physiological factors affecting weight regain	16
Endosomal trafficking in metabolic homeostasis and diseases	16
Applying the WHO global targets for diabetes mellitus	16
Emerging mechanisms of obesity-associated immune dysfunction	15
Genomic alterations in thyroid cancer: biological and clinical insights	15
Programming of metabolism by adipokines during development	15
Current and future pharmacotherapies for obesity in children and adolescents	14
The genetics of autoimmune Addison disease: past, present and future	14
Targeting the central melanocortin system for the treatment of metabolic disorders	14
The emerging evidence for non-skeletal health benefits of vitamin D supplementation in adults	14
SARS-CoV-2 fires up inflammation in adipose tissue	13
An individualized approach to the management of Cushing disease	13
Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement	13
The manifold roles of protein S-nitrosylation in the life of insulin	13
Kid influencers — a new arena of social media food marketing	12
Obesity and the kidney: mechanistic links and therapeutic advances	12
Adrenal cysts: an emerging condition	11
Weight stigma in healthcare settings is detrimental to health and must be eradicated	11
Is the association between diabetes mellitus and pulmonary fibrosis real?	11
Paracetamol use in pregnancy — caution over causal inference from available data	11
New anti-osteoporosis drug target identified	11
Clustering for a better prediction of type 2 diabetes mellitus	11
Taking a closer look at metabolically healthy obesity	11
High-intensity exercise training — too much of a good thing?	10

Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy	10
Drug resistance in pituitary tumours: from cell membrane to intracellular signalling	10
Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa?	10
The ageing thyroid: implications for longevity and patient care	9
Effects of pancreatic SARS-CoV-2 infection identified	9
Do diet and microbes really ‘PREDICT’ cardiometabolic risks?	8
Macrophage and T cell networks in adipose tissue	8
Author Correction: A perspective on treating type 1 diabetes mellitus before insulin is needed	8
The emerging role of lipidomics in prediction of diseases	8
The emerging role of incretins and twincretins	8
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification	8
Co-agonist therapeutics come of age for obesity	8
Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies	7
Glucose-lowering treatments and COVID-19 mortality in T2DM	7
From Wingspread to CLARITY: a personal trajectory	7
Metformin and GDF15: where are we now?	7
Isthmin 1 — a novel insulin-like adipokine	7
Metabolic regulation of skeletal cell fate and function	7
PCOS — a metabolic condition with health impacts on women and men	7
A view on vitamin D: a pleiotropic factor?	7
Targeting the incretin system in obesity and type 2 diabetes mellitus	7
Thyroid dysfunction in COVID-19	6
The importance of human brown adipose tissue volume	6
Accumulation of macrophages in adipose tissue	6
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action	6
Paracetamol use in pregnancy — neglecting context promotes misinterpretation	6
Sex differences for fasting levels of glucose and insulin: expanding our understanding	6
Is calorie labelling on menus the solution to obesity?	6
Origins of the ‘KNDy hypothesis’ of GnRH pulse generation	6
Protein tyrosine phosphatase 1B in metabolic diseases and drug development	6
Time-restricted feeding and circadian autophagy for long life	6
Post-operative radioactive iodine administration in patients with low-risk thyroid cancer	6
Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss	6
Key role for gut microbiota in PCOS development	5
Oxytocin deficiency — a ‘new’ human disorder?	5
TIM4+ adipose tissue-resident macrophages: new modulators of adiposity	5
Low brown adipose tissue activity linked to NAFLD	5
Tirzepatide highly effective for weight loss	5
Metabolic and feeding adjustments during pregnancy	5
Skeletal muscle weakness in hypothyroidism	5
Luteal phase support in assisted reproductive technology	5
Stem-cell derived pancreatic endoderm cells in the treatment of T1DM	5
How COVID-19 disrupts glycometabolic control	5
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism	5
Approaches to addressing the rise in obesity levels	5
Logic and mechanisms of metabolite signalling	5
Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy	5
Adipocytes enter the cell cycle in obesity	5
Type 1 diabetes mellitus and polycystic ovary syndrome	5
Advances in incretin-based therapeutics for obesity	5
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work	5
Statins and diabetes mellitus progression: a fly in the ointment?	5
Functional diversity of corticotropin-releasing hormone	5
Shortening the paths to type 1 diabetes mellitus prevention	5
Metabolic liver disease — what’s in a name?	5
Functional diversity of human adipose tissue revealed by spatial mapping	4
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus	4
Anatomical and functional heterogeneity of ‘hypothalamic’ peptidergic neuron populations	4
Detouring adrenergic stimulation to induce adipose thermogenesis	4
PPAR mediates intestinal stem cell tumorigenesis	4
Stem cell-derived islet therapy: is this the end of the beginning?	4
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit	4
Remission of T2DM requires early diagnosis and substantial weight reduction	4
Bone fragility in type 2 diabetes mellitus: a lot left to explore	4
Relugolix — new treatment for uterine fibroid-related heavy bleeding	4
Do psychedelics have therapeutic potential for obesity?	4
Reply to ‘Lactate as a major myokine and exerkine’	4
Pituitary stem cells: past, present and future perspectives	4
Melatonin prevents diabetes mellitus-induced bone loss	4
PDL1 reduces adipose inflammation in obesity	4
Autocrine FGF21 signalling promotes beiging	4
Autonomic dyshomeostasis in patients with diabetes mellitus during COVID-19	4
Late dumping syndrome or postprandial reactive hypoglycaemic syndrome after bariatric surgery	3
Diagnosis of gestational diabetes mellitus: the debate continues	3
Control loop designs in health and disease	3
Artificial intelligence in diabetes mellitus and endocrine diseases — what can we expect?	3
Endocrine disrupting chemicals are a threat to hormone health: a commentary on behalf of the ESE	3
Understanding the complexity of insulin resistance	3
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches	3
Research in metabolic ageing — a tale of mice versus humans?	3
Identification of thermogenic adipocyte lineages	3
T2DM remission — consensus on definition	3
Glucocorticoid-induced bone loss linked with marrow adipocyte senescence	3
Thyroid hormone action during development	3
Food odour recognition adjusts systemic metabolism to nutrient availability	3
New insights into β-cell failure, regeneration and replacement	3
Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications	3
Glucagon receptor antagonists might stimulate β-cell expansion	3
Unravelling the molecular basis of futile creatine cycling	3
Molecular transducers and the cardiometabolic benefits of exercise	3
The shift of therapeutic strategy for prolactinomas: surgery as the first-line option	3
HOTAIR underlies the region-specific development of adipose tissue	3
Service dog handlers in STEM: diversity and inclusion efforts need work to remove barriers	3
A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus	3
Health equity in endocrinology	3